Search Result
Results for "
GR–14-3-3 stabilizer-1
" in MedChemExpress (MCE) Product Catalog:
29
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N2011
-
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n-Octyl gallate; stabilizer GA 8
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VSV
Bacterial
HSV
Influenza Virus
Reactive Oxygen Species
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Infection
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Octyl gallate (Progallin O) is widely used as a food additive, with antimicrobial and antioxidant activity . Octyl gallate (Progallin O) shows selective and sensitive fluorescent property . Octyl gallate shows a marked antiviral effect against HSV-1, vesicular stomatitis virus (VSV) and poliovirus .
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- HY-43747
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Acetobromo-α-D-glucose, contains 1% CaCO3 as stabilizer; Acetobromo-alpha-D-glucose, contains 1% CaCO3 as stabilizer
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Biochemical Assay Reagents
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Others
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α-Acetobromoglucose, contains 1% CaCO3 as stabilizer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-108285
-
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Ser/Thr Protease
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Inflammation/Immunology
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(Rac)-Telmesteine is a protease inhibitor and is thus a suitable enzyme stabilizer extracted from patent WO 2017220302 A1, compound II-1. (Rac)-Telmesteine can be used as an enzyme stabilizer in protease-containing detergents and cleaning agents .
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- HY-156125
-
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Estrogen Receptor/ERR
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Others
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14-3-3σ/ERα stabilizer-1 (Compound 181) is a covalent 14-3-3σ/ERα stabilizer. 14-3-3σ/ERα stabilizer-1 can be used for research of molecular glues .
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-
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- HY-145890
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-
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- HY-159658
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-
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- HY-149779
-
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Calcium Channel
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Cardiovascular Disease
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RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca 2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca 2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias .
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- HY-145889
-
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Biochemical Assay Reagents
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Others
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LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
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- HY-169905
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Molecular Glues
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Others
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GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glues targeting glucocorticoids (GR) and block the interaction between GR and 14-3-3 .
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-
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- HY-126927
-
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Transthyretin (TTR)
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Neurological Disease
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TTR stabilizer L6 (L6) binds to the T4 binding pocket of transthyretin (TTR), which can prevent the dissociation of TTR to monomer. TTR stabilizer L6 is promising for research of familial amyloid polyneuropathy .
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-
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- HY-153767
-
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MDM-2/p53
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Cancer
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PK095 is a p53 mutant stabilizer. PK095 can be used for research of cancer .
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-
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- HY-Y0102
-
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2-Mercaptobenzoic acid
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Biochemical Assay Reagents
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Others
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Thiosalicylic acid (2-Mercaptobenzoic acid) is a stabilizer that can be used in the synthesis of metal nanoparticles. Thiosalicylic acid is a biomaterial or organic compound that can be used in life science research .
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-
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- HY-W115798
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Magnesium citrate tribasic nonahydrate, 99%
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Biochemical Assay Reagents
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Others
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Trimagnesium dicitrate nonahydrate, 99% (Magnesium citrate tribasic nonahydrate, 99%) is an orally active magnesium salt of citric acid in the nonahydrate form. Trimagnesium dicitrate nonahydrate, 99% used as a stabilizer and anticaking agent in food supplements in solid and chewable forms .
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- HY-113811
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DIXDS; Diproxide
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Biochemical Assay Reagents
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Others
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Diisopropyl xanthogen disulfide (DIXDS) is a superaccelerator for natural rubber and latex, styrene-butadiene rubber and latex, nitrile butadiene rubber and recycled rubber. It can also be used as a neoprene rubber modifier and an insoluble sulfur stabilizer .
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- HY-155206
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5-HT Receptor
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Neurological Disease
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(+)-OSU6162 is an stabilizer on dopaminergic and serotonergic brain signaling. (+)-OSU6162 is a partial agonist of 5-HT2A receptor. (+)-OSU6162 can be used for neurological research .
