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Results for "

Curcumin

" in MedChemExpress (MCE) Product Catalog:

51

Inhibitors & Agonists

1

Biochemical Assay Reagents

20

Natural
Products

9

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0005
    Curcumin
    Maximum Cited Publications
    71 Publications Verification

    Diferuloylmethane; Natural Yellow 3; Turmeric yellow

    		 Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis Cancer
    Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
    Curcumin
  • HY-138795
    Curcumin-β-D-glucuronide

    		Others Cancer
    Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer .
    Curcumin-β-D-glucuronide
  • HY-148598
    Curcumin 5-8

    CUR5-8

    		 Apoptosis Autophagy Metabolic Disease
    Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity .
    Curcumin 5-8
  • HY-N0007A
    Bisdemethoxycucurmin

    Curcumin III; DidemethoxyCurcumin

    		 Others Inflammation/Immunology
    Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities .
    Bisdemethoxycucurmin
  • HY-N0007S
    Bisdemethoxycurcumin-d8

    Curcumin III-d8; DidemethoxyCurcumin-d8

    		 Apoptosis Autophagy Cancer
    Bisdemethoxycurcumin-d8 is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
    Bisdemethoxycurcumin-d8
  • HY-N0006
    Demethoxycurcumin
    3 Publications Verification

    Curcumin II; DesmethoxyCurcumin; MonodemethoxyCurcumin

    		 Apoptosis Bacterial Cholinesterase (ChE) NO Synthase Infection Neurological Disease Inflammation/Immunology Cancer
    Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .
    Demethoxycurcumin
  • HY-143421
    Curcumin monoglucuronide

    CMG

    		 Drug Metabolite Cancer
    Curcumin monoglucuronide is known as a glucuronic acid conjugate, which is one of the in vivo metabolites of curcumin. Curcumin monoglucuronide is used for research on the metabolism of curcumin and examination of its development as a pharmaceutical. Curcumin monoglucuronide has the potential for the research of cancer disease (extracted from patent WO2022004873A1) .
    Curcumin monoglucuronide
  • HY-N0005R
    Curcumin (Standard)

    		Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis Cancer
    Curcumin (Standard) is the analytical standard of Curcumin. This product is intended for research and analytical applications. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
    Curcumin (Standard)
  • HY-150673S
    Curcumin diglucoside-d6

    		Isotope-Labeled Compounds Others
    Curcumin diglucoside-d6 is the deuterium labeled Curcumin diglucoside[1].
    Curcumin diglucoside-d6
  • HY-150674S
    Curcumin-diglucoside tetraacetate-d6

    Curcumin-d6-β-di-glucoside tetraacetate; DiglucosylCurcumin-d6 octaacetate

    		 Isotope-Labeled Compounds Others
    Curcumin-diglucoside tetraacetate-d6 is the deuterium labeled Curcumin-diglucoside tetraacetate[1].
    Curcumin-diglucoside tetraacetate-d6
  • HY-N0005S
    Curcumin-d6

    Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

    		 Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus Infection Metabolic Disease Inflammation/Immunology
    Curcumin-d6is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.
    Curcumin-d6
  • HY-N0006S1
    Demethoxycurcumin-d4

    Curcumin II-d4; DesmethoxyCurcumin-d4; MonodemethoxyCurcumin-d4

    		 Apoptosis Autophagy Bacterial Cancer
    Demethoxycurcumin-d4 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties[1].
    Demethoxycurcumin-d4
  • HY-N0006S
    Demethoxycurcumin-d7

    Curcumin II-d7; DesmethoxyCurcumin-d7; MonodemethoxyCurcumin-d7

    		 Isotope-Labeled Compounds Apoptosis Autophagy Bacterial Inflammation/Immunology Cancer
    Demethoxycurcumin-d7 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.
    Demethoxycurcumin-d7
  • HY-139211
    Difluorinated Curcumin

    3,4-Difluorobenzylidene Curcumin

    		 Others Cancer
    Difluorinated Curcumin (3,4-Difluorobenzylidene curcumin) is a fluorinated curcumin analog with high bioavailability and anticancer activity. Difluorinated Curcumin inhibits the self-renewal ability of tumor stem/stem-like cells, clonogenicity, invasiveness and angiogenesis of tumor cells. Difluorinated Curcumin also increases cell sensitivity to chemotherapy .
    Difluorinated Curcumin
  • HY-N0007
    (E,E)-Bisdemethoxycurcumin
    3 Publications Verification

