1. Gene
  2. INSR - insulin receptor Gene

INSR - insulin receptor Gene

Homo sapiens

Also known as HHF5; CD220

Gene ID: 3643 | Gene type: protein coding

About INSR

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,112,265-7,294,414 (from NCBI)

This gene has 7 transcripts (splice variants), 289 orthologues, 53 paralogues and is associated with 10 phenotypes. Ubiquitous expression in kidney (RPKM 16.5), spleen (RPKM 15.9) and 25 other tissues.

Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of Insulin or Other ligands to this receptor activates the Insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe Insulin resistance syndromes including type A Insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

INSR Products(4)

mRNA Protein Name
XM_011527988.3 XP_011526290.2 insulin receptor isoform X1
NM_001079817.3 NP_001073285.1 insulin receptor isoform Short preproprotein
NM_000208.4 NP_000199.2 insulin receptor isoform Long preproprotein
XM_011527989.4 XP_011526291.2 insulin receptor isoform X2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
6849137 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
9092559 GOA
enables PTB domain binding IPI
IPI: Inferred from physical interaction
7559478 GOA
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
19406747 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16957736 GOA
enables insulin binding IDA
IDA: Inferred from direct assay
8440175 GOA
enables insulin binding IPI
IPI: Inferred from physical interaction
8452530 GOA
enables insulin receptor activity IDA
IDA: Inferred from direct assay
6849137 GOA
enables insulin receptor substrate binding IPI
IPI: Inferred from physical interaction
7493946 GOA
enables insulin-like growth factor I binding IPI
IPI: Inferred from physical interaction
8452530 GOA
enables insulin-like growth factor II binding IPI
IPI: Inferred from physical interaction
12138094 GOA
enables insulin-like growth factor receptor binding IDA
IDA: Inferred from direct assay
8452530 GOA
enables phosphatidylinositol 3-kinase binding IPI
IPI: Inferred from physical interaction
7537849 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7493946 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
16246733 GOA
enables protein kinase activator activity IMP
IMP: Inferred from mutant phenotype
9819385 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8496180 GOA
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
7537849 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
19406747 GOA
enables structural molecule activity IDA
IDA: Inferred from direct assay
1898103 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9092559 GOA
involved in activation of protein kinase B activity IDA
IDA: Inferred from direct assay
7556070 GOA
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
8440175 GOA
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
7693131 GOA
involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
7693131 GOA
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
6849137 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
8496180 GOA
involved in positive regulation of D-glucose import IDA
IDA: Inferred from direct assay
3518947 GOA
acts upstream of positive regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
17001305 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
20455999 GOA
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
11500939 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
12138094 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17925406 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12138094 GOA
involved in positive regulation of developmental growth IMP
IMP: Inferred from mutant phenotype
7693131 GOA
involved in positive regulation of glycogen biosynthetic process IDA
IDA: Inferred from direct assay
17925406 GOA
involved in positive regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
7693131 GOA
involved in positive regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
11500939 GOA
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
10747347 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
11500939 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
7556070 GOA
involved in positive regulation of receptor internalization IDA
IDA: Inferred from direct assay
25401701 GOA
involved in positive regulation of respiratory burst IDA
IDA: Inferred from direct assay
9092559 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
6849137 GOA
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
7537849 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12881524 GOA
involved in regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
7693131 GOA
involved in symbiont entry into host cell IMP
IMP: Inferred from mutant phenotype
17001305 GOA
Cellular Component GO Annotation Evidence Reference Source
located in caveola IDA
IDA: Inferred from direct assay
15182363 GOA
part of insulin receptor complex IDA
IDA: Inferred from direct assay
1898103 GOA
part of insulin receptor complex IMP
IMP: Inferred from mutant phenotype
15069075 GOA
located in membrane IDA
IDA: Inferred from direct assay
8452530 GOA
colocalizes with nuclear envelope IDA
IDA: Inferred from direct assay
19406747 GOA
colocalizes with nuclear lumen IDA
IDA: Inferred from direct assay
19406747 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
9092559 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSR Protein Structure

Recep_L_domain

Recep_L_domain: Receptor L domain (52 - 163)

Furin-like

Furin-like: Furin-like cysteine rich region (179 - 340)

