2. Anti-infection
  3. SARS-CoV
  4. RdRP-IN-2

RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication.

For research use only. We do not sell to patients.

RdRP-IN-2 Chemical Structure

RdRP-IN-2 Chemical Structure

CAS No. : 2863657-16-1

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 121 In-stock
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Based on 1 publication(s) in Google Scholar

RdRP-IN-2 Related Antibodies

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Description

RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication[1].

In Vitro

RdRP-IN-2 (Compound 17) completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV). RdRP-IN-2 is not cytotoxic for Vero and CRFK cells[1].
RdRP-IN-2 (Compound 17) shows anti-SARS-CoV-2 activities with an EC50 value of 527.3 nM in Vero cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RdRP-IN-2 Related Antibodies
Molecular Weight

566.67

Formula

C33H30N2O5S
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(O)[C@H](CC1=CC=CC=C1)NC(C(C=C2C3=CC=CC=C3)=C(SC4=CC=C(OC5CCCCC5)C=C46)N6C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (176.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7647 mL 8.8235 mL 17.6470 mL
5 mM 0.3529 mL 1.7647 mL 3.5294 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7647 mL 8.8235 mL 17.6470 mL 44.1174 mL
5 mM 0.3529 mL 1.7647 mL 3.5294 mL 8.8235 mL
10 mM 0.1765 mL 0.8823 mL 1.7647 mL 4.4117 mL
15 mM 0.1176 mL 0.5882 mL 1.1765 mL 2.9412 mL
20 mM 0.0882 mL 0.4412 mL 0.8823 mL 2.2059 mL
25 mM 0.0706 mL 0.3529 mL 0.7059 mL 1.7647 mL
30 mM 0.0588 mL 0.2941 mL 0.5882 mL 1.4706 mL
40 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1029 mL
50 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.8823 mL
60 mM 0.0294 mL 0.1471 mL 0.2941 mL 0.7353 mL
80 mM 0.0221 mL 0.1103 mL 0.2206 mL 0.5515 mL
100 mM 0.0176 mL 0.0882 mL 0.1765 mL 0.4412 mL
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RdRP-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RdRP-IN-22863657-16-1SARS-CoVSARS coronavirusRNApolymeraseRdRpSARS-CoV-2FelinecoronavirusInhibitorinhibitorinhibit

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