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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

Cell localization

" in MedChemExpress (MCE) Product Catalog:

138

Inhibitors & Agonists

1

Screening Libraries

20

Fluorescent Dye

5

Biochemical Assay Reagents

16

Peptides

1

Inhibitory Antibodies

1

Natural
Products

1

Click Chemistry

8

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119726
    Fosmanogepix

    APX001; E1211

    		 Fungal Infection Inflammation/Immunology Cancer
    Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research .
    Fosmanogepix
  • HY-111299
    Psammaplysene A

    		Apoptosis Cancer
    Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research .
    Psammaplysene A
  • HY-119726A
    Fosmanogepix (tautomerism)

    APX001 (tautomerism); E1211 (tautomerism)

    		 Fungal Infection Inflammation/Immunology
    Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections .
    Fosmanogepix (tautomerism)
  • HY-P10594
    Myr-Arf1(2–17)

    		Ras Endocrinology
    Myr-Arf1(2–17) is a sarcosinated peptide that mimics the localization and function of Arf1 protein on the cell membrane. Myr-Arf1(2–17) can be used to study the desensitization mechanism of luteinizing hormone/chorionic gonadotropin receptor (LH/CGR) .
    Myr-Arf1(2–17)
  • HY-P10600
    BIMAX2

    		Ras Others
    BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .
    BIMAX2
  • HY-149709
    ICMT-IN-35

    		ICMT Cancer
    ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT +/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines .
    ICMT-IN-35
  • HY-153421
    PRMT5-IN-28

    		Histone Methyltransferase Cancer
    PRMT5-IN-28 (compound 36) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) enzyme. Protein arginine methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape .
    PRMT5-IN-28
  • HY-D1399
    Kdn probe-1

    		Fluorescent Dye Others
    Kdn probe-1 is a fluorescent Kdn probe and reveals the localization of AfS in vesicles at the cell surface.
    Kdn probe-1
  • HY-D2359
    Glucosamine-FITC

    		Fluorescent Dye Metabolic Disease
    Glucosamine-FITC is FITC-labeled Glucosamine (HY-B1125). Glucosamine-FITC can be used to localize Glucosamine in living cells .
    Glucosamine-FITC
  • HY-D1585
    BODIPY TR methyl ester

    		Fluorescent Dye Others
    BODIPY TR methyl ester is a lipophilic GFP Counterstain. BODIPY TR methyl ester dye readily permeates cell membranes and localizes in endomembranous organelles but not localize strongly in plasma membranes. BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo .
    BODIPY TR methyl ester
  • HY-P10600A
    BIMAX2 acetate

    		Ras Others
    BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .
    BIMAX2 acetate
  • HY-P2739
    Citrate synthase

    		Endogenous Metabolite Others
    Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .
    Citrate synthase
  • HY-D2357
    Lactat-CY5

    		Fluorescent Dye Metabolic Disease
    Lactat-CY5 is Cy5-labeled Lactat (HY-B2227). Lactat-CY5 can be used to localize Lactat in living cells .
    Lactat-CY5
  • HY-D1745
    Liptracker-Green

    fac-[Re(CO)3(phen)L]

    		 Fluorescent Dye Others
    Liptracker-green (fac-[Re(CO)3(phen)L]) is a cell-permeable fluorogenic probe that localizes to polar lipids, and can be used to label lipid droplets and other high lipid-content compartments in live and fixed cells using fluorescent microscopy.
    Liptracker-Green
  • HY-153890
    NVOC cage-TMP-Halo

    		Biochemical Assay Reagents Others
    NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .
    NVOC cage-TMP-Halo
  • HY-P10036
    G-Subtide

    		PKG Others
    G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. G-Subtide has little activity distinct from background and is a preferentially phosphorylated peptide substrate of recombinant PfPKG2 protein .
    G-Subtide
  • HY-122066
    NSC47924

    		Integrin Infection
    NSC47924 is a laminin receptor (LR) inhibitor. NSC47924 affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein. NSC47924 can be used for testing prion diseases .
    NSC47924
  • HY-D2358
    Glucosamine-CY5.5

    		Fluorescent Dye Metabolic Disease
    Glucosamine-CY5.5 is CY5.5-labeled Glucosamine (HY-B1125). Glucosamine-CY5.5 can be used to localize Glucosamine in living cells .
    Glucosamine-CY5.5
  • HY-101894
    Dihydrorhodamine 123
    10+ Cited Publications

    DHR 123

    		 Fluorescent Dye Others
    Dihydrorhodamine 123 (DHR 123) is a non-fluorescent reactive oxygen species (ROS) indicator. Dihydrorhodamine 123 is oxidized to fluorescent Rhodamine 123 (HY-D0816) within cells in the presence of reactive oxygen species and it localizes in mitochondria.
    Dihydrorhodamine 123
  • HY-163462
    Poacic acid

