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Results for "

HCT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (2) Apoptosis (52) Arenavirus (1) Autophagy (5) Bacterial (5) Bcl-2 Family (2) Bcr-Abl (1) Biochemical Assay Reagents (3) c-Kit (1) c-Met/HGFR (2) Calcium Channel (1) Carbonic Anhydrase (2) Casein Kinase (2) CDK (9) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (1) COX (2) Dihydrofolate reductase (DHFR) (1) DNA-PK (1) DNA/RNA Synthesis (3) Drug-Linker Conjugates for ADC (1) EGFR (7) Endogenous Metabolite (4) FAK (2) Farnesyl Transferase (1) Ferroptosis (1) FLT3 (1) Fungal (2) Glutaminase (1) HDAC (14) Histone Acetyltransferase (1) Histone Methyltransferase (2) HIV (1) HSP (1) ICMT (2) Insulin Receptor (1) JAK (2) Liposome (1) MDM-2/p53 (2) MEK (1) Methionine Adenosyltransferase (MAT) (2) MicroRNA (1) Microtubule/Tubulin (11) Mps1 (1) mTOR (1) NF-κB (1) Notch (1) Parasite (1) PARP (1) PDK-1 (1) PI3K (4) Pim (4) PKA (1) PKC (1) Polo-like Kinase (PLK) (2) PROTACs (9) Proteasome (1) Pyruvate Kinase (1) Raf (5) Reactive Oxygen Species (4) Src (2) STAT (3) Topoisomerase (5) Trk Receptor (1) Tyrosinase (1) VEGFR (2) Virus Protease (1) Wnt (1) YAP (1) β-catenin (2)
By Research Areas:	Cancer (149) Cardiovascular Disease (2) Infection (15) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Amyloid-β (1)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (2)

Apoptosis (52)

Arenavirus (1)

Autophagy (5)

Bacterial (5)

Bcl-2 Family (2)

Bcr-Abl (1)

Biochemical Assay Reagents (3)

c-Kit (1)

c-Met/HGFR (2)

Calcium Channel (1)

Carbonic Anhydrase (2)

Casein Kinase (2)

CDK (9)

Checkpoint Kinase (Chk) (1)

Cholinesterase (ChE) (1)

COX (2)

Dihydrofolate reductase (DHFR) (1)

DNA-PK (1)

DNA/RNA Synthesis (3)

Drug-Linker Conjugates for ADC (1)

EGFR (7)

Endogenous Metabolite (4)

FAK (2)

Farnesyl Transferase (1)

Ferroptosis (1)

FLT3 (1)

Fungal (2)

Glutaminase (1)

HDAC (14)

Histone Acetyltransferase (1)

Histone Methyltransferase (2)

HIV (1)

HSP (1)

ICMT (2)

Insulin Receptor (1)

JAK (2)

Liposome (1)

MDM-2/p53 (2)

MEK (1)

Methionine Adenosyltransferase (MAT) (2)

MicroRNA (1)

Microtubule/Tubulin (11)

Mps1 (1)

mTOR (1)

NF-κB (1)

Notch (1)

Parasite (1)

PARP (1)

PDK-1 (1)

PI3K (4)

Pim (4)

PKA (1)

PKC (1)

Polo-like Kinase (PLK) (2)

PROTACs (9)

Proteasome (1)

Pyruvate Kinase (1)

Raf (5)

Reactive Oxygen Species (4)

Src (2)

STAT (3)

Topoisomerase (5)

Trk Receptor (1)

Tyrosinase (1)

VEGFR (2)

Virus Protease (1)

Wnt (1)

YAP (1)

β-catenin (2)

By Research Areas:

Cancer (149)

Cardiovascular Disease (2)

Infection (15)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (2)

163

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Nitroflurbiprofen HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen	COX	Cardiovascular Disease
Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Amyloid-β Liposome	Neurological Disease
DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner .

Naproxcinod AZD 3582; HCT 3012; Nitronaproxen	COX	Inflammation/Immunology
Naproxcinod (Nitronaproxen) is the first in class of cyclooxygenase (COX)-inhibiting nitric oxide donators (CINODs). Naproxcinod shows analgesic and anti-inflammatory effects, it can be used for the research of osteoarthritis and inflammation .

WES-1	Carbonic Anhydrase	Cancer
WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (K_i: 55.9 μM). WES-1 has broad spectrum anti-proliferative activity against the cancer cells, such as leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15) and melanoma (LOX IMVI) cell lines .

