2. Gene
  3. MIP - major intrinsic protein of lens fiber Gene

MIP - major intrinsic protein of lens fiber Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AQP0; LIM1; MP26; MIP26; CTRCT15

Gene ID: 4284 | Gene type: protein coding

About MIP

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,449,502-56,456,553 (from NCBI)

This gene has 4 transcripts (splice variants), 271 orthologues, 11 paralogues and is associated with 8 phenotypes. Low expression observed in reference dataset.

Summary

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]

MIP Products(1)

mRNA Protein Name
NM_012064.4 NP_036196.1 lens fiber major intrinsic protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables water channel activity IDA
IDA: Inferred from direct assay
24120416 GOA
Biological Process GO Annotation Evidence Reference Source
involved in gap junction-mediated intercellular transport IDA
IDA: Inferred from direct assay
24120416 GOA
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
24120416 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
24120416 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24120416 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
24120416 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIP Protein Structure

MIP

MIP: Major intrinsic protein (3 - 219)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

lens fiber major intrinsic protein

aquaporin 0

MIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MIP P30301 FKBP1A Homo sapiens Q0VDC6
Validated Y2H
32814053
Intra MIP P30301 FKBP1A Homo sapiens Q0VDC6
Y2H Pooling
32814053
Intra MIP P30301 FKBP1A Homo sapiens Q0VDC6
Y2H Array
32814053
Intra MIP P30301 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra MIP P30301 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra MIP P30301 RELL2 Homo sapiens Q8NC24
Validated Y2H
32296183
Intra MIP P30301 MRM3 Homo sapiens Q9HC36
Validated Y2H
32296183
Intra MIP P30301 MRM3 Homo sapiens Q9HC36
Y2H Array
32296183
Intra MIP P30301 MRM3 Homo sapiens Q9HC36
Y2H Prey Pooling
32296183
Intra MIP P30301 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra MIP P30301 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra MIP P30301 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra MIP P30301 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra MIP P30301 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra MIP P30301 SYAP1 Homo sapiens Q96A49
Validated Y2H
32296183
Intra MIP P30301 SYAP1 Homo sapiens Q96A49
Y2H Array
32296183
Intra MIP P30301 SYAP1 Homo sapiens Q96A49
Y2H Prey Pooling
32296183
Intra MIP P30301 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra MIP P30301 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra MIP P30301 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra MIP P30301 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra MIP P30301 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra MIP P30301 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra MIP P30301 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra MIP P30301 STX2 Homo sapiens P32856-2
Validated Y2H
32296183
Intra MIP P30301 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra MIP P30301 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra MIP P30301 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra MIP P30301 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
Intra MIP P30301 TMEM154 Homo sapiens Q6P9G4
Validated Y2H
32296183
Intra MIP P30301 TMEM154 Homo sapiens Q6P9G4
Y2H Array
32296183
Intra MIP P30301 TMEM154 Homo sapiens Q6P9G4
Y2H Prey Pooling
32296183
Intra MIP P30301 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra MIP P30301 TM4SF18 Homo sapiens Q96CE8
Validated Y2H
32296183
Intra MIP P30301 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra MIP P30301 FCGR2A Homo sapiens P12318-2
Y2H Prey Pooling
32296183
Intra MIP P30301 FCGR2A Homo sapiens P12318-2
Y2H Array
32296183
Intra MIP P30301 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra MIP P30301 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra MIP P30301 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra MIP P30301 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra MIP P30301 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra MIP P30301 AQP9 Homo sapiens O43315
Y2H Array
32296183
Intra MIP P30301 AQP9 Homo sapiens O43315
Y2H Prey Pooling
32296183
Intra MIP P30301 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra MIP P30301 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra MIP P30301 SLC18A1 Homo sapiens P54219-3
Validated Y2H
32296183
Intra MIP P30301 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra MIP P30301 ERVFRD-1 Homo sapiens P60508
Validated Y2H
32296183
Intra MIP P30301 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra MIP P30301 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra MIP P30301 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra MIP P30301 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra MIP P30301 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra MIP P30301 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra MIP P30301 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra MIP P30301 CLDN5 Homo sapiens O00501
Y2H Prey Pooling
32296183
Intra MIP P30301 CLDN5 Homo sapiens O00501
Y2H Array
32296183
Intra MIP P30301 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra MIP P30301 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra MIP P30301 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra MIP P30301 SLC14A1 Homo sapiens Q13336-2
Y2H Prey Pooling
32296183
Intra MIP P30301 SLC14A1 Homo sapiens Q13336-2
Validated Y2H
32296183
Intra MIP P30301 SLC14A1 Homo sapiens Q13336-2
Y2H Array
32296183
Intra MIP P30301 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra MIP P30301 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra MIP P30301 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra MIP P30301 LRP10 Homo sapiens Q7Z4F1
Y2H Prey Pooling
32296183
Intra MIP P30301 LRP10 Homo sapiens Q7Z4F1
Validated Y2H
32296183
Intra MIP P30301 LRP10 Homo sapiens Q7Z4F1
Y2H Array
32296183
Intra MIP P30301 ATP6V0B Homo sapiens Q99437
Y2H Prey Pooling
32296183
Intra MIP P30301 ATP6V0B Homo sapiens Q99437
Y2H Array
32296183
Intra MIP P30301 ATP6V0B Homo sapiens Q99437
Validated Y2H
32296183
Intra MIP P30301 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra MIP P30301 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra MIP P30301 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra MIP P30301 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra MIP P30301 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra MIP P30301 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra MIP P30301 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra MIP P30301 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra MIP P30301 SYT1 Homo sapiens P21579
Y2H Array
32296183
Intra MIP P30301 SYT1 Homo sapiens P21579
Y2H Prey Pooling
32296183
Intra MIP P30301 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra MIP P30301 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra MIP P30301 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra MIP P30301 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra MIP P30301 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra MIP P30301 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra MIP P30301 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra MIP P30301 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra MIP P30301 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra MIP P30301 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra MIP P30301 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra MIP P30301 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra MIP P30301 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra MIP P30301 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra MIP P30301 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra MIP P30301 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra MIP P30301 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra MIP P30301 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra MIP P30301 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra MIP P30301 MRPS18B Homo sapiens Q9Y676
Validated Y2H
32296183
Intra MIP P30301 MRPS18B Homo sapiens Q9Y676
Y2H Prey Pooling
32296183
Intra MIP P30301 MRPS18B Homo sapiens Q9Y676
Y2H Array
32296183
Intra MIP P30301 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra MIP P30301 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra MIP P30301 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra MIP P30301 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra MIP P30301 SYT2 Homo sapiens Q8N9I0
Validated Y2H
32296183
Intra MIP P30301 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cataract 15, Multiple Types

