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Results for "

β-lactams

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (119) Apoptosis (5) Aurora Kinase (7) Bacterial (129) Beta-lactamase (33) Biochemical Assay Reagents (2) CFTR (2) Complement System (1) Cytochrome P450 (1) DNA/RNA Synthesis (4) Drug Intermediate (3) Drug Metabolite (3) Elastase (1) Endogenous Metabolite (3) Endothelin Receptor (1) Estrogen Receptor/ERR (1) Factor Xa (1) Fluorescent Dye (1) Fungal (1) GSK-3 (6) Histamine Receptor (3) HIV (1) HSP (4) iGluR (2) Isotope-Labeled Compounds (7) MAGL (1) Melanocortin Receptor (6) Neurokinin Receptor (1) Orthopoxvirus (4) PACAP Receptor (1) Parasite (4) Penicillin-binding protein (PBP) (17) Phospholipase (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (5) Endocrinology (1) Infection (142) Inflammation/Immunology (20) Metabolic Disease (4) Neurological Disease (5)
Click Chemistry:	Azide (1)

175

Inhibitors & Agonists

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Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156009

CDFI	Others	Infection
CDFI is an inhibitor of the lipid II flippase MurJ. CDFI potentiates the activity of β-lactams against MRSA .

HY-109008

Nacubactam 2 Publications Verification OP0595 free acid	Beta-lactamase Bacterial	Infection
Nacubactam (OP0595 free acid) is a potent *non-β-lactam-β-lactamase* inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs .

HY-E70012

Penicillinase	Endogenous Metabolite	Infection Metabolic Disease
Penicillinase is a beta-lactamase. beta-lactamase enzymes inactivate beta-lactam antibiotics by hydrolyzing the peptide bond of the characteristic four-membered beta-lactam ring rendering the antibiotic ineffective .

HY-B1463

Penicillin G sodium salt 15+ Cited Publications Benzylpenicillin sodium salt	Beta-lactamase Bacterial Antibiotic	Infection
Penicillin G sodium salt is a typical β-lactam antibiotic.

HY-16251A

Hetacillin	Bacterial	Infection
Hetacillin is a beta-lactam antibiotic that is part of the aminopenicillin family.

HY-10004

Faropenem daloxate Faropenem medoxil	Bacterial Antibiotic	Infection
Faropenem daloxate is the first oral penem in a new class of beta-lactam antibiotics.

HY-114780

Lactivicin	Penicillin-binding protein (PBP) Bacterial	Infection
Lactivicin is a non-beta-lactam antibiotic showing beta-lactam action through binding to penicillin-binding protein (PBP). Lactivicin is moderately active against a wide range of Gram-negative bacteria and highly active against Gram-positive bacteria .

HY-129814

MM 42842 free acid	Antibiotic Bacterial	Infection
MM 42842 free acid is a member of the monobactam family of β-lactam antibiotics .

HY-105113

Cefluprenam	Antibiotic Bacterial	Infection
Cefluprenam is a β-lactam antibiotic with broad-spectrum antibacterial activity .

HY-137927

Benapenem	Antibiotic	Others
Benapenem is a carbapenem-type agent that belongs to the broad-spectrum β-lactam antibiotic class.

HY-122505

Cephamycin C	Antibiotic Bacterial	Infection
Cephamycin C (CepC) is a β-lactam antibiotic that can be isolated from the Streptomyces clavuligerus .

HY-N14895

Chitinovorin A	Antibiotic Bacterial	Infection
Chitinovorin A is a β-lactam antibiotic with a weak inhibitory activity against Gram-negative bacteria .

HY-B0522

Ampicillin 50+ Cited Publications D-(-)-α-Aminobenzylpenicillin	Bacterial Antibiotic	Infection
Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

HY-N14896

Chitinovorin C	Antibiotic Bacterial	Infection
Chitinovorin C is a β-lactam antibiotic with a weak inhibitory activity against Gram-negative bacteria .

HY-E70137

AMG 118 (Immobilized cephalosporin C acylase)	Drug Intermediate	Others
AMG 118 Immobilized cephalosporin C acylase is an enzyme that catalyzes in immobilized form and is generally used in industrial catalytic production of the important pharmaceutical intermediate 7-aminocephalosporanic acid (7-ACA). It contains CPC acylase, a highly specialized beta-lactam acylase or peptidase that cleaves the amide bonds between beta-lactams .

