Search Result

Isoforms Recommended:	GSK-3β

Results for "

GSK-3β

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GSK-3 (124) AAK1 (1) Akt (3) AMPK (1) Amyloid-β (3) Antibiotic (7) Apoptosis (16) Aurora Kinase (6) Autophagy (9) Bacterial (6) Bcl-2 Family (1) Beta-secretase (1) c-Met/HGFR (2) c-Myc (2) Calcium Channel (2) Caspase (1) CDK (26) CFTR (1) Cholinesterase (ChE) (7) DYRK (5) ERK (3) HDAC (2) HIV (1) HSV (2) IAP (1) IKK (2) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (2) JAK (6) JNK (2) Keap1-Nrf2 (2) Lipoxygenase (1) LRRK2 (1) MEK (2) Microtubule/Tubulin (1) Mitophagy (2) MMP (1) Organoid (2) p38 MAPK (2) Parasite (2) PDK-1 (1) Phosphatase (1) Phospholipase (1) PI3K (2) Pim (2) PKC (6) PROTACs (2) Proton Pump (2) RANKL/RANK (1) Reactive Oxygen Species (4) ROS Kinase (1) SGK (1) Src (1) Syk (1) Tau Protein (5) TGF-β Receptor (1) VEGFR (1) Wnt (2) β-catenin (7)
By Research Areas:	Cancer (79) Cardiovascular Disease (4) Infection (14) Inflammation/Immunology (25) Metabolic Disease (26) Neurological Disease (72)

By Targets:

GSK-3 (124)

AAK1 (1)

Akt (3)

AMPK (1)

Amyloid-β (3)

Antibiotic (7)

Apoptosis (16)

Aurora Kinase (6)

Autophagy (9)

Bacterial (6)

Bcl-2 Family (1)

Beta-secretase (1)

c-Met/HGFR (2)

c-Myc (2)

Calcium Channel (2)

Caspase (1)

CDK (26)

CFTR (1)

Cholinesterase (ChE) (7)

DYRK (5)

ERK (3)

HDAC (2)

HIV (1)

HSV (2)

IAP (1)

IKK (2)

Integrin (1)

Interleukin Related (2)

Isotope-Labeled Compounds (2)

JAK (6)

JNK (2)

Keap1-Nrf2 (2)

Lipoxygenase (1)

LRRK2 (1)

MEK (2)

Microtubule/Tubulin (1)

Mitophagy (2)

MMP (1)

Organoid (2)

p38 MAPK (2)

Parasite (2)

PDK-1 (1)

Phosphatase (1)

Phospholipase (1)

PI3K (2)

Pim (2)

PKC (6)

PROTACs (2)

Proton Pump (2)

RANKL/RANK (1)

Reactive Oxygen Species (4)

ROS Kinase (1)

SGK (1)

Src (1)

Syk (1)

Tau Protein (5)

TGF-β Receptor (1)

VEGFR (1)

Wnt (2)

β-catenin (7)

By Research Areas:

Cancer (79)

Cardiovascular Disease (4)

Infection (14)

Inflammation/Immunology (25)

Metabolic Disease (26)

Neurological Disease (72)

160

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: GSK-3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-164907

GSK-3β inhibitor 22	GSK-3	Neurological Disease
GSK-3β inhibitor 22 (compound 20o) is a *GSK-3β* inhibitor with an IC₅₀ of 3.1 nM. GSK-3β inhibitor 22 has the potential of the study of Alzheimer's disease .

HY-126144

GSK-3β inhibitor 1 3 Publications Verification	GSK-3	Metabolic Disease Cancer
GSK-3β inhibitor 1 (compound 3a) inhibits *GSK-3β* with an IC₅₀ of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753)-treated rats .

HY-141480

GSK-3β inhibitor 3	GSK-3 Apoptosis	Cancer
GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC₅₀ of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia .

