2. Search Result
Search Result
Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA complex

" in MedChemExpress (MCE) Product Catalog:

47

Inhibitors & Agonists

3

Fluorescent Dye

2

Biochemical Assay Reagents

2

Natural
Products

2

Isotope-Labeled Compounds

2

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160839
    SPB-PEG4-AAD

    		Others Others
    SPB-PEG4-AAD (compound 6) is a BFPX probe. SPB-PEG4-AAD shows significant crosslinking of the Nkx2.5/DNA complex or p53/DNA complex while displaying little effect on the DNA alone .
    SPB-PEG4-AAD
  • HY-160840
    SPB-AAD

    		Others Others
    SPB-AAD is a BFPX probe. SPB-AAD has covalent capture of in vitro assembled MEF2/DNA and NFAT1/DNA complexes .
    SPB-AAD
  • HY-100777
    DACA

    		Topoisomerase Cancer
    DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells .
    DACA
  • HY-155556
    ZG36

    		ClpP Biochemical Assay Reagents Cancer
    ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model .
    ZG36
  • HY-163177
    HIV-1 inhibitor-63

    		HIV Infection
    HIV-1 inhibitor-63 (compound S17) is a potent HIV-1 inhibitor. HIV-1 inhibitor-63 inhibits integrase-Ku70 complex formation with an IC50 value of 12 µM. HIV-1 inhibitor-63 inhibits HIV-1 post-integration DNA repair .
    HIV-1 inhibitor-63
  • HY-103713
    Seclidemstat
    4 Publications Verification

    SP-2577

    		 Histone Demethylase Cancer
    Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma .
    Seclidemstat
  • HY-103713A
    Seclidemstat mesylate
    4 Publications Verification

    SP-2577 mesylate

    		 Histone Demethylase Cancer
    Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma .
    Seclidemstat mesylate
  • HY-16562S1
    Irinotecan-d10 hydrochloride

    		Isotope-Labeled Compounds Topoisomerase Autophagy Cancer
    Irinotecan-d10 (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1][2].
    Irinotecan-d10 hydrochloride
  • HY-16562S
    Irinotecan-d10

    (+)-Irinotecan-d10; CPT-11-d10; VAL-413-d10

    		 Topoisomerase Autophagy Cancer
    Irinotecan-d10 is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].
    Irinotecan-d10
  • HY-16562
    Irinotecan
    40+ Cited Publications

    (+)-Irinotecan; CPT-11; VAL-413(free base)

    		 Topoisomerase Autophagy Cancer
    Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
    Irinotecan
  • HY-E70209
    EcoRI Methyltransferase

    		DNA Methyltransferase Cancer
    EcoRI Methyltransferase is a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase. EcoRI Methyltransferase relies on a complex conformational mechanism to achieve its remarkable specificity, including DNA bending, base flipping and intercalation into the DNA .
    EcoRI Methyltransferase
  • HY-143210
    Transfectam

    		Liposome Metabolic Disease
    Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .
    Transfectam
  • HY-125930
    T-2513

    		Topoisomerase DNA/RNA Synthesis Cancer
    T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .
    T-2513
  • HY-125930A
    T-2513 hydrochloride

    		Topoisomerase DNA/RNA Synthesis Cancer
    T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .
    T-2513 hydrochloride
  • HY-142943
    DNA-PK-IN-1

    		DNA-PK Cancer
    DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .
    DNA-PK-IN-1
  • HY-142944
    DNA-PK-IN-2

    		DNA-PK Cancer
    DNA-PK-IN-2 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .
    DNA-PK-IN-2
  • HY-162503
    ST166 free acid

    		Bacterial Infection
    ST166 free acid is a inhibitor of formation of the PhoP-DNA complex with the IC50 values of 18 and 24 μM against PhoP and MtrAC binding with DNA, respectively. ST166 free acid shows antibacterial activity against Macrobacterium marinum .
    ST166 free acid
  • HY-15233
    Letermovir
    15+ Cited Publications

    AIC246; MK-8228

    		 CMV Infection
    Letermovir (AIC246) is a potent inhibitor of CMV, which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
    Letermovir
  • HY-19024
    Merbarone

    NSC 336628

    		 Topoisomerase Cancer
    Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent .
    Merbarone
  • HY-160841
    Biotin-16-dCTP

    		DNA/RNA Synthesis Others
    Biotin-16-dCTP is a dNTP with a high incorporation rate that can be used to optimize dNTP DNA polymerase complexes for target nucleic acid amplification .
    Biotin-16-dCTP
  • HY-15435
    CHAPS
    1 Publications Verification

    		 Others Others
    CHAPS, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution .
    CHAPS
  • HY-151862
    3-Azidopropylamine

    		ADC Linker Others
    3-Azidopropylamine is a click chemistry reagent containing an azide group. 3-Azidopropylamine can react with the starch sugar of potato starch for complexation and transfection of plasmid DNA .
    3-Azidopropylamine
  • HY-15435A
    CHAPS hydrate
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    CHAPS hydrate, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS hydrate is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution .
    CHAPS hydrate
  • HY-15233R
    Letermovir (Standard)

    		CMV Infection
    Letermovir (Standard) is the analytical standard of Letermovir. This product is intended for research and analytical applications. Letermovir (AIC246) is a potent inhibitor of CMV, which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
    Letermovir (Standard)
  • HY-D0971
    Pyronin Y
    3 Publications Verification

    Pyronine G; C.I. 45005

    		 DNA Stain Others
    Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells .
    Pyronin Y
  • HY-W040129
    Chromomycin A3

