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Results for "

GRP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (8) Autophagy (4) Bacterial (1) Biochemical Assay Reagents (4) Bombesin Receptor (8) Endogenous Metabolite (18) Fluorescent Dye (1) HSP (53) Interleukin Related (1) Isotope-Labeled Compounds (14) JNK (1) Mitochondrial Metabolism (1) PACAP Receptor (2) PSMA (1) RABV (2) Radionuclide-Drug Conjugates (RDCs) (1) Small Interfering RNA (siRNA) (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (58) Cardiovascular Disease (19) Endocrinology (3) Infection (3) Inflammation/Immunology (3) Metabolic Disease (32) Neurological Disease (27)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

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Click Chemistry

Oligonucleotides

GRP-60367 hydrochloride 1 Publications Verification	RABV	Infection
GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein .

GRP78-IN-3	HSP	Cancer
GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC₅₀ of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC₅₀ of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC₅₀ of 13.9 μM) .

Grp94 Inhibitor-1 2 Publications Verification	HSP	Inflammation/Immunology Cancer
Grp94 Inhibitor-1 is a potent, selective *Grp94* inhibitor with an IC₅₀ value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α .

GRP78-IN-1	HSP Apoptosis	Cancer
GRP78-IN-1 exhibits several interactions with *GRP78* residues with binding energy of -8.07 kcal/mol. GRP78-IN-1 shows the potent cytotoxic, anti-proliferative in cancer cells. GRP78-IN-1 exhibits promising apoptosis in breast cancer cells and wound healing properties .

GRP78-IN-2	HSP	Cardiovascular Disease Cancer
GRP78-IN-2 (Compound FL5) is a *GRP78* (Glucose Regulated Protein 78 kDa) inhibitor. GRP78-IN-2 preferentially targeting cell surface GRP78 and shows potent antiangiogenic and anticancer activities without affecting other normal cells .

GRP75-IN-1 hydrochloride	Apoptosis	Cancer
GRP75-IN-1 hydrochloride (compound 33) is an anti-endometrial cancer (EC) agent that induces apoptosis. GRP75-IN-1 hydrochloride reduces Ca ²⁺ levels in mitochondria by targeting *GRP75* and disrupting its interaction with IP3R .

GRP-60367	RABV	Infection
GRP-60367 is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains .

Grp94 Inhibitor-2	HSP	Cancer
Grp94 Inhibitor-2 (compound 23), a cyclopropane analog, exhibits high affinity for glucose-regulated protein 94 (Grp94) with a K_d of 0.48 µM and 0.65 µM for Grp94 and Hsp90α, respectively .

GRP (14-27) (human, porcine, canine)	Bombesin Receptor	Metabolic Disease
GRP (14-27) (human, porcine, canine) is a bombesin receptor ligand. The specific binding of GRP (14-27) is inhibited by GTP and GDP, whereas GMP was without effect .

GRP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GRP Human Pre-designed siRNA Set A contains three designed siRNAs for GRP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Neuromedin C (porcine) GRP(18-27) (porcine)	Biochemical Assay Reagents	Neurological Disease
Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases .

Biotin-Gastrin Releasing Peptide, human	Fluorescent Dye	Neurological Disease Cancer
Biotin-Gastrin Releasing Peptide, human is a biotinylated gastrin releasing peptide (GRP). Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties .

Radamide	Others	Cancer
Radamide is an inhibitor of Grp94 with anti-migratory activity. Radamide is used to inhibit Grp94-related diseases such as glaucoma, cancer metastasis, and multiple myeloma. Radamide exhibits selective inhibitory activity by acting on the specific structure of Grp94. Radamide derivatives show better potency and selectivity in improved structure-activity relationship studies .

BIM 23042	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

Versipelostatin	HSP	Cancer
Versipelostatin is a *GRP78/Bip* molecular chaperone down-regulator and can be isolated from the culture broth of Streptomyces versipellis 4083-SVS6 .

PU-H54	HSP	Cancer
PU-H54, a *Grp94*-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy . PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

PU-WS13 2 Publications Verification	HSP	Cancer
PU-WS13 is a selective *Grp94* inhibitor, with an EC₅₀ of 0.22 μM.

Retaspimycin Hydrochloride 3 Publications Verification IPI-504	HSP	Cancer
Retaspimycin Hydrochloride is a potent inhibitor of Hsp90 with EC₅₀s of 119 nM for both Hsp90 and Grp9.

