P-selectin

By Targets:	P-selectin (12) Endogenous Metabolite (1) Integrin (1) NF-κB (1) Parasite (1) Protease Activated Receptor (PAR) (3) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (10) Infection (1) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (1)

Targets Recommended: P-selectin E-Selectin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15526

PSI-697 Maximum Cited Publications 6 Publications Verification P-selectin Inhibitor	P-selectin	Cancer
PSI-697 is an oral *P-selectin* inhibitor with an IC₅₀ of 125 μM .

HY-103358

KF38789 1 Publications Verification	P-selectin	Inflammation/Immunology
KF38789 is a selective inhibitor of *P-selectin-PSGL-1* binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC₅₀ value of 1.97 μM .

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets *P-selectin* with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

HY-P9987

Crizanlizumab	P-selectin	Cardiovascular Disease
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease .

HY-106139

Bimosiamose 2 Publications Verification TBC-1269	P-selectin	Inflammation/Immunology
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC₅₀s of 88 μM, 20 μM, and 86 μM for *E-selectin, P-selectin, and L-selectin*, respectively. Bimosiamose has anti-inflammatory effects .

HY-13965

Parmodulin 2 2 Publications Verification ML161	Protease Activated Receptor (PAR)	Cardiovascular Disease
Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC₅₀ of 0.26 μM . Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo .

HY-161646

P-selectin antagonist 1	P-selectin	Cardiovascular Disease
P-selectin antagonist 1 (Compound 11b) is an antagonist for pan-selectin (IC₅₀ is 82 μM) and E-selectin (K_D is 0.91 μM) .

HY-119158

VU0652925	Protease Activated Receptor (PAR) P-selectin	Inflammation/Immunology
VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC₅₀ values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation .

HY-122655

HMCEF	P-selectin	Cardiovascular Disease Inflammation/Immunology
HMCEF is an orally active *P-selectin* inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice .

HY-106139A

Bimosiamose disodium TBC-1269Z	P-selectin	Inflammation/Immunology
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC₅₀s of 88 μM, 20 μM, and 86 μM for *E-selectin, P-selectin, and L-selectin*, respectively. Bimosiamose disodium has anti-inflammatory effects .

HY-146332

Collagen-IN-1	P-selectin	Cardiovascular Disease
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC₅₀ value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research .

HY-106428

Icrocaptide ITF1697	P-selectin	Cardiovascular Disease Inflammation/Immunology
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca ²⁺-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits *P-selectin* and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders .

HY-132828

Odatroltide LT3001; DHDMIQK(KAP)	P-selectin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Odatroltide (LT3001; DHDMIQK(KAP)) is a *P-selectin* inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .

HY-146333

TRAP-6-IN-1	Protease Activated Receptor (PAR)	Cardiovascular Disease
TRAP-6-IN-1 (Compound 8) is a dual collagen and TRAP-6 inhibitor with IC₅₀ values of 17.12 µM and 11.88 µM against collagen and TRAP-6, respectively. TRAP-6-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner .

HY-N8903

Mumefural	Integrin NF-κB Toll-like Receptor (TLR) TNF Receptor	Cardiovascular Disease Neurological Disease
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .

HY-W020790

Sialyl-Lewis X sLeX	Endogenous Metabolite	Inflammation/Immunology
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

HY-N10534

Lewis X trisaccharide Lewis X	Parasite	Infection Inflammation/Immunology Cancer
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

Cat. No.	Product Name	Target	Research Area

HY-106428

Icrocaptide ITF1697	P-selectin	Cardiovascular Disease Inflammation/Immunology
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca ²⁺-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits *P-selectin* and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders .

Cat. No.	Product Name	Target	Research Area

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets *P-selectin* with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

HY-P9987

Crizanlizumab	P-selectin	Cardiovascular Disease
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W020790

Sialyl-Lewis X sLeX	Structural Classification Polysaccharides Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

HY-N10534

Lewis X trisaccharide Lewis X	Infection Structural Classification Natural Products Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

Species:	Human (8) Rhesus Macaque (2) Mouse (4) Rat (2)
Tag:	His (9) Tag Free (1) Avi (3) Fc (7)
Source:	HEK293 (16)

Cat. No.	Compare	Product Name	Species	Source

HY-P73383

	P-Selectin Protein, Mouse (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Mouse	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes.It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X.P-Selectin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73689

	P-Selectin Protein, Rat (HEK293, His) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rat	HEK293
	P-Selectin, a Ca(2+)-dependent receptor on myeloid cells, binds to neutrophils and monocytes via carbohydrates. It interacts with SELPLG to enable rapid leukocyte rolling over vascular surfaces in early inflammation. P-Selectin also interacts with SNX17 and promotes neutrophil adhesion and rolling, requiring SELPLG's sialyl-Lewis X and tyrosine sulfation. P-Selectin Protein, Rat (HEK293, His) is the recombinant rat-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag.

HY-P73687

	P-Selectin Protein, Rhesus Macaque (HEK293, His) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rhesus Macaque	HEK293
	P-Selectin Protein, Rhesus Macaque (HEK293, His) is a member of the selectin family of cell adhesion molecules. P-selectin (CD62P) has an N-terminal lectin domain, an epidermal growth factor motif, (generally) nine regulatory protein repeats, a transmembrane section and a short intracytoplasmic tail. P-selectin mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. P-selectin glycoprotein ligand-1 (PSGL-1) is a major ligand for P-selectin. P-Selectin Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag.

HY-P70803

	P-selectin Protein, Human (HEK293, His) P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; PADGEM	Human	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that critically binds to sialic acid-Lewis X on neutrophils and monocytes, promoting the interaction between activated endothelial cells or platelets and leukocytes interaction. This binding primarily to SELPLG/PSGL1 and PODXL2 is critical for rapid rolling of leukocytes during early inflammation. P-selectin Protein, Human (HEK293, His) is the recombinant human-derived P-selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-selectin Protein, Human (HEK293, His) is 730 a.a., with molecular weight of 95-130 kDa.

HY-P78349

	P-Selectin Protein, Mouse (HEK293, His) FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-selectin; SELP; CD62P; CD62; LECAM3	Mouse	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes.It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X.P-Selectin Protein, Mouse (HEK293, His) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag.

HY-P78201

	P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-selectin; SELP; CD62P; CD62; LECAM3	Human	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that critically binds to sialic acid-Lewis X on neutrophils and monocytes, promoting the interaction between activated endothelial cells or platelets and leukocytes interaction. This binding primarily to SELPLG/PSGL1 and PODXL2 is critical for rapid rolling of leukocytes during early inflammation. P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived P-Selectin protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) is 730 a.a., with molecular weight of 115-140 kDa.

HY-P73385

	P-Selectin Protein, Rat (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rat	HEK293
	P-Selectin, a Ca(2+)-dependent receptor on myeloid cells, binds to neutrophils and monocytes via carbohydrates. It interacts with SELPLG to enable rapid leukocyte rolling over vascular surfaces in early inflammation. P-Selectin also interacts with SNX17 and promotes neutrophil adhesion and rolling, requiring SELPLG's sialyl-Lewis X and tyrosine sulfation. P-Selectin Protein, Rat (HEK293, Fc) is the recombinant rat-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73690

	P-Selectin Protein, Human (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Human	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that critically binds to sialic acid-Lewis X on neutrophils and monocytes, promoting the interaction between activated endothelial cells or platelets and leukocytes interaction. This binding primarily to SELPLG/PSGL1 and PODXL2 is critical for rapid rolling of leukocytes during early inflammation. P-Selectin Protein, Human (HEK293, Fc) is the recombinant human-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of P-Selectin Protein, Human (HEK293, Fc) is 730 a.a., with molecular weight of 130-150 kDa.