    		Bacterial Fungal Apoptosis Antibiotic Infection Cancer
    Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg 2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor .
    Chromomycin A3
  • HY-158230
    SN-398

    		Topoisomerase Cancer
    SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells .
    SN-398
  • HY-126877
    3-Deaza-2'-deoxyadenosine

    		HSV Infection
    3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity .
    3-Deaza-2'-deoxyadenosine
  • HY-124325
    PIP-199

    		DNA Alkylator/Crosslinker Cancer
    PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics .
    PIP-199
  • HY-161385
    Topoisomerase I inhibitor 16

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM .
    Topoisomerase I inhibitor 16
  • HY-156376
    Cu(II)-Elesclomol

    		Cuproptosis Apoptosis Topoisomerase Cancer
    Cu(II)-Elesclomol is a Cu 2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity .
    Cu(II)-Elesclomol
  • HY-155693
    Topoisomerase II inhibitor 16

    		Topoisomerase Parasite Infection
    Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research .
    Topoisomerase II inhibitor 16
  • HY-135797
    DB1976

    		Apoptosis Cancer
    DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 has apoptosis-inducing effect .
    DB1976
  • HY-135797A
    DB1976 dihydrochloride
    4 Publications Verification

    		 Apoptosis Cancer
    DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect .
    DB1976 dihydrochloride
  • HY-143266
    Topoisomerase I inhibitor 3

    		Topoisomerase Apoptosis Cancer
    Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .
    Topoisomerase I inhibitor 3
  • HY-155060
    Antibacterial agent 144

    		Bacterial DNA/RNA Synthesis Infection
    Antibacterial agent 144 (compound 8e) is an antibacterial agent，with better effect against multi-resistant Staphylococcus aureus than Chloromycin and Amoxicillin (HY-B0467A). Antibacterial agent 144 destroys the cytoplasmic membrane of bacteria，and inhibits the biofilms formation. Antibacterial agent 144 binds to HSA (Kd=13.2 μM)，and exerts bactericidal efficacy. Antibacterial agent 144 also binds with DNA to for supramolecular complex to obstruct DNA replications .
    Antibacterial agent 144
  • HY-146437
    Topoisomerase I inhibitor 6

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases .
    Topoisomerase I inhibitor 6
  • HY-160745
    2'-O-methyladenosine 5'-phosphate

    		DNA/RNA Synthesis Others
    2'-O-methyladenosine 5'-phosphate is the nucleotide complex group of ribosomes and is mainly used for DNA conjugation. 2'-O-methyladenosine 5'-phosphate is used to prepare RNA vaccines and is the main part of the RNA molecule, while the 5'-end is blocked by 2'-O-Methylguanosine 5'-monophosphate .
    2'-O-methyladenosine 5'-phosphate
  • HY-125018
    QM31

    SVT016426

    		 Caspase Cancer
    QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint .
    QM31
  • HY-160693
    2′-O-Methylguanosine 5′-monophosphate

    		DNA/RNA Synthesis Others
    2′-O-Methylguanosine 5′-monophosphate is the nucleotide complex group (pGm) of the ribosome and is primarily used for DNA conjugation. Today's antibodies recognize pGm, in descending order of importance, as the parent base, the methylated ribose moiety, and the phosphate group. 2′-O-Methylguanosine 5′-monophosphate can also be used to prepare RNA vaccines as a 5′-terminal nucleotide to block the RNA molecule .
    2′-O-Methylguanosine 5′-monophosphate
  • HY-13721
    Phenoxodiol
    1 Publications Verification

    Idronoxil; Dehydroequol; Haginin E

    		 Caspase Apoptosis Topoisomerase Cancer
    Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21 WAF1 via a p53 independent manner .
    Phenoxodiol
  • HY-N8270
    Physalin H

    		Hedgehog Endogenous Metabolite Cancer
    Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively .
    Physalin H
  • HY-158156
    NF-κB-IN-16

    		NF-κB Apoptosis Cancer
    NF-κB-IN-16 (compound 9) is a complex (Pt(IV) complex) of NF-κB inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-κB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-κB-IN-16 potently inhibits the NF-κB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-κB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models .
    NF-κB-IN-16
  • HY-151662
    4-Azido-2,3,5,6-tetrafluorobenzoic Acid

    N3-TFBA

    		 ADC Linker Others
    4-Azido-2,3,5,6-tetrafluorobenzoic Acid (N3-TFBA) is a click chemistry reagent containing an azide group. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid is a complex with FAM-labeled DNA probe. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid can be used as versatile photoaffinity labeling agents to probe biological receptors.
    4-Azido-2,3,5,6-tetrafluorobenzoic Acid
  • HY-D0079
    Dihydroethidium
    Maximum Cited Publications
    59 Publications Verification

    Hydroethidine; PD-MY 003

    		 Fluorescent Dye Others
    Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
    Dihydroethidium
  • HY-117693
    Mirin
    1 Publications Verification

    		 ATM/ATR Cancer
    Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .
    Mirin
  • HY-W014837
    NDSB-201

    3-(1-Pyridinio)-1-propanesulfonate

    		 Biochemical Assay Reagents Others
    NDSB-201 consists of a pyridine group attached to a propane chain, which in turn is attached to a sulfonate group. This compound is commonly used as a buffer in biochemical and biological research, especially in electrophoretic applications. It maintains a stable pH in aqueous solutions and has low UV absorption, making it suitable for use in the UV spectrum. Furthermore, due to its ability to form stable complexes with DNA and other biomolecules, 3-(pyridin-1-ium-1-yl)propane-1-sulfonate has been investigated for its potential in drug delivery and genetic research.
    NDSB-201

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: