2. Gene
  3. PVR - PVR cell adhesion molecule Gene

PVR - PVR cell adhesion molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PVS; HVED; CD155; NECL5; TAGE4; Necl-5

Gene ID: 5817 | Gene type: protein coding

About PVR

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:44,643,910-44,666,162 (from NCBI)

This gene has 6 transcripts (splice variants), 600 orthologues and 14 paralogues. Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues.

Summary

The protein encoded by this gene is a Transmembrane Glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

PVR Products(4)

mRNA Protein Name
NM_001135768.3 NP_001129240.1 poliovirus receptor isoform beta precursor
NM_001135769.3 NP_001129241.1 poliovirus receptor isoform gamma precursor
NM_001135770.4 NP_001129242.2 poliovirus receptor isoform delta precursor
NM_006505.5 NP_006496.4 poliovirus receptor isoform alpha precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
12913096 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19011627 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16304049 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
IMP: Inferred from mutant phenotype
12913096 GOA
involved in susceptibility to T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15039383 GOA
involved in susceptibility to natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
12913096 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
16831868 GOA
located in membrane IDA
IDA: Inferred from direct assay
12913096 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PVR Protein Structure

V-set

V-set: Immunoglobulin V-set domain (30 - 128)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (148 - 231)

ig

ig: Immunoglobulin domain (260 - 314)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
Protein Preferred Names Protein Names

poliovirus receptor

nectin-like protein 5

PVR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PVR P15151 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
PVR P15151 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
PVR P15151 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
PVR P15151 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
PVR P15151 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
PVR P15151 EDDM3B Homo sapiens P56851
Validated Y2H
32296183
Intra
PVR P15151 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra
PVR P15151 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
32296183
Intra
PVR P15151 ZDHHC22 Homo sapiens Q8N966
Validated Y2H
32296183
Intra
PVR P15151 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra
PVR P15151 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
Intra
PVR P15151 SLC41A2 Homo sapiens Q96JW4
Validated Y2H
32296183
Intra
PVR P15151 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
PVR P15151 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
PVR P15151 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
PVR P15151 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
PVR P15151 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Intra
PVR P15151 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
Intra
PVR P15151 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra
PVR P15151 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
PVR P15151 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
PVR P15151 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
PVR P15151 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
PVR P15151 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
PVR P15151 TMEM276 Homo sapiens P0DTL5
Validated Y2H
32296183
Intra
PVR P15151 CTXN3 Homo sapiens Q4LDR2
Validated Y2H
32296183
Intra
PVR P15151 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra
PVR P15151 TMEM229B Homo sapiens Q8NBD8
Validated Y2H
32296183
Intra
PVR P15151 BRICD5 Homo sapiens Q6PL45-2
Validated Y2H
32296183
Intra
PVR P15151 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
PVR P15151 AQP10 Homo sapiens Q96PS8
Validated Y2H
32296183
Intra
PVR P15151 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
PVR P15151 TAS2R19 Homo sapiens P59542
Validated Y2H
32296183
Intra
PVR P15151 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
PVR P15151 SYS1 Homo sapiens Q8N2H4
Validated Y2H
32296183
Intra
PVR P15151 SYS1 Homo sapiens Q8N2H4
Y2H Prey Pooling
32296183
Intra
PVR P15151 TM6SF2 Homo sapiens Q9BZW4
Validated Y2H
32296183
Intra
PVR P15151 CD47 Homo sapiens Q08722-3
Validated Y2H
32296183
Intra
PVR P15151 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
PVR P15151 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
PVR P15151 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
PVR P15151 KRTAP6-3 Homo sapiens Q3LI67
Validated Y2H
32296183
Intra
PVR P15151 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
PVR P15151 NINJ1 Homo sapiens Q92982
Y2H Array
32296183
Intra
PVR P15151 NINJ1 Homo sapiens Q92982
Validated Y2H
32296183
Intra
PVR P15151 OLFM4 Homo sapiens Q6UX06
Validated Y2H
32296183
Intra
PVR P15151 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
PVR P15151 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
PVR P15151 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
PVR P15151 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
PVR P15151 TMEM54 Homo sapiens Q969K7
Validated Y2H
32296183
Intra
PVR P15151 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
PVR P15151 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
PVR P15151 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
PVR P15151 CD226 Homo sapiens Q15762
GMS
30591568
Intra
PVR P15151 TIGIT Homo sapiens Q495A1
Protein Array
21982860
Intra
PVR P15151 HHATL Homo sapiens Q9HCP6
Validated Y2H
32296183
Intra
PVR P15151 PLP2 Homo sapiens Q04941
Validated Y2H
32296183
Intra
PVR P15151 TSPO Homo sapiens P30536
Validated Y2H
32296183
Intra
PVR P15151 TMEM65 Homo sapiens Q6PI78
Validated Y2H
32296183
Intra
PVR P15151 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
PVR P15151 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
PVR P15151 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
PVR P15151 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
PVR P15151 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra
PVR P15151 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
PVR P15151 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
25416956
Intra
PVR P15151 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
Intra
PVR P15151 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
31515488
Intra
PVR P15151 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Intra
PVR P15151 TMEM79 Homo sapiens Q9BSE2
Y2H Array
32296183
Intra
PVR P15151 TMEM79 Homo sapiens Q9BSE2
Y2H Prey Pooling
32296183
Intra
PVR P15151 TMEM79 Homo sapiens Q9BSE2
Validated Y2H
32296183
Intra
PVR P15151 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
PVR P15151 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra
PVR P15151 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra
PVR P15151 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra
PVR P15151 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PVR Proteins