Retaspimycin	HSP	Cancer
Retaspimycin is a potent inhibitor of Hsp90, with EC₅₀s of 119 nM for both Hsp90 and Grp9.

YUM70 1 Publications Verification	HSP Apoptosis	Cancer
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC₅₀ of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model .

BiP inducer X 5 Publications Verification	Apoptosis	Neurological Disease
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress .

SNX-2112 2 Publications Verification PF-04928473	HSP Autophagy	Cancer
SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a K_d of 16 nM for Hsp90 and IC₅₀s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC₅₀s of 10 nM, 4.275 μM and 0.862 μM, respectively . SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with K_ds of 4 nM, 6 nM and 484 nM, respectively .

KUNG65	HSP	Neurological Disease
KUNG65 is a selective inhibitor of *Grp94, with a target K_d* of 540 nM and at least 73 fold selectivity vs. the other Hsp90 isoforms .

PSB-CB5	Others	Metabolic Disease
PSB-CB5 is a potent and selective antagonist of GRP18. PSB-CB5 has the potential for the research of metabolic disease and obesity .

HA15 25+ Cited Publications	HSP Autophagy Apoptosis	Cancer
HA15 is a potent and specific inhibitor of ER chaperone *BiP/GRP78/HSPA5*, inhibits the ATPase activity of BiP, with anti-cancerous activity .

HM03 3 Publications Verification	HSP	Cancer
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

Antagonist G	Vasopressin Receptor Apoptosis	Cancer
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy .

HM03 trihydrochloride	HSP	Cancer
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity .

Antagonist G TFA	Vasopressin Receptor Apoptosis	Cancer
Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy .

PSMA targeting peptide TFA PSMA-1 TFA	PSMA	Cancer
PSMA targeting peptide TFA (PSMA-1 TFA) is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells .

TRAP1-IN-1	HSP Mitochondrial Metabolism	Cancer
TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism .

NVP-HSP990 3 Publications Verification HSP-990	HSP Apoptosis	Cancer
NVP-HSP990 is a potent, selective and orally active Hsp90 inhibitor, with IC₅₀ values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.

AlF-NOTA-c-d-VAP	Radionuclide-Drug Conjugates (RDCs) HSP	Cancer
AlF-NOTA-c-d-VAP is a peptide positron emission tomography (PET) probe that used for targeted tumor imaging of GRP78. AlF-NOTA-c-d-VAP demonstrates high stability in vitro and in vivo .

VER-155008 15+ Cited Publications	HSP Autophagy	Neurological Disease Cancer
VER-155008 is an inhibitor of Hsp70, with IC₅₀s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a K_d of 0.3 μM for Hsp70.

Kuwanon H	Bombesin Receptor	Cancer
Kuwanon H is a flavonoid isolated from Morus alba, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a K_i value of 290 nM in cells .

Hexadecanoate-13C16 potassium 2 Publications Verification	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Hexadecanoate- ¹³C₁₆ (potassium) is the ¹³C-labeled Hexadecanoate sodium. Hexadecanoate potassium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

BIM-26226	Bombesin Receptor	Cancer
BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC₅₀s in the nanomolar range. BIM-26226 can be used for the research of cancer .

PACAP (1-38) free acid TFA	PACAP Receptor	Endocrinology
PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

PACAP (1-38) free acid	PACAP Receptor	Endocrinology
PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

ICI 216140	Bombesin Receptor	Neurological Disease
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC₅₀ of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure .

Palmitic acid Maximum Cited Publications 41 Publications Verification	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model .

Palmitic acid sodium Maximum Cited Publications 41 Publications Verification	Biochemical Assay Reagents HSP Endogenous Metabolite	Cancer
Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

Questiomycin A Phx-3	HSP Bacterial Antibiotic	Infection Cancer
Questiomycin A (Phx-3) is a *GRP78* (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases .

VER-82576 5 Publications Verification NVP-BEP800	HSP	Cancer
VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC₅₀ of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC₅₀s of 4.1 and 5.5 μM, respectively.

Palmitic acid-d1	Isotope-Labeled Compounds HSP Endogenous Metabolite	Metabolic Disease
Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

Palmitic acid-d3	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-d₃ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

Cat. No.	Product Name	Type

HY-D2334

AlF-NOTA-c-d-VAP	Dyes
AlF-NOTA-c-d-VAP is a peptide positron emission tomography (PET) probe that used for targeted tumor imaging of GRP78. AlF-NOTA-c-d-VAP demonstrates high stability in vitro and in vivo .