Recep_L_domain

Recep_L_domain: Receptor L domain (359 - 469)

fn3

fn3: Fibronectin type III domain (863 - 936)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (1023 - 1290)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1382 a.a.
Protein Preferred Names Protein Names

insulin receptor

IR

INSR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
INSR P06213 DUSP18 Homo sapiens Q8NEJ0
Anti Tag CoIP
28065597
Intra
INSR P06213 PTPRR Homo sapiens Q15256
Anti Tag CoIP
28065597
Intra
INSR P06213 AGAP2 Homo sapiens Q99490
Anti Tag CoIP
21720388
Intra
INSR P06213 PTPN11 Homo sapiens Q06124
BioID
35384245
Intra
INSR P06213 SH2B1 Homo sapiens Q9NRF2
CoIP
9742218
Intra
INSR P06213 SH2B1 Homo sapiens Q9NRF2
Y2H
9742218
Intra
INSR P06213 PTPRK Homo sapiens Q15262
Phosphatase Assay
19167335
Intra
INSR P06213 IGF1R Homo sapiens P08069
Affinity Chrom
35384245
Intra
INSR P06213 IGF1R Homo sapiens P08069
BioID
35384245
Intra
INSR P06213 IGF1R Homo sapiens P08069
Anti Tag CoIP
35384245
Intra
INSR P06213 IRS1 Homo sapiens P35568
Anti Tag CoIP
16582879
Intra
INSR P06213 IRS1 Homo sapiens P35568
Y2H
7935368
Intra
INSR P06213 INSRR Homo sapiens P14616
Affinity Chrom
35384245
Intra
INSR P06213 INSRR Homo sapiens P14616
Anti Tag CoIP
35384245
Intra
INSR P06213 IGF1 Homo sapiens P05019
Competition Binding
8452530
Intra
INSR P06213 PLCG1 Homo sapiens P19174
CoIP
9593725
Intra
INSR P06213 PLCG1 Homo sapiens P19174
CoIP
14568990
Intra
INSR P06213 PIK3R1 Homo sapiens P27986
FRET
10500481
Intra
INSR P06213 PIK3R1 Homo sapiens P27986
Affinity Chrom
35384245
Intra
INSR P06213 PIK3R1 Homo sapiens P27986
BioID
35384245
Intra
INSR P06213 GRB10 Homo sapiens Q13322
Protein 3 Hybrid
9506989
Intra
INSR P06213 GRB10 Homo sapiens Q13322
Y2H
9506989
Intra
INSR P06213 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
INSR P06213 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
INSR P06213 PTPN1 Homo sapiens P18031
CoIP
11579209
Intra
INSR P06213 PTPN1 Homo sapiens P18031
CoIP
8999839
Intra
INSR P06213 PTPN1 Homo sapiens P18031
BiFC
17092689
Intra
INSR P06213 PTPN1 Homo sapiens P18031
Phosphatase Assay
17159996
Intra
INSR P06213 PTPN1 Homo sapiens P18031
Phosphatase Assay
15588987
Intra
INSR P06213 PTPN1 Homo sapiens P18031
BRET
12634852
Intra
INSR P06213 PTPN1 Homo sapiens P18031
Phosphatase Assay
11163213
Intra
INSR P06213 PTPN1 Homo sapiens P18031
Genetic Interference
8702689
Intra
INSR P06213 PTPN1 Homo sapiens P18031
X-Ray Diffraction
11163213
Intra
INSR P06213 PTPN1 Homo sapiens P18031
Phosphatase Assay
17481567
Intra
INSR P06213 PTPN1 Homo sapiens P18031
Phosphatase Assay
21806020
Intra
INSR P06213 PTPN1 Homo sapiens P18031
Anti Bait CoIP
14722096
Intra
INSR P06213 PTPN1 Homo sapiens P18031
BioID
35384245
Intra
INSR P06213 PTPN1 Homo sapiens P18031
FRET
14722096
Cross
INSR P06213 INS Bos taurus P01317
Competition Binding
8452530
Cross
INSR P06213 Irs1 Rattus norvegicus P35570
Phosphatase Assay
17135270
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INSR Proteins

Cat. No. Product Name Accession Purity
HY-P73244 Insulin R/CD220 Protein, Human (sf9, His-GST) P06213-1/NP_000199.2 (G989-S1382) ≥95%
HY-P73873 Insulin R/CD220 Protein, Human (HEK293, His, solution) P06213-1 (H28-K956) ≥95%
HY-P77515 Insulin R/CD220 Protein, Human (Biotinylated, HEK293, His) P06213-1 (H28-K956) ≥95%