HY-148133

GSK-3β inhibitor 12	GSK-3	Neurological Disease
GSK-3β inhibitor 12 (compound 15) is an inhibitor of *GSK-3β. GSK-3β inhibitor 12 inhibits 49.11% and 37.11% activity of 25 μM and 50 μM GSK-3β, respectively. GSK-3*β inhibitor 12 can be used for the research of neurodegenerative diseases .

HY-130795

GSK-3β inhibitor 2 1 Publications Verification	GSK-3	Neurological Disease
GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active *GSK-3β* inhibitor with an IC₅₀ of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease .

HY-147134

GSK-3β inhibitor 10	GSK-3	Neurological Disease
GSK-3β inhibitor 10 (compound 14a) is a highly potent *GSK-3β* inhibitor with an IC₅₀ value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease .

HY-162913

GSK-3β inhibitor 20	GSK-3	Neurological Disease
GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC₅₀ value of 74.4 nM .

HY-149542

GSK-3β inhibitor 15	Tau Protein Apoptosis GSK-3	Neurological Disease
GSK-3β inhibitor 15 (Compound 54) is a *GSK-3β* inhibitor (IC₅₀: 3.4 nM). GSK-3β inhibitor 15 inhibits Aβ_1-42-induced GSK-3β and tau protein phosphorylation. GSK-3β inhibitor 15 inhibits LPS-induced iNOS expression. GSK-3β inhibitor 15 has neuroprotective effects on Aβ_1-42-induced neurotoxicity. GSK-3β inhibitor 15 can be used for research of Alzheimer’s disease (AD) .

HY-169024

GSK-3β inhibitor 19	GSK-3	Neurological Disease Inflammation/Immunology
GSK-3β inhibitor 19 (compound 36) is a *GSK-3β* inhibitor, with IC₅₀ of 70 nM. GSK-3β inhibitor 19 can be used in anti-inflammatory and Alzheimer's disease related research .

HY-143261

GSK-3β inhibitor 7	GSK-3	Metabolic Disease Inflammation/Immunology Cancer
GSK-3β inhibitor 7 is a *GSK-3β* inhibitor with an IC₅₀ value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder .

HY-143260

GSK-3β inhibitor 6	GSK-3	Metabolic Disease Inflammation/Immunology Cancer
GSK-3β inhibitor 6 is a potent *GSK-3β* inhibitor with an IC₅₀ value of 24.4 μM. GSK-3β inhibitor 6 shows high hepatocyte glucose uptake (38%). GSK-3β inhibitor 6 can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder .

HY-162638

GSK-3β inhibitor 18	GSK-3	Neurological Disease
GSK-3β inhibitor 18 (compound 2) is a potent inhibitor of *GSK-3β, with the IC₅₀* of 0.0021 μM .

HY-120902

GSK-3β inhibitor 8	GSK-3	Inflammation/Immunology
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of *GSK-3β* (IC₅₀=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation .

HY-148132

GSK-3β inhibitor 11	GSK-3	Neurological Disease
GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC₅₀=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research .

HY-153760

GSK-3β inhibitor 14	GSK-3	Neurological Disease Metabolic Disease
GSK-3β inhibitor 14 (Compound 6i), benzothiazepinone derivative, is a weak *GSK-3β* inhibitor (IC₅₀ >100 μM) .

HY-161458

GSK-3β inhibitor 16	GSK-3 Tau Protein	Neurological Disease
GSK-3β inhibitor 16 (compound 7c) is a *GSK-3β* inhibitor with the IC₅₀ of 4.68 nM. GSK-3β inhibitor 16 decreases Tau hyperphosphorylated aggregate and alleviates cognitive impairments in the Scopolamin (HY-N0296)-induced model in mice .

HY-168079

GSK-3β inhibitor 21	GSK-3 Tau Protein	Neurological Disease Inflammation/Immunology
GSK-3β inhibitor 21 (compound 44) is an ATP-competitive *GSK-3β* inhibitor (IC₅₀=6.06 μM) with anti-amyloid aggregation and tau phosphorylation inhibitory activities. GSK-3β inhibitor 21 can be used in the study of Alzheimer's disease .

