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Results for "

IgG2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Akt (1) Amyloid-β (5) Anaplastic lymphoma kinase (ALK) (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (3) Bacterial (2) Biochemical Assay Reagents (1) c-Fms (3) c-Kit (2) Cadherin (1) CCR (1) CD19 (1) CD2 (1) CD20 (3) CD22 (1) CD28 (3) CD3 (5) CD38 (1) CD47 (1) CGRP Receptor (1) Complement System (2) CRAC Channel (1) CTLA-4 (1) CXCR (2) Dipeptidyl Peptidase (1) E-Selectin (1) EGFR (5) ERK (1) FGFR (1) Flavivirus (1) GCGR (1) Glutathione Peroxidase (1) HIV (1) HSP (1) IGF-1R (1) Influenza Virus (1) Insulin Receptor (2) Integrin (9) Interleukin Related (22) LAG-3 (1) MHC (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) MMP (1) Neurokinin Receptor (1) Notch (2) P-glycoprotein (1) PD-1/PD-L1 (6) Phosphatase (1) Radionuclide-Drug Conjugates (RDCs) (1) RANKL/RANK (1) SARS-CoV (1) Ser/Thr Kinase (1) STAT (1) TGF-beta/Smad (2) Thrombin (1) TNF Receptor (11) Toll-like Receptor (TLR) (6) Transferrin Receptor (1) Transmembrane Glycoprotein (15) Trk Receptor (3) Tyrosinase (1) VEGFR (1) Wnt (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (75) Metabolic Disease (2) Neurological Disease (12)
Click Chemistry:	Azide (1)
Oligonucleotides:	CpG ODNs (2)

152

Inhibitors & Agonists

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256

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Antibodies

Click Chemistry

Oligonucleotides

Sotevtamab 16B5; AB-16B5	Apoptosis	Cancer
Sotevtamab (16B5) is a humanized IgG2 anti-clusterin monoclonal antibody (mAb). Sotevtamab is an inhibitor of the epithelial to mesenchymal transition. Sotevtamab can be used for cancer research ^[2] .

Ersodetug	Insulin Receptor	Inflammation/Immunology
Ersodetug is an anti-INSR (insulin receptor) human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

Visilizumab Anti-Human CD3E Recombinant Antibody; HuM291	Apoptosis	Inflammation/Immunology Cancer
Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related	Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting *ST2*, the IL-33 receptor. Astegolimab has the potential for chronic obstructive pulmonary disease (COPD) research .

Panitumumab 1 Publications Verification ABX-EGF	EGFR	Cancer
Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer ^[2] .

*Donanemab (Mouse IgG2a)*	Amyloid-β	Neurological Disease
Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.

AMG-820	c-Fms	Cancer
AMG-820 is a fully human IgG2 antibody that targets CSF-1R. AMG-820 inhibits binding of the ligands CSF1 and IL34 and subsequent ligand-induced receptor activation. The isotype control for AMG-820 can refer to Human IgG2 kappa, Isotype Control (HY-P99002) .

Befovacimab BAY 1093884	Thrombin	Cardiovascular Disease
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research .

Ontamalimab SHP647	Integrin	Inflammation/Immunology
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease .

Nolavetbart	Interleukin Related	Inflammation/Immunology
Nolavetbart is an anti-Canlupfam IL31RA human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

Glembatumumab	ADC Antibody	Cancer
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .

Panitumumab (anti-EGFR)	EGFR	Cancer
Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer ^[2] .

Riltovetbart ZTS-00008183	Interleukin Related	Inflammation/Immunology
Riltovetbart is a canine-derived IgG2 κ monoclonal antibody raised against Canlupfam IL13 .

Utomilumab PF 05082566	TNF Receptor	Inflammation/Immunology Cancer
Utomilumab (PF 05082566) is a fully human IgG2 mAb agonist of the T-cell costimulatory receptor 4-1BB/CD137. Utomilumab can be used for the research of relapsed/refractory follicular lymphoma (FL) and other CD20 ⁺ non-Hodgkin lymphomas (NHL) ^[2].

Fulranumab	Trk Receptor	Neurological Disease
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

Omoprubart	Complement System	Inflammation/Immunology
Omoprubart is an anti-C5 human?IgG2-G4 κ monoclonal antibody .