HY-A0269

Mecillinam 2 Publications Verification Amdinocillin; FL 1060	Bacterial Antibiotic	Infection
Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms .

HY-139628

JPD447	Bacterial	Infection Cancer
JPD447, a MAC-0547630 derivative, is a novel class of UppS inhibitor to potentiate β-lactam antibiotics.

HY-N14108

Chlorocardicin	Bacterial	Infection
Chlorocardicin is a monocyclic beta-lactam. Chlorocardicin has moderate in vitro activity against Enterobacteriaceae and Pseudomonas aeruginosa .

HY-P2998

β-Lactamase	Beta-lactamase Biochemical Assay Reagents	Infection
β-Lactamase is the enzyme produced by bacteria. β-Lactamase mediates β-lactam resistance .

HY-B1682

Loracarbef	Antibiotic Bacterial	Infection
Loracarbef, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class .

HY-B1682A

Loracarbef hydrate	Antibiotic Bacterial	Infection
Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class .

HY-117074

BMS-247243	Antibiotic Bacterial	Infection
BMS-247243 is a β-lactam antibiotic against methicillin (HY-121544)-resistant Staphylococcus aureus.

HY-121120

Isosulfazecin	Antibiotic	Infection
Isosulfazecin (iSZ) is a novel β-lactam antibiotic produced by Pseudomonas acidophilus sp., synthesized in a nutrient solution supplemented with glycerol and sodium thiosulfate under aerobic conditions in parallel with bacterial growth. It is purified by chromatography and crystallization from aqueous methanol. Physicochemical analysis determined its molecular formula to be C12H20N4O9S, showing a structure with a β-lactam ring, methoxyl and sulfonate groups. Acid hydrolysis yields L-alanine and D-glutamic acid. iSZ is a diastereomer of sulfadiazine and exhibits moderate activity against both gram-positive and gram-negative bacteria, but potent activity against bacteria resistant to β-lactam antibiotics .

HY-N7120

Penicillin G procaine hydrate PGP hydrate	Bacterial Antibiotic	Infection
Penicillin G Procaine hydrate (PGP hydrate), a β-lactam antibiotic, is a crystalline complex produced by chemically combining penicillin G with procaine .

HY-B0925S

Oxacillin-13C6 sodium	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Oxacillin- ¹³C₆ (sodium) is the ¹³C₆ labeled Oxacillin (sodium). Oxacillin sodium salt is a narrow-spectrum β-lactam antibiotic of the penicillin class.

HY-B0522A

Ampicillin sodium 50+ Cited Publications D-(-)-α-Aminobenzylpenicillin sodium salt	Bacterial Antibiotic	Infection
Ampicillin sodium (D-(-)-α-Aminobenzylpenicillin sodium salt) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria .

HY-N15062

2-Hydroxymethylclavam	Antibiotic Fungal	Infection
2-Hydroxymethylclavam is a β-lactam antibiotic. 2-Hydroxymethylclavam has antifungal activity, especially for plant pathogenic fungi .

HY-167644

Cefoxazole	Antibiotic Bacterial	Infection
Cefoxazole is a β-lactam antibiotic containing an isoxazole moiety and exhibits antibacterial activity. Cefoxazole can be used in studies related to infectious diseases .

HY-128889

FXIa-IN-1	Factor Xa	Cardiovascular Disease
FXIa-IN-1 (compound EP-7041) is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor .

HY-B1463R

Penicillin G sodium salt (Standard)	Beta-lactamase Bacterial Antibiotic	Infection
Penicillin G sodium salt (Standard) is the analytical standard of Penicillin G sodium salt. This product is intended for research and analytical applications. Penicillin G sodium salt is a typical β-lactam antibiotic.

HY-105549

Quinacillin	Antibiotic	Infection
Quinacillin is a compound that undergoes hydrolysis catalyzed by penicillinase. Quinacillin is irreversibly covalently bound to proteins via its β-lactam carboxyl group .