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- HY-162838
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Estrogen Receptor/ERR
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Others
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TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ .
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- HY-109027
-
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N91115
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GSNOR
CFTR
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Inflammation/Immunology
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Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research .
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- HY-153193
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GLP Receptor
Molecular Glues
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Metabolic Disease
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LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R .
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- HY-B1619
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Cromoglicic acid
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Others
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Inflammation/Immunology
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Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis .
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- HY-16967
-
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G-quadruplex
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Cancer
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MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of <10 nM .
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- HY-N7059
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Bacterial
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Infection
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Lactobionic acid is a bionic acid naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties .
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- HY-159063
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Biochemical Assay Reagents
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Others
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Soy Polysaccharides are biochemical reagents that can be added to beverages, sauces, and dairy products as thickeners, emulsifiers, and dietary fiber ingredients. Soy Polysaccharides are non-toxic, hydrophilic, and biodegradable, allowing for widespread application in various food sectors. Additionally, Soy Polysaccharides serve as effective stabilizers in oil/water emulsions. Even under acidic conditions, Soy Polysaccharides can stabilize β-conglycinin-based emulsions to prevent flocculation .
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- HY-149513
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c-Myc
Apoptosis
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Cancer
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EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth .
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- HY-108468
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Cryptochrome
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Metabolic Disease
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KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .
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- HY-W250308
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Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
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Bacterial
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Others
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Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
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-
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- HY-W250308A
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Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
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Bacterial
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Infection
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ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
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- HY-126127
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Histamine Receptor
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Inflammation/Immunology
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BRL 22321 free base is a stabilizer with similar mast cell stabilizing activity to Cromolyn sodium (HY-B0320A) and also has some smooth muscle relaxant activity. BRL 22321 free base is more potent than Cromolyn sodium (HY-B0320A) in inhibiting rat passive cutaneous and peritoneal anaphylaxis and antigen-induced histamine release from passively sensitized rat peritoneal cells .
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- HY-W094474
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hydrate/monohydrateortrihydrate
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GSK-3
Apoptosis
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Infection
Neurological Disease
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Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease .
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- HY-122815
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Fusicoccin A
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Apoptosis
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Cancer
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Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H +-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .
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- HY-159502
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- HY-15278
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- HY-108567
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- HY-B2233A
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- HY-N11067
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Apoptosis
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Cancer
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Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.
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- HY-111297
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Others
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Cancer
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BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
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- HY-112794
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Others
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Others
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Topanol CA serves as an effective antioxidant and stabilizer for resins and light-colored rubber products.
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- HY-145937
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MDM-2/p53
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Cancer
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PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.
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- HY-B0538A
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- HY-13656
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KOS-1803
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Microtubule/Tubulin
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Cancer
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Isofludelone (KOS-1803) is a potential microtubule stabilizer for the treatment of solid tumors. Isofludelone has antitumor activity .
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- HY-Y1175A
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Biochemical Assay Reagents
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Others
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Calcium acetate monohydrate, ACS, 99% is a monohydrate form of calcium acetate used to precipitate oxalates in solution; it also serves as a stabilizer, buffer, and chelating agent.
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- HY-169426
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Amyloid-β
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Cancer
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Anti-amyloid agent-2 (compound (R)-38) is an amyloidogenic immunoglobulin light chain stabilizer .
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- HY-135776
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o-BMVC
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G-quadruplex
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Cancer
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BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer .
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- HY-15595
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G-quadruplex
Telomerase
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Cancer
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360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
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- HY-14270
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- HY-138694
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Antibiotic
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Infection
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5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities .
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-
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- HY-15595A
-
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360 A iodide
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G-quadruplex
Telomerase
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Cancer
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360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
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- HY-126899
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Microtubule/Tubulin
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Cancer
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TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain .
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-
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- HY-W344875
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Biochemical Assay Reagents
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Sodium ligninsulfonate is a natural polymer compound with good surface activity, which can be used as a stabilizer for liposomes, a promoter for nanocrystal production, and a dispersant for nanoparticle preparation.