Cat. No.	Product Name	Type

HY-N0830B

Palmitic acid sodium 40+ Cited Publications	Cell Assay Reagents
Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

Cat. No.	Product Name	Target	Research Area

HY-103283

Neuromedin C (porcine) GRP(18-27) (porcine)	Biochemical Assay Reagents	Neurological Disease
Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases .

HY-P0238

Gastrin-Releasing Peptide, human	Peptides	Cancer
Gastrin-Releasing Peptide, human (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release.

HY-P1185

Antagonist G	Vasopressin Receptor Apoptosis	Cancer
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy .

HY-P5972

GRP20–29, frog	Peptides	Cancer
GRP20–29, frog is a 10-amino acid antigen peptide that can be isolated from Xenopus .

HY-P5072

GRP (14-27) (human, porcine, canine)	Bombesin Receptor	Metabolic Disease
GRP (14-27) (human, porcine, canine) is a bombesin receptor ligand. The specific binding of GRP (14-27) is inhibited by GTP and GDP, whereas GMP was without effect .

HY-103285

GRP (porcine) Porcine gastrin-releasing peptide 27	Peptides	Cancer
GRP (porcine) (Porcine gastrin-releasing peptide 27) is the putative mammalian analog of Bombesin (HY-P0195). GRP (porcine) activates the release of a number of gastroenteropancreatic (GEP) peptides into the peripheral circulation. GRP (porcine) stimulates gastrin release and exocrine pancreatic secretion. GRP (porcine) is a useful marker of neuroendocrine differentiation in many tumors .

HY-P3576

Biotin-Gastrin Releasing Peptide, human	Fluorescent Dye	Neurological Disease Cancer
Biotin-Gastrin Releasing Peptide, human is a biotinylated gastrin releasing peptide (GRP). Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties .

HY-P3084

Human follicular gonadotropin releasing peptide hF-GRP	Peptides	Endocrinology
Human follicular gonadotropin releasing peptide (hF-GRP) is a hormone peptide. Human follicular gonadotropin releasing peptide can stimulate pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in vitro .

HY-103277

BIM 23042	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-P4689

Prolactin-Releasing Peptide (1-31) (rat)	Peptides	Metabolic Disease
Prolactin-Releasing Peptide (1-31) (rat) is a UHR-1/GRP10 receptor ligand. Prolactin-Releasing Peptide (1-31) (rat) reduces fasting-induced food intake, increases plasma levels of LH, FSH, and testosterone in rats .

HY-P1185A

Antagonist G TFA	Vasopressin Receptor Apoptosis	Cancer
Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy .

HY-P10055A

PSMA targeting peptide TFA PSMA-1 TFA	PSMA	Cancer
PSMA targeting peptide TFA (PSMA-1 TFA) is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells .

HY-P0039

BIM-26226	Bombesin Receptor	Cancer
BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC₅₀s in the nanomolar range. BIM-26226 can be used for the research of cancer .

HY-P0221B

PACAP (1-38) free acid TFA	PACAP Receptor	Endocrinology
PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P0221C

PACAP (1-38) free acid	PACAP Receptor	Endocrinology
PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P3112

ICI 216140	Bombesin Receptor	Neurological Disease
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC₅₀ of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure .

HY-103277A

BIM 23042 TFA	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-P10055

PSMA targeting peptide PSMA-1	Peptides	Cancer
PSMA-1 is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells.?PSMA-1 is selected and polyarginine sequences R6?or R9?were added at the C terminus to generate the CTPs. FITC labeling of the peptide with an aminohexanoic acid (Ahx) linker at the N terminus produced FITC-PSMA-1, to track PSMA binding on PCa cells .?

HY-103544

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P	JNK Interleukin Related Bombesin Receptor	Inflammation/Immunology Cancer
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca ²⁺ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer

Cat. No.	Product Name	Target	Research Area

HY-P990239

*Anti-Human/Mouse GRP78 Antibody (N88)*	Inhibitory Antibodies	Others
Anti-Human/Mouse GRP78 Antibody (N88) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to human/mouse GRP78.

HY-P990805

*Anti-Human/Mouse GRP78 Antibody (C38)*	Inhibitory Antibodies	Others
Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b kappa in vivo mouse antibody, targeting to *GRP78. The recommend isotype control of Anti-Human/Mouse GRP*78 Antibody (C38): Mouse IgG2b kappa, Isotype Control (HY-P99982).

