2. Gene
  3. STX3 - syntaxin 3 Gene

STX3 - syntaxin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MVID2; STX3A; DIAR12; RDMVID

Gene ID: 6809 | Gene type: protein coding

About STX3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,754,188-59,805,878 (from NCBI)

This gene has 8 transcripts (splice variants), 271 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 9.8), duodenum (RPKM 8.8) and 25 other tissues.

Summary

The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

STX3 Products(2)

mRNA Protein Name
NM_001178040.2 NP_001171511.1 syntaxin-3 isoform 2
NM_004177.5 NP_004168.1 syntaxin-3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18588921 GOA
Biological Process GO Annotation Evidence Reference Source
involved in organelle membrane fusion IMP
IMP: Inferred from mutant phenotype
24726755 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in regulation of gene expression IDA
IDA: Inferred from direct assay
29475951 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16339081 GOA
located in azurophil granule IDA
IDA: Inferred from direct assay
18588921 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
15576373 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
21720706 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21720706 GOA
is active in presynapse IDA
IDA: Inferred from direct assay
27662481 GOA
is active in presynapse IMP
IMP: Inferred from mutant phenotype
27662481 GOA
located in specific granule IDA
IDA: Inferred from direct assay
18588921 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX3 Protein Structure

Syntaxin

Syntaxin: Syntaxin (31 - 131)

SNARE

SNARE: SNARE domain (197 - 258)

  • 0
  • 100
  • 200
  • 289 a.a.
Protein Preferred Names Protein Names

syntaxin-3

syntaxin 3A

STX3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STX3 Q13277 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
STX3 Q13277 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
STX3 Q13277 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
STX3 Q13277 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 RMDN3 Homo sapiens Q96TC7
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 RMDN3 Homo sapiens Q96TC7
Validated Y2H
32296183
Intra
STX3 Q13277 RMDN3 Homo sapiens Q96TC7
Y2H Array
32296183
Intra
STX3 Q13277 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
STX3 Q13277 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
STX3 Q13277 TMPPE Homo sapiens Q6ZT21
Validated Y2H
32296183
Intra
STX3 Q13277 TMPPE Homo sapiens Q6ZT21
Y2H Array
32296183
Intra
STX3 Q13277 TMPPE Homo sapiens Q6ZT21
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
STX3 Q13277 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
Intra
STX3 Q13277 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra
STX3 Q13277 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
STX3 Q13277 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
STX3 Q13277 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
STX3 Q13277 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
STX3 Q13277 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
STX3 Q13277 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
STX3 Q13277 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
STX3 Q13277 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
STX3 Q13277 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
STX3 Q13277 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
STX3 Q13277 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
STX3 Q13277 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
STX3 Q13277 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
STX3 Q13277 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
STX3 Q13277 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
STX3 Q13277 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
STX3 Q13277 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 ZFYVE9 Homo sapiens O95405
Anti Tag CoIP
17693260
Intra
STX3 Q13277 ZFYVE9 Homo sapiens O95405
Pull Down
17693260
Intra
STX3 Q13277 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
Intra
STX3 Q13277 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
STX3 Q13277 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
Intra
STX3 Q13277 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra
STX3 Q13277 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 NAPB Homo sapiens Q9H115
Y2H Array
25416956
Intra
STX3 Q13277 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra
STX3 Q13277 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
STX3 Q13277 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
STX3 Q13277 SNAP29 Homo sapiens O95721
Anti Tag CoIP
33961781
Intra
STX3 Q13277 SNAP29 Homo sapiens O95721
Y2H Array
32296183
Intra
STX3 Q13277 SNAP29 Homo sapiens O95721
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra
STX3 Q13277 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
STX3 Q13277 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
STX3 Q13277 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
STX3 Q13277 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
STX3 Q13277 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
STX3 Q13277 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
STX3 Q13277 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
STX3 Q13277 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 STX5 Homo sapiens Q13190
Anti Tag CoIP
33961781
Intra
STX3 Q13277 STX5 Homo sapiens Q13190
Y2H Array
32296183
Intra
STX3 Q13277 STX5 Homo sapiens Q13190
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra
STX3 Q13277 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
STX3 Q13277 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
STX3 Q13277 STX4 Homo sapiens Q12846
Validated Y2H
25416956
Intra
STX3 Q13277 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
STX3 Q13277 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
STX3 Q13277 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
STX3 Q13277 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
STX3 Q13277 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
STX3 Q13277 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
STX3 Q13277 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
STX3 Q13277 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
STX3 Q13277 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Intra
STX3 Q13277 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra
STX3 Q13277 MSMO1 Homo sapiens Q15800
Y2H Array
32296183
Intra
STX3 Q13277 MSMO1 Homo sapiens Q15800
Validated Y2H
32296183
Intra
STX3 Q13277 MSMO1 Homo sapiens Q15800
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STX3 Proteins

