Halofuginone lactate (Synonyms: RU-19110 lactate)

Cat. No.: HY-N1584C Purity: 98.32%: FAQs
Data Sheet SDS COA Handling Instructions

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Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca²⁺ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

For research use only. We do not sell to patients.

Halofuginone lactate Chemical Structure

CAS No. : 82186-71-8

Size	Price	Stock	Quantity
5 mg	USD 68	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 106	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 162	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 268	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 395	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 11 publication(s) in Google Scholar

Other Forms of Halofuginone lactate:

11 Publications Citing Use of MCE Halofuginone lactate

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Purity & Documentation
References
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Description

Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM^[1]^[2]. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity^[3]^[4]. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca²⁺ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects^[5].

Molecular Weight

504.76

Formula

C₁₉H₂₃BrClN₃O₆

CAS No.

82186-71-8

Appearance

Solid

Color

White to off-white

SMILES

OC(C(O)C)=O.O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 35 mg/mL (69.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9811 mL	9.9057 mL	19.8114 mL
5 mM	0.3962 mL	1.9811 mL	3.9623 mL
10 mM	0.1981 mL	0.9906 mL	1.9811 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.32%

Select Batch:

Data Sheet (276 KB) SDS (642 KB)

COA (252 KB) HNMR (266 KB) RP-HPLC (245 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247. [Content Brief]

[2]. Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. [Content Brief]

[3]. Cui Z, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21. [Content Brief]

[4]. Tracy L McGaha, et al. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol. 2002 Mar;118(3):461-70. [Content Brief]

[5]. Pritesh P Jain, et al. Halofuginone, a Promising Drug for Treatment of Pulmonary Hypertension. Br J Pharmacol. 2021 Mar 10. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9811 mL	9.9057 mL	19.8114 mL	49.5285 mL
	5 mM	0.3962 mL	1.9811 mL	3.9623 mL	9.9057 mL
	10 mM	0.1981 mL	0.9906 mL	1.9811 mL	4.9528 mL
	15 mM	0.1321 mL	0.6604 mL	1.3208 mL	3.3019 mL
	20 mM	0.0991 mL	0.4953 mL	0.9906 mL	2.4764 mL
	25 mM	0.0792 mL	0.3962 mL	0.7925 mL	1.9811 mL
	30 mM	0.0660 mL	0.3302 mL	0.6604 mL	1.6509 mL
	40 mM	0.0495 mL	0.2476 mL	0.4953 mL	1.2382 mL
	50 mM	0.0396 mL	0.1981 mL	0.3962 mL	0.9906 mL
	60 mM	0.0330 mL	0.1651 mL	0.3302 mL	0.8255 mL

Halofuginone lactate Related Classifications

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Halofuginone lactate (Synonyms: RU-19110 lactate)

Customer Review

Other Forms of Halofuginone lactate:

Halofuginone lactate Related Antibodies

11 Publications Citing Use of MCE Halofuginone lactate

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

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View All Sodium Channel Isoform Specific Products:

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Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Halofuginone lactate Related Classifications

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