Dimethoxycurcumin (Synonyms: DiMC; CHC 004; Di-O-methylcurcumin)

Cat. No.: HY-100977 Purity: 98.89%: FAQs
Data Sheet SDS COA Handling Instructions

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Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities.

For research use only. We do not sell to patients.

Dimethoxycurcumin Chemical Structure

CAS No. : 160096-59-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 105	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 105	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 510	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 740	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dimethoxycurcumin:

Dimethoxycurcumin-d₆ Get quote

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nNOS iNOS eNOS

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
Customer Review

Description

Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	> 20 μM Compound: 8	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability at 20 uM measured after 48 hrs by resazurin reagent based multilabel reader analysis Cytotoxicity against human HEK293 cells assessed as reduction in cell viability at 20 uM measured after 48 hrs by resazurin reagent based multilabel reader analysis	[PMID: 36608774]
HEK293	EC₅₀	200 μM Compound: 7	Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay	[PMID: 20004045]
MCF7	IC₅₀	1.07 μM Compound: 4	Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]
SK-BR-3	IC₅₀	0.955 μM Compound: 4	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]

Molecular Weight

396.43

Formula

C₂₃H₂₄O₆

CAS No.

160096-59-3

Appearance

Solid

Color

Yellow to brown

SMILES

O=C(CC(/C=C/C1=CC=C(OC)C(OC)=C1)=O)/C=C/C2=CC=C(OC)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (252.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5225 mL	12.6126 mL	25.2251 mL
5 mM	0.5045 mL	2.5225 mL	5.0450 mL
10 mM	0.2523 mL	1.2613 mL	2.5225 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.89%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (243 KB) HNMR (266 KB) RP-HPLC (250 KB) MS (179 KB)

Handling Instructions (2659 KB)

References

[1]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol [Content Brief]

[2]. Pae HO, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5225 mL	12.6126 mL	25.2251 mL	63.0628 mL
	5 mM	0.5045 mL	2.5225 mL	5.0450 mL	12.6126 mL
	10 mM	0.2523 mL	1.2613 mL	2.5225 mL	6.3063 mL
	15 mM	0.1682 mL	0.8408 mL	1.6817 mL	4.2042 mL
	20 mM	0.1261 mL	0.6306 mL	1.2613 mL	3.1531 mL
	25 mM	0.1009 mL	0.5045 mL	1.0090 mL	2.5225 mL
	30 mM	0.0841 mL	0.4204 mL	0.8408 mL	2.1021 mL
	40 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5766 mL
	50 mM	0.0505 mL	0.2523 mL	0.5045 mL	1.2613 mL
	60 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0510 mL
	80 mM	0.0315 mL	0.1577 mL	0.3153 mL	0.7883 mL
	100 mM	0.0252 mL	0.1261 mL	0.2523 mL	0.6306 mL

Dimethoxycurcumin Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethoxycurcumin160096-59-3DiMC CHC 004 Di-O-methylcurcuminCHC004CHC 004CHC-004NO SynthaseNF-κBNitric oxide synthasesNOSNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Dimethoxycurcumin (Synonyms: DiMC; CHC 004; Di-O-methylcurcumin)

Customer Review

Other Forms of Dimethoxycurcumin:

Dimethoxycurcumin Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All NO Synthase Isoform Specific Products:

View All NF-κB Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Dimethoxycurcumin Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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