CTRCT15

Cataract 15 Multiple Types

Cataract, Type 15, Multiple Types
Cataract 7

Cca1

CTRCT7

Cerulean Cataract

Cataract 7, Cerulean Type

Cataract, Congenital, Cerulean Type, 1

Cerulean Type Cataract 7

Congenital Cerulean Type Cataract 1

Cataract, Congenital, Blue Dot Type 1

Cataract, Congenital, Cerulean Type 1

Blue-Dot Cataract
Early-Onset Sutural Cataract

Early-Onset Cataract With Y-Shaped Suture Opacities
Early-Onset Posterior Polar Cataract
Early-Onset Lamellar Cataract
Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44
Early-Onset Nuclear Cataract
Brain Edema

Cerebral Edema

Intracranial Swelling

Wet Brain
Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus

Diabetes Insipidus, Nephrogenic

Diabetes Insipidus Nephrogenic

Congenital Nephrogenic Diabetes Insipidus

Adh Resistant Diabetes Insipidus

Diabetes Insipidus Nephrogenic X-Linked

Diabetes Insipidus Nephrogenic Type 1

Adh-Resistant Diabetes Insipidus

Diabetes Insipidus Renalis

Ndi

Renal Diabetes Insipidus

Familial Nephrogenic Diabetes

Antidiuretic-Hormone-Resistant Diabetes Insipidus

Adiuretin-Resistant Diabetes Insipidus

Ndi - [Nephrogenic Diabetes Insipidus]

