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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

HIV-1 protease

" in MedChemExpress (MCE) Product Catalog:

114

Inhibitors & Agonists

12

Peptides

26

Natural
Products

1

Recombinant Proteins

11

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147650

    HIV Protease Infection
    HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC50 of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants .
    HIV-1 protease-IN-5
  • HY-155691

    HIV Protease Infection
    HIV-1 protease-IN-12 (compound 35b) is a HIV-1 protease inhibitor with an IC50 of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant .
    HIV-1 protease-IN-12
  • HY-155690

    HIV Protease Infection
    HIV-1 protease-IN-11 (compound 34a) is a HIV-1 protease inhibitor with an IC50 of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant .
    HIV-1 protease-IN-11
  • HY-146804

    HIV HIV Protease Infection
    HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of HIV-1 protease (IC50=71 nM; EC50=0.86 μM) .
    HIV-1 protease-IN-3
  • HY-144688

    HIV Infection
    HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC50 of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC50 value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC50 value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC50 value of 8.23 nM against C-HIV strain Indie [1].
    HIV-1 protease-IN-1
  • HY-146012

    HIV Infection
    HIV-1 protease-IN-4 (Compound II-22) is a potent HIV-1 protease inhibitor. HIV-1 protease-IN-4 is a proagent of atazanavir. HIV-1 protease-IN-4 as a proagent that delivers the parent 1 to rat plasma with a 5-fold higher AUC and 67-fold higher C24 when compared to oral administration of the parent agent .
    HIV-1 protease-IN-4
  • HY-149936

    HIV Protease Infection
    HIV-1 protease-IN-8 (compound 34b) is a potent HIV-1 protease inhibitor with an IC50 value of 0.32 nM. HIV-1 protease-IN-8 displays IC50s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1NL4-3) and drug-resistant variant (HIV-1MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant .
    HIV-1 protease-IN-8
  • HY-161270

    HIV Protease Infection
    HIV-1 protease-IN-13 (compound 18d) is a potent HIV-1 protease inhibitor with an IC50 value of 0.54 nM. HIV-1 protease-IN-13 also shows potent activity against HIV-1DRVRS (DRV-resistant mutation) and HIV-1NL4_3 variant (wild type) .
    HIV-1 protease-IN-13
  • HY-146888

    HIV Protease Infection
    HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants .
    HIV-1 protease-IN-2
  • HY-169166

    HIV Protease Infection
    HIV-1 protease-IN-14 (compound 5ae) is a potent HIV-1 protease inhibitor with Ki values of 0.28, 56.9 nM for WT HIV-1 PR, R41T HIV-1 PR, respectively. HIV-1 protease-IN-14 shows low cytotoxicity .
    HIV-1 protease-IN-14
  • HY-155076

    HIV Protease Infection
    HIV-1 protease-IN-9 (compound 5b) is a HIV-1 protease inhibitor, with a Ki of 0.028 nM. HIV-1 protease-IN-9 shows potent antiviral activity, with an IC50 of 66.8 nM .
    HIV-1 protease-IN-9
  • HY-155599

    HIV PKC Infection
    HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis .
    HIV-1 protease-IN-10
  • HY-150549

    HIV Protease HIV Infection Inflammation/Immunology
    HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus .
    HIV-1 protease-IN-6
  • HY-151250

    HIV Protease Infection
    HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM) .
    HIV-1 protease-IN-7
  • HY-P3980

    HIV Protease Infection
    HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease. And there are 4 residues for conservative substitutions of the substrate binding residues of HIV-1 and HIV-2 protease .
    HIV-1, HIV-2 Protease Substrate
  • HY-118057

    HIV Inflammation/Immunology
    L-739594 is a HIV-1 protease inhibitor, with an IC50 of 1.8 nM .
    L-739594
  • HY-125551

    HIV Protease Infection
    L-687908 is a HIV-1 protease inhibitor (CIC95: 12 nM) .
    L-687908
  • HY-P4466

    HIV Protease Infection
    Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1 protease activity .
    Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2
  • HY-120863

    Virus Protease Infection
    (Rac)-PD 135390 is a dipeptide and an HIV-1 protease inhibitor with an IC50 of 2 nM. (Rac)-PD 135390 can be utilized in antiviral research .
    (Rac)-PD 135390
  • HY-152200

    HIV Protease Reverse Transcriptase Infection Inflammation/Immunology
    HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC50 values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .
    HIV-1 inhibitor-53
  • HY-P1436

    HIV Infection
    Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR Ki values of 712 nM and 13 nM .
    Acetyl-pepstatin
  • HY-N10420
    Hinokinin
    1 Publications Verification

    (-)-Hinokinin

    HIV Protease Infection
    Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .
    Hinokinin
  • HY-N10420R

    HIV Protease Infection
    Hinokinin (Standard) is the analytical standard of Hinokinin. This product is intended for research and analytical applications. Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .
    Hinokinin (Standard)
  • HY-N11940

    HIV Protease Infection
    Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A has low inhibitory activity against HIV-1 protease, with IC50 >100 μg/mL .
    Acetyl-binankadsurin A
  • HY-N2565

