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Results for "

COX-2-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (46) Apoptosis (6) Autophagy (4) Drug Metabolite (1) Endogenous Metabolite (10) Epoxide Hydrolase (1) FAAH (4) Ferroptosis (4) Fluorescent Dye (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Lipoxygenase (4) NF-κB (3) NO Synthase (5) PGE synthase (2) Phospholipase (2) Progesterone Receptor (3) Prostaglandin Receptor (3) RAR/RXR (1) Reactive Oxygen Species (4) TNF Receptor (3) Topoisomerase (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (4) Endocrinology (4) Inflammation/Immunology (39) Metabolic Disease (4) Neurological Disease (4)
Oligonucleotides:	Antioxidants (1) Preservatives (1) Chelating Agents (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: COX Dan family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101655

COX-2-IN-2	COX	Inflammation/Immunology
COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC₅₀ of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

HY-118078

Robenacoxib	COX	Inflammation/Immunology
Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective *COX-2* inhibitor .

HY-W109812

Sinapyl alcohol 1 Publications Verification	COX	Inflammation/Immunology
Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and *COX-2* .

HY-U00275

*COX-2-IN-1*	COX	Inflammation/Immunology
COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC₅₀ of 3.9 μM.

HY-161513

iNOS/COX-2-IN-1	COX NO Synthase	Inflammation/Immunology
iNOS/COX-2-IN-1 (Compound 12e) is an inhibitor of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). iNOS/COX-2-IN-1 inhibits the NF-κB and MAPKs signaling pathways and thus exerts anti-inflammatory effects .

HY-150685

Topo I/COX-2-IN-1	Topoisomerase Prostaglandin Receptor Apoptosis	Inflammation/Immunology Cancer
Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC₅₀ value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity .

HY-146161

COX-2/NO-IN-1	COX NO Synthase	Inflammation/Immunology
COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), COX-2 expression and NO (IC₅₀ of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects .

HY-163187

COX-2/LOX-IN-1	COX Lipoxygenase	Inflammation/Immunology
COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC₅₀s of 30 μM and 0.55 μM, for LOX and *COX-2*, respectively. .

HY-138128

Acetaminophen mercapturate	Drug Metabolite	Inflammation/Immunology
Acetaminophen mercapturate is a metabolite of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor .

HY-146704

COX-2/sEH-IN-1	Epoxide Hydrolase COX	Cardiovascular Disease
COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC₅₀ values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks .

HY-15123

(S)-Flurbiprofen 1 Publications Verification Esflurbiprofen	COX PGE synthase	Inflammation/Immunology
(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC₅₀ values of 0.48 μM and 0.47 μM for COX-1 and *COX-2*, respectively .

HY-139129

N-(3-Pyridyl)indomethacinamide	COX	Inflammation/Immunology
N-(3-Pyridyl)indomethacinamide is a derivative of Indomethacin (HY-14397). N-(3-Pyridyl)indomethacinamide is a *COX2* inhibitor .

HY-N0481

Roburic acid	COX	Inflammation/Immunology
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-118078R

Robenacoxib (Standard)	COX	Inflammation/Immunology
Robenacoxib (Standard) is the analytical standard of Robenacoxib. This product is intended for research and analytical applications. Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective *COX-2* inhibitor .

HY-17485

Alminoprofen EB-382	Phospholipase COX	Inflammation/Immunology
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and *COX-2* .

HY-N11880

2-O-Sinapoyl makisterone A	COX	Cancer
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

HY-B0253A

Piroxicam olamine CP-16171 olamINe	COX	Inflammation/Immunology Cancer
Piroxicam olamine (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC₅₀s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively .

HY-W015007

Metyrosine	COX	Cardiovascular Disease
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

HY-162173

WYZ90	COX	Inflammation/Immunology
WYZ90 ((compound 6a) is a potent and selective COX-2 inhibitor with IC₅₀ values of 75, 5734, 19940 nM for COX-2, COX-1 and DPPH, respectively. WYZ90 shows antioxidant and analgesic activity .

HY-B1227

Carprofen 2 Publications Verification	COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N0523

Gallic acid Maximum Cited Publications 8 Publications Verification 3,4,5-Trihydroxybenzoic acid	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite	Metabolic Disease Cancer
Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-N0698

Crocin II	NO Synthase COX Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and *COX-2* .