HY-163748

GSK-3β inhibitor 17	GSK-3	Inflammation/Immunology
GSK-3β inhibitor 17 (compound 5 n) is a potent *GSK-3β* inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury .

HY-149054

GSK-3β inhibitor 13	GSK-3 Tau Protein AAK1 Pim PKC	Neurological Disease
GSK-3β inhibitor 13 (compound 47) is an orally active and potent *GSK-3β* inhibitor with blood-brain permeability. GSK-3β inhibitor 13 inhibits *GSK-3β* and *GSK-3α* with IC₅₀s of 0.73 nM and 0.35 nM, respectively. GSK-3β inhibitor 13 significantly decreases the phosphorylation of tau (IC₅₀=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimer's disease .

HY-169606

GSK-3β inhibitor 25	GSK-3	Neurological Disease Metabolic Disease
GSK-3β inhibitor 25 (Compound 6h) exhibits a weak inhibitory activity against *GSK-3β* wih an IC₅₀>100 μM .

HY-170491

GSK-3β inhibitor 23	GSK-3	Infection Neurological Disease
GSK-3β inhibitor 23 (Compound 11726169) is the inhibitor for glycogen synthase kinase-3, that inhibits *GSK-3β* and *GSK-3α* with IC₅₀ of 12.1 nM and 18.8 nM. GSK-3β inhibitor 23 exhibits antiviral activity against HIV 1. GSK-3β inhibitor 23 exhibits good metabolic stablility in mouse/human liver microsomes and plasma, but poor Caco-2 permeability (which predicts low oral bioavailability) .

HY-14679

GSK3β inhibitor II	GSK-3	Neurological Disease
GSK3β inhibitor II is an inhibitor of *GSK3β. GSK3*β inhibitor II can be used for research of Alzheimer’s disease (AD) .

HY-11012

TDZD-8 10+ Cited Publications GSK-3β Inhibitor I; NP 01139	GSK-3	Cancer
TDZD-8 is an inhibitor of *GSK-3β, with an IC₅₀* of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC₅₀s of >100 μM.

HY-P10605

GSK3β-peptide	Akt GSK-3	Cancer
GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of *GSK3-β* and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs .

HY-169632

GSK3β-IN-1	GSK-3	Neurological Disease
GSK3β-IN-1 (compound 1) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC₅₀=65 nM), which can be used in the study of Alzheimer's disease .

HY-161667

GSK-3β/HDAC-IN-1	GSK-3 HDAC	Neurological Disease
GSK-3β/HDAC-IN-1 (Compd 4) is a brain-penetrant and first in class dual non-ATP-competitive Glycogen Synthase Kinase 3β/Histone Deacetylases (GSK-3β/HDACs) Inhibitor with IC₅₀s of 0.142, 0.03 and 0.045 μM against GSK-3β, HDAC2 and HDAC6, respectively. GSK-3β/HDAC-IN-1 can be used for Alzheimer’s disease research .

HY-10512

AR-A014418 15+ Cited Publications AR 0133418; GSK 3β inhibitor VIII; AR 014418	GSK-3	Metabolic Disease Cancer
AR-A014418 is a potent, selective and ATP-competitive *GSK3β* inhibitor (IC₅₀=104 nM; K_i=38 nM) .

HY-10512S

AR-A014418-d3 AR 0133418-d₃; GSK 3β inhibitor VIII-d₃; AR 014418-d₃	Isotope-Labeled Compounds GSK-3	Metabolic Disease Cancer
AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].

HY-P1173

L803-mts Myristoylated L 803; GSK-3β Inhibitor XIII	GSK-3 Amyloid-β	Neurological Disease
L803-mts (Myristoylated L 803) is a selective and substrate-competitive *GSK-3* peptide inhibitor (IC₅₀: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .

HY-149845

*PROTAC GSK-3β Degrader-1*	GSK-3 PROTACs	Neurological Disease
PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets *GSK-3β* degradation with an IC₅₀ value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ_25-35 peptide and CuSO₄. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease .

HY-151260

*AChE/BACE1/GSK3β-IN-1*	Beta-secretase Cholinesterase (ChE) GSK-3	Neurological Disease
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of *AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC₅₀* values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD) .

HY-126144A

*(E/Z)-GSK-3β inhibitor 1*	GSK-3	Metabolic Disease
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC₅₀ of 4.9 nM .

HY-117194

18BIOder	HIV GSK-3	Infection
18BIOder is a neuroprotective *GSK-3β inhibitor, highly selectively inhibiting HIV*-1 .

HY-170417

*hAChE/hBuChE/GSK-3β-IN-1*	Cholinesterase (ChE) GSK-3	Neurological Disease
hAChE/hBuChE/GSK-3β-IN-1 (Compound 6c) is a BBB-penatrable and multi-target anti-Alzheimer's disease compound. hAChE/hBuChE/GSK-3β-IN-1 is the inhibitors of hAChE (IC₅₀: 28.88 nM), hBuChE (IC₅₀: 131.90 nM) and *GSK-3β* (IC₅₀: 51.42 nM). hAChE/hBuChE/GSK-3β-IN-1 is the tau and Aβ protein aggregation inhibitors .

HY-136679

TD114-2	GSK-3	Neurological Disease Metabolic Disease
TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC₅₀=48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to *GSK-3β, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3β. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3β* .

HY-144290

ARN25068	GSK-3 DYRK	Neurological Disease
ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation .

HY-151375

*CDK9/10/GSK3β-IN-1*	CDK	Cancer
CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits *HsGSK3β* (IC₅₀=59 nM), HsCDK9/CyclinT (IC₅₀=64 nM), HsCDK5/p25 (IC₅₀=1.093 μM) and HsCDK2/CyclinA (IC₅₀=1.725 μM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines .

HY-144316

ZLWH-23	Cholinesterase (ChE) GSK-3	Neurological Disease
ZLWH-23 is a selective AChE inhibitor (IC₅₀=0.27 μM) with *GSK-3β* inhibitory property (IC₅₀=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC₅₀=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease .

HY-137472

SAR502250	GSK-3	Neurological Disease
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of *GSK3, with an IC₅₀* of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD) .

HY-112388

GSK-3b Inhibitor XI	GSK-3	Neurological Disease
GSK3β inhibitor XI is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; Ki=25 nM). It is selective for GSK3β over a panel of 79 kinases at a concentration of 10 μM. GSK3β inhibitor XI inhibits GSK3β in HEK293 cells (EC₅₀=32 nM).

HY-150537

*AChE/GSK-3β-IN-1*	Cholinesterase (ChE) GSK-3 Microtubule/Tubulin ROS Kinase	Neurological Disease
AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual *AChE/GSK-3β* inhibitor with IC₅₀ values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research .

HY-10096

TCS2002	GSK-3	Neurological Disease
TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent *GSK-3β* inhibitor with the IC₅₀ of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease .

HY-14872

Tideglusib 5 Publications Verification NP031112	GSK-3	Neurological Disease
Tideglusib (NP031112) is an irreversible *GSK-3* inhibitor with IC₅₀s of 5 nM and 60 nM for GSK-3β ^WT (1 h preincubation) and GSK-3β ^C199A (1 h preincubation), respectively.

HY-12292

IM-12 5+ Cited Publications	GSK-3	Cancer
IM-12 is an inhibitor of *GSK-3β, with an IC₅₀* of 53 nM, and also enhances Wnt signalling.

HY-113914

9-ING-41 3 Publications Verification Elraglusib	GSK-3 Apoptosis Autophagy	Cancer
9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC₅₀ of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents ^[3] .

HY-10590

TWS119 25+ Cited Publications	GSK-3 Autophagy	Neurological Disease Cancer
TWS119 is a specific inhibitor of *GSK-3β, with an IC₅₀* of 30 nM, and activates the wnt/β-catenin pathway.

HY-110074

TWS119 TFA	Others	Others
TWS119 TFA is a specific inhibitor of *GSK-3β, with an IC₅₀* of 30 nM, and activates the wnt/β-catenin pathway.