Cat. No. Product Name Accession Purity
HY-P73622 Syntaxin-3 Protein, Human (His) Q13277 (M1-N289) ≥95%

STX3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82357 Syntaxin 3 Antibody (YA2102) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Retinal Dystrophy And Microvillus Inclusion Disease

RDMVID
Diarrhea 12, With Microvillus Atrophy

DIAR12

Microvillus Inclusion Disease 2

Mvid2
Microvillus Inclusion Disease

Congenital Microvillous Atrophy

Intractable Diarrhea Of Infancy

Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities

Davidson Disease

Microvillous Inclusion Disease

Congenital Microvillus Atrophy

Mvid

Diarrhea 2 With Microvillus Atrophy

Mvd

Congenital Familial Protracted Diarrhea

Davidson'S Disease

Familial Enteropathy, Microvillus

Microvillus Atrophy, Congenital

Congenital Enteropathy

Familial Protracted Enteropathy

Microvillous Atrophy

Microvillus Atrophy With Diarrhea 2

Idi
Congenital Diarrhea
Secretory Diarrhea
Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin
Tetanus

Lockjaw

Clostridial Tetanus

Infection Due To Clostridium Tetani

Lock-Jaw
Retinitis Pigmentosa 77

RP77

Retinitis Pigmentosa, Type 77
Familial Hemophagocytic Lymphohistiocytosis 5

Fhl5

Hlh5

Hplh5

Lymphohistiocytosis, Hemophagocytic, Familial, Type 5
Diarrhea 4, Malabsorptive, Congenital

Enteric Anendocrinosis

Congenital Malabsorptive Diarrhea 4

DIAR4

Congenital Malabsorptive Diarrhea Due To Paucity Of Enteroendocrine Cells

Congenital Malabsorptive Diarrhoea 4

Congenital Malabsorptive Diarrhoea Due To Paucity Of Enteroendocrine Cells

Diarrhea, Type 4, Malabsorptive, Congenital
Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4

FHL4

Hplh4

Hlh4

Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Type 1 Diabetes Mellitus 10

Diabetes Mellitus, Insulin-Dependent, 10

IDDM10

Insulin-Dependent Diabetes Mellitus 10

Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10

T1D10

Diabetes, Mellitus, Insulin-Dependent 10

Diabetes Mellitus, Insulin-Dependent, Type 10
Diarrhea 5, With Tufting Enteropathy, Congenital

Congenital Diarrhea 5 With Tufting Enteropathy

Congenital Tufting Enteropathy

DIAR5

Cte

Intestinal Epithelial Cell Dysplasia

Tufting Enteropathy

Ied

Intestinal Epithelial Dysplasia

Enteropathy, Congenital Tufting

Congenital Diarrhoea 5 With Tufting Enteropathy

Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities

Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities

Congenital Enteropathy

Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities

Non-Syndromic Congenital Tufting Enteropathy

Diarrhea, Type 5, With Tufting Enteropathy, Congenital

Intestinal Intraepithelial Neoplasia
Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome

Fipa

Gastrointestinal Defects And Immunodeficiency Syndrome

Multiple Gastrointestinal Atresias

Familial Isolated Pituitary Adenoma

Intestinal Atresia, Multiple

Multiple Intestinal Atresia

GIDID1

Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Minat

Gidid

Meddra:10028210

Familial Isolated Pituitary Adenoma Syndrome

Intestinal Atresia Multiple

Combined Immunodeficiency-Enteropathy Spectrum

Cid-Mia/Early-Onset Ibd

Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Mia

Gastrointestinal Defect And Immunodeficiency Syndrome

Pituitary Adenoma Predisposition

Pituitary Adenoma, Familial Isolated
Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic

Haemophagocytic Syndrome

Lymphohistiocytosis Hemophagocytic

Hemophagocytic Syndrome

Familial Hemophagocytic Lymphocytosis

Histiocytoses Of Mononuclear Phagocytes

Haemophagocytic Lymphohistiocytosis Nos
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13983 STX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STX3 VGNC VGNC:65813
Rattus norvegicus STX3 RGD RGD:621005
Canis familiaris STX3 VGNC VGNC:46955
Macaca mulatta STX3 VGNC VGNC:78044
Bos taurus STX3 VGNC VGNC:35439
Mus musculus STX3 MGD MGI:103077