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Isoforms Recommended:	BACE1

Results for "

BACE1

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (7) Infection (2) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (77)
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Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

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BACE-1 inhibitor 2	Beta-secretase	Neurological Disease
BACE-1 inhibitor 2 is a potent and CNS permeable *BACE-1* inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay ^[1].

BACE1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BACE1 Human Pre-designed siRNA Set A contains three designed siRNAs for BACE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bace1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bace1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bace1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bace1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bace1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bace1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

BACE-1 inhibitor 1	Beta-secretase	Neurological Disease
BACE-1 inhibitor 1 (Compound 8a) is a potent *BACE-1* inhibitor with an IC₅₀ of 56 nM ^[1].

BACE1-IN-11	Beta-secretase	Neurological Disease
BACE1-IN-11 is a *BACE1* inhibitor. BACE1-IN-11 has the BACE1 inhibitory activity with an IC₅₀ value of 72 μM. BACE1-IN-11 can be used for the research of Alzheimer’s disease (AD) ^[1].

BACE1-IN-13	Beta-secretase	Neurological Disease
BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC₅₀ value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC₅₀ = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models ^[1].

BACE1-IN-12	Beta-secretase	Neurological Disease
BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated *BACE1* inhibitor, with an IC₅₀ of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC₅₀ of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC₅₀ of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent ^[1].

BACE1-IN-10	Beta-secretase	Cancer
BACE1-IN-10 is a potent *BACE1* Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1) ^[1].

BACE1-IN-14	Beta-secretase	Neurological Disease
BACE1-IN-14 (compound 27f) is a *BACE1* inhibitor, with the EC₅₀ values of 0.7 μM and 1.6 μM for *BACE1* and *BACE2. BACE1*-IN-14 is can be used in Alzheimer's disease (AD) research ^[1].

BACE1-IN-6	Beta-secretase	Neurological Disease
BACE1-IN-6 is a *BACE1* inhibitor with an IC₅₀ value of 1.5 nM.

BACE1-IN-1	Beta-secretase	Neurological Disease
BACE1-IN-1 is a potent and highly brain penetrant *BACE1* inhibitor with IC₅₀s of 32 and 47 nM for human BACE1 and BACE2, respectively.

BACE1-IN-4	Beta-secretase	Neurological Disease
BACE1-IN-4 is a potent and highly selective *BACE1* inhibitor, with an IC₅₀ of 3.8 nM and a K_i of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease ^[1].

BACE1-IN-2	Beta-secretase	Neurological Disease
BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM ^[1].

BACE1-IN-8	Beta-secretase	Neurological Disease
BACE1-IN-8 (compound 70b) is a potent *BACE1* (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 3.9 µM ^[1].

BACE1-IN-9	Beta-secretase	Neurological Disease
BACE1-IN-9 (compound 82b) is a potent *BACE1* (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 1.2 µM ^[1].

BACE1-IN-5	Beta-secretase	Neurological Disease
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC₅₀ of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux ^[1].

BACE1/2-IN-1	Beta-secretase Amyloid-β	Neurological Disease
BACE1/2-IN-1 (compound 34) is a potent *BACE1* and *BACE2* inhibitor, with an IC₅₀ of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability ^[1].

*AChE/BACE1/GSK3β-IN-1*	Beta-secretase Cholinesterase (ChE) GSK-3	Neurological Disease
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of *AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1* and GSK3β with IC₅₀ values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD) ^[1].

AChE-IN-77	Cholinesterase (ChE)	Metabolic Disease
AChE-IN-77 (5d) is a potent AChE and *BACE1* inhibitor, with IC₅₀ values of 29.46 µM ans 2.85 µM for AChE and BACE1 in vitro metal chelating ability against Fe ³⁺ ^[1].

RE(EDANS)EVNLDAEFK(DABCYL)R	Beta-secretase	Neurological Disease
RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction ^[1].

*AChE/BChE/BACE-1-IN-2*	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and *BACE-1* with IC₅₀ values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential ^[1].

*AChE/BChE/BACE-1-IN-1*	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and *BACE-1* with IC₅₀ values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential ^[1].

Umibecestat CNP520	Beta-secretase	Neurological Disease
Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC₅₀s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively ^[1]. Umibecestat can be used for the research of alzheimer's disease.

LY2886721 2 Publications Verification	Beta-secretase	Neurological Disease
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human *BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2* (IC₅₀ of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment ^[1].

LY2886721 hydrochloride	Beta-secretase	Neurological Disease
LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human *BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2* (IC₅₀ of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment ^[1].