HY-145669

DIF-3 2 Publications Verification	CDK GSK-3	Cancer
DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of *GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF*-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression .

HY-144826

ZDWX-25	GSK-3	Neurological Disease
ZDWX-25 is a highly potent *GSK-3β* and DYRK1A dual inhibitor with an IC₅₀ value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease .

HY-112394

2-Cyanoethylalsterpaullone	GSK-3 CDK	Cancer
2-Cyanoethylalsterpaullone (compound 7) is an Alsterpaullone (HY-108359) derivative, which exhibits potent and selective inhibitory activities against CDK1/Cyclin B and *GSK-3β* (GSK-3β: IC₅₀=0.8 nM; CDK1/Cyclin B: IC₅₀=0.23 nM) .

Cat. No.	Product Name	Type

HY-134393B

6-Me-ATP (trisodium) solution (100mM) N6-Methyl-ATP (trisodium) solution (100mM)	Gene Sequencing and Synthesis
6-Me-ATP (N6-Methyl-ATP) trisodium solution (100mM) is a N ⁶-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to *GSK3, serving as the phosphate group donor for GSK3*β-catalyzed phosphorylation of its substrate peptide .

Cat. No.	Product Name	Target	Research Area

HY-P4858

C-Peptide 1 (rat)	GSK-3	Cancer
C-Peptide 1 (rat), a peptide, is aβ-catenin/GSK-3β activator. C-Peptide 1 (rat) can regulate the Wnt/β-catenin signaling pathway. C-Peptide 1 (rat) can be used for the research of cancer .

HY-P10605

GSK3β-peptide	Akt GSK-3	Cancer
GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of *GSK3-β* and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs .

HY-P1173

L803-mts Myristoylated L 803; GSK-3β Inhibitor XIII	GSK-3 Amyloid-β	Neurological Disease
L803-mts (Myristoylated L 803) is a selective and substrate-competitive *GSK-3* peptide inhibitor (IC₅₀: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .

HY-P3713

Presenilin 1 (349-361)	GSK-3	Cancer
Presenilin 1 (349-361) is an active petide, and synthetic peptides representing amino acids 349–361 can be phosphorylated by glycogen synthase kinase-3β(GSK3β) in vitro. Presenilin 1 (349-361) can be used for the research of various diseases .

HY-P1114

2B-(SP)	GSK-3	Neurological Disease
2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) is readily phosphorylated by both the α and β isoforms of GSK-3 .

HY-P1114A

2B-(SP) (TFA)	GSK-3	Cancer
2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8423

α-Amyrin 1 Publications Verification	Triterpenes Structural Classification other families Terpenoids Plants	ERK GSK-3
α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and *GSK-3β* signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission ^[3].

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Source classification Marine natural products Pyridine Alkaloids Indole Alkaloids Infection Alkaloids Piperidine Alkaloids Animals Sponge Disease Research Fields	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically *GSK-3β* and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 ^[3] .

HY-N6973

Boldine 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Litsea cubeba (Lour.) Pers.	RANKL/RANK Apoptosis
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and *GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK* signaling pathway. It can be used in rheumatoid arthritis research ^[3].

HY-N7176

Kaempferol 3-O-β-D-glucuronide 2 Publications Verification Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide	Flavonols Structural Classification Flavonoids Microorganisms other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Interleukin Related
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide) is a metabolite of kaempferol that can be taken orally and has anti-inflammatory properties. Kaempferol 3-O-β-D-glucuronide can activate AKT/GSK3β phosphorylation and improve glucose metabolism ^[3].

HY-124344

Avenanthramide C	Structural Classification Simple Phenylpropanols Avena sativa Linn. Gramineae Source classification Phenylpropanoids Plants	Interleukin Related
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-N0527

Pentagalloylglucose Maximum Cited Publications 10 Publications Verification Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the *GSK3β/β-catenin* pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities ^[3].