    HIV Protease Apoptosis Infection
    Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin has inhibitory effects against HIV-1 protease . Rosamultin has the potential for treating H2O2-induced oxidative stress injury through its antioxidant and antiapoptosis effects .
    Rosamultin
  • HY-15899

    HIV Protease HIV Drug Metabolite Infection
    Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective HIV-1 protease inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects .
    Des(benzylpyridyl) Atazanavir
  • HY-134851
    HIV-1 inhibitor-6
    1 Publications Verification

    HIV Infection
    HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM .
    HIV-1 inhibitor-6
  • HY-130366

    HIV Protease Others
    JG-365 is an HIV-1 protease inhibitor that binds to the active site of HIV-1 protease.
    JG-365
  • HY-123415

    HIV Protease Renin Infection
    PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC50 of 15 nM against HIV-1 protease .
    PD 134922
  • HY-125712

    HIV HIV Protease Infection
    CGP 53820 is an inhibitor for HIV protease, inhibits the complex of HIV-1 and HIV-2 protease with Ki of 9 and 53 nM for HIV-1 protease and HIV-2 protease. CGP 53820 can be used in AIDS research .
    CGP 53820
  • HY-116537

    HIV Protease Infection
    A76889 is an HIV-1 protease inhibitor.
    A76889
  • HY-P3934

    HIV Protease Infection
    HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease .
    HIV Protease Substrate I
  • HY-100212

    AG1776; KNI-764

    HIV HIV Protease Infection
    JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro .
    JE-2147
  • HY-170969

    HIV HIV Protease Infection
    HIV-1 inhibitor-81 (Compound 14g) is an HIV-1 protease inhibitor with a Ki of 1.6 nM. HIV-1 inhibitor-81 exhibits certain antiviral activity, with an EC50 of 250 nM .
    HIV-1 inhibitor-81
  • HY-125148

    HIV Protease Infection
    AQ148 is a HIV-1 protease inhibitor (Ki=137 nM). The IC50 values ??of AQ148 for the inhibition of HIV-1, HIV-2 and SIV aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively .
    AQ148
  • HY-120331

    HIV HIV Protease Infection
    U-89360E is an inhibitor for HIV-1 protease. U-89360E inhibits the protease of HIV-1 wildtype, V82D mutant and V82N mutant with Ki of 20 nM, 560 nM and 2100 nM, respectively .
    U-89360E
  • HY-P2138

    HIV Protease Others
    U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.
    U-85548E
  • HY-N12716

    HIV Protease Infection
    Longipedunin A is a HIV-1 Protease inhibitor with an IC50 value of 50 µg/mL .
    Longipedunin A
  • HY-W702986

    HIV Protease Infection
    Hydroxy darunavir is a metabolite of the HIV-1 protease inhibitor Darunavir (HY-17040).
    Hydroxy darunavir
  • HY-N2786

    HIV Protease Infection
    8-Prenylluteone is a HIV-1 protease inhibitor, with an IC50 of 4 μM .
    8-Prenylluteone
  • HY-P4543

    HIV HIV Protease Infection
    HIV-IN petide is a competitive inhibitor of HIV-1 protease (Ki=50 nM) .
    HIV-IN petide
  • HY-120880

    HIV Protease Infection
    SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research .
    SKF107457
  • HY-129678

    HIV Protease HIV Infection
    UK-88947 hydrochloride is a protease inhibitor with activity in inhibiting the replication of human immunodeficiency virus HIV-1. UK-88947 hydrochloride can be added to cells before infection to block the early steps of HIV-1 replication. The use of UK-88947 hydrochloride shows its specific inhibitory effect on HIV-1. At the same time, when the virus infects cells, it inhibits the action of viral protease and affects the virus replication process .
    UK-88947 hydrochloride
  • HY-19194

    HIV Protease Infection
    A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease .
    A-80987
  • HY-119337

    Ser/Thr Protease Infection
    CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease .
    CE-2072
  • HY-17041
    Darunavir Ethanolate
    10+ Cited Publications

    TMC114 Ethanolate

    HIV HIV Protease Infection
    Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a Ki of 1 nM for wild type HIV-1 protease.
    Darunavir Ethanolate
  • HY-107468

    HIV Protease Infection Inflammation/Immunology
    PL-100 is a potent HIV-1 protease inhibitor with a Ki of 36 pM and an EC50 of 16 nM. PL-100 inhibits viral replication by suppressing HIV-1 protease activity and demonstrates excellent antiviral efficacy against drug-resistant HIV strains. PL-100 can be used in research on drug-resistant HIV disease .
    PL-100
  • HY-15148
    Tipranavir
    5+ Cited Publications

    PNU-140690

    HIV Protease HIV SARS-CoV Infection
    Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL pro activity .
    Tipranavir
  • HY-125571

    HIV Protease Infection
    A 74704 is a pseudo C2-symmetric inhibitor of HIV-1 protease and its diester analog .
    A 74704
  • HY-139794

    HIV Infection
    SDZ283-910 is a potent human immunodeficiency virus type-1 (HIV-1) protease inhibitor .
    SDZ283-910

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