β-Secretase Inhibitor IV	Beta-secretase	Neurological Disease
β-Secretase Inhibitor IV is a potent, cell-active *BACE-1* inhibitor with IC₅₀s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

AChE/Aβ-IN-6	Beta-secretase Amyloid-β	Neurological Disease
BACE1-IN-15 (compound 4j) is a potent inhibitor of BACE1 (β-secretase) that can inhibited the copper ion induced Aβ toxicity, with the EC₅₀ of 0.68 μM ^[1].

Verubecestat tosylate MK-8931 tosylate	Beta-secretase	Neurological Disease
Verubecestat tosylate is an orally active, high-affinity *BACE1* and *BACE2* inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat tosylate effectively reduces Aβ40 and has the potential for Alzheimer's Disease ^[1] .

SEVNLDAEFR	Beta-secretase	Neurological Disease
SEVNLDAEFR is a substrate for *BACE1* ^[1].

PF-06751979 1 Publications Verification	Beta-secretase	Neurological Disease
PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 7.3 nM in BACE1 binding assay.

Verubecestat 3 Publications Verification MK-8931	Beta-secretase	Neurological Disease
Verubecestat (MK-8931) is an orally active, high-affinity *BACE1* and *BACE2* inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer's Disease ^[1] .

(Rac)-AZD3839	Potassium Channel	Neurological Disease
(Rac)-AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac)-AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac)-AZD3839 can be used in the research of Alzheimer's disease ^[1].

Verubecestat TFA MK-8931 TFA	Beta-secretase	Neurological Disease
Verubecestat (MK-8931) TFA is an orally active, high-affinity *BACE1* and *BACE2* inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat TFA effectively reduces Aβ40 and has the potential for Alzheimer's Disease ^[1] .

OM99-2	Beta-secretase	Neurological Disease
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM ^[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor . OM99-2 has the potential for the research of the Alzheimer's disease .

Glabrolide	Beta-secretase	Neurological Disease
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

OM99-2 TFA	Beta-secretase	Neurological Disease
OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM ^[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor . OM99-2 has the potential for the research of the Alzheimer's disease .

SEW06622	Beta-secretase	Neurological Disease
SEW06622 is a *BACE-1* inhibitor with an IC₅₀ value of 6.3 μM and can be used in Alzheimer's disease research ^[1].

AMG-8718	Beta-secretase	Neurological Disease
AMG-8718 is a potent, selective and orally active *BACE1* inhibitor with IC₅₀ values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ₄₀ levels in the CSF and brain ^[1].

BuChE-IN-8	Cholinesterase (ChE)	Neurological Disease
BuChE-IN-8 (compound 19c) is a butyrylcholinesterase (BuChE) inhibitor with an IC₅₀ of 559 nM. BuChE-IN-8 possesses human β-secretase (BACE1) and Aβ40 aggregation inhibitory activities. BuChE-IN-8 has significant antiamnesic properties ^[1].

β-Secretase Inhibitor III	Beta-secretase	Neurological Disease
β-Secretase Inhibitor III is an extremely selective *BACE1* inhibitor (K_i = 0.13 nM).

Deoxyneocryptotanshinone	Beta-secretase Phosphatase	Neurological Disease
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity *BACE1* (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research ^[1] .

Elenbecestat E2609	Beta-secretase	Neurological Disease
Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant *BACE-1* inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research ^[1] .

Atabecestat JNJ-54861911	Beta-secretase	Neurological Disease
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat s tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat has the potential for Alzheimer's Disease treatment ^[1].

JNJ-67569762	Beta-secretase	Neurological Disease
JNJ-67569762 is a selective *BACE1* inhibitor targeting the S3 pocket (IC₅₀ = 2.7 nM).

Semilicoisoflavone B	Amyloid-β	Neurological Disease
Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation ^[1].

Cat. No.	Product Name	Type

HY-15908

BCA 5 Publications Verification Disodium bicinchoninate	Biochemical Assay Reagents
BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ value of 28 µM, a K_i value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P4920

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 ^[1].

HY-P5274

BACE1 (485-501)	Peptides	Others
BACE1 (485-501) is the carboxyl terminal of BACE1 (Beta-site APP cleaving enzyme 1). BACE1 (485-501) can be used as antigen to produce anti-BACE1-C antibody ^[1].

HY-P3426

BACE1-IN-10	Beta-secretase	Cancer
BACE1-IN-10 is a potent *BACE1* Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1) ^[1].

HY-P4899

RE(EDANS)EVNLDAEFK(DABCYL)R	Beta-secretase	Neurological Disease
RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction ^[1].

HY-P2714

SEVNLDAEFR	Beta-secretase	Neurological Disease
SEVNLDAEFR is a substrate for *BACE1* ^[1].

HY-P2713

OM99-2	Beta-secretase	Neurological Disease
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM ^[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor . OM99-2 has the potential for the research of the Alzheimer's disease .

HY-P2713A

OM99-2 TFA	Beta-secretase	Neurological Disease
OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM ^[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor . OM99-2 has the potential for the research of the Alzheimer's disease .

HY-P1962

β-Secretase inhibitor [Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)	Beta-secretase	Neurological Disease
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and *BACE1* inhibitor (IC₅₀: 25 nM for β-secretase) ^[1].

HY-P4919

Mca-SEVNLDAEFK(Dnp)	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

Cat. No.	Product Name	Target	Research Area

HY-P990343

*Anti-BACE1* Antibody**	Inhibitory Antibodies	Inflammation/Immunology

HY-P990344

Anti-Bcl-2 Antibody	Inhibitory Antibodies	Inflammation/Immunology

Species:	Human (5) Mouse (1)
Tag:	His (3) Tag Free (1) Fc (2)
Source:	HEK293 (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P72840

	BACE1 Protein, Human (HEK293) Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Human	HEK293
	The BACE1 protein is an important member of the aspartic protease family and is critical in Alzheimer's disease pathology.Alternative splicing generates multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to produce the mature protease.BACE1 Protein, Human (HEK293) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with tag free.

HY-P72843

	BACE1 Protein, Mouse (HEK293, His) Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Mouse	HEK293
	BACE1 protein is an important member of the peptidase A1 family and is involved in the pathogenesis of Alzheimer's disease.They produce mature proteases through proteolytic processing of preprotein, which catalyze the initial steps in the formation of amyloid beta peptide from the amyloid precursor protein.BACE1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BACE1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700606

	BACE1 Protein, Human (HEK293, N-His) Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Human	HEK293
	BACE1 protein is crucial in proteolytic processing of amyloid precursor protein (APP), initiating cleavage at the N-terminus of the A-beta peptide sequence. This process results in the extracellular release of beta-cleaved soluble APP and a cell-associated C-terminal fragment. BACE1's cleavage activity extends to CHL1, demonstrating its versatility in substrate processing. BACE1 Protein, Human (HEK293, N-His) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P72842

	BACE1 Protein, Human (HEK293, His) Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Human	HEK293
	The BACE1 protein is an important member of the aspartic protease family and is critical in Alzheimer's disease pathology. Alternative splicing generates multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to produce the mature protease. BACE1 Protein, Human (HEK293, His) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P703845

	BACE-1 Protein, Human (HEK293, hFc)	Human	HEK293

HY-P77569

	BACE1 Protein, Human (HEK293, Fc) Beta-secretase 1; ASP2; Asp 2; BACE1; BACE; FLJ90568; HSPC104; KIAA1149; Memapsin-2; BACE-1; EC 3.4.23; EC 3.4.23.46	Human	HEK293
	BACE1 protein is crucial in proteolytic processing of amyloid precursor protein (APP), initiating cleavage at the N-terminus of the A-beta peptide sequence.This process results in the extracellular release of beta-cleaved soluble APP and a cell-associated C-terminal fragment.BACE1's cleavage activity extends to CHL1, demonstrating its versatility in substrate processing.BACE1 Protein, Human (HEK293, Fc) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with C-hFc labeled tag.

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HY-P82169

	BACE1 Antibody (YA1914) BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2	WB, IP	Human, Mouse, Rat
	BACE1 Antibody (YA1914) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1914), targeting BACE1, with a predicted molecular weight of 56 kDa (observed band size: 68 kDa). BACE1 Antibody (YA1914) can be used for WB, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-159151

AChE/Aβ-IN-6		Azide
BACE1-IN-15 (compound 4j) is a potent inhibitor of BACE1 (β-secretase) that can inhibited the copper ion induced Aβ toxicity, with the EC₅₀ of 0.68 μM ^[1].

HY-128774

AM-6494		Alkynes
AM-6494 is a potent and orally active *BACE1* (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM) ^[1]. AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS01333

BACE1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
BACE1 Human Pre-designed siRNA Set A contains three designed siRNAs for BACE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01334

Bace1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bace1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bace1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01335

Bace1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bace1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bace1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BACE1

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