Species:	Human (10) Mouse (2) Canine (1)
Tag:	His (10) Strep (2) GST (1) Fc (1) Flag (1)
Source:	HEK293 (2) E. coli Cell-free (1) P. pastoris (2) Sf9 insect cells (3) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P790077

	GRPR Protein, Human (Cell-free, Twin-Strep) GRP-R; GRPR; Gastrin-releasing peptide receptor	Human	E. coli Cell-free
	GRPR Protein, Human (Cell-free, Twin-Strep) is the recombinant human-derived GRPR, expressed by E. coli Cell-free , with C-Twin-Strep labeled tag. The total length of GRPR Protein, Human (Cell-free, Twin-Strep) is 384 a.a.,

HY-P70851

	LGALSL Protein, Human (His) Galectin-Related Protein; Lectin Galactoside-Binding-Like Protein; LGALSL; GRP; HSPC159	Human	E. coli
	The LGALSL protein was identified as a member of the galectin family, exhibits no affinity for lactose, and may not be involved in carbohydrate binding. This unique feature distinguishes LGALSL from typical galectins, which are known for their carbohydrate recognition domain and interaction with specific sugar moieties. LGALSL Protein, Human (His) is the recombinant human-derived LGALSL protein, expressed by E. coli , with C-6*His labeled tag. The total length of LGALSL Protein, Human (His) is 171 a.a., with molecular weight of ~18.0 kDa.

HY-P72239

	*HSPA5/GRP-78 Protein, Human (His)* Endoplasmic reticulum chaperone BiP; GRP-78; BiP; GRP78	Human	E. coli
	HSPA5/GRP-78 is an endoplasmic reticulum chaperone that coordinates protein folding and quality control. It cooperates with DNAJC10/ERdj5 to facilitate correct protein folding and participates in the degradation of misfolded proteins, potentially releasing DNAJC10/ERdj5. HSPA5/GRP-78 Protein, Human (His) is the recombinant human-derived HSPA5/GRP-78 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPA5/GRP-78 Protein, Human (His) is 269 a.a., with molecular weight of ~33.6 kDa.

HY-P71742

	*HSPA5/GRP-78 Protein, Mouse (P.pastoris, His)* Hspa5; GRP78; Endoplasmic reticulum chaperone BiP; EC 3.6.4.10; 78kDa glucose-regulated protein; GRP-78; HSP70 family protein 5	Mouse	P. pastoris
	The HSPA5/GRP-78 protein is an endoplasmic reticulum chaperone involved in protein folding and quality control. It interacts with DNAJC10/ERdj5 to fold and degrade misfolded proteins. HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived HSPA5/GRP-78 protein, expressed by P. pastoris , with N-6*His, N-His labeled tag. The total length of HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) is 636 a.a., with molecular weight of ~72.5 kDa.

HY-P71742Y

	*HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution)* Hspa5; GRP78; Endoplasmic reticulum chaperone BiP; EC 3.6.4.10; 78kDa glucose-regulated protein; GRP-78; HSP70 family protein 5	Mouse	P. pastoris
	The HSPA5/GRP-78 protein is an endoplasmic reticulum chaperone involved in protein folding and quality control. It interacts with DNAJC10/ERdj5 to fold and degrade misfolded proteins. HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived HSPA5/GRP-78 protein, expressed by P. pastoris , with N-His labeled tag. The total length of HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) is 636 a.a., with molecular weight of ~72.5 kDa.

HY-P700868

	GRP-10 Protein, Canine (HEK293, hFc) Gastrin-releasing peptide; GRP	Canine	HEK293

HY-P70944

	LSM4 Protein, Human (His) U6 snRNA-Associated Sm-Like Protein LSm4; Glycine-Rich Protein; GRP; LSM4	Human	E. coli
	The LSM4 protein plays a crucial role in pre-mRNA splicing, participating in the U4/U6-U5 tri-snRNP complex during spliceosome assembly, and as a component of the precatalytic spliceosome (spliceosome B complex).In the heptameric LSM2-8 complex, LSM4 specifically binds to the 3' U region of U6 snRNA.LSM4 Protein, Human (His) is the recombinant human-derived LSM4 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P703226

	HSP90B1 Protein, Human (His, Strep) GRP94; HSPC4; TRA1	Human	E. coli
	HSP90B1 Protein, Human (His, Strep) is the recombinant human-derived HSP90B1, expressed by E. coli , with Strep, His labeled tag. ,