HY-B0522B

Ampicillin trihydrate 50+ Cited Publications D-(-)-α-Aminobenzylpenicillin trihydrate	Bacterial Antibiotic	Infection
Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

HY-158977

β-Lactamase-IN-9	Beta-lactamase Bacterial	Infection
β-Lactamase-IN-9 (compound 2) is a β-lactamase inhibitor that can restore the sensitivity of pathogens to β-lactam antibiotics .

HY-145158

Temocillin	Bacterial Antibiotic	Infection
Temocillin, a 6-alpha-methoxy penicillin derivative, is a semisynthetic beta-lactam antibiotic with a spectrum of activity against most aerobic Gram-negative bacteria .

HY-141808

AZD-CO-Ph-PEG4-Ph-CO-AZD	Beta-lactamase	Cancer
AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis .

HY-113557

DNAC-1	Bacterial Antibiotic Beta-lactamase	Infection
DNAC-1 is a potent antibacterial agent. DNAC-1 enhances β-lactam activity against Gram positive and Gram negative pathogens .

HY-B1252

Cefalonium	Antibiotic Bacterial	Infection Inflammation/Immunology
Cefalonium is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci .

HY-111019A

SCH 34343 sodium	Antibiotic Bacterial	Infection
SCH 34343 sodium is a potent β-lactam Antibiotic with bactericidal activity against Streptococcus pneumoniae, viridans streptococci, streptococci of groups A, B, C and G, and Str. bovis .

HY-B1252A

Cefalonium hydrate	Antibiotic Bacterial	Infection Inflammation/Immunology
Cefalonium hydrate is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci .

HY-W764182

Cephalosporinase,bacillus	Antibiotic	Infection
Cephalosporinase, bacillus are enzymes produced by bacillus, inactivated and degrade the ability of the cephalosporin class of antibiotics. Cephalosporins are a class of β-lactam antibiotics that are widely used to treat bacterial infections .

HY-B1459A

Dicloxacillin	Beta-lactamase Bacterial Antibiotic	Infection
Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .

HY-165272

Antibiotic SF-2132	Bacterial Antibiotic	Infection
Antibiotic SF-2132 is a peptide antibiotic identified in Nocardiopsis sp., which exhibits inhibitory activity against β-lactam antibiotic-resistant strains, such as Pseudomonas and Escherichia .

HY-B1459

Dicloxacillin sodium	Beta-lactamase Bacterial Antibiotic	Infection
Dicloxacillin sodium is a β-lactam antibiotic of the penicillin family. Dicloxacillin sodium against Gram-positive bacteria. Dicloxacillin sodium is active against β-lactamase-producing organisms such as Staphylococcus aureus .

HY-136502

(E)-Aztreonam SQ-28429	Antibiotic Bacterial	Infection
(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic. (E)-Aztreonam has the potential for the research of infections caused by gram-negative pathogens .

HY-B0129

Aztreonam 5+ Cited Publications SQ-26,776	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection Cancer
Aztreonam (SQ-26,776) is a synthetic monocyclic beta-lactam antibiotic, which has a very high affinity for penicillin-binding protein 3 (PBP-3).

HY-A0269S

Mecillinam-d12 Amdinocillin-d₁₂; FL 1060-d₁₂	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Mecillinam-d₁₂ is deuterium labeled Mecillinam. Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms[1].

HY-24470B

1-(9H-Fluoren-9-yl)ethanol	Antibiotic	Infection Inflammation/Immunology
1-(9H-Fluoren-9-yl)ethanol is a prominent fragment in β-lactam antibiotic modification and an important building block for anti-inflammatory agent .

HY-B0522R

Ampicillin (Standard)	Bacterial Antibiotic	Infection
Ampicillin (Standard) is the analytical standard of Ampicillin. This product is intended for research and analytical applications. Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

HY-B0529A

Azlocillin sodium salt Sodium azlocillin	Bacterial Parasite Antibiotic	Infection
Azlocillin sodium salt (Sodium azlocillin), a semisynthetic penicillin, is a broad spectrum β-lactam antibiotic. Azlocillin sodium salt shows antipseudomonal activity, and also potent against the malarial parasite Plasmodium falciparum .