    		Fungal Infection
    Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants .
    Poacic acid
  • HY-D2263
    BODIPY-cholesterol conjugate-3

    		Fluorescent Dye Others
    BODIPY-cholesterol conjugate-3 (compound 7) is a cholesterol analogue with a fluorescent BODIPY group. BODIPY-cholesterol conjugate-3 can be used to simultaneously visualize multiple cholesterol pools in cells, as it is primarily localized to the plasma membrane .
    BODIPY-cholesterol conjugate-3
  • HY-164513
    NHTD

    		Ras Phosphodiesterase (PDE) Cancer
    NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC) .
    NHTD
  • HY-170814
    G-quadruplex ligand 3

    		G-quadruplex Cancer
    G-quadruplex ligand 3 (Compound 16) is a G-quadruplex ligand with anticancer effects that chelate iron. G-quadruplex ligand 3 stabilizes G-quadruplexes in human leukemia Jurkat cells. G-quadruplex ligand 3 localizes in the cell nucleus, serving as a fluorescent nuclear tracer for the labile iron pool .
    G-quadruplex ligand 3
  • HY-D0986
    TMA-DPH
    5+ Cited Publications

    		 Fluorescent Dye Others
    TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .
    TMA-DPH
  • HY-P10357
    TAT-CBD3

    		HIV iGluR Infection Inflammation/Immunology
    TAT-CBD3, a 15-amino acid peptide from CRMP2, fused to the TAT cell-penetrating motif of the HIV-1 protein, disrupts CRMP2-NMDAR interaction without change in NMDAR localization .
    TAT-CBD3
  • HY-139286
    Photoclick sphingosine

    Pacsph; Pacsphingosine (d18:1)

    		 Biochemical Assay Reagents Others
    Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .
    Photoclick sphingosine
  • HY-153851
    RNA Aptamer Peach Ⅱ sodium

    		DNA Alkylator/Crosslinker Others
    RNA Aptamer Peach Ⅱ (sodium) has an exceptionally high affinity to TO3-Biotin (TO3-B, red channel, ex: 637 nm, em: 658 nm), and can be used to visualize RNA expression or localization in live cells.
    RNA Aptamer Peach Ⅱ sodium
  • HY-N6747
    Stauprimide

    		c-Myc Autophagy Cancer
    Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation. Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which results in down-regulation of MYC transcription .
    Stauprimide
  • HY-134913
    Rhodblock 1a

    		ROCK Cardiovascular Disease Cancer
    Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway. It inhibits the normal formation of the cleavage furrow during cell division by interfering with the localization and function of Rho pathway proteins, causing some cells to fail to form a cleavage furrow or the formed cleavage furrow to break, resulting in binucleated cells. Rhodblock 1a can be used to study the mechanism of cell division and is expected to be used in the research of diseases such as cardiovascular diseases and cancer .
    Rhodblock 1a
  • HY-137854
    Naphthol AS-BI N-acetyl-β-D-glucosaminide

    		Biochemical Assay Reagents Others
    Naphthol AS-BI N-acetyl-β-D-glucosaminide acts as a substrate and reacts directly with N-acetyl-β-glucosaminidase enzyme. Naphthol AS-BI N-acetyl-β-D-glucosaminide can detect and localize the active region of N-acetyl-β-glucosaminidase enzyme visually .
    Naphthol AS-BI N-acetyl-β-D-glucosaminide
  • HY-W020012
    Fluoresterol

    22-NBD Cholesterol

    		 Fluorescent Dye Metabolic Disease
    Fluoresterol is a fluorescently labeled cholesterol analog that can be used as a fluorescent probe to study the behavior and metabolism of cholesterol in cells, including lipid uptake and esterification analysis, intracellular localization and targeting, and lipid metabolism in mammalian and bacterial cells. Fluoresterol has an excitation maximum at 472 nm and an emission maximum at 540 nm. Fluoresterol is expected to be useful in the study of metabolic diseases .
    Fluoresterol
  • HY-B2062
    Chlorthal-dimethyl

    Dimethyl tetrachloroterephthalate

    		 Biochemical Assay Reagents Others
    Chlorthal-dimethyl (Dimethyl tetrachloroterephthalate) is a plant growth regulator. Chlorthal-dimethyl affects cell division and differentiation, interfering with the normal development of vascular tissue. Chlorthal-dimethyl causes localized swelling of tomato hypocotyls and disrupts normal mitosis in germinating millet seedlings .
    Chlorthal-dimethyl
  • HY-173241
    Poly-L-lysine-Ahx-FITC (MW 15000-30000)