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- HY-17029
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- HY-B1068
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Biochemical Assay Reagents
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Metabolic Disease
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Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol is used to induce hyperlipidemia in animals .
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- HY-B1620D
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PVP K25; Polyvidone K25; Povidone K25
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Biochemical Assay Reagents
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Others
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Polyvinylpyrrolidone K25 is a multifunctional synthetic polymer. Polyvinylpyrrolidone K25 can be used as stabilizer, emulsifier, suspension agent, solubilizer, protective colloid and complexing agent .
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- HY-B1620E
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PVP K60; Polyvidone K60; Povidone K60
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Biochemical Assay Reagents
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Others
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Polyvinylpyrrolidone K60 is a multifunctional synthetic polymer. Polyvinylpyrrolidone K60 can be used as stabilizer, emulsifier, suspension agent, solubilizer, protective colloid and complexing agent .
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- HY-108567R
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Biochemical Assay Reagents
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Others
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Bisphenol A diglycidyl ether (Standard) is the analytical standard of Bisphenol A diglycidyl ether. This product is intended for research and analytical applications. Bisphenol A diglycidyl ether is used as a stabilizer and embedding agent.
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- HY-15278A
-
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(16R)-KOS 862
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Microtubule/Tubulin
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Infection
Cancer
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(16R)-Epothilone D is the isomer of Epothilone D (HY-15278), and can be used as an experimental control. Epothilone D (KOS 862) is a potent microtubule stabilizer.
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- HY-119506
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KL044
1 Publications Verification
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Cryptochrome
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Metabolic Disease
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KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity .
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- HY-158209
-
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Biochemical Assay Reagents
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Others
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Block polyoxyethylene-polyoxypropylene is a block copolymer composed of hydrophilic polyoxyethylene (POE) and hydrophobic polyoxypropylene (POP), which can be used to prepare biological materials such as emulsifiers, drug delivery carriers, and stabilizers .
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- HY-109165
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- HY-109165A
-
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AG10 hydrochloride
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Transthyretin (TTR)
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Metabolic Disease
Endocrinology
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Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis .
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- HY-106083
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RHC 3988
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Others
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Inflammation/Immunology
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Quazolast (RHC 3988) is a orally active mast cell stabilizer. Quazolast also is a potent mediator release inhibitor. Quazolast reduces the gastric damage. Quazolast has the potential for the research of gastric ulcers .
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- HY-14270R
-
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
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Lodoxamide (Standard) is the analytical standard of Lodoxamide. This product is intended for research and analytical applications. Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.
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- HY-134194
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KL201
1 Publications Verification
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Cryptochrome
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Metabolic Disease
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KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues .
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- HY-W414069
-
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Endogenous Metabolite
Liposome
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Others
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Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .
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- HY-156228
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Ras
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Cancer
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RGB-1 is a polycyclic aromatic hydrocarbon molecule and a stabilizer of RNA G-quadruplexes. RGB-1 can promote the inhibition of RNA translation and reduce the expression of NRAS proto-oncogene in breast cancer cells .
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- HY-W243303O
-
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Biochemical Assay Reagents
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Cancer
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Poly(acrylic acid) (Mv 1250000) (viscous liquid) is an anionic polymer with a molecular weight of 1,250,000. It can be used as a corrosion inhibitor and surface stabilizer, as well as a biomaterial or organic compound relevant to life sciences research .
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- HY-155647
-
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Microtubule/Tubulin
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Cancer
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Microtubule stabilizing agent-1 (compound 3l) is a Paclitaxel derivative that efficiently promotes tubulin polymerization. Microtubule stabilizing agent-1 shows antitumor efficacy .
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- HY-B0157AS
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- HY-148953
-
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G-quadruplex
DNA/RNA Synthesis
Apoptosis
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Cancer
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MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer .
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- HY-B0640A
-
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WAL801 hydrochloride
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
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Epinastine hydrochloride (WAL801 hydrochloride) is an antihistamine and mast cell stabilizer. Epinastine hydrochloride is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine hydrochloride also inhibits IL-8 release and has an antiallergic action .
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- HY-103403
-
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PNU96391 hydrochloride
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5-HT Receptor
Dopamine Receptor
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Neurological Disease
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(-)-OSU6162 (PNU96391) hydrochloride is a dopamine stabilizer. (-)-OSU6162 hydrochloride acts as partial agonist at 5-HT2A and is a dopamine D2 antagonist. (-)-OSU6162 hydrochloride can be used for the research of aggression and irritability .
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- HY-B1068R
-
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Biochemical Assay Reagents
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Metabolic Disease
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Tyloxapol (Standard) is the analytical standard of Tyloxapol. This product is intended for research and analytical applications. Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol is used to induce hyperlipidemia in animals .
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- HY-B0640
-
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WAL801
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
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Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action .
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- HY-122295
-
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Apoptosis
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Inflammation/Immunology
Cancer
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Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .
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- HY-B1619S
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Cromoglicic acid-d5
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Isotope-Labeled Compounds
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Inflammation/Immunology
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Cromoglicic acid-d5 is the deuterium labeled Cromolyn[1]. Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[2].
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- HY-W142663
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Endogenous Metabolite
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Bisphenol M is a synthetic organic compound with antioxidant activity. Bisphenol M is commonly used in industry to make plastics and resins, and is used as a stabilizer and preservative in cosmetics. Bisphenol M can also be used in certain food packaging materials to improve product durability and safety.
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- HY-109017
-
-
- HY-W243303C
-
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Biochemical Assay Reagents
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Others
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Poly(acrylic acid) (Mv 4000000) is a polyacrylic acid (and an anionic polymer) with a molecular weight of 4000000. Poly(acrylic acid) (Mv 4000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 4000000) is a biomaterial or organic compound that can be used in life science research .
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- HY-W062109
-
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Endogenous Metabolite
Histamine Receptor
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Inflammation/Immunology
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Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis .
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- HY-W127640
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Biochemical Assay Reagents
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Others
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Phosphocholine Chloride Sodium Salt is an organic compound containing phosphate, choline and chloride ions. It is commonly used to prepare cell membranes and liposomes for drug delivery systems. Phosphocholine Chloride Sodium Salt has various applications in the pharmaceutical industry, especially as a stabilizer and surfactant. In addition, it is used as an emulsifier and conditioning agent in the manufacture of cosmetic and personal care products.
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- HY-141543
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β-catenin
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Cancer
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YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and AMPK activation .
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- HY-Y0667
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Biochemical Assay Reagents
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Others
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Benzyltriethylammonium chloride is a quaternary ammonium salt commonly used as a phase transfer catalyst, surfactant and stabilizer in various chemical reactions, especially in organic synthesis. Benzyltriethylammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
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- HY-W093282
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Soybean oil epoxide
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Biochemical Assay Reagents
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Others
|
|
Epoxidized soya bean oil (ESBO) is a vegetable oil-derived organic compound used as a plasticizer and stabilizer in various applications. It is produced by epoxidation of soybean oil, which introduces epoxy groups into the fatty acid chains of the oil. ESBO is a viscous, pale yellow liquid that is soluble in many organic solvents, such as chloroform and ethanol, but insoluble in water. It is commonly used as a plasticizer in polyvinyl chloride (PVC) products, including toys, food packaging materials and medical devices. In addition to its plasticizing properties, ESBO acts as an antioxidant and UV stabilizer, helping to prevent degradation and discoloration of PVC products over time. ESBOs have been investigated for their potential use in biodegradable plastics and as bio-based alternatives to traditional petroleum-derived plasticizers.