    (E,E)-Curcumin III; (E,E)-DidemethoxyCurcumin

    		 Apoptosis Autophagy Cancer
    (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .
    (E,E)-Bisdemethoxycurcumin
  • HY-143676S
    (1E,4Z,6E)-Curcumin-d6

    		Isotope-Labeled Compounds Others
    (1E,4Z,6E)-Curcumin-d6 is the deuterium labeled (1E,4Z,6E)-Curcumin[1].
    (1E,4Z,6E)-Curcumin-d6
  • HY-163451
    Apoptosis inducer 17

    		Apoptosis Cancer
    Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells .
    Apoptosis inducer 17
  • HY-W009731
    Dibenzoylmethane

    		Keap1-Nrf2 Metabolic Disease Cancer
    Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .
    Dibenzoylmethane
  • HY-N2521
    Tetramethylcurcumin

    FLLL31

    		 STAT Apoptosis Inflammation/Immunology Cancer
    Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .
    Tetramethylcurcumin
  • HY-W009731R
    Dibenzoylmethane (Standard)

    		Keap1-Nrf2 Metabolic Disease Cancer
    Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .
    Dibenzoylmethane (Standard)
  • HY-126154
    L48H37

    		Toll-like Receptor (TLR) Inflammation/Immunology
    L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment .
    L48H37
  • HY-N0894
    Octahydrocurcumin

    HexahydrobisdemethoxyCurcumin

    		 Reactive Oxygen Species Others
    Octahydrocurcumin is a hydrogenated derivative of curcumin and a metabolite of curcumin.
    Octahydrocurcumin
  • HY-151342
    Ser@TPP@CUR

    		Others Others
    Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .
    Ser@TPP@CUR
  • HY-N0007R
    (E,E)-Bisdemethoxycurcumin (Standard)

    		Apoptosis Autophagy Cancer
    (E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .
    (E,E)-Bisdemethoxycurcumin (Standard)
  • HY-100977
    Dimethoxycurcumin

    DiMC; CHC 004; Di-O-methylCurcumin

    		 NO Synthase NF-κB Inflammation/Immunology
    Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities .
    Dimethoxycurcumin
  • HY-N0893
    Tetrahydrocurcumin
    1 Publications Verification

    HZIV 81-2

    		 Cytochrome P450 Autophagy Endogenous Metabolite Inflammation/Immunology Cancer
    Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.
    Tetrahydrocurcumin
  • HY-N7275
    Di-O-methyldemethoxycurcumin

    		Interleukin Related Inflammation/Immunology
    Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits IL-6 production with an EC50 of 16.20 μg/mL. Anti-inflammatory and antioxidant properties .
    Di-O-methyldemethoxycurcumin
  • HY-100977S
    Dimethoxycurcumin-d6

    DiMC-d6; CHC 004-d6; Di-O-methylCurcumin-d6

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Dimethoxycurcumin-d6 is the deuterium labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin is a derivative of Curcumin that has anti-inflammatory and antioxidant activities .
    Dimethoxycurcumin-d6
  • HY-116117
    Salicylcurcumin

    		Others Others
    Salicylcurcumin is a synthetic curcumin analogue with antioxidant activity. Salicylcurcumin may affect lipid peroxidation in fish, favoring increased survival, disease resistance, and ultimately growth rate .
    Salicylcurcumin
  • HY-N7080
    Dihydroferulic acid

    Hydroferulic acid

    		 Others Metabolic Disease
    Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid .
    Dihydroferulic acid
  • HY-N0929
    Hexahydrocurcumin

    		COX Reactive Oxygen Species Cancer
    Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .
    Hexahydrocurcumin
  • HY-107336
    Cyclovalone

    Beveno

    		 COX Inflammation/Immunology
    Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities . Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active .
    Cyclovalone
  • HY-N0893R
    Tetrahydrocurcumin (Standard)

    		Cytochrome P450 Autophagy Endogenous Metabolite Inflammation/Immunology Cancer
    Tetrahydrocurcumin (Standard) is the analytical standard of Tetrahydrocurcumin. This product is intended for research and analytical applications. Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.
    Tetrahydrocurcumin (Standard)
  • HY-163458
    Anti-inflammatory agent 77

    		Interleukin Related Inflammation/Immunology
    Anti-inflammatory agent 77 (C12) is a β-cycloacinamide derived mono-carbonyl curcumin analog and an inhibitor of interleukin-6 (IL-6). Anti-inflammatory agent 77 can be used in the study of wound healing .
    Anti-inflammatory agent 77
  • HY-135702
    UBS109

