PTK6 - protein tyrosine kinase 6 Gene

Homo sapiens

Also known as BRK

Gene ID: 5753 | Gene type: protein coding

About PTK6

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,528,001-63,537,376 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues, 32 paralogues and is associated with 50 phenotypes. Biased expression in esophagus (RPKM 27.3), skin (RPKM 21.0) and 9 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

PTK6 Products(2)

mRNA	Protein	Name
NM_001256358.2	NP_001243287.1	protein-tyrosine kinase 6 isoform 2
NM_005975.4	NP_005966.1	protein-tyrosine kinase 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15056653	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10913193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10913193	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	16568091	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	15572663	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in negative regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	15539407	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	12121988	GOA
involved in tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	16568091	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15572663	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10913193	GOA
located in ruffle	IDA IDA: Inferred from direct assay	15572663	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTK6 Protein Structure

Pkinase_Tyr

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

protein-tyrosine kinase 6

PTK6 protein tyrosine kinase 6

PTK6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTK6	Q13882	KIAA1217	Homo sapiens	Q5T5P2-6	Validated Y2H	32296183
Intra	PTK6	Q13882	KIAA1217	Homo sapiens	Q5T5P2-6	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	KIAA1217	Homo sapiens	Q5T5P2-6	Y2H Array	32296183
Intra	PTK6	Q13882	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	PTK6	Q13882	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	PTK6	Q13882	KIT	Homo sapiens	P10721	FPS	24728074
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	25416956
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Anti Tag CoIP	31980649
Intra	PTK6	Q13882	PTK6	Homo sapiens	Q13882	Protein Kinase Assay	18719096
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	PTK6	Homo sapiens	Q13882	SPR	15056653
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Array	31515488
Intra	PTK6	Q13882	PTK6	Homo sapiens	Q13882	NMR	19401189
Intra	PTK6	Q13882	EXOC5	Homo sapiens	O00471	Y2H Array	32296183
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Array	25416956
Intra	PTK6	Q13882	EXOC5	Homo sapiens	O00471	Validated Y2H	25416956
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	PTK6	Q13882	ANKRD55	Homo sapiens	Q3KP44	Y2H Array	32296183
Intra	PTK6	Q13882	ANKRD55	Homo sapiens	Q3KP44	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	ANKRD55	Homo sapiens	Q3KP44	Validated Y2H	32296183
Intra	PTK6	Q13882	SLA	Homo sapiens	Q13239-3	Y2H Array	32296183
Intra	PTK6	Q13882	SLA	Homo sapiens	Q13239-3	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	PTK6	Q13882	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	PTK6	Q13882	ACTN3	Homo sapiens	Q08043	Y2H Array	32296183
Intra	PTK6	Q13882	ACTN3	Homo sapiens	Q08043	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	PTK6	Q13882	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	PTK6	Q13882	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	PTK6	Q13882	SFPQ	Homo sapiens	P23246	SLCA	19439179
Intra	PTK6	Q13882	SFPQ	Homo sapiens	P23246	GMS	19439179
Intra	PTK6	Q13882	SFPQ	Homo sapiens	P23246	Anti Bait CoIP	19439179
Intra	PTK6	Q13882	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	PTK6	Q13882	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	PTK6	Q13882	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	18719096
Intra	PTK6	Q13882	ERBB2	Homo sapiens	P04626	PLA	20700126
Intra	PTK6	Q13882	FCHO1	Homo sapiens	O14526	Y2H Array	31515488
Intra	PTK6	Q13882	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	PTK6	Q13882	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	31515488
Intra	PTK6	Q13882	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	PTK6	Q13882	CBLB	Homo sapiens	Q13191	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	CBLB	Homo sapiens	Q13191	Y2H Array	32296183
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Validated Y2H	32296183
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Y2H Array	32296183
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	PTK6	Q13882	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	PTK6	Q13882	ZNF341	Homo sapiens	Q9BYN7	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	ZNF341	Homo sapiens	Q9BYN7	Validated Y2H	32296183
Intra	PTK6	Q13882	ZNF341	Homo sapiens	Q9BYN7	Y2H Array	32296183
Intra	PTK6	Q13882	WASL	Homo sapiens	O00401	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTK6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75470	Brk Protein, Human (sf9, GST)	Q13882-1 (M1-T451)	≥95%

PTK6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81458	Brk/PTK6 Antibody (YA1203)	IHC-P	Human

Related Diseases

Diseases

Alias

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110244	Tilfrinib	Inhibitor	99.69%	Unkown
HY-108333	SB-633825	Inhibitor	98.52%	Unkown
HY-115514A	BRK inhibitor P21d hydrochloride	Inhibitor	≥98.0%	Unkown
HY-139660	PROTAC PTK6 ligand-1		95.03%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-163214	(S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid		/	Unkown
HY-163215	(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163216	PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163217	PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc		/	Unkown
HY-163218	PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid		/	Unkown
HY-163224	(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-163228	PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-RS11403	PTK6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTK6	VGNC	VGNC:84902
Felis catus	PTK6	VGNC	VGNC:81161
Mus musculus	PTK6	MGD	MGI:99683
Bos taurus	PTK6	VGNC	VGNC:33520
Rattus norvegicus	PTK6	RGD	RGD:1309098
Others	PTK6	NCBI

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