SB-1295	Reactive Oxygen Species Apoptosis CDK	Cancer
SB-1295 is an orally active CDK9/T1 inhibitor (IC₅₀=0.17 μM). SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer .

Diaporthein B	Bacterial	Infection Cancer
Diaporthein B is one of the most highly oxidized pimarane diterpenes. Diaporthein B exhibits activity against M. tuberculosis, with a MIC of 3.1 μg/mL. Diaporthein B reveals IC₅₀s of 1.5-3 μM against HCT 116 and LoVo colon cancer cells .

Verrucarin J Muconomycin B	Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species	Infection Cancer
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL .

ASR-490	Notch	Cancer
ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice .

Anticancer agent 131	Others	Cancer
HCT-116-IN-1, a γ-lactam-fused pyridone derivative, has anticancer activity and displayed high cytotoxicity against HCT116 cells with an IC₅₀ of 5.59 μM .

EGFR/HER2/DHFR-IN-2	EGFR Dihydrofolate reductase (DHFR)	Cancer
EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC₅₀: 0.248, 0.156, 0.138 μM respectively). EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC₅₀: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 μM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells). EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth .

RJ-34	Others	Cancer
RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI₅₀ values in the subnanomolar range (GI₅₀ <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells) .

Cyclo(Ala-Pro)	Biochemical Assay Reagents	Cancer
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

RecQ helicase-IN-1	DNA/RNA Synthesis Apoptosis	Cancer
Frangulin B (Compd 11g), a potent anticancer agent, is a potential pan RecQ helicase inhibitor . Frangulin B (Compd 11g) induces apoptosis in both HCT-116 and MDA-MB-231 cell lines, but also causes an G2/M phase cell cycle arrest in HCT-116 cells .

HDAC1/CDK7-IN-1	HDAC CDK Apoptosis	Cancer
HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC₅₀s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells .

Cyclo(Pro-Ala)	Biochemical Assay Reagents	Cancer
Cyclo(Pro-Ala) is an anticancer agent that has toxic to cancer cells such as A549, HCT-116, and HepG2 .

Emeguisin A	Bacterial	Infection
Emeguisin A is a depsidone with an antibacterial activity. Emeguisin A inhibits the human colon carcinoma (HCT-116) cell viability with rate of 87.06% .

Kinetin riboside 2 Publications Verification N6-Furfuryladenosine	Apoptosis	Cancer
Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC₅₀ of 2.5 μM.

Rostratin B	Endogenous Metabolite	Cancer
Rostratin B, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ of 1.9 μg/mL .

Angiogenesis inhibitor 3	Apoptosis	Cancer
Angiogenesis inhibitor 3 (compound 8) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 3 inhibits the proliferation of HUVEC and HCT-15 cells, with IC₅₀ values of 1.00 and 0.71 μM. Angiogenesis inhibitor 3 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 3 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 3 inhibits the angiogenesis in zebrafish embryos .

Angiogenesis inhibitor 2	Apoptosis	Cancer
Angiogenesis inhibitor 2 (compound 72) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 2 inhibits the proliferation of HUVEC and HCT-15 cells, with IC₅₀ values of 1.93 and 0.21 μM. Angiogenesis inhibitor 2 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 2 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 2 inhibits the angiogenesis in zebrafish embryos .

Rostratin C	Endogenous Metabolite	Cancer
Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ value of 0.76μg /mL .

Eupenifeldin	Others	Cancer
Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia .

Germanicol	Apoptosis	Cancer
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

Rostratin A	Endogenous Metabolite	Cancer
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC₅₀ of 8.5 μg/mL .

Goniothalenol	Others	Cancer
Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines .

Anticancer agent 160	Others	Cancer
Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC₅₀=5.0 μM .

Antitumor agent-93	Biochemical Assay Reagents	Cancer
Antitumor agent-93 (compound 7D) is an anticancer agent that can effectively inhibit the growth of several tumor cell lines, such as MDA-MB-231 and HCT-116 cell lines .

Anticancer agent 16	Others	Cancer
Anticancer agent 16 exhibits good cytotoxic activity against HCT-116, NCI-H460, and SKOV3 cell lines with IC₅₀ 8.55 μΜ, 5.41 μΜ, and 6.4 μΜ, respectively.

Braftide	Raf	Cancer
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF ^G469A with IC₅₀ of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC₅₀ is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence .

Antiproliferative agent-15	Others	Cancer
Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines .

Mps-BAY2a	Mps1 Apoptosis	Cancer
Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC₅₀ of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells .

Vitexolide E 12-epi-Vitexolide D; Curcucomosin C	Others	Cancer
Vitexolide E is a diterpenoid compound isolated from the leaves of the Malaysian species Vitex vestita. Vitexolide E shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line .

Broussonol E	Others	Cancer
Broussonol E is a diprenylated flavonol. Broussonol E can be isolated from the leaves of Broussonetia kazinoki. Unlike some dinonylated flavonol derivatives, Broussonol E has no cytotoxicity to human tumor cell lines (A549, HCT-8, KB) .

PARP1-IN-16	PARP Apoptosis	Cancer
PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor, with an IC₅₀ of 1.89 nM. PARP1-IN-16 can arrest the cell cycle in S phase and induce apoptosis in HCT-116 cells .

Antitumor agent-125	Others	Cancer
Antitumor agent-125 (compound 17A) is a novel platinum(IV) prodrug. Antitumor agent-125 can activate the mitochondrion-dependent apoptosis pathway. Antitumor agent-125 induces ferroptosis in HCT-116/OXA .

CX-5461 Maximum Cited Publications 31 Publications Verification	DNA/RNA Synthesis	Cancer
CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC₅₀s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively .

Chlorovaltrate K	Others	Cancer
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

T-1-DOCA	EGFR Apoptosis	Cancer
T-1-DOCA ia a EGFR inhibitor, with the IC₅₀ of 56.94 and 269.01?nM for EGFR ^WT and EGFR ^T790M, respectively. T-1-DOCA can induces cell apoptosis of HCT-116 cells .

CX-5461 dihydrochloride Maximum Cited Publications 31 Publications Verification	DNA/RNA Synthesis	Cancer
CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC₅₀s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC₅₀ ≥25 μM).

ICMT-IN-1	ICMT	Cancer
ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC₅₀=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .

ICMT-IN-7	ICMT	Cancer
ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC₅₀=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .

Topoisomerase II/EGFR-IN-1	Topoisomerase EGFR	Cancer
Topoisomerase II/EGFR-IN-1 is topoisomerase II/EGFR dual inhibitor. Topoisomerase II/EGFR-IN-1 has superior cytotoxic activity to MCF-7, A549 and HCT-116 cell lines, displays strong apoptotic activity and can be used for the research of cancer .

Anticancer agent 158	Others	Cancer
Anticancer agent 158 (compound 7c) is a potent anticancer agent. The IC₅₀s for inhibiting HepG-2, MDA-MB-231, and HCT-116 cell lines are 7.93 μM, 9.28 μM, 13.28 μM, and 181.89 μM, respectively .

Kribb3	Microtubule/Tubulin Apoptosis	Cancer
Kribb3 is an inhibitor for microtubule. KRIBB3 inhibits the proliferation of cancer cells with GI₅₀ of 0.2-2.5 μM, arrests cell cycle at G2/M phase, and induces apoptosis in HCT-116. Kribb3 exhibits antitumor activity in mouse models .

Antitumor agent-59	Apoptosis	Cancer
Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase .

FAK-IN-12	FAK	Cancer
FAK-IN-12 (Compound 12S) is a FAK inhibitor (IC₅₀ = 47 nM). FAK-IN-12 inhibits MGC-803, HCT-116 and KYSE30 cell proliferation (IC₅₀: 0.24, 0.45, 0.44 μM). FAK-IN-12 induces apoptosis and cellular senescence .

Cat. No.	Product Name	Type

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Drug Delivery
DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner .

Cat. No.	Product Name	Target	Research Area

HY-P4079

hCT(18-32)	Peptides	Metabolic Disease
hCT(18-32) is a hCT (human calcitonin)-derived peptide .

HY-P1935

Cyclo(Ala-Pro)	Biochemical Assay Reagents	Cancer
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-139425

Cyclo(Pro-Ala)	Biochemical Assay Reagents	Cancer
Cyclo(Pro-Ala) is an anticancer agent that has toxic to cancer cells such as A549, HCT-116, and HepG2 .

HY-P10028

DC432	Peptides	Cancer
HCT116 is a peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC₅₀ of 54 nM. HCT116 can inhibit the N-terminal methylation level of NTMT1/2 substrates in HCT116 cells, and is used for the study of NTMT1/2 probes.

HY-P10436

Braftide	Raf	Cancer
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF ^G469A with IC₅₀ of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC₅₀ is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence .

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