2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Anti-infection Membrane Transporter/Ion Channel Neuronal Signaling
  3. DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
  4. Halofuginone lactate

Halofuginone lactate  (Synonyms: RU-19110 lactate)

Cat. No.: HY-N1584C Purity: 98.32%
Data Sheet
SDS
COA
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Solubility

In Vivo Dissolution Calculator

Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

For research use only. We do not sell to patients.

Halofuginone lactate Chemical Structure

Halofuginone lactate Chemical Structure

CAS No. : 82186-71-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 72 In-stock
Solution
10 mM * 1 mL in DMSO USD 76 In-stock
Solid
5 mg USD 68 In-stock
10 mg USD 106 In-stock
25 mg USD 162 In-stock
50 mg USD 268 In-stock
100 mg USD 395 In-stock
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500 mg   Get quote  

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Based on 11 publication(s) in Google Scholar

Other Forms of Halofuginone lactate:

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].

Molecular Weight

504.76

Formula

C19H23BrClN3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C(O)C)=O.O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (69.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9811 mL 9.9057 mL 19.8114 mL
5 mM 0.3962 mL 1.9811 mL 3.9623 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9811 mL 9.9057 mL 19.8114 mL 49.5285 mL
5 mM 0.3962 mL 1.9811 mL 3.9623 mL 9.9057 mL
10 mM 0.1981 mL 0.9906 mL 1.9811 mL 4.9528 mL
15 mM 0.1321 mL 0.6604 mL 1.3208 mL 3.3019 mL
20 mM 0.0991 mL 0.4953 mL 0.9906 mL 2.4764 mL
25 mM 0.0792 mL 0.3962 mL 0.7925 mL 1.9811 mL
30 mM 0.0660 mL 0.3302 mL 0.6604 mL 1.6509 mL
40 mM 0.0495 mL 0.2476 mL 0.4953 mL 1.2382 mL
50 mM 0.0396 mL 0.1981 mL 0.3962 mL 0.9906 mL
60 mM 0.0330 mL 0.1651 mL 0.3302 mL 0.8255 mL
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Halofuginone lactate Related Classifications

Keywords:

Halofuginone82186-71-8RU-19110RU19110RU 19110DNA/RNA SynthesisTGF-beta/SmadParasiteSodium ChannelCalcium ChannelTransforming growth factor betaNa channelsNa+ channelsCa2+ channelsCa channelstype-Icollagencollagen-1prolyl-tRNAosteoarthritisTGF-βInhibitorinhibitorinhibit

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