Related Diseases

Diseases Alias
Hypertrichosis
Gestational Diabetes

Gestational Diabetes Mellitus

GDM

Diabetes Mellitus Arising In Pregnancy

Maternal Gestational Diabetes Mellitus

Diabetes Mellitus, Gestational

Diabetes Mellitus, Pregnancy Related

Diabetes, Pregnancy-Induced

Diabetes Gestational

Diabetes, Gestational

Diabetes Of Pregnancy

Gdm - [Gestational Diabetes Mellitus]

Gestational Diabetes Mellitus Nos

Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Myotonic Dystrophy 2

Myotonic Dystrophy Type 2

Proximal Myotonic Myopathy

Promm

Ricker Syndrome

DM2

Dystrophia Myotonica 2

Myotonic Myopathy, Proximal

Myotonic Disorders

Dystrophia Myotonica Type 2

Proximal Myotonic Dystrophy

Ricker Disease

Myotonic Dystrophy, Type 2

Dystrophy, Myotonic, Type 2

Hyperinsulinemic Hypoglycemia

Nesidioblastosis

Islet Cell Hyperplasia

Persistent Hyperinsulinemia Hypoglycemia Of Infancy

Hyperinsulinemic Hypoglycaemia

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome

Pcos

Polycystic Ovaries

Stein-Leventhal Syndrome

Multicystic Ovaries

Polycystic Ovarian Disease

Polycystic Ovary

Sclerocystic Ovaries

Sclerocystic Ovary Syndrome

Stein-Leventhal Synd.

Cystic Disease Of Ovaries

Cystic Disease Of Ovary

Pco

Pcod

Sclerocystic Ovarian Degeneration

Polycystic Ovary Syndrome, Susceptibility To

Pcos - [Polycystic Ovary Syndrome]

Polycystic Ovary Nos

Pco - [Polycystic Ovary]

Ovarian Disease

Ovarian Dysfunction

Ovarian Diseases

Ovarian Disorders

Disorder Of Endocrine Ovary

Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities

Rabson-Mendenhall Syndrome

Mendenhall Syndrome

Pineal Hyperplasia And Diabetes Mellitus Syndrome

RMS

Leprechaunism

Insr-Related Severe Syndromic Insulin Resistance

Donohue Syndrome

Werner Syndrome

Werner'S Syndrome

WRN

Adult Progeria

Ws

Adult Premature Ageing Syndrome

Adult Premature Aging Syndrome

Werners Syndrome

Donohue Syndrome

Leprechaunism

Leprechaunism Syndrome

Donohue'S Syndrome

LEPRCH

Myotonic Disease

Myotonic Disorders

Myotonic Syndrome

Symptomatic Myotonia

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Insulin-Like Growth Factor I