    		NF-κB Others
    UBS109, as a curcumin analogue, can promote the differentiation and mineralization of osteoblasts. UBS109 shows to regulate bone cell function by activating Smad and inhibiting NF-kB. UBS109 can be used in bone tissue engineering and osteoporosis research .
    UBS109
  • HY-149265
    ROS-generating agent 1

    		Reactive Oxygen Species TrxR Ferroptosis Apoptosis Cancer
    ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities .
    ROS-generating agent 1
  • HY-150228
    MitoCur-1

    		Others Cancer
    MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy .
    MitoCur-1
  • HY-138962
    κ-Carrageenan

    K-Carrageenan Karra Type

    		 Apoptosis Inflammation/Immunology Cancer
    κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective agent carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation .
    κ-Carrageenan
  • HY-N0929R
    Hexahydrocurcumin (Standard)

    		COX Reactive Oxygen Species Cancer
    Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .
    Hexahydrocurcumin (Standard)
  • HY-119272
    EF24
    1 Publications Verification

    		 ERK Caspase Cancer
    EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .
    EF24
  • HY-136477
    Pentagamavunon-1

    PGV-1

    		 Apoptosis COX VEGFR NF-κB Cancer
    Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation .
    Pentagamavunon-1
  • HY-N1967
    Dihydrocurcumin

    		Fatty Acid Synthase (FASN) Metabolic Disease
    Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways .
    Dihydrocurcumin
  • HY-N0006R
    Demethoxycurcumin (Standard)

    		Apoptosis Bacterial Cholinesterase (ChE) NO Synthase Infection Neurological Disease Inflammation/Immunology Cancer
    Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .
    Demethoxycurcumin (Standard)
  • HY-137315S
    TML-6-d3

    		Isotope-Labeled Compounds Amyloid-β Keap1-Nrf2 mTOR NF-κB Neurological Disease
    TML-6-d3 is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-
    TML-6-d3
  • HY-139804
    CTK7A

    		Epigenetic Reader Domain Histone Acetyltransferase HIF/HIF Prolyl-Hydroxylase Cancer
    CTK7A is a curcumin derivative with anticancer activity by inhibiting the HAT activity of p300 and reducing the autoacetylation of p300, thereby affecting its interaction with HIF-1α. The inhibition of CTK7A leads to decreased HIF-1α accumulation and activity, which can be used for cancer treatment research .
    CTK7A
  • HY-137315
    TML-6

    		Amyloid-β NF-κB mTOR Keap1-Nrf2 Neurological Disease
    TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research .
    TML-6
  • HY-123715
    Anticancer agent 255

    		Others Cancer
    Anticancer agent 255 is a monocarbonylated curcumin-1,2,3-oxazole conjugate with significant anticancer activity. The IC50 values of Anticancer agent 255 in prostate cancer cells PC-3 and DU-145 are 8.8μM and 9.5μM respectively. The IC50 values of Anticancer agent 255 against breast cancer cells MCF-7, MDA-MB-231 and 4T1 are 6μM, 10μM and 6.4μM, showing good anti-cancer activity Effect. Anticancer agent 255 can induce mitochondria-mediated apoptosis in cancer cells and prevent cell cycle progression. Anticancer agent 255 down-regulated the cell proliferation marker PCNA and inhibited the activation of cell survival proteins. Anticancer agent 255 up-regulated the pro-apoptotic protein Bax and down-regulated the anti-apoptotic protein Bcl-2 .
    Anticancer agent 255
  • HY-120914
    TrxR1-IN-B19

    GO-Y015

    		 TrxR Apoptosis Cancer
    TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis .
    TrxR1-IN-B19
  • HY-W440901
    DSPE-PEG-SPDP (MW 5000)

    		Liposome Others
    DSPE-PEG-SPDP, MW 5000 is an amphiphilic polyPEG which forms lipid bilayer in water. It can be used to encapsualte therapeutic agents. The core can encapsulate hydrophilic nutrients, such as protein/peptide and mRNA/DNA/siRNA etc. while the lipid bilayer can solubilize hydrophobic drugs, such as doxorubicin, curcumin etc. The SPDP moiety can react with thiol molecule to form a disulfide bond. Reagent grade, for research use only.
    DSPE-PEG-SPDP (MW 5000)
  • HY-148552
    Anti-inflammatory agent 35

    		p38 MAPK ERK NF-κB Interleukin Related TNF Receptor Inflammation/Immunology
    Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo .
    Anti-inflammatory agent 35

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