|
-
- HY-W004963
-
|
TBAT
|
Biochemical Assay Reagents
|
Others
|
|
Tetrabutylammonium difluorotriphenylsilicate(IV) (TBAT) is an organic compound commonly used as a catalyst and surfactant. It can play a catalytic role in some organic synthesis reactions, and can be used as a cleaning agent, lubricant and stabilizer. In addition, the compound is widely used in certain industrial fields, such as in the plastic, rubber and textile manufacturing processes.
|
-
- HY-117113
-
|
|
Notch
|
Cancer
|
|
JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity .
|
-
- HY-W127540
-
|
Hexadecyl acetate
|
Biochemical Assay Reagents
|
Others
|
|
Palmityl acetate is an ester compound with a waxy odor commonly used as a lubricant or emollient in various cosmetic and personal care products. In addition, it can be used as a plasticizer or stabilizer in the production of plastics and resins. Its unique chemical properties make it an important ingredient in a variety of commercial products, including perfumes, lotions and hair care products.
|
-
- HY-Y0791
-
|
Tetra-n-butylammonium iodide; TBAI
|
Biochemical Assay Reagents
|
Others
|
|
Tetrabutylammonium iodide is a quaternary ammonium salt commonly used as a phase transfer catalyst, surfactant, and stabilizer in various chemical reactions, especially in organic synthesis. Tetrabutylammonium iodide has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
|
-
- HY-W243303B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(acrylic acid) (Mv 3000000) is a polyacrylic acid (an anionic polymer) with a molecular weight of 3000000. Poly(acrylic acid) (Mv 3000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 3000000) is a biomaterial or organic compound that can be used as a life science research related biomaterial or organic compound .
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-
- HY-W243303D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(acrylic acid) (Mv 1250000) is a polyacrylic acid (an anionic polymer) with a molecular weight of 1250000. Poly(acrylic acid) (Mv 1250000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 1250000) is a biomaterial or organic compound that can be used as a life science research related biomaterial or organic compound .
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-
- HY-124484
-
|
|
Notch
|
Cancer
|
|
JI130 (JI051 derivative ) is a stabilizer for the Hes1-PHB2 interaction. JI130 inhibits the ability of Hes1 to repress transcription. JI130 significantly reduces the tumor growth in a murine pancreatic tumor model and has the potential for managing pancreatic cancer .
|
-
- HY-10684
-
|
ACR16; ASP2314; FR310826
|
Dopamine Receptor
|
Neurological Disease
|
|
Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
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-
- HY-135775
-
BMVC
1 Publications Verification
|
G-quadruplex
Telomerase
DNA/RNA Synthesis
|
Cancer
|
|
BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities .
|
-
- HY-N3028
-
|
|
Microtubule/Tubulin
|
Cancer
|
|
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM .
|
-
- HY-Y0080
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl trioctyl ammonium chloride is a quaternary ammonium salt commonly used as a surfactant, stabilizer and phase transfer catalyst in various chemical reactions, especially in organic synthesis. Methyl trioctyl ammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
|
-
- HY-Y1039
-
|
1-Monostearin; 2,3-Dihydroxypropyl stearate
|
Biochemical Assay Reagents
|
Others
|
|
Stearic acid 1-monoglyceride is an ester composed of stearic acid and glycerin, commonly known as glyceryl monostearate. 1-Monoglyceride stearate has unique chemical properties that make it an important ingredient in a variety of industrial processes, including food production, cosmetics, and pharmaceuticals. It acts as an emulsifier, stabilizer and thickener in these products, enhancing their texture and shelf life.
|
-
- HY-14852
-
|
|
Transthyretin (TTR)
|
Neurological Disease
|
|
Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis .
|
-
- HY-113649
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects .
|
-
- HY-W115731
-
|
|
Biochemical Assay Reagents
Endogenous Metabolite
|
Others
|
|
Dextrins are a group of low molecular weight carbohydrates produced by the hydrolysis of starch. Dextrin is commonly used as a thickener, stabilizer or binder in a variety of foods including baked goods, beverages and confectionary. In addition, it is used in the production of adhesives, paper and textiles. Its unique chemical properties make it an important ingredient in a variety of industrial processes, especially in construction and packaging.