HY-120876

L-680833	Beta-lactamase Elastase	Inflammation/Immunology
L-680833 is a monocyclic β-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNE) inhibitor. L-680833 can be used for the study of PMNE-damaged tissue diseases .

Cat. No.	Product Name

HY-L914

Serine/Threonine Focused Covalent Fragment Library

3,300 compounds

In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P1195

PDZ1 Domain inhibitor peptide	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-P0267

Melanotan (MT)-II 1 Publications Verification	Melanocortin Receptor	Neurological Disease
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

HY-P10857

Microcin J25 MccJ25	Bacterial Antibiotic	Infection
Microcin J25 (MccJ25) is a cyclic peptide antibiotic consisting of 21 unmodified amino acid residues. Microcin J25 inhibits DNA-dependent RNA polymerase (RNAP) of Gram-negative bacteria. Microcin J25 has antibacterial activity .

HY-P1195A

PDZ1 Domain inhibitor peptide TFA	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-P10278

Anantin	Peptides	Endocrinology
Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (K_d = 0.6 μM) and acts as natriuretic peptide receptor A antagonist .

HY-P10135

RES-701-1	Endothelin Receptor	Cardiovascular Disease
RES-701-1 is a cyclic peptide composed of 16 common L-amino acids, acting as a specific antagonist for the ET_B receptor. RES-701-1 can inhibit the binding of 125I-ET-1 (125I-labeled Endothelin (ET)-1) to the ET_B receptor, with an IC₅₀ value of 10 nM .

HY-P2064

Lariatin A	Bacterial	Infection
Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171 .

HY-P0007

Elcatonin Carbocalcitonin	Drug Intermediate	Metabolic Disease
Elcatonin (Carbocalcitonin) is a synthetic analog of eel calcitonin. Elcatonin increases bone mineral density, inhibits bone resorption and processes a central analgesic effect .

HY-P10768

Ro 25-1553	PACAP Receptor	Neurological Disease
Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-P2123A

Colistin A sulfate hydrate	Bacterial Antibiotic	Infection
Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria .

HY-P1193

GR 82334	Neurokinin Receptor	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .

HY-106178

PMX-53 4 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P1209

PG106	Melanocortin Receptor	Inflammation/Immunology
PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀=210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor .

HY-P1209A

PG106 TFA	Melanocortin Receptor	Metabolic Disease
PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀= 210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor .

HY-P0227

SHU 9119 3 Publications Verification	Melanocortin Receptor	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P5568

Siamycin III RP 71955	HIV	Infection
RP 71955 is an antimicrobial peptide against HIV-1 .

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins .

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1463

Penicillin G sodium salt 15+ Cited Publications Benzylpenicillin sodium salt	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Infection Plant Cell Culture Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Disease Research Fields Beta-lactam Antibiotics	Beta-lactamase Bacterial Antibiotic
Penicillin G sodium salt is a typical β-lactam antibiotic.

HY-B0425A

Novobiocin sodium 5+ Cited Publications Albamycin sodium; Cathomycin sodium	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-N14895

Chitinovorin A	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Antibiotic Bacterial
Chitinovorin A is a β-lactam antibiotic with a weak inhibitory activity against Gram-negative bacteria .

HY-N14896

Chitinovorin C	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Antibiotic Bacterial
Chitinovorin C is a β-lactam antibiotic with a weak inhibitory activity against Gram-negative bacteria .

HY-N14108

Chlorocardicin	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Bacterial
Chlorocardicin is a monocyclic beta-lactam. Chlorocardicin has moderate in vitro activity against Enterobacteriaceae and Pseudomonas aeruginosa .

HY-121120

Isosulfazecin	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Antibiotic
Isosulfazecin (iSZ) is a novel β-lactam antibiotic produced by Pseudomonas acidophilus sp., synthesized in a nutrient solution supplemented with glycerol and sodium thiosulfate under aerobic conditions in parallel with bacterial growth. It is purified by chromatography and crystallization from aqueous methanol. Physicochemical analysis determined its molecular formula to be C12H20N4O9S, showing a structure with a β-lactam ring, methoxyl and sulfonate groups. Acid hydrolysis yields L-alanine and D-glutamic acid. iSZ is a diastereomer of sulfadiazine and exhibits moderate activity against both gram-positive and gram-negative bacteria, but potent activity against bacteria resistant to β-lactam antibiotics .