HY-133102

Dihydronarwedine Lycoraminone	Structural Classification Alkaloids Other Alkaloids Source classification Narcissus pseudonarcissus L. Plants Amaryllidaceae	GSK-3
Dihydronarwedine (Lycoraminone) is the alkaloid. Dihydronarwedine inhibits 39% activity of glycogen synthase kinase-3β (GSK-3β) at a concentration of 10 μM .

HY-N11576

Secalonic acid D	Structural Classification Natural Products Microorganisms Classification of Application Fields Sunscreen Source classification Cosmetic Research Disease Research Fields Cancer	Apoptosis GSK-3 c-Myc β-catenin
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates *GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc* expression, arrests cell cycle at G1 phase, induces cell apoptosis .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically *GSK-3β* and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 ^[3] .

HY-N8423R

α-Amyrin (Standard)	Triterpenes Structural Classification other families Terpenoids Plants	ERK GSK-3
α-Amyrin (Standard) is the analytical standard of α-Amyrin. This product is intended for research and analytical applications. α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission ^[3].

HY-N6064

Polygalacin D 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Source classification Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer	Apoptosis IAP
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

HY-N0527R

Pentagalloylglucose (Standard)	Structural Classification other families Source classification Phenols Polyphenols Plants	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities ^[3].

HY-N7676

Marein 2 Publications Verification	Cardiovascular Disease Structural Classification Chalcones Flavonoids other families Neurological Disease Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects ^[3].

HY-N7363

Isolongifolene (-)-Isolongifolene	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Rutaceae Murraya koenigii (L.) Spreng Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of PI3K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties .

Species:	Human (3) Mouse (1)
Tag:	His (3) GST (1)
Source:	Sf9 insect cells (3) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73090

	GSK-3 beta Protein, Mouse (sf9, His) Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3b	Mouse	Sf9 insect cells
	GSK-3 beta is a protein kinase that regulates cellular circadian rhythm, autophagy, and apoptosis. GSK-3 beta Protein, Mouse (sf9, His) is the recombinant mouse-derived GSK-3 beta protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of GSK-3 beta Protein, Mouse (sf9, His) is 420 a.a., with molecular weight of ~47 kDa.

HY-P74114

	GSK-3 beta Protein, Human (sf9, His) Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3b	Human	Sf9 insect cells
	GSK-3β is a serine-threonine kinase and negative regulator of glucose homeostasis. GSK-3β has been implicated in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. GSK-3β is widely expressed in multiple tissues, with particularly high levels in the brain and thyroid gland. GSK-3 beta Protein, Human (sf9, His) is the recombinant human-derived GSK-3 beta protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P700591

	GSK-3 beta Protein, Human (P. pastoris, His) Serine/threonine-protein kinase GSK3B	Human	P. pastoris
	GSK-3 beta is an active protein kinase that regulates a variety of cellular processes. It negatively regulates glucose homeostasis, Wnt signaling, and transcription factors by phosphorylating substrates such as glycogen synthase, CTNNB1, and JUN. GSK-3 beta Protein, Human (P. pastoris, His) is the recombinant human-derived GSK-3 beta protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P702734

	GSK3B Protein, Human (sf9, GST) GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B	Human	Sf9 insect cells

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HY-10512S

AR-A014418-d3
AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].

HY-B0712S1

Ceftriaxone-13C2,d3 triethylammonium salt

Ceftriaxone- ¹³C₂,d₃ triethylammonium salt is ¹³C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC₅₀ value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis ^[3] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80497

	GSK3 beta Antibody (YA397)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	GSK3 beta Antibody (YA397) is a non-conjugated and Rabbit origined monoclonal antibody about 47 kDa, targeting to GSK3 beta. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80698

	GSK3 beta Antibody (YA744) GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B	WB, IHC-P, FC	Human, Mouse, Rat
	GSK3 beta Antibody (YA744) is a non-conjugated and Mouse origined monoclonal antibody about 47 kDa, targeting to GSK3 beta. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80820

	*Phospho-GSK3* beta (Ser9) Antibody** GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-GSK3 beta (Ser9) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 47 kDa, targeting to Phospho-GSK3 beta (Ser9). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.