|
-
- HY-W011060
-
|
4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
|
Biochemical Assay Reagents
|
Others
|
|
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+) .
|
-
- HY-B0640AR
-
|
WAL801 (hydrochloride) (Standard)
|
Histamine Receptor
|
Inflammation/Immunology
Endocrinology
|
|
Epinastine (hydrochloride) (Standard) is the analytical standard of Epinastine (hydrochloride). This product is intended for research and analytical applications. Epinastine hydrochloride (WAL801 hydrochloride) is an antihistamine and mast cell stabilizer. Epinastine hydrochloride is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine hydrochloride also inhibits IL-8 release and has an antiallergic action .
|
-
- HY-W008816
-
|
Octyl carbinol; Pelargonic alcohol
|
Biochemical Assay Reagents
|
Others
|
|
Nonan-1-ol is an organic compound commonly used in the manufacture of surfactants and lubricants, among others. It can be used as a detergent, emulsifier and stabilizer, and is widely used in some cosmetics, personal care products and printing inks. In addition, the compound has important applications in certain industrial fields, for example in the production of plastics and rubber.
|
-
- HY-134924
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Succinyl-β-cycloaltrin is a modified cyclodextrin with unique chemical properties that make it an effective solubilizer and stabilizer for various compounds, especially in the pharmaceutical industry. Succinyl-β-cycloaltrin has a hydrophobic interior and a hydrophilic exterior, enabling it to form stable clathrates with hydrophobic molecules such as drugs and nutrients. This increases their solubility and bioavailability, making them more effective for recreational or nutritional purposes.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-43747
-
|
Acetobromo-α-D-glucose, contains 1% CaCO3 as stabilizer; Acetobromo-alpha-D-glucose, contains 1% CaCO3 as stabilizer
|
Carbohydrates
|
|
α-Acetobromoglucose, contains 1% CaCO3 as stabilizer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W250308
-
|
Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
|
Cell Assay Reagents
|
|
Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
|
-
- HY-W250308A
-
|
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Cell Assay Reagents
|
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
-
- HY-Y0102
-
|
2-Mercaptobenzoic acid
|
Drug Delivery
|
|
Thiosalicylic acid (2-Mercaptobenzoic acid) is a stabilizer that can be used in the synthesis of metal nanoparticles. Thiosalicylic acid is a biomaterial or organic compound that can be used in life science research .
|
-
- HY-W115798
-
|
Magnesium citrate tribasic nonahydrate, 99%
|
Buffer Reagents
|
|
Trimagnesium dicitrate nonahydrate, 99% (Magnesium citrate tribasic nonahydrate, 99%) is an orally active magnesium salt of citric acid in the nonahydrate form. Trimagnesium dicitrate nonahydrate, 99% used as a stabilizer and anticaking agent in food supplements in solid and chewable forms .
|
-
- HY-159063
-
|
|
Carbohydrates
|
|
Soy Polysaccharides are biochemical reagents that can be added to beverages, sauces, and dairy products as thickeners, emulsifiers, and dietary fiber ingredients. Soy Polysaccharides are non-toxic, hydrophilic, and biodegradable, allowing for widespread application in various food sectors. Additionally, Soy Polysaccharides serve as effective stabilizers in oil/water emulsions. Even under acidic conditions, Soy Polysaccharides can stabilize β-conglycinin-based emulsions to prevent flocculation .
|
-
- HY-108567
-
-
- HY-B2233A
-
|
|
Buffer Reagents
|
|
Calcium phosphorylcholine chloride, 98% is used as a stabilizer or enhancer in experiments.
|
-
- HY-Y1175A
-
|
|
Buffer Reagents
|
|
Calcium acetate monohydrate, ACS, 99% is a monohydrate form of calcium acetate used to precipitate oxalates in solution; it also serves as a stabilizer, buffer, and chelating agent.
