UBE2D2 - ubiquitin conjugating enzyme E2 D2 Gene

Homo sapiens

Also known as UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2

Gene ID: 7322 | Gene type: protein coding

About UBE2D2

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,526,240-139,628,434 (from NCBI)

This gene has 10 transcripts (splice variants), 140 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 32.5), brain (RPKM 24.1) and 25 other tissues.

Summary

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of Enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) Enzymes. This gene encodes a member of the E2 Enzyme family. Substrates of this Enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

UBE2D2 Products(2)

mRNA	Protein	Name
NM_003339.3	NP_003330.1	ubiquitin-conjugating enzyme E2 D2 isoform 1
NM_181838.2	NP_862821.1	ubiquitin-conjugating enzyme E2 D2 isoform 2

UBE2D2 Protein Structure

UQ_con

0
100
147 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 D2

(E3-independent) E2 ubiquitin-conjugating enzyme D2

Recombinant UBE2D2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79449	UbcH5b/UBE2D2 Protein, Human	P62837-1 (M1-M147)	≥95%

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15340	UBE2D2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2D2	MGD	MGI:1930715
Bos taurus	UBE2D2	VGNC	VGNC:36580
Macaca mulatta	UBE2D2	VGNC	VGNC:84510
Rattus norvegicus	UBE2D2	RGD	RGD:1591897
Canis familiaris	UBE2D2	VGNC	VGNC:48051
Others	UBE2D2	NCBI

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