HY-B0253S

Piroxicam-d3 CP-16171 d₃	COX	Inflammation/Immunology Cancer
Piroxicam-d₃ is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].

HY-N0523A

Gallic acid hydrate Maximum Cited Publications 8 Publications Verification 3,4,5-Trihydroxybenzoic acid hydrate	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-W109812S

Sinapyl alcohol-d3	Isotope-Labeled Compounds COX	Inflammation/Immunology
Sinapyl alcohol-d₃ is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and *COX-2* .

HY-15123R

(S)-Flurbiprofen (Standard)	COX PGE synthase	Inflammation/Immunology
(S)-Flurbiprofen (Standard) is the analytical standard of (S)-Flurbiprofen. This product is intended for research and analytical applications. (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC₅₀ values of 0.48 μM and 0.47 μM for COX-1 and *COX-2*, respectively .

HY-N0481R

Roburic acid (Standard)	COX	Inflammation/Immunology
Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-D2297

AIE-GA	Fluorescent Dye	Others
AIE-GA is a Golgi apparatus (GA) fluorescent probe (green channel: λex = 405 nm, λem = 500-700 nm). AIE-GA has a favourable binding ability to interact with COX-2. AIE-GA binds to the cyclooxygenase catalytic site of COX-2 .

HY-W012399

2,5-Di-tert-butylhydroquinone	Lipoxygenase COX	Inflammation/Immunology
2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC₅₀=1.8 and 14.1 μM for 5-LO and COX-2, respectively) .

HY-161862

COX-2-IN-44	COX	Inflammation/Immunology
COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC₅₀ values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity .

HY-B1227S

Carprofen-d3	COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-119671

BW 755C	COX Lipoxygenase	Endocrinology
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC₅₀s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively .

HY-153980

K-80001	RAR/RXR COX	Inflammation/Immunology
K-80001 is an RXRα-binder and COX-1/2 inhibitor, with IC₅₀s of with an IC₅₀ of 82.9μM, 3.4μM, 1.2μM for RXRα, COX-1 and COX-2, respectively .

HY-17485R

Alminoprofen (Standard)	Phospholipase COX	Inflammation/Immunology
Alminoprofen (Standard) is the analytical standard of Alminoprofen. This product is intended for research and analytical applications. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and *COX-2* .

HY-W015007R

Metyrosine (Standard)	COX	Cardiovascular Disease
Metyrosine (Standard) is the analytical standard of Metyrosine. This product is intended for research and analytical applications. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

HY-B1227R

Carprofen (Standard)	COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen (Standard) is the analytical standard of Carprofen. This product is intended for research and analytical applications. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-B0084

Dienogest 1 Publications Verification STS 557	Progesterone Receptor	Endocrinology
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of *COX-2, mPGES-1* and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-N0523R

Gallic acid (Standard)	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite	Metabolic Disease Cancer
Gallic acid (Standard) is the analytical standard of Gallic acid. This product is intended for research and analytical applications. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-N0523AR

Gallic acid (hydrate) (Standard)	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of *COX-2, IL-1β*, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-146419

Anti-inflammatory agent 20	NF-κB COX TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of NF-κB and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation .

HY-N0698R

Crocin II (Standard)	NO Synthase COX Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Crocin II (Standard) is the analytical standard of Crocin II. This product is intended for research and analytical applications. Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and COX-2 .

HY-N2252

Licarin A (+)-LicarIN A	TNF Receptor Prostaglandin Receptor COX	Neurological Disease Metabolic Disease Inflammation/Immunology
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and *COX-2* expression .

HY-W015007S

Metyrosine-13C9,15N,d7	COX	Cardiovascular Disease
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

HY-B1227S1

Carprofen-13C,d3	FAAH COX Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].

HY-B0084R

Dienogest (Standard)	Progesterone Receptor	Endocrinology
Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of *COX-2, mPGES-1* and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-129113R

α-Chaconine (Standard)	COX	Inflammation/Immunology
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N0632

Esculentoside A 2 Publications Verification	COX NF-κB	Inflammation/Immunology
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-129284

APHS	COX	Cancer
APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition .

HY-111310

ML351 1 Publications Verification	Lipoxygenase	Neurological Disease Metabolic Disease
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC₅₀ of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .

Cat. No.	Product Name	Type

HY-D2297

AIE-GA	Fluorescent Dyes/Probes
AIE-GA is a Golgi apparatus (GA) fluorescent probe (green channel: λex = 405 nm, λem = 500-700 nm). AIE-GA has a favourable binding ability to interact with COX-2. AIE-GA binds to the cyclooxygenase catalytic site of COX-2 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W109812

Sinapyl alcohol 1 Publications Verification	Structural Classification Monophenols Microorganisms Source classification Phenols	COX
Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and *COX-2* .

HY-N0481

Roburic acid	Triterpenes Structural Classification Gentiana macrophylla Pall. Classification of Application Fields Terpenoids Source classification Gentianaceae Plants Inflammation/Immunology Disease Research Fields	COX
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-B1227

Carprofen 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX FAAH Autophagy Endogenous Metabolite
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N0523

Gallic acid Maximum Cited Publications 8 Publications Verification 3,4,5-Trihydroxybenzoic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Metabolic Disease Plants Endogenous metabolite Microorganisms other families Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite
Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-N0698

Crocin II	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Rubiaceae Diterpenoids Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NO Synthase COX Endogenous Metabolite
Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and *COX-2* .

HY-N0523A

Gallic acid hydrate Maximum Cited Publications 8 Publications Verification 3,4,5-Trihydroxybenzoic acid hydrate	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite
Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-B1227R

Carprofen (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	COX FAAH Autophagy Endogenous Metabolite
Carprofen (Standard) is the analytical standard of Carprofen. This product is intended for research and analytical applications. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N11880

2-O-Sinapoyl makisterone A	Structural Classification Source classification Fibraurea recisa Pierre Plants Menispermaceae Steroids	COX
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

HY-N0481R

Roburic acid (Standard)	Triterpenes Structural Classification Gentiana macrophylla Pall. Terpenoids Source classification Gentianaceae Plants	COX
Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-N0523R

Gallic acid (Standard)	Structural Classification Microorganisms other families Source classification Phenols Polyphenols Plants Endogenous metabolite	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite
Gallic acid (Standard) is the analytical standard of Gallic acid. This product is intended for research and analytical applications. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-N0523AR

Gallic acid (hydrate) (Standard)	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite
Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Inflammation/Immunology Disease Research Fields	COX
α-Chaconine inhibits the expressions of *COX-2, IL-1β*, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N0698R

Crocin II (Standard)	Structural Classification Terpenoids Source classification Rubiaceae Diterpenoids Plants Gardenia jasminoides Ellis	NO Synthase COX Endogenous Metabolite
Crocin II (Standard) is the analytical standard of Crocin II. This product is intended for research and analytical applications. Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and COX-2 .

HY-N2252

Licarin A (+)-LicarIN A	Structural Classification Neurological Disease Classification of Application Fields Saururus chinensis (Lour.) Baill. Source classification Plants Monophenols Saururaceae Simple Phenylpropanols Phenols Phenylpropanoids Inflammation/Immunology Disease Research Fields	TNF Receptor Prostaglandin Receptor COX
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and *COX-2* expression .

HY-129113R

α-Chaconine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Gramineae Source classification Plants	COX
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N0632

Esculentoside A 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Phytolacca acinosa Roxb. Plants Inflammation/Immunology Disease Research Fields Phytolaccaceae	COX NF-κB
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-N0632R

Esculentoside A (Standard)	Triterpenes Structural Classification Terpenoids Source classification Phytolacca acinosa Roxb. Plants Phytolaccaceae	COX NF-κB
Esculentoside A (Standard) is the analytical standard of Esculentoside A. This product is intended for research and analytical applications. Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both COX-1 and *COX-2* (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-B0253S

Piroxicam-d3
Piroxicam-d₃ is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].

HY-W109812S

Sinapyl alcohol-d3
Sinapyl alcohol-d₃ is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and *COX-2* .

HY-B1227S

Carprofen-d3
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-W015007S

Metyrosine-13C9,15N,d7
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

HY-B1227S1

Carprofen-13C,d3
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

Cat. No.	Product Name		Classification

HY-N0523A

Gallic acid hydrate 5+ Cited Publications 3,4,5-Trihydroxybenzoic acid hydrate		Antioxidants Chelating Agents Preservatives
Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

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