|
-
- HY-W344875
-
|
|
Drug Delivery
|
|
Sodium ligninsulfonate is a natural polymer compound with good surface activity, which can be used as a stabilizer for liposomes, a promoter for nanocrystal production, and a dispersant for nanoparticle preparation.
|
-
- HY-B1620D
-
|
PVP K25; Polyvidone K25; Povidone K25
|
Thickeners
|
|
Polyvinylpyrrolidone K25 is a multifunctional synthetic polymer. Polyvinylpyrrolidone K25 can be used as stabilizer, emulsifier, suspension agent, solubilizer, protective colloid and complexing agent .
|
-
- HY-B1620E
-
|
PVP K60; Polyvidone K60; Povidone K60
|
Thickeners
|
|
Polyvinylpyrrolidone K60 is a multifunctional synthetic polymer. Polyvinylpyrrolidone K60 can be used as stabilizer, emulsifier, suspension agent, solubilizer, protective colloid and complexing agent .
|
-
- HY-108567R
-
|
|
Cell Assay Reagents
|
|
Bisphenol A diglycidyl ether (Standard) is the analytical standard of Bisphenol A diglycidyl ether. This product is intended for research and analytical applications. Bisphenol A diglycidyl ether is used as a stabilizer and embedding agent.
|
-
- HY-158209
-
|
|
Biochemical Assay Reagents
|
|
Block polyoxyethylene-polyoxypropylene is a block copolymer composed of hydrophilic polyoxyethylene (POE) and hydrophobic polyoxypropylene (POP), which can be used to prepare biological materials such as emulsifiers, drug delivery carriers, and stabilizers .
|
-
- HY-W414069
-
|
|
Drug Delivery
|
|
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .
|
-
- HY-W243303C
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (Mv 4000000) is a polyacrylic acid (and an anionic polymer) with a molecular weight of 4000000. Poly(acrylic acid) (Mv 4000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 4000000) is a biomaterial or organic compound that can be used in life science research .
|
-
- HY-W127640
-
|
|
Enzyme Substrates
|
|
Phosphocholine Chloride Sodium Salt is an organic compound containing phosphate, choline and chloride ions. It is commonly used to prepare cell membranes and liposomes for drug delivery systems. Phosphocholine Chloride Sodium Salt has various applications in the pharmaceutical industry, especially as a stabilizer and surfactant. In addition, it is used as an emulsifier and conditioning agent in the manufacture of cosmetic and personal care products.
|
-
- HY-Y0667
-
|
|
Cell Assay Reagents
|
|
Benzyltriethylammonium chloride is a quaternary ammonium salt commonly used as a phase transfer catalyst, surfactant and stabilizer in various chemical reactions, especially in organic synthesis. Benzyltriethylammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
|
-
- HY-W093282
-
|
Soybean oil epoxide
|
Co-solvents
|
|
Epoxidized soya bean oil (ESBO) is a vegetable oil-derived organic compound used as a plasticizer and stabilizer in various applications. It is produced by epoxidation of soybean oil, which introduces epoxy groups into the fatty acid chains of the oil. ESBO is a viscous, pale yellow liquid that is soluble in many organic solvents, such as chloroform and ethanol, but insoluble in water. It is commonly used as a plasticizer in polyvinyl chloride (PVC) products, including toys, food packaging materials and medical devices. In addition to its plasticizing properties, ESBO acts as an antioxidant and UV stabilizer, helping to prevent degradation and discoloration of PVC products over time. ESBOs have been investigated for their potential use in biodegradable plastics and as bio-based alternatives to traditional petroleum-derived plasticizers.
