1. Gene
  2. RIGI - RNA sensor RIG-I Gene

RIGI - RNA sensor RIG-I Gene

Homo sapiens

Also known as RIG1; DDX58; RIG-I; RLR-1; SGMRT2

Gene ID: 23586 | Gene type: protein coding

About RIGI

Cytogenetic location: 9p21.1 Genomic coordinates (GRCh38): 9:32,455,302-32,526,196 (from NCBI)

This gene has 10 transcripts (splice variants), 171 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in appendix (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a Caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the Antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

RIGI Products(7)

mRNA Protein Name
NM_001385907.1 NP_001372836.1 antiviral innate immune response receptor RIG-I isoform 2
NM_001385909.1 NP_001372838.1 antiviral innate immune response receptor RIG-I isoform 3
NM_001385910.1 NP_001372839.1 antiviral innate immune response receptor RIG-I isoform 4
NM_001385912.1 NP_001372841.1 antiviral innate immune response receptor RIG-I isoform 5
NM_001385913.1 NP_001372842.1 antiviral innate immune response receptor RIG-I isoform 6
NM_001385914.1 NP_001372843.1 antiviral innate immune response receptor RIG-I isoform 7
NM_014314.4 NP_055129.2 antiviral innate immune response receptor RIG-I isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP hydrolysis activity IMP
IMP: Inferred from mutant phenotype
19211564 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
21233210 GOA
enables RNA helicase activity IMP
IMP: Inferred from mutant phenotype
19211564 GOA
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
19576794 GOA
enables double-stranded RNA binding IMP
IMP: Inferred from mutant phenotype
19211564 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17190814 GOA
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
19576794 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16127453 GOA
enables single-stranded RNA binding IMP
IMP: Inferred from mutant phenotype
19211564 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
23950712 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
18243112 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RIG-I signaling pathway IDA
IDA: Inferred from direct assay
28469175 GOA
involved in RIG-I signaling pathway IMP
IMP: Inferred from mutant phenotype
19211564 GOA
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
28469175 GOA
involved in cellular response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
21957149 GOA
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
19576794 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
21478870 GOA
involved in detection of virus IDA
IDA: Inferred from direct assay
17079289 GOA
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
24409285 GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: Inferred from direct assay
24409285 GOA
involved in positive regulation of interferon-alpha production IDA
IDA: Inferred from direct assay
19576794 GOA
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
17079289 GOA
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
24409285 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21957149 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
24409285 GOA
involved in positive regulation of response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
21957149 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17079289 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
21957149 GOA
involved in regulation of cell migration IDA
IDA: Inferred from direct assay
19122199 GOA
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
19122199 GOA
located in bicellular tight junction IDA
IDA: Inferred from direct assay
19122199 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
15208624 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21102435 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
31006531 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
19122199 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIGI Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (247 - 416)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (672 - 733)

RIG-I_C-RD

RIG-I_C-RD: C-terminal domain of RIG-I (804 - 924)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 925 a.a.
Protein Preferred Names Protein Names

antiviral innate immune response receptor RIG-I

ATP-dependent RNA helicase DDX58

Recombinant RIGI Proteins

Cat. No. Product Name Accession Purity
HY-P72170 DDX58 Protein, Human (His) O95786 (M1-L430) ≥95%

Related Diseases

Diseases Alias
Singleton-Merten Syndrome 2

SGMRT2

Singleton-Merten Syndrome, Type 2

Singleton-Merten Syndrome

Singleton-Merten Dysplasia

Widened Medullary Cavities Of Bone, Aortic Calcification, Abnormal Dentition, And Muscular Weakness

Singleton Merten Syndrome

Merten-Singleton Syndrome

Sm Syndrome

Syndrome Of Widened Medullary Cavities Of The Metacarpals And Phalanges, Aortic Calcification And Abnormal Dentition

Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots

Stomatitis
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava

Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis

Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever

West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever

Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Mouth Disease

Mouth Diseases

Mouth Disorders

Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu

Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis

Rabies

Lyssa

Hydrophobia

St Hubert Disease

Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus

Severe Acute Respiratory Syndrome

Sars

Sars-Cov Infection

Sars-1

Sar Deficiency

Sars - [Severe Acute Respiratory Syndrome]

