2. Gene
  3. SCLY - selenocysteine lyase Gene

SCLY - selenocysteine lyase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SCL; hSCL

Gene ID: 51540 | Gene type: protein coding

About SCLY

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,061,001-238,099,413 (from NCBI)

This gene has 21 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 6.4), liver (RPKM 4.7) and 25 other tissues.

Summary

Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]

SCLY Products(1)

mRNA Protein Name
NM_016510.7 NP_057594.5 selenocysteine lyase
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCLY Protein Structure

Aminotran_5

Aminotran_5: Aminotransferase class-V (40 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

selenocysteine lyase

SCLY Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SCLY Q96I15 LNX2 Homo sapiens Q8N448
Y2H Array
29892012
Intra
SCLY Q96I15 LNX2 Homo sapiens Q8N448
Y2H Array
31515488
Intra
SCLY Q96I15 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCLY Proteins

Cat. No. Product Name Accession Purity
HY-P71280 SCLY Protein, Human (His) Q96I15-1 (M1-A445) ≥95%

Related Diseases

Diseases Alias
Glomerulonephritis

Bright'S Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17474 Parecoxib Inhibitor 99.29% Yes
HY-B0455 Lomefloxacin hydrochloride Inhibitor 99.84% Unkown
HY-17474A Parecoxib Sodium Inhibitor 99.94% Yes
HY-B0318A Metronidazole hydrochloride / Unkown
HY-B0455B Lomefloxacin (aspartate) Inhibitor / Unkown
HY-B0561R Spironolactone (Standard) 98.55% Unkown
HY-B0455A Lomefloxacin Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99590 Sotatercept 99.61% Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-132587 Fitusiran Inhibitor / Phase 3
HY-16012A Domatinostat 99.43% Phase 2
HY-16012 Domatinostat tosylate 99.66% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-100934 SC-9 Activator / Phase 2
HY-19500 SC-75416 Inhibitor / Phase 2
HY-19897 4SC-203 Inhibitor 98.98% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99886 Pexelizumab Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (98)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18749 SC79 Activator ≥98.0% Unkown
HY-10496 SC75741 Inhibitor 99.51% Unkown
HY-107410 SC-26196 Inhibitor 99.68% Unkown
HY-145799 5A2-SC8 Chemical 99.19% Unkown
HY-148559 4A3-SC8 99.21% Unkown
HY-15614 SC144 98.50% Unkown
HY-136657 SC-43 99.02% Unkown
HY-59105 SC-560 Inhibitor 99.79% Unkown
HY-145758 FEN1-IN-SC13 Inhibitor 98.21% Unkown
HY-103226 SC-57461A Inhibitor 99.89% Unkown
HY-19832 SC66 99.47% Unkown
HY-13802 SC-514 Inhibitor 99.89% Unkown
HY-W010983 SC-236 99.56% Unkown
HY-124876 SynuClean-D 99.89% Unkown
HY-15614A SC144 hydrochloride 99.34% Unkown
HY-161409 SC912 99.13% Unkown
HY-126681 SC-VC-PAB-MMAE 99.29% Unkown
HY-129982 SC-435 98.73% Unkown
HY-18086 TCS PIM-1 1 Inhibitor 98.01% Unkown
HY-144880 SC209 Inhibitor 99.52% Unkown
HY-Y0079 D-Phenylalanine 99.93% Unkown
HY-132306 CCF0058981 Inhibitor 98.02% Unkown
HY-100931 SC-10 Activator 98.65% Unkown
HY-108563A SC 51089 free base Antagonist 98.64% Unkown
HY-131236 EBNA1-IN-SC7 99.92% Unkown
HY-P0323A GP(33-41) TFA Inhibitor 99.62% Unkown
HY-108562 SC-51322 Antagonist 98.90% Unkown
HY-124858 SC99 98.96% Unkown
HY-164373 SC428 ≥98.0% Unkown
HY-W013164 SC-58125 Inhibitor 99.92% Unkown
HY-155656 Anti-inflammatory agent 49 Inhibitor 98.26% Unkown
HY-W028047 JFD01307SC Inhibitor ≥98.0% Unkown
HY-102065 SC-19220 Antagonist 99.71% Unkown
HY-138865 BiCAPPA 98.35% Unkown
HY-158031 PLK1/BRD4-IN-5 99.55% Unkown
HY-148402 p53 Activator 3 Activator 98.35% Unkown
HY-148404 p53 Activator 5 Activator 98.43% Unkown
HY-148528 SC-VC-PAB-N-Me-L-Ala-Maytansinol 98.16% Unkown
HY-N9319 Fulvotomentoside A 98.94% Unkown
HY-47968 SC209 intermediate-1 ≥96.0% Unkown
HY-118827 Vedaprofen Inhibitor 99.81% Unkown
HY-108563 SC 51089 Antagonist / Unkown
HY-126693 SC-VC-PAB-DM1 97.04% Unkown
HY-W009934 2-Phenyl-2-(2-pyridyl)acetonitrile 99.97% Unkown
HY-120113 SC-2001 / Unkown
HY-U00129 SC57666 Inhibitor 98.94% Unkown
HY-U00232 Bidisomide 99.62% Unkown
HY-100857 PrPSc-IN-1 / Unkown
HY-14398GL Celecoxib (GMP Like) Inhibitor / Unkown
HY-148194 SC239 99.97% Unkown
HY-14908A Vidofludimus hemicalcium / Unkown
HY-105052 SC 34301 / Unkown
HY-106395A (Rac)-Telinavir Inhibitor / Unkown
HY-112739 SC-41930 Agonist / Unkown
HY-114857 Clofencet / Unkown
HY-117896 SC-50605 Antagonist / Unkown
HY-118795 SC-22716 Inhibitor / Unkown
HY-120776 SC-51316 Antagonist / Unkown
HY-121598 Actisomide Inducer / Unkown
HY-122134 SC-58272 Inhibitor / Unkown
HY-123229 Ropizine / Unkown
HY-124775 (S)-C33 Inhibitor 99.46% Unkown
HY-125494 Droxinavir hydrochloride Inhibitor / Unkown
HY-126667 SC-Val-Cit-PAB / Unkown
HY-129782 SC-55858 / Unkown
HY-139678 SC13 Agonist / Unkown
HY-156271 Tubulin polymerization-IN-52 Inhibitor / Unkown
HY-162791 (1s,4s)-C1-Piperidine-C1-cyclohexane-C1 / Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-168730 Anticancer agent 259 Modulator / Unkown
HY-400056 SC209 intermediate-2 99.60% Unkown
HY-N12871 Floramanoside D Inhibitor / Unkown
HY-P3326 Targeting the bacterial sliding clamp peptide 46 Inhibitor / Unkown
HY-RS12473 SC5D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12514 SCLY Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-112333 SC-68376 Inhibitor / Unkown
HY-115360 IND45193 / Unkown
HY-117717 (Rac)-SC-31391 Activator / Unkown
HY-120045A DuP 747 hydrochloride / Unkown
HY-120550 RS 49676 Inhibitor / Unkown
HY-120586 SC-46944 Inhibitor / Unkown
HY-122288 SC 28538 Inhibitor / Unkown
HY-123014 (Rac)-SC-45694 / Unkown
HY-123156 SC-23110 Inhibitor / Unkown
HY-123354 SC 44914 Inhibitor / Unkown
HY-123747 SC-53116 Agonist / Unkown
HY-123747A SC-53116 hydrochloride Agonist / Unkown
HY-125337 SC4453 Inhibitor / Unkown
HY-126837 SPM VIII / Unkown
HY-137089 Azacosterol dihydrochloride Inhibitor / Unkown
HY-137225 HTS07944 / Unkown
HY-157405 DENV-IN-11 Inhibitor / Unkown
HY-163631 Antibacterial agent 218 Inhibitor / Unkown
HY-N12164 Linearmycin B Inhibitor / Unkown
HY-W004297 1-Nonadecanol ≥98.0% Unkown
HY-P0323 GP(33-41) Inhibitor / Unkown
HY-U00200 Dicirenone Antagonist / Unkown
HY-U00239 SC58451 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99506 Tamrintamab / Unkown
HY-P991041 Anti-SEZ6 Antibody (SC17) / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SCLY MGD MGI:1355310
Felis catus SCLY VGNC VGNC:80349
Canis familiaris SCLY VGNC VGNC:59093
Rattus norvegicus SCLY RGD RGD:1359514
Macaca mulatta SCLY VGNC VGNC:81563
Bos taurus SCLY VGNC VGNC:55677
Others SCLY NCBI