|
-
- HY-W004963
-
|
TBAT
|
Biochemical Assay Reagents
|
|
Tetrabutylammonium difluorotriphenylsilicate(IV) (TBAT) is an organic compound commonly used as a catalyst and surfactant. It can play a catalytic role in some organic synthesis reactions, and can be used as a cleaning agent, lubricant and stabilizer. In addition, the compound is widely used in certain industrial fields, such as in the plastic, rubber and textile manufacturing processes.
|
-
- HY-W127540
-
|
Hexadecyl acetate
|
Drug Delivery
|
|
Palmityl acetate is an ester compound with a waxy odor commonly used as a lubricant or emollient in various cosmetic and personal care products. In addition, it can be used as a plasticizer or stabilizer in the production of plastics and resins. Its unique chemical properties make it an important ingredient in a variety of commercial products, including perfumes, lotions and hair care products.
|
-
- HY-Y0791
-
|
Tetra-n-butylammonium iodide; TBAI
|
Biochemical Assay Reagents
|
|
Tetrabutylammonium iodide is a quaternary ammonium salt commonly used as a phase transfer catalyst, surfactant, and stabilizer in various chemical reactions, especially in organic synthesis. Tetrabutylammonium iodide has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
|
-
- HY-W243303B
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (Mv 3000000) is a polyacrylic acid (an anionic polymer) with a molecular weight of 3000000. Poly(acrylic acid) (Mv 3000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 3000000) is a biomaterial or organic compound that can be used as a life science research related biomaterial or organic compound .
|
-
- HY-Y0080
-
|
|
Biochemical Assay Reagents
|
|
Methyl trioctyl ammonium chloride is a quaternary ammonium salt commonly used as a surfactant, stabilizer and phase transfer catalyst in various chemical reactions, especially in organic synthesis. Methyl trioctyl ammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
|
-
- HY-Y1039
-
|
1-Monostearin; 2,3-Dihydroxypropyl stearate
|
Thickeners
|
|
Stearic acid 1-monoglyceride is an ester composed of stearic acid and glycerin, commonly known as glyceryl monostearate. 1-Monoglyceride stearate has unique chemical properties that make it an important ingredient in a variety of industrial processes, including food production, cosmetics, and pharmaceuticals. It acts as an emulsifier, stabilizer and thickener in these products, enhancing their texture and shelf life.
|
-
- HY-W115731
-
|
|
Thickeners
|
|
Dextrins are a group of low molecular weight carbohydrates produced by the hydrolysis of starch. Dextrin is commonly used as a thickener, stabilizer or binder in a variety of foods including baked goods, beverages and confectionary. In addition, it is used in the production of adhesives, paper and textiles. Its unique chemical properties make it an important ingredient in a variety of industrial processes, especially in construction and packaging.
|
-
- HY-W011060
-
|
4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
|
Biochemical Assay Reagents
|
|
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+) .
|
-
- HY-W008816
-
|
Octyl carbinol; Pelargonic alcohol
|
Biochemical Assay Reagents
|
|
Nonan-1-ol is an organic compound commonly used in the manufacture of surfactants and lubricants, among others. It can be used as a detergent, emulsifier and stabilizer, and is widely used in some cosmetics, personal care products and printing inks. In addition, the compound has important applications in certain industrial fields, for example in the production of plastics and rubber.
|
-
- HY-134924
-
|
|
Co-solvents
|
|
Succinyl-β-cycloaltrin is a modified cyclodextrin with unique chemical properties that make it an effective solubilizer and stabilizer for various compounds, especially in the pharmaceutical industry. Succinyl-β-cycloaltrin has a hydrophobic interior and a hydrophilic exterior, enabling it to form stable clathrates with hydrophobic molecules such as drugs and nutrients. This increases their solubility and bioavailability, making them more effective for recreational or nutritional purposes.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B0157AS
-
|
|
|
Ketotifen-d3 (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks[1][2].
|
-
-
- HY-B1619S
-
|
|
|
Cromoglicic acid-d5 is the deuterium labeled Cromolyn[1]. Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[2].
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W414069
-
|
|
|
Cholesterol
|
|
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .
|
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