Catumaxomab	CD3	Cancer
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers ^[2].

Sibeprenlimab VIS649	SARS-CoV	Inflammation/Immunology Cancer
Sibeprenlimab (VIS649) is a humanized *IgG2* monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) ^[2] .

Vantictumab OMP-18R5	Wnt	Cancer
Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to *FZD1/2/5/7/8* receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma ^[2] .

Pacibekitug	Interleukin Related	Inflammation/Immunology
HY-P990937 is an IL6-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

Denrakibart	CCR	Inflammation/Immunology
HY-P990982 is an CCL17-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

Elranatamab PF-06863135	TNF Receptor	Inflammation/Immunology
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

Tarextumab OMP 59R5; Anti-Human NOTCH2 Recombinant Antibody	Notch	Cancer
Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity .

Brodalumab 3 Publications Verification AMG 827; KHK4827	Interleukin Related	Inflammation/Immunology
Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis ^[2].

Brazikumab AMG 139; MEDI2070	Interleukin Related	Inflammation/Immunology
Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a K_D of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .

Ascrinvacumab 2 Publications Verification Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962	Anaplastic lymphoma kinase (ALK)	Cancer
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K_d value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) .

Abituzumab EMD 525797; DI17E6	Integrin	Cancer
Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer .

Melrilimab GSK 3772847; CNTO-7160	Interleukin Related	Inflammation/Immunology
Melrilimab (GSK 3772847) is an IgG2-kappa *anti-IL1RL1/ST2/IL33R/DER4/FIT-1* monoclonal antibody. Melrilimab can be used for the research of asthma .

Rozibafusp alfa AMG-570	CD28 TNF Receptor	Others
Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE) ^[2].

Anti-TrkB/NTRK2 Antibody	Trk Receptor	Neurological Disease
Anti-TrkB/NTRK2 Antibody is a human antibody expressed in CHO cells, targeting TrkB. Anti-TrkB/NTRK2 Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Ponezumab 1 Publications Verification PF-04360365; RN 1219	EGFR	Neurological Disease
Ponezumab (PF-04360365) is a humanised anti-amyloid *IgG2* monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves performance in mice in various models of learning and memory. Ponezumab can be used in study of Alzheimer's disease .

Olendalizumab ALXN1007	Complement System	Infection
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (K_i=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus ^[2].

Seribantumab SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

FR104	CD28	Inflammation/Immunology
FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Glembatumumab vedotin CDX-011; CR011-vcMMAE	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Glembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .

Sapelizumab	Interleukin Related	Inflammation/Immunology
Sapelizumab is a CHO-expressed humanized antibody targeting IL-6Ra/CD126. Sapelizumab has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Sapelizumab can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-LAP Antibody	TGF-beta/Smad	Inflammation/Immunology
Anti-LAP Antibody is a humanized antibody expressed in CHO cells, targeting LAP. The Anti-LAP Antibody features a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For isotype control of the Anti-LAP Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Insulin efsitora alfa LY-3209590	Insulin Receptor	Metabolic Disease
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes .

Anti-MICB Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
The Anti-MICB Antibody is a humanized antibody expressed in CHO cells, targeting MICB. The Anti-MICB Antibody contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 143.66 kDa. The isotype control for the Anti-MICB Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Eflepedocokin alfa	STAT	Inflammation/Immunology
Eflepedocokin alfa is a recombinant fusion protein with potential cell protective activity. Eflepedocokin alfa consists of human IL-22 fused to human *IgG2-Fc* domain. Eflepedocokin alfa leads to the activation of IL-22/IL-22R-mediated signal transduction pathways as well as STAT3. Eflepedocokin alfa plays a role in immune response and bacterial infection, enhancing intestinal barrier function, intestinal immunity, and tissue repair .

Anti-NGF/bNGF Antibody	Trk Receptor	Inflammation/Immunology
Anti-NGF/bNGF Antibody is a CHO-expressed humanized antibody that targets NGF/bNGF. Anti-NGF/bNGF Antibody has a huIgG2a heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.14 kDa. The isotype control for Anti-NGF/bNGF Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

NI-0701	CXCR	Inflammation/Immunology
NI-0701 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES. NI-0701 has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0701 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HuGAL-F2	FGFR	Inflammation/Immunology
HuGAL-F2 is a human-derived antibody expressed in CHO cells, targeting *FGF2. HuGAL-F2 contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for HuGAL-F2 can refer to Human IgG2* kappa, Isotype Control (HY-P99002).