    		Fluorescent Dye Others
    Poly-L-lysine-Ahx-FITC (MW 15000-30000) is a cationic polymer, which is a polylysine modified with FITC (HY-66019). Poly-L-lysine-Ahx-FITC (MW 15000-30000) is used to fix cells on glass substrates or negatively charged substrates for subsequent labeling and localization experiments.
    Poly-L-lysine-Ahx-FITC (MW 15000-30000)
  • HY-133846
    Iodothiouracil

    		Thyroid Hormone Receptor Cancer
    Iodothiouracil exhibits high selectivity for melanoma, remains stable in the melanin in melanoma cells, and localizes remote secondary metastases of melanoma. Iodothiouracil can be used for melanoma imaging when labeled with iodine-123, and can be used for radiation therapy when labeled with iodine-131 .
    Iodothiouracil
  • HY-173241A
    Poly-L-lysine-Ahx-FITC (MW 30000-70000)

    		Fluorescent Dye Others
    Poly-L-lysine-Ahx-FITC (MW 30000-70000) is a cationic polymer, which is a polylysine modified with FITC (HY-66019). Poly-L-lysine-Ahx-FITC (MW 30000-70000) is used to fix cells on glass substrates or negatively charged substrates for subsequent labeling and localization experiments.
    Poly-L-lysine-Ahx-FITC (MW 30000-70000)
  • HY-D2300
    mgc(3Me)FDA

    		Fluorescent Dye Others
    mgc(3Me)FDA is fluorescein diacetate (FDA) modified with a cell-permeable myrGC 3Me motif. mgc(3Me)FDA can enter cells and be converted into fluorescently active mgc(3Me)FL (HY-D2301) within the cells. mgc(3Me)FDA is subcellularly localized in the Golgi apparatus and is a visualized Golgi probe .
    mgc(3Me)FDA
  • HY-145422
    KIRA9

    		IRE1 Apoptosis Others
    KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis .
    KIRA9
  • HY-121607
    INI-43

    		AP-1 Apoptosis Cancer
    INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G2-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway .
    INI-43
  • HY-134963
    SBI-0087702

    		PKC Cancer
    SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε .
    SBI-0087702
  • HY-P1105
    GaTx2

    		Chloride Channel Neurological Disease
    GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types .
    GaTx2
  • HY-D1106
    Py-BODIPY-NHS ester

    		Fluorescent Dye Cancer
    BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions . Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells .
    Py-BODIPY-NHS ester
  • HY-109538
    Secretin (swine)

    		Secretin Receptor Neurological Disease Metabolic Disease
    Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism .
    Secretin (swine)
  • HY-D1533
    RhoNox-1
    5+ Cited Publications

    		 Fluorescent Dye Others
    RhoNox-1 is a fluorescent probe for the specific detection of divalent iron ions, and when RhoNox-1 reacts with Fe 2+. RhoNox-1 can generate an irreversible orange (red) fluorescent product (Ex/Em：540/575 nm) . FeRhoNox-1 can enter the cell well, suitable for the detection of Fe 2+ in living cells, and tends to be localized in the Golgi apparatus .
    RhoNox-1
  • HY-114043
    NCGC00092410

    		Glycosidase Metabolic Disease
    NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease .
    NCGC00092410
  • HY-19979
    RCM-1
    4 Publications Verification

    		 DNA/RNA Synthesis Cancer
    RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research .
    RCM-1
  • HY-148755
    ERX-41

    		Lipase Cancer
    ERX-41 is an orally active and stereospecific small molecule targeting to lysosomal acid lipase A (LIPA). ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, indicating a function independent of LIPA but dependent on its ER localization. ERX-41 involves in a targeted strategy for solid tumors .
    ERX-41
  • HY-P10108
    Hexokinase II VDAC binding domain peptide, cell-permeable

    Hxk2VBD peptide, Cell-permeable

    		 Hexokinase Neurological Disease
    Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .
    Hexokinase II VDAC binding domain peptide, cell-permeable
  • HY-131364
    Nur77 modulator 1

    		Nuclear Hormone Receptor 4A/NR4A Apoptosis Cancer
    Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis. Anti-hepatoma activity .
    Nur77 modulator 1
  • HY-147110
    APX2039

    		Fungal Infection Inflammation/Immunology
    APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research .
    APX2039
  • HY-110334
    FFN 206 dihydrochloride

    		Fluorescent Dye Others
    FFN 206 dihydrochloride, a fluorescent probe, is used as an excellent Vesicular Monoamine Transporter 2 (VMAT2) substrate with an apparent Km of 1.16 μM. FFN 206 dihydrochloride is capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles .
    FFN 206 dihydrochloride

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