Sirt2 - sirtuin 2 Gene

Mus musculus

Also known as Sir2l; SIR2L2; 5730427M03Rik

Gene ID: 64383 | Gene type: protein coding

About Sirt2

Chromosome 7: 28,466,160-28,488,086 forward strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 187 orthologues, 6 paralogues and is associated with 24 phenotypes. Ubiquitous expression in testis adult (RPKM 56.8), cerebellum adult (RPKM 53.7) and 28 other tissues.

Summary

Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (Sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sirt2 Products(3)

mRNA	Protein	Name
NM_022432.4	NP_071877.3	NAD-dependent protein deacetylase sirtuin-2 isoform 1
NM_001122765.1	NP_001116237.1	NAD-dependent protein deacetylase sirtuin-2 isoform 2
NM_001122766.1	NP_001116238.1	NAD-dependent protein deacetylase sirtuin-2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	34059674	MGI
enables histone deacetylase activity	IMP IMP: Inferred from mutant phenotype	24334550	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17521387	MGI
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	17681146	MGI
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	17521387	MGI
enables tubulin deacetylase activity	IMP IMP: Inferred from mutant phenotype	24334550	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	23502856	MGI
involved in cellular lipid catabolic process	IMP IMP: Inferred from mutant phenotype	19037106	MGI
involved in cellular response to caloric restriction	IDA IDA: Inferred from direct assay	17521387	MGI
involved in cellular response to epinephrine stimulus	IDA IDA: Inferred from direct assay	19037106	MGI
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	17521387	MGI
acts upstream of or within chromatin organization	IGI IGI: Inferred from genetic interaction	20562830	MGI
involved in epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23908241	MGI
involved in myelination in peripheral nervous system	IMP IMP: Inferred from mutant phenotype	21949390	MGI
acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	23502856	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17681146	MGI
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	21949390	MGI
involved in negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	17521387	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17681146	MGI
involved in positive regulation of DNA binding	IDA IDA: Inferred from direct assay	17521387	MGI
involved in positive regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	24334550	MGI
involved in positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	24334550	MGI
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	17521387	MGI
involved in positive regulation of meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	24334550	MGI
involved in positive regulation of oocyte maturation	IMP IMP: Inferred from mutant phenotype	24334550	MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24681946	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17521387	MGI
involved in protein deacetylation	IDA IDA: Inferred from direct assay	17681146	MGI
involved in protein deacetylation	IMP IMP: Inferred from mutant phenotype	17521387	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23126280	MGI
involved in regulation of myelination	IMP IMP: Inferred from mutant phenotype	21949390	MGI
acts upstream of or within tubulin deacetylation	IGI IGI: Inferred from genetic interaction	20562830	MGI
acts upstream of or within tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	23126280	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	16933150	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11056054	MGI
located in meiotic spindle	IDA IDA: Inferred from direct assay	24334550	MGI
located in midbody	IDA IDA: Inferred from direct assay	24334550	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	26767982	MGI
located in myelin sheath	IDA IDA: Inferred from direct assay	16933150	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19037106	MGI
located in paranodal junction	IDA IDA: Inferred from direct assay	16933150	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	16933150	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16933150	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt2 Protein Structure

SIRT1

0
100
200
300
389 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein deacetylase sirtuin-2

NAD-dependent deacetylase sirtuin-2	NAD-dependent protein defatty-acylase sirtuin-2
SIR2-like protein 2	mSIR2L2
regulatory protein SIR2 homolog 2	silent mating type information regulation 2, (S.cerevisiae, homolog)-like
sirtuin 2

Sirt2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Sirt2	Q8VDQ8	AURKA	Homo sapiens	O14965	Anti Tag CoIP	22014574
Intra	Sirt2	Q8VDQ8	Fzr1	Mus musculus	Q9R1K5	Anti Bait CoIP	22014574

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0150	Nicotinamide	Inhibitor	99.99%	Unkown
HY-B0879A	Suramin sodium salt	Inhibitor	99.48%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown
HY-B0150A	Nicotinamide Hydrochloride	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10532	SRT 1720	Activator	99.90%	Unkown
HY-107454	OSS_128167	Inhibitor	98.63%	Unkown
HY-100578	AGK2	Inhibitor	99.62%	Unkown
HY-15145	SRT 1720 monohydrochloride	Activator	99.92%	Unkown
HY-13515	Sirtinol	Inhibitor	≥98.0%	Unkown
HY-101278	Thiomyristoyl	Inhibitor	99.74%	Unkown
HY-100591	SirReal2	Inhibitor	≥99.0%	Unkown
HY-16691	AK-7	Inhibitor	99.93%	Unkown
HY-100732	Cambinol	Inhibitor	99.89%	Unkown
HY-15510	Tenovin-6	Inhibitor	98.33%	Unkown
HY-101073	Salermide	Inhibitor	≥98.0%	Unkown
HY-136199	SIRT1-IN-1	Inhibitor	98.19%	Unkown
HY-103636	PROTAC Sirt2 Degrader-1	Inhibitor	98.71%	Unkown
HY-N1926	Dihydrocoumarin	Inhibitor	99.81%	Unkown
HY-101465	AK-1	Inhibitor	99.97%	Unkown
HY-146689	SIRT1-IN-2	Inhibitor	98.86%	Unkown
HY-16616	SIRT-IN-2	Inhibitor	98.08%	Unkown
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	Unkown
HY-107660	SIRT2-IN-8	Inhibitor	99.32%	Unkown
HY-B0150R	Nicotinamide (Standard)	Inhibitor	99.85%	Unkown
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	Unkown
HY-112427	Sirt2-IN-1	Inhibitor	98.71%	Unkown
HY-16615	SIRT-IN-1	Inhibitor	98.58%	Unkown
HY-146690	SIRT1-IN-3	Inhibitor	99.18%	Unkown
HY-147233	MIND4-19	Inhibitor	99.94%	Unkown
HY-148408	SIRT2-IN-11	Inhibitor	99.94%	Unkown
HY-111522	RK-9123016	Inhibitor	99.02%	Unkown
HY-111329	JGB1741	Inhibitor	99.05%	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-115979	Sirt2-IN-5	Inhibitor	/	Unkown
HY-163532	FLS-359	Modulator	/	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-160944	hsa62	Inhibitor	/	Unkown
HY-145958	Sirt2-IN-6	Inhibitor	/	Unkown
HY-123653	SirReal-1	Inhibitor	/	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown
HY-118343	AC-93253	Inhibitor	/	Unkown
HY-149637	HSP70/SIRT2-IN-1	Inhibitor	/	Unkown
HY-W841840	SR94	Inhibitor	/	Unkown
HY-160617	SIRT2-IN-14	Inhibitor	/	Unkown
HY-146013	Sirt1/2-IN-1	Inhibitor	/	Unkown
HY-117442	A2B57	Inhibitor	/	Unkown
HY-119889	A1B11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirt2	NCBI	NCBI:22933

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