Anti-NOTCH1 Antibody	Notch	Inflammation/Immunology
The Anti-NOTCH1 Antibody is a CHO-expressed human antibody targeting NOTCH1. The Anti-NOTCH1 Antibody has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-NOTCH1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-MMP9 Antibody	MMP	Inflammation/Immunology
Anti-MMP9 Antibody is a CHO-expressed human antibody that targets MMP9. The Anti-MMP9 Antibody is composed of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.76 kDa. For the isotype control of the Anti-MMP9 Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-Orai1 Antibody	CRAC Channel	Inflammation/Immunology
Anti-Orai1 Antibody is a humanized antibody expressed in CHO cells that targets Orai1. The Anti-Orai1 Antibody has a huIgG2 heavy chain and a huλ light chain, with an predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Orai1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Cat. No.	Product Name

HY-K0214

Protein G Agarose 2 Publications Verification
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

Cat. No.	Product Name	Target	Research Area

HY-P99002

*Human IgG2* kappa, Isotype Control**	Inhibitory Antibodies	Inflammation/Immunology
Human IgG2 kappa, Isotype Control, a human monoclonal antibody, is an isotype control for human IgG2κ antibody .

HY-P99589

Sotevtamab 16B5; AB-16B5	Apoptosis	Cancer
Sotevtamab (16B5) is a humanized IgG2 anti-clusterin monoclonal antibody (mAb). Sotevtamab is an inhibitor of the epithelial to mesenchymal transition. Sotevtamab can be used for cancer research ^[2] .

HY-P99460

Bapotulimab BAY-1905254	Inhibitory Antibodies	Inflammation/Immunology Cancer
Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects .

HY-P990712

Ersodetug	Insulin Receptor	Inflammation/Immunology
Ersodetug is an anti-INSR (insulin receptor) human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P991045

*Donanemab (Mouse IgG2a)*	Amyloid-β	Neurological Disease
Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.

HY-P991048

AMG-820	c-Fms	Cancer
AMG-820 is a fully human IgG2 antibody that targets CSF-1R. AMG-820 inhibits binding of the ligands CSF1 and IL34 and subsequent ligand-induced receptor activation. The isotype control for AMG-820 can refer to Human IgG2 kappa, Isotype Control (HY-P99002) .

HY-P99465

Befovacimab BAY 1093884	Thrombin	Cardiovascular Disease
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research .

HY-P990732

Cepeprubart	Inhibitory Antibodies	Inflammation/Immunology
Cepeprubart is an anti-SELPLG human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99411

Ontamalimab SHP647	Integrin	Inflammation/Immunology
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease .

HY-P990713

Nolavetbart	Interleukin Related	Inflammation/Immunology
Nolavetbart is an anti-Canlupfam IL31RA human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99332

Visilizumab Anti-Human CD3E Recombinant Antibody; HuM291	Apoptosis	Inflammation/Immunology Cancer
Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related	Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting *ST2*, the IL-33 receptor. Astegolimab has the potential for chronic obstructive pulmonary disease (COPD) research .

HY-P99041

Panitumumab 1 Publications Verification ABX-EGF	EGFR	Cancer
Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer ^[2] .

HY-P99205

Glembatumumab	ADC Antibody	Cancer
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .

HY-P99041A

Panitumumab (anti-EGFR)	EGFR	Cancer
Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer ^[2] .

HY-P990699

Riltovetbart ZTS-00008183	Interleukin Related	Inflammation/Immunology
Riltovetbart is a canine-derived IgG2 κ monoclonal antibody raised against Canlupfam IL13 .

HY-P99056

Utomilumab PF 05082566	TNF Receptor	Inflammation/Immunology Cancer
Utomilumab (PF 05082566) is a fully human IgG2 mAb agonist of the T-cell costimulatory receptor 4-1BB/CD137. Utomilumab can be used for the research of relapsed/refractory follicular lymphoma (FL) and other CD20 ⁺ non-Hodgkin lymphomas (NHL) ^[2].