Diabetes Tenuifluus

Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

Hereditary Nephrogenic Diabetes Insipidus

Familial Nephrogenic Diabetes Insipidus

Primary Nephrogenic Diabetes Insipidus
Presbyopia

Subnormal Accommodation

Accommodation Insufficiency Of Old Age
Eye Accommodation Disease
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Diabetes Insipidus
Hydrarthrosis
Priapism

Mentulagra

Priapism, Familial Idiopathic

Familial Idiopathic Priapism

Pathologic Erection

Painful Erection
Meniere Disease

Meniere'S Disease

Otogenic Vertigo

Ménière Disease

Ménière'S Disease

Mnire'S Vertigo

Auditory Vertigo

Aural Vertigo

Meniere'S Syndrome

Ménière'S Vertigo

Primary Endolymphatic Hydrops

Menieres Disease

Vertigo, Aural

Labyrinth Hydrops

Labyrinthine Hydrops

Labyrinthine Vertigo

Ménière Syndrome

Ménière Vertigo

Idiopathic Endolymphatic Hydrops
Mature Cataract

Total Or Mature Cataract

Total, Mature Senile Cataract
Intraocular Pressure Quantitative Trait Locus

Glaucoma

IOPQTL

Glaucoma, Susceptibility To

Postinfectious Glaucoma

Glaucoma With Ocular Inflammation

Glaucoma Secondary To Eye Inflammation

Traumatic Glaucoma

Glaucoma With Concussion Of Globe

Glaucoma Due To Ocular Trauma

Glaucoma Associated With Ocular Trauma

Glaucoma Secondary To Drugs
Lens Disease

Lens Diseases
Diabetic Cataract

Cataract - Diabetic
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Inner Ear Disease

Labyrinthine Dysfunction

Diseases Of Inner Ear

Labyrinthine Disease

Abnormality Of The Inner Ear

Labyrinth Diseases

Labyrinthine Disorder

Nonfunctioning Labyrinth

Labyrinthine Loss Of Function

Labyrinthine Syndrome

Labyrinthine Disorder Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.53% Phase 3
HY-B0155 Vicriviroc / Phase 3
HY-19974 TAK-220 99.95% Phase 1
Pre-clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139644 MIPS521 Agonist 98.21% Unkown
HY-156371 MIPS-21335 Inhibitor 99.61% Unkown
HY-149650 TLR4 agonist-1 Agonist / Unkown
HY-P4191 Met-RANTES (human) Antagonist / Unkown
HY-P4200 Lugdunin Inhibitor 95.44% Unkown
HY-123733 MIP-1095 Inhibitor / Unkown
HY-123733A MIP-1095 TFA / Unkown
HY-129615 MIP-1072 Inhibitor / Unkown
HY-149650A TLR4 agonist-1 TEA Agonist / Unkown
HY-149861 Mip-IN-1 / Unkown
HY-15544 CCR1 antagonist 10 Antagonist / Unkown
HY-161901 BC-1293 Inhibitor / Unkown
HY-B0155B Vicriviroc malate / Unkown
HY-RS08460 MIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W014081 Ethyl 3-coumarincarboxylate 99.79% Unkown
HY-103360B trans-J-113863 Antagonist / Unkown
HY-120265 MIPS-9922 Inhibitor / Unkown
HY-123661 MIPS1455 / Unkown
HY-168149 Mip-IN-2 Inhibitor / Unkown
HY-P4191A Met-RANTES (human) (acetate) Antagonist 99.62% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MIP MGD MGI:96990
Rattus norvegicus MIP RGD RGD:3090
Felis catus MIP VGNC VGNC:68259
Macaca mulatta MIP VGNC VGNC:74872
Canis familiaris MIP VGNC VGNC:43241
Bos taurus MIP VGNC VGNC:31482
Others MIP NCBI