HY-N15062

2-Hydroxymethylclavam	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal
2-Hydroxymethylclavam is a β-lactam antibiotic. 2-Hydroxymethylclavam has antifungal activity, especially for plant pathogenic fungi .

HY-B1463R

Penicillin G sodium salt (Standard)	Structural Classification Plant Cell Culture Microorganisms Antibiotics Source classification Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Beta-lactam Antibiotics	Beta-lactamase Bacterial Antibiotic
Penicillin G sodium salt (Standard) is the analytical standard of Penicillin G sodium salt. This product is intended for research and analytical applications. Penicillin G sodium salt is a typical β-lactam antibiotic.

HY-165272

Antibiotic SF-2132	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Antibiotic
Antibiotic SF-2132 is a peptide antibiotic identified in Nocardiopsis sp., which exhibits inhibitory activity against β-lactam antibiotic-resistant strains, such as Pseudomonas and Escherichia .

HY-117108

Nocardicin A	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Antibiotic Bacterial
Nocardicin A is a beta-lactam antibiotic with selective antibacterial activity. Nocardicin A has moderate antibacterial activity against a broad spectrum of Gram-negative bacteria including Proteus and Pseudomonas; it has no inhibitory effect on Staphylococcus, Mycobacterium, fungi, and yeast .

HY-B0425AR

Novobiocin (sodium) (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Source classification Antiviral Antibacterial Disease Research Other Antibiotics	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (sodium) (Standard) is the analytical standard of Novobiocin (sodium). This product is intended for research and analytical applications. Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-W013549

6-Aminopenicillanic acid 6-APA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Drug Metabolite Bacterial
6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses .

HY-W013549R

6-Aminopenicillanic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Drug Metabolite Bacterial
6-Aminopenicillanic acid (Standard) is the analytical standard of 6-Aminopenicillanic acid. This product is intended for research and analytical applications. 6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses .

HY-129200

Aspergillomarasmine A	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

Cat. No.	Product Name	Chemical Structure

HY-B0522S

Ampicillin-d5
Ampicillin-d₅ is the deuterium labeled Ampicillin. Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria[1][2][3].

HY-B0129S

Aztreonam-d6
Aztreonam-d₆ is deuterium labeled Aztreonam. Aztreonam (SQ-26,776) is a synthetic monocyclic beta-lactam antibiotic, which has a very high affinity for penicillin-binding protein 3 (PBP-3).

HY-B1252AS

Cefalonium-d4 hydrate
Cefalonium-d4 (hydrate) is the deuterium labeled Cefalonium (hydrate)(HY-B1252A).Cefalonium hydrate is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci .

HY-B0925S

Oxacillin-13C6 sodium
Oxacillin- ¹³C₆ (sodium) is the ¹³C₆ labeled Oxacillin (sodium). Oxacillin sodium salt is a narrow-spectrum β-lactam antibiotic of the penicillin class.

HY-A0269S

Mecillinam-d12
Mecillinam-d₁₂ is deuterium labeled Mecillinam. Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms[1].

HY-B1459AS

Dicloxacillin-13C4
Dicloxacillin- ¹³C₄ is the ¹³C labeled Dicloxacillin[1]. Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[2].

HY-14879S2

Avibactam sodium salt-13C5
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-A0294S

Ertapenem-d4
Ertapenem-d₄ (MK-0826-d₄) is deuterium labeled Ertapenem. Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .

HY-B0712S1

Ceftriaxone-13C2,d3 triethylammonium salt

Ceftriaxone- ¹³C₂,d₃ triethylammonium salt is ¹³C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC₅₀ value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .

Cat. No.	Product Name		Classification

HY-B2091

Azidocillin		Azide
Azidocillin, a semi-synthetic Penicillin, is an orally active β-lactam antibiotic. Azidocillin bears an azide functionality and retains on-target activity within bacteria. Azidocillin can be used to research osteitis caused by dental surgery, otitis media, enterococcal septicemia and other bacterial infectious diseases . Azidocillin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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