HY-P99200

Fulranumab	Trk Receptor	Neurological Disease
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

HY-P990753

Omoprubart	Complement System	Inflammation/Immunology
Omoprubart is an anti-C5 human?IgG2-G4 κ monoclonal antibody .

HY-P9954

Catumaxomab	CD3	Cancer
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers ^[2].

HY-P99901

Sibeprenlimab VIS649	SARS-CoV	Inflammation/Immunology Cancer
Sibeprenlimab (VIS649) is a humanized *IgG2* monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) ^[2] .

HY-P9974

Vantictumab OMP-18R5	Wnt	Cancer
Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to *FZD1/2/5/7/8* receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma ^[2] .

HY-P990937

Pacibekitug	Interleukin Related	Inflammation/Immunology
HY-P990937 is an IL6-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

HY-P990982

Denrakibart	CCR	Inflammation/Immunology
HY-P990982 is an CCL17-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

HY-P99438

Anivovetmab KIND-030	Inhibitory Antibodies	Infection
Anivovetmab (KIND-030) is an *anti-VP2* (parvovirus major capsid protein) monoclonal antibody (IgG2 type). Anivovetmab has the potential to study canine parvovirus infection.

HY-P99909

Elranatamab PF-06863135	TNF Receptor	Inflammation/Immunology
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99320

Tarextumab OMP 59R5; Anti-Human NOTCH2 Recombinant Antibody	Notch	Cancer
Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity .

HY-P9925

Brodalumab 3 Publications Verification AMG 827; KHK4827	Interleukin Related	Inflammation/Immunology
Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis ^[2].

HY-P99485

Brazikumab AMG 139; MEDI2070	Interleukin Related	Inflammation/Immunology
Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a K_D of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .

HY-P99353

Ascrinvacumab 2 Publications Verification Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962	Anaplastic lymphoma kinase (ALK)	Cancer
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K_d value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) .

HY-P99183

Abituzumab EMD 525797; DI17E6	Integrin	Cancer
Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer .

HY-P99729

Melrilimab GSK 3772847; CNTO-7160	Interleukin Related	Inflammation/Immunology
Melrilimab (GSK 3772847) is an IgG2-kappa *anti-IL1RL1/ST2/IL33R/DER4/FIT-1* monoclonal antibody. Melrilimab can be used for the research of asthma .

HY-P99893

Rozibafusp alfa AMG-570	CD28 TNF Receptor	Others
Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE) ^[2].

HY-P991098

Anti-TrkB/NTRK2 Antibody	Trk Receptor	Neurological Disease
Anti-TrkB/NTRK2 Antibody is a human antibody expressed in CHO cells, targeting TrkB. Anti-TrkB/NTRK2 Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99216

Ponezumab 1 Publications Verification PF-04360365; RN 1219	EGFR	Neurological Disease
Ponezumab (PF-04360365) is a humanised anti-amyloid *IgG2* monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves performance in mice in various models of learning and memory. Ponezumab can be used in study of Alzheimer's disease .

HY-P99767

Olendalizumab ALXN1007	Complement System	Infection
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (K_i=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus ^[2].

HY-P990407

Anti-EPOR Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-EPOR Antibody is a humanized antibody expressed in CHO, targeting EPOR. The predicted molecular weight (MW) of Anti-EPOR Antibody is 150 kDa. The isotype control for Anti-EPOR Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-P990587

FR104	CD28	Inflammation/Immunology
FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990662

Sapelizumab	Interleukin Related	Inflammation/Immunology
Sapelizumab is a CHO-expressed humanized antibody targeting IL-6Ra/CD126. Sapelizumab has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Sapelizumab can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990460

Anti-LAP Antibody	TGF-beta/Smad	Inflammation/Immunology
Anti-LAP Antibody is a humanized antibody expressed in CHO cells, targeting LAP. The Anti-LAP Antibody features a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For isotype control of the Anti-LAP Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99665

Insulin efsitora alfa LY-3209590	Insulin Receptor	Metabolic Disease
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes .

HY-P990467

Anti-MICB Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
The Anti-MICB Antibody is a humanized antibody expressed in CHO cells, targeting MICB. The Anti-MICB Antibody contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 143.66 kDa. The isotype control for the Anti-MICB Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99917

Eflepedocokin alfa	STAT	Inflammation/Immunology
Eflepedocokin alfa is a recombinant fusion protein with potential cell protective activity. Eflepedocokin alfa consists of human IL-22 fused to human *IgG2-Fc* domain. Eflepedocokin alfa leads to the activation of IL-22/IL-22R-mediated signal transduction pathways as well as STAT3. Eflepedocokin alfa plays a role in immune response and bacterial infection, enhancing intestinal barrier function, intestinal immunity, and tissue repair .

HY-P990474

Anti-NGF/bNGF Antibody	Trk Receptor	Inflammation/Immunology
Anti-NGF/bNGF Antibody is a CHO-expressed humanized antibody that targets NGF/bNGF. Anti-NGF/bNGF Antibody has a huIgG2a heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.14 kDa. The isotype control for Anti-NGF/bNGF Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990638

NI-0701	CXCR	Inflammation/Immunology
NI-0701 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES. NI-0701 has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0701 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990597

HuGAL-F2	FGFR	Inflammation/Immunology
HuGAL-F2 is a human-derived antibody expressed in CHO cells, targeting *FGF2. HuGAL-F2 contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for HuGAL-F2 can refer to Human IgG2* kappa, Isotype Control (HY-P99002).

HY-P990476

Anti-NOTCH1 Antibody	Notch	Inflammation/Immunology
The Anti-NOTCH1 Antibody is a CHO-expressed human antibody targeting NOTCH1. The Anti-NOTCH1 Antibody has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-NOTCH1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990468

Anti-MMP9 Antibody	MMP	Inflammation/Immunology
Anti-MMP9 Antibody is a CHO-expressed human antibody that targets MMP9. The Anti-MMP9 Antibody is composed of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.76 kDa. For the isotype control of the Anti-MMP9 Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990656

RG-6125	Inhibitory Antibodies	Inflammation/Immunology
RG-6125 is a humanized antibody expressed in CHO, targeting CDH11/Cadherin-11. RG-6125 has a huIgG2 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for RG-6125 can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Recombinant Proteins Recommended:

IgG2

Species:	Human (3) Mouse (4) Rat (1)
Tag:	Tag Free (8) Fc (1)
Source:	HEK293 (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P78700

	IgG2B Fc Protein, Llama IgG2B; IgG2b Fc	Others	HEK293
	IgG2B Fc Protein, Llama is the recombinant IgG2B Fc protein, expressed by HEK293 , with tag free. The total length of IgG2B Fc Protein, Llama is 243 a.a., with molecular weight of 35-40 kDa.

HY-P700737

	IgG2C Fc Protein, Mouse (HEK293) Ighg2c; IgG2C	Mouse	HEK293
	IgG2C Fc is a subclass of IgG2. Mouse IgG2c Fc loop residues have stronger receptor binding affinity than mouse IgG2b or human IgG1. IgG2C Fc Protein, Mouse (HEK293) is the recombinant mouse-derived IgG2C Fc protein, expressed by HEK293 , with tag free. The total length of IgG2C Fc Protein, Mouse (HEK293) is 234 a.a., with molecular weight of 30-40 kDa.

HY-P72603

	IgG2A Fc Protein, Mouse (HEK293) Ig gamma-2 chain C region; IgG2A Fc	Mouse	HEK293
	Ig gamma-2A chain C region (Immunoglobulin heavy chain gamma polypeptide) is one of the five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. Heavy chain γ defines the classes of immunoglobulins IgG. IgG2A Fc Protein, Mouse (HEK293) is the recombinant mouse-derived IgG2A Fc protein, expressed by HEK293 , with tag free. The total length of IgG2A Fc Protein, Mouse (HEK293) is 232 a.a., with molecular weight of 30-35 kDa.

HY-P72604

	IgG2A Fc Protein, Rat (HEK293) Ig gamma-2 chain C region; IgG2A Fc	Rat	HEK293
	Ig gamma-2A chain C region (IgG2a) is one of the IgG antibodies subclasses and responses to an antigen. IgG2a plays a crucial role in the adaptive immune response. IgG2A Fc Protein, Rat (HEK293) is the recombinant rat-derived IgG2A Fc protein, expressed by HEK293 , with tag free. The total length of IgG2A Fc Protein, Rat (HEK293) is 225 a.a., with molecular weight of 30-35 kDa.