HY-P703569

	CCR5 Protein, Human (Sf9, Flag, His) GRP75; HSPA9B; mt-HSP70	Human	Sf9 insect cells
	CCR5 Protein, Human (Sf9, Flag, His) is the recombinant human-derived CCR5, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

HY-P702943

	HSPA9 protein, Human (sf9, GST) GRP75; HSPA9B; mt-HSP70; Mortalin Protein	Human	Sf9 insect cells
	HSPA9 protein, Human (sf9, GST) is the recombinant human-derived HSPA9, expressed by Sf9 insect cells , with GST labeled tag. The total length of HSPA9 protein, Human (sf9, GST) is 633 a.a.,

HY-P70943

	HYOU1 Protein, Human (HEK293, His) Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170; HYOU1; ORP150	Human	HEK293
	The HYOU1 protein plays a crucial role in coordinating cytoprotective mechanisms in response to hypoxia, indicating its importance in cellular stress responses. It involves a potential molecular chaperone function and is actively involved in the protein folding process. HYOU1 Protein, Human (HEK293, His) is the recombinant human-derived HYOU1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P790088

	HSPA5 Protein, Human (sf9, His) Binding-immunoglobulin protein; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; HSPA5; GRP78	Human	Sf9 insect cells

HY-P72111

	Calreticulin/CALR Protein, Human (His) Autoantigen RO; CALR; CALR protein; CALR_HUMAN; Calregulin; Calreticulin; cC1qR; CRP55; CRT; CRTC; Endoplasmic reticulum resident protein 60; Epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; GRP60; HACBP; HEL S 99n; RO; Sicca syndrome antigen A autoantigen Ro; calreticulin; ; Sicca syndrome antigen A; SSA	Human	E. coli
	The calreticulin/CALR protein is a calcium-binding molecular chaperone that promotes ER folding and quality control. It interacts with monoglucosylated glycoproteins and promotes nuclear export of NR3C1. Calreticulin/CALR Protein, Human (His) is the recombinant human-derived Calreticulin/CALR protein, expressed by E. coli , with N-6*His labeled tag. The total length of Calreticulin/CALR Protein, Human (His) is 400 a.a., with molecular weight of ~50.6 kDa.

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HY-P82774

	GRP94 Antibody (YA2519) Endoplasmin; GRP-94; gp96 homolog; HSP90B1; GRP 94; TRA1	WB, IHC-P, ICC/IF	Human, Mouse
	GRP94 Antibody (YA2519) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2519), targeting GRP94, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). GRP94 Antibody (YA2519) can be used for WB, IHC-P, ICC/IF experiment in human, mouse background.

HY-P80496

	GRP78 BiP Antibody	WB, IHC-P, ICC/IF	Human, Mouse
	GRP78 BiP Antibody is a non-conjugated and Mouse origined monoclonal antibody about 72kDa, targeting to GRP78 BiP. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80696

	GRP78 BiP Antibody (YA746) HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein GRP78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, ICC/IF, IP	Human, Mouse, Rat
	GRP78 BiP Antibody (YA746) is a non-conjugated and Mouse origined monoclonal antibody about 72 kDa, targeting to GRP78 BiP (4F11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81733

	ORP150 Antibody (YA1478) GRP170; HSP12A; Hyou1; Orp150	WB, IHC-P	Human, Mouse, Rat
	ORP150 Antibody (YA1478) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1478), targeting ORP150, with a predicted molecular weight of 111 kDa (observed band size: 150 kDa). ORP150 Antibody (YA1478) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P82097

	LGR5 Antibody (YA1842) FEX; GPR49; GPR67; GRP49; LGR5; HG38; 8	WB, IP, FC	Human, Mouse, Rat
	LGR5 Antibody (YA1842) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1842), targeting LGR5, with a predicted molecular weight of 100 kDa (observed band size: 100 kDa). LGR5 Antibody (YA1842) can be used for WB, IP, FC experiment in human, mouse, rat background.

HY-P83410

	GRP75 Antibody (YA3155) HSPA9; GRP75; HSPA9B; Stress-70 protein; mitochondrial; 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74	WB	Human, Mouse, Rat
	GRP75 Antibody (YA3155) is a biotin-conjugated non-conjugated IgG antibody, targeting GRP75, with a predicted molecular weight of 74 kDa. GRP75 Antibody (YA3155) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-117395

PU-H54		Alkynes
PU-H54, a *Grp94*-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy . PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS05844

GRP Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GRP Human Pre-designed siRNA Set A contains three designed siRNAs for GRP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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