HY-P73688

	P-Selectin Protein, Rhesus Macaque (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rhesus Macaque	HEK293
	P-Selectin Protein, Rhesus Macaque (HEK293, His) is a member of the selectin family of cell adhesion molecules. P-selectin (CD62P) has an N-terminal lectin domain, an epidermal growth factor motif, (generally) nine regulatory protein repeats, a transmembrane section and a short intracytoplasmic tail. P-selectin mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. P-selectin glycoprotein ligand-1 (PSGL-1) is a major ligand for P-selectin. P-Selectin Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78511

	P-Selectin Protein, Human (HEK293, His-Avi) FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-selectin; SELP; CD62P; CD62; LECAM3	Human	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that critically binds to sialic acid-Lewis X on neutrophils and monocytes, promoting the interaction between activated endothelial cells or platelets and leukocytes interaction. This binding primarily to SELPLG/PSGL1 and PODXL2 is critical for rapid rolling of leukocytes during early inflammation. P-Selectin Protein, Human (HEK293, His-Avi) is the recombinant human-derived P-Selectin protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of P-Selectin Protein, Human (HEK293, His-Avi) is 730 a.a., with molecular weight of 100-120 kDa.

HY-P72408

	P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) CD62 antigen-like family member P; GMP-140; LECAM3; PADGEM	Mouse	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes.It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X.P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) is the recombinant mouse-derived P-selectin protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P77165

	CD162/PSGL-1 Protein, Mouse (HEK293) P-selectin glycoprotein ligand 1; PSGL-1; selectin P ligand; CD162; SELPLG	Mouse	HEK293
	The CD162/PSGL-1 protein is an SLe(x)-type proteoglycan that mediates rapid rolling of leukocytes through high-affinity interactions with E- and P-selectin, thereby promoting early inflammatory stages.CD162 forms homodimers linked by disulfide bonds and interacts with selectins through the lectin/EGF domain.CD162/PSGL-1 Protein, Mouse (HEK293) is the recombinant mouse-derived CD162/PSGL-1 protein, expressed by HEK293 , with tag free.

HY-P72485

	CD162/PSGL-1 Protein, Human (HEK293, hFc) P-selectin glycoprotein ligand 1; PSGL-1; selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein, a cell surface receptor, plays a crucial role in leukocyte trafficking and adhesion. Dysregulation of CD162/PSGL-1 Protein has been associated with inflammatory diseases and impaired immune responses. Targeting CD162/PSGL-1 Protein may offer potential therapeutic interventions in these conditions by modulating leukocyte trafficking, enhancing immune responses, and managing inflammatory disorders. CD162/PSGL-1 Protein, Human (HEK293, hFc) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77163

	CD162/PSGL-1 Protein, Human (HEK293, His) P-selectin glycoprotein ligand 1; PSGL-1; selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein, a cell surface receptor, plays a crucial role in leukocyte trafficking and adhesion. Dysregulation of CD162/PSGL-1 Protein has been associated with inflammatory diseases and impaired immune responses. Targeting CD162/PSGL-1 Protein may offer potential therapeutic interventions in these conditions by modulating leukocyte trafficking, enhancing immune responses, and managing inflammatory disorders. CD162/PSGL-1 Protein, Human (HEK293, His) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293, with C-His labeled tag. The total length of CD162/PSGL-1 Protein, Human (HEK293, His) is 295 a.a., with molecular weight of ~89 & 61 kDa, respectively.

HY-P77164

	CD162/PSGL-1 Protein, Human (HEK293, mFc) P-selectin glycoprotein ligand 1; PSGL-1; selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein is a sialomucin expressed on leukocytes, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. CD162/PSGL-1 Protein, Human (HEK293, mFc) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P77162

	CD162/PSGL-1 Protein, Human (HEK293, His-Fc) P-selectin glycoprotein ligand 1; PSGL-1; selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein is a sialomucin expressed on leukocytes, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. CD162/PSGL-1 Protein, Human (HEK293, His-Fc) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His, C-hFc labeled tag. The total length of CD162/PSGL-1 Protein, Human (HEK293, His-Fc) is 278 a.a., with molecular weight of 110-120 kDa.

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HY-P83529

	CD62P Antibody (YA3274) SELP; GMRP; GRMP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P	WB, IHC-P	Human
	CD62P Antibody (YA3274) is a non-conjugated IgG antibody, targeting CD62P, with a predicted molecular weight of 91 kDa. CD62P Antibody (YA3274) can be used for WB, IHC-P experiment in human background.

HY-P81737

	SELP Antibody (YA1482) SELP; GMRP; GRMP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P	FC, ELISA	Human
	SELP Antibody (YA1482) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1482), targeting SELP. SELP Antibody (YA1482) can be used for FC, ELISA experiment in human background.

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