HY-P72602

	IgG2B Fc Protein, Mouse (HEK293) Ig gamma-2B chain C region; IgG2B Fc; Igh-3	Mouse	HEK293
	IgG2B Fc Protein is a member of many immunoglobulin G developed and secreted by effective B cells. IgG2B Fc Protein, Mouse (HEK293) is the recombinant mouse-derived IgG2B Fc protein, expressed by HEK293 , with tag free. The total length of IgG2B Fc Protein, Mouse (HEK293) is 239 a.a., with molecular weight of 30-32 kDa.

HY-P704090

	IgG2 Fc Protein, Human (HEK293) Immunoglobulin heavy constant gamma 2; IGHG2; Ig gamma-2 chain C region; IgG2 Fc	Human	HEK293

HY-P72605

	IgG2 Fc Protein, Human (V161M, S257A, HEK293) Immunoglobulin heavy constant gamma 2; IGHG2; Ig gamma-2 chain C region; IgG2 Fc	Human	HEK293
	The IgG2 Fc protein is the constant region of the immunoglobulin heavy chain and acts as an antigen receptor, triggering the expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells.IgG2 Fc Protein, Human (V161M, S257A, HEK293) is the recombinant human-derived IgG2 Fc protein, expressed by HEK293 , with tag free.

HY-P77530

	IgG2A Fc Protein, Mouse (Biotinylated, HEK293) Ig gamma-2A chain C region; IgG2A Fc	Mouse	HEK293
	Ig gamma-2A chain C region (Immunoglobulin heavy chain gamma polypeptide) is one of the five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. Heavy chain γ defines the classes of immunoglobulins IgG. IgG2A Fc Protein, Mouse (Biotinylated, HEK293) is the recombinant mouse-derived IgG2A Fc protein, expressed by HEK293 , with tag free. The total length of IgG2A Fc Protein, Mouse (Biotinylated, HEK293) is 233 a.a., with molecular weight of ~26.4 KDa.

HY-P701273

	*FITC-Labeled CD7 Protein, Human (HEK293, Llama IgG2b Fc)* CD7; GP40; TP41; LEU-9; Tp40	Human	HEK293
	CD7 Protein, with an elusive function, interacts with SECTM1, implying involvement in SECTM1-related cellular processes. Further research is essential to uncover the specific functions and molecular pathways in which CD7 intricately participates. The current lack of detailed information emphasizes the ongoing exploration needed to elucidate CD7's functional significance and its interplay with SECTM1 in cellular contexts. FITC-Labeled CD7 Protein, Human (HEK293, Llama IgG2b Fc) is the recombinant human-derived FITC-Labeled CD7 protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-Labeled CD7 Protein, Human (HEK293, Llama IgG2b Fc) is 155 a.a., with molecular weight of 55-65 kDa.

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Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
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Storage & Stability
Shipping
Free Sample	Yes No
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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82451

	*Human IgG2* Antibody (YA2196)** IGHG2; immunoglobulin Gm2; immunoglobulin heavy constant gamma 2 (G2m marker)	WB, IHC-P, ICC/IF	Human
	Human IgG2 Antibody (YA2196) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2196), targeting Human IgG2, with a predicted molecular weight of 36 kDa (observed band size: 53 kDa). Human IgG2 Antibody (YA2196) can be used for WB, IHC-P, ICC/IF experiment in human background.

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Products	In-stock - + Add to Cart
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Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-159102

PVP-037.2		Azide
PVP-037.2 is a TLR7/8 agonist. PVP-037.2 can serve as an adjuvant to enhance vaccine-induced T_H1 type immune responses, increasing the production of antigen-specific antibodies IgG1 and IgG2c .

Cat. No.	Product Name		Classification

HY-150726C

ODN 1668 sodium		CpG ODNs
ODN 1668 sodium, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 sodium has strong immune regulatory properties, can enhance the level of antibody *IgG2* subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 sodium induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’ ^[2] .

HY-150726

ODN 1668		CpG ODNs
ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 has strong immune regulatory properties, can enhance the level of antibody *IgG2* subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’ ^[2] .

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