Rubella

German Measles

Three Day Measles

Rubella Nos

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus

Hepatitis E
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies

Psoriasis
Lassa Fever

Lf

Lassa Hemorrhagic Fever

Lf - [Lassa Fever]

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever

Junin Hemorrhagic Fever

Hemorrhagic Fever, Argentinian

Ahf - [Argentinian Haemorrhagic Fever]

Argentine Haemorrhagic Fever

Junin Haemorrhagic Fever

Herpangina

Vesicular Pharyngitis

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Bolivian Hemorrhagic Fever

Machupo Hemorrhagic Fever

Hemorrhagic Fever, Bolivian

Bhf - [Bolivian Haemorrhagic Fever]

Machupo Haemorrhagic Fever

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Zika Fever

Zika Virus Infection

Zika Virus Disease

Zika Virus

Zika Virus Fever

Mosquito-Borne Viral Fever, Zika

West Nile Encephalitis

West-Nile Encephalitis

West Nile Fever

West Nile Fever Encephalitis

West Nile Fever With Encephalitis

West-Nile Fever

Encephalitis, West Nile Fever

Hantavirus Pulmonary Syndrome

Hps

Four Corners Hantavirus

Hards

Hantavirus

Hantavirus-Associated Respiratory Distress Syndrome

Hanta Virus

Hantavirus Cardiopulmonary Syndrome

Hps - [Hantavirus Pulmonary Syndrome]

Hcps - [Hantavirus Cardiopulmonary Syndrome]

Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Poliomyelitis

Polio

Infantile Paralysis

Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Viral Encephalitis

Epidemic Encephalitis

Encephalitis Viral

Encephalitis, Arbovirus

Arbovirus Encephalitis

Postviral Encephalitis Nos

Equine Encephalitis

Tick-Borne Encephalitis

Viral Encephalitis Transmitted By Tick

Mosquito-Borne Encephalitis

Acute Haemorrhagic Encephalitis

Acute Idiopathic Encephalitis

Chronic Viral Encephalitis

Endemic Encephalitis

Subacute Viral Encephalitis

Viral Haemorrhagic Encephalitis

Viral Nonepidemic Encephalitis

Nonepidemic Encephalitis

Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos

Dengue Shock Syndrome

Dss

Dengue Hemorrhagic Fever

Severe Dengue

Dengue Haemorrhagic Fever

Dhf

Severe Dengue Haemorrhagic Fever

Severe Dengue Fever

Dengue Shock Syndrome

Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection

Dengue Disease

Dengue Fever

Dengue

Df

Dengue Shock Syndrome

Dengue Virus Infection

Breakbone Fever

Classic Dengue

Classical Dengue

Dengue Hemorrhagic Fever

Hemorrhagic Dengue

Philippine Hemorrhagic Fever

Singapore Hemorrhagic Fever

Thai Hemorrhagic Fever

Severe Dengue

Dengue Fever Without Warning Signs

Dengue Haemorrhagic Fever Grade 1

Dengue Haemorrhagic Fever Without Warning Signs

Bangkok Haemorrhagic Fever

Singapore Haemorrhagic Fever

Thailand Haemorrhagic Fever

Southeast Asia Haemorrhagic Fever

Dhf -[Dengue Haemorrhagic Fever]

Dengue Fever With Warning Signs

Dengue Haemorrhagic Fever With Warning Signs

Dengue Haemorrhagic Fever Grade 2

Philippine Haemorrhagic Fever

West Nile Fever
Hantavirus Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever, Russian

Hemorrhagic Nephrosonephritis

Hfrs

Puumala Virus Nephropathy

Hemorrhagic Fever With Renal Syndrome

Coronavirus Infectious Disease
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Atrial Septal Defect 8

ASD8

Atrial Heart Septal Defect 8

Septal Defect, Atrial, Type 8

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta RIGI VGNC VGNC:71672
Felis catus RIGI VGNC VGNC:61418
Mus musculus RIGI MGD MGI:2442858
Canis familiaris RIGI VGNC VGNC:39867
Rattus norvegicus RIGI RGD RGD:1309460
Bos taurus RIGI VGNC VGNC:27979
Others RIGI NCBI