Cat. No. Product Name Accession Purity
HY-P7401 PVR/CD155 Protein, Human (HEK293, Fc) P15151-1 (W21-N343) ≥95%
HY-P70807 PVR/CD155 Protein, Human (HEK293, His) NP_006496 (W21-N343) ≥95%
HY-P75614 PVR/CD155 Protein, Human (HEK293) P15151-1 (W21-N343) ≥95%
HY-P78082 PVR/CD155 Protein, Human (Biotinylated, HEK293, Fc-Avi) P15151-1 (W21-N343) ≥95%
HY-P78084 PVR/CD155 Protein, Human (Biotinylated, HEK293, His-Avi) P15151-1 (W21-N343) ≥95%
HY-P78400 PVR/CD155 Protein, Human (HEK293, mFc) P15151-1 (W21-N343) ≥95%
HY-P78402 PVR/CD155 Protein, Human (HEK293, His-Avi) P15151-1 (W21-N343) ≥95%

Related Diseases

Diseases Alias
Poliomyelitis

Polio

Infantile Paralysis
Paralytic Poliomyelitis

Poliomyelitis, Paralytic
Bulbar Polio

Poliomyelitis, Bulbar

Bulbar Poliomyelitis
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7

Zlotogora-Ogur Syndrome

CLPED1

Ectodermal Dysplasia, Margarita Island Type

Ed4

Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

Ectodermal Dysplasia 4

Ectodermal Dysplasia Margarita Type

Ectodermal Dysplasia, Type 4

Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

Margarita Type Of Ectodermal Dysplasia

Zlotogora-Zilberman-Tenenbaum Syndrome

Ectd4

Ectodermal Dysplasia 4, Hair/Nail Type

EDMI

Ectodermal Dysplasia Type 4

Margarita Island Ectodermal Dysplasia

Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

Non-Syndromic Orofacial Cleft 7

OFC7

Non-Syndromic Cleft Lip/Palate 7

Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Postpoliomyelitis Syndrome

Postpolio Syndrome

Post-Polio Syndrome

Post Polio Syndrome

Polio Late Effects

Post-Polio Muscular Atrophy

Post-Polio Sequelae

Post-Poliomyelitic Syndrome

Postpolio Sequelae

Postpoliomyelitic Syndrome

Postpoliomyelitis Sequelae
Acute Flaccid Myelitis
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0070A Liothyronine Activator 99.82% Yes
HY-14252A Milrinone lactate / Unkown
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11473 PVR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-112352 SU9518 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PVR RGD RGD:3813
Felis catus PVR VGNC VGNC:69186
Mus musculus PVR MGD MGI:107741
Canis familiaris PVR VGNC VGNC:82568
Macaca fascicularis PVR NCBI
Macaca mulatta PVR NCBI NCBI:712851
Others PVR NCBI