2. Gene
  3. HOXC8 - homeobox C8 Gene

HOXC8 - homeobox C8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HOX3; HOX3A

Gene ID: 3224 | Gene type: protein coding

About HOXC8

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,008,985-54,012,769 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 42 paralogues. Biased expression in fat (RPKM 3.5), adrenal (RPKM 3.0) and 9 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]

HOXC8 Products(1)

mRNA Protein Name
NM_022658.4 NP_073149.1 homeobox protein Hox-C8
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXC8 Protein Structure

Homeobox

Homeobox: Homeobox domain (150 - 206)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-C8

Hox-3.1, mouse, homolog of

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06320 HOXC8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HOXC8 VGNC VGNC:29927
Mus musculus HOXC8 MGD MGI:96198
Felis catus HOXC8 VGNC VGNC:67629
Rattus norvegicus HOXC8 RGD RGD:2821