Insulin-Like Growth Factor I Deficiency

IGF1 DEFICIENCY

Insulin-Like Growth Factor I, Resistance To

Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor I Resistance

IGF1RES

Igf-I Resistance

Growth Retardation With Sensorineural Deafness And Mental Retardation

Somatomedin, End-Organ Insensitivity To

Somatomedin-C

Somatomedin-C, Resistance To

Insulin-Like Growth Factor 1 Resistance To

Igf-1 Resistance

Somatomedin End-Organ Insensitivity To

Somatomedin-C Resistance To

Growth Delay-Deafness-Intellectual Disability Syndrome

Growth Delay-Hearing Loss-Intellectual Disability Syndrome

Igf-1 Deficiency

Primary Insulin-Like Growth Factor Deficiency

Resistance To Igf-1

Insulin-Like Growth Factor 1 Resistance

End-Organ Insensitivity To Somatomedin

Igf1 Resistance

Resistance To Insulin-Like Growth Factor I

Resistance To Somatomedin-C

Insulin-Like Growth Factor 1, Resistance To

Lipid Metabolism Disorder

Dyslipidemia

Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors

Dyslipidemias

Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism

Glucose Intolerance

Glucose: Intolerance

Glucose: Malabsorption

Malabsorption Of Glucose

Impaired Glucose Tolerance

Hyperinsulinism

Hyperinsulinemia

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency

HHF5

Familial Hyperinsulinemic Hypoglycemia 5

Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

Congenital Hyperinsulinism

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

Hyperinsulinemic Hypoglycemia Familial 5

Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy

Acanthosis Nigricans

Keratosis Nigricans

An

Diabetes Mellitus, Insulin-Resistant, With Acanthosis Nigricans

Insulin-Resistant Diabetes Mellitus And Acanthosis Nigricans

Iran, Type A

Type A Insulin Resistance Syndrome

Insulin Resistance - Type A

Insulin-Resistance Syndrome Type A

Insulin Receptor, Defect In, With Insulin-Resistant Diabetes Mellitus And Acanthosis Nigricans

Diabetes Mellitus, Insulin-Resistant, With Acanthosis Nigricans, Type A

Insulin-Resistant Acanthosis Nigricans, Type A

Extreme Insulin Resistance With Acanthosis Nigricans, Hirsutism And Abnormal Insulin Receptors

Insulin Resistance Syndrome, Type A

Type A Insulin Resistance

Insulin-Resistant Diabetes Mellitus With Acanthosis Nigricans Type A

IRAN TYPE A

Myopathy, Congenital, With Fiber-Type Disproportion

CFTD

Fiber-Type Disproportion Myopathy, Congenital

Cftdm

Myopathy, Congenital, With Fiber-Type Disproportion 1

Congenital Fiber-Type Disproportion Myopathy

Myopathy, Congenital, With Fiber Type Disproportion

Fetal Macrosomia
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Hyperandrogenism

Hyperandrogenization Syndrome

Disorder Of Sexual Development

Disorder Of Sex Development

Sex Development Disorder

Sex Differentiation Disease

Dsd

Disorders Of Sex Development

Sex Differentiation Disorders

Hyperinsulinemic Hypoglycemia, Familial, 4

Hyperinsulinism Due To Glutamodehydrogenase Deficiency

HHF4

Familial Hyperinsulinemic Hypoglycemia 4

Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

Hyperinsulinism Due To Schad Deficiency

Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

Congenital Hyperinsulinism

Schad Deficiency

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2

Vagus Nerve Disease

Vagus Nerve Diseases

Disorder Of Pneumogastric [10th] Nerve

Disorder Of Vagal Nerve

Disorder Of Vagus Nerve

Vagus Nerve Disorder

Disorders Of The Tenth Cranial Nerve

Disorders Of 10th Cranial Nerve

Disorder Of Pneumogastric Nerve

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Fatty Liver Disease

Alcoholic Fatty Liver

Fatty Liver

Fatty Liver, Alcoholic

Fatty Change Of Liver

Hepatic Lipidosis

Steatosis Of Liver

Fatty Liver Alcoholic

Steatohepatitis

Etoh Fatty Liver

Etoh Fatty Liver Metamorphosis

Fatty Etoh Liver Necrosis

Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure

Diabetes Mellitus

Diabetes

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Liver Cirrhosis

Cirrhosis

Cirrhosis Of Liver

CIRRH

Cryptogenic Cirrhosis

Cirrhosis, Cryptogenic

Cirrhosis Nos

Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset

Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash

Prediabetes Syndrome

Impaired Glucose Tolerance

Prediabetes

Prediabetic State

IGT

Igt - [Impaired Glucose Tolerance]

Impaired Glucose Tolerance With Unspecified Complication

Impaired Glucose Tolerance Without Complication

Abnormal Glucose Tolerance

Migraine With Aura

Classic Migraine

Migraine With Typical Aura

Migraine Accompagnée

Complicated Migraine

Classical Migraine

Acute Migraine With Aura

Hyperglycemia
Pigmentation Disease

Pigmentation Disorders

Skin Pigmentation Disorder

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Insulin-Dependent Diabetes Mellitus

Type 1 Diabetes

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications

Hypoglycemia

Hypoglycaemia

Low Blood Sugar

Hypoglycaemia Nos

Spontaneous Hypoglycaemia

Nondiabetic Hypoglycaemia

Hypoglycaemic Disorder Nos

Hypoglycaemic Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus INSR RGD RGD:2917
Bos taurus INSR VGNC VGNC:30221
Canis familiaris INSR VGNC VGNC:42043
Felis catus INSR VGNC VGNC:67811
Mus musculus INSR MGD MGI:96575
Others INSR NCBI