Moracin P

Name: Moracin P
Brand: MedChemExpress
SKU: HY-N3243
Rating: 4.5 (1 reviews)

Cat. No.: HY-N3243 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects.

For research use only. We do not sell to patients.

Moracin P Chemical Structure

CAS No. : 102841-46-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Moracin P

•Res Sq. 2024 Nov 19.

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HIF-1α HIF

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	> 30 μM Compound: 16, Moracin P	Cytotoxicity against human Hep3B cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human Hep3B cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 25461329]
Hep 3B2	IC₅₀	> 30 μM Compound: (+/-)-2	Cytotoxicity against human Hep3B cells after 24 hrs by MTT assay Cytotoxicity against human Hep3B cells after 24 hrs by MTT assay	[PMID: 21481991]
Hep 3B2	IC₅₀	0.65 nM Compound: 16, Moracin P	Inhibition of HIF-1alpha in human Hep3B cells cotransfected with pGL3-HRE-luciferase plasmid after 24 hrs by dual-luciferase reporter assay Inhibition of HIF-1alpha in human Hep3B cells cotransfected with pGL3-HRE-luciferase plasmid after 24 hrs by dual-luciferase reporter assay	[PMID: 25461329]
Hep 3B2	IC₅₀	10.6 μM Compound: 16, Moracin P	Inhibition of HIF-1alpha in human Hep3B cells assessed as decrease in VEGF level after 20 hrs by ELISA Inhibition of HIF-1alpha in human Hep3B cells assessed as decrease in VEGF level after 20 hrs by ELISA	[PMID: 25461329]
Hep 3B2	IC₅₀	10.7 μM Compound: (+/-)-2	Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay	[PMID: 21481991]

In Vitro

Moracin P enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC₅₀ value of 10.4 μM. Moracin P reduces ROS production in OGD-induced cell death (IC₅₀ values of 1.9 μM). Consequently, reactive oxygen species (ROS) are overexpressed in OGD-induced cells and Moracin P reduces ROS induced by OGD in dosedependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

326.34

Formula

C₁₉H₁₈O₅

CAS No.

102841-46-3

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1CC2=C(OC1(C)C)C=C(OC(C3=CC(O)=CC(O)=C3)=C4)C4=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (306.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0643 mL	15.3214 mL	30.6429 mL
5 mM	0.6129 mL	3.0643 mL	6.1286 mL
10 mM	0.3064 mL	1.5321 mL	3.0643 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (248 KB) HNMR (222 KB) CNMR (211 KB) RP-HPLC (228 KB) MS (601 KB)

Handling Instructions (2659 KB)

References

[1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80. [Content Brief]

[2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96. [Content Brief]

[3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0643 mL	15.3214 mL	30.6429 mL	76.6072 mL
	5 mM	0.6129 mL	3.0643 mL	6.1286 mL	15.3214 mL
	10 mM	0.3064 mL	1.5321 mL	3.0643 mL	7.6607 mL
	15 mM	0.2043 mL	1.0214 mL	2.0429 mL	5.1071 mL
	20 mM	0.1532 mL	0.7661 mL	1.5321 mL	3.8304 mL
	25 mM	0.1226 mL	0.6129 mL	1.2257 mL	3.0643 mL
	30 mM	0.1021 mL	0.5107 mL	1.0214 mL	2.5536 mL
	40 mM	0.0766 mL	0.3830 mL	0.7661 mL	1.9152 mL
	50 mM	0.0613 mL	0.3064 mL	0.6129 mL	1.5321 mL
	60 mM	0.0511 mL	0.2554 mL	0.5107 mL	1.2768 mL
	80 mM	0.0383 mL	0.1915 mL	0.3830 mL	0.9576 mL
	100 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.7661 mL

Moracin P Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moracin P102841-46-3HIF/HIF Prolyl-HydroxylaseReactive Oxygen SpeciesHypoxia-inducible factorsHIFsHIF-PHHIF-12-arylbenzofuranneuroprotectiveanti-inflammatoryROSInhibitorinhibitorinhibit

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Moracin P

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Moracin P Related Antibodies

1 Publications Citing Use of MCE Moracin P

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References

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Moracin P Related Antibodies

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Complete Stock Solution Preparation Table

Moracin P Related Classifications

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