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Results for "

STING Agonist

" in MedChemExpress (MCE) Product Catalog:

87

Inhibitors & Agonists

7

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-143896
    STING agonist-7

    		STING Cancer
    STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly .
    STING agonist-7
  • HY-103665
    STING agonist-3
    5+ Cited Publications

    		 STING Cancer
    STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer .
    STING agonist-3
  • HY-149781
    STING agonist-34

    		STING Cancer
    STING agonist-34 (Compound 12L) is a potent STING agonist with an IC50 value of 1.15 μM and an EC50 of 0.38 μM in THP1 cells. STING agonist-34 could be used in cancer research .
    STING agonist-34
  • HY-153546
    STING agonist-31

    		STING Cancer
    STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency .
    STING agonist-31
  • HY-122568
    STING agonist-15

    		STING Cancer
    STING agonist-15 (Compound STING agonist-C11) Is a STING agonist. STING agonist-15 can be used for research of cancer and immune response .
    STING agonist-15
  • HY-147834
    STING agonist-9

    		STING Cancer
    STING agonist-9 (Compound 45) is a potent STING agonist with an EC50 of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity .
    STING agonist-9
  • HY-139179
    STING agonist-14

    		STING Infection Cancer
    STING agonist-14 (compound 12b) is a potent STING agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections .
    STING agonist-14
  • HY-152960
    STING agonist-27

    		STING Infection
    STING agonist-27 (CF509) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .
    STING agonist-27
  • HY-152962
    STING agonist-29

    		STING Infection
    STING agonist-29 (CF511) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .
    STING agonist-29
  • HY-160910
    STING agonist-35

    		STING ADC Cytotoxin Cancer
    STING agonist-35 (Compoind 2) is an agonist for stimulator of interferon genes (STING), which activates the wild type STING and mutated type STING (R232H), with a rate of 112% and 77%. STING agonist-35 is a potent payload for ADC .
    STING agonist-35
  • HY-143321
    STING agonist-13

    		STING Cancer
    STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .
    STING agonist-13
  • HY-148546
    STING agonist-21

    		STING Cancer
    STING agonist-21 (compound 1) is a STING agonist, with an EC50 of 592.8 nM. STING agonist-21 can be used for cancer research .
    STING agonist-21
  • HY-152956
    STING agonist-23

    		STING Infection Cancer
    STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-23
  • HY-152957
    STING agonist-24

    		STING Infection
    STING agonist-24 (CF504) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-24
  • HY-152958
    STING agonist-25

    		STING Infection
    STING agonist-25 (CF505) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-25
  • HY-152959
    STING agonist-26

    		STING Infection Cancer
    STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-26
  • HY-152961
    STING agonist-28

    		STING Infection
    STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-28
  • HY-149267
    STING agonist-30

    		STING SARS-CoV Infection
    STING agonist-30 is a potent STING agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) .
    STING agonist-30
  • HY-131994
    STING agonist-16

    		STING Infection Cancer
    STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool .
    STING agonist-16
  • HY-143320
    STING agonist-17

    		STING Cancer
    STING agonist-17 (compound 4a) is a potent STING agonist with an IC50 value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization .
    STING agonist-17
  • HY-152955
    STING agonist-22

    		STING Infection Inflammation/Immunology
    STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research .
    STING agonist-22
  • HY-158711
    STING agonist-38

    		STING Cancer
    STING agonist-38 (compound 58) is a potent agonist of STING, with the EC50 of 0.05 μM in THP1 cells. STING agonist-38 has certain oral bioactivity .
    STING agonist-38
  • HY-123943
    STING agonist-4
    5 Publications Verification

    		 STING Cancer
    STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .
    STING agonist-4
  • HY-148068
    STING agonist-20

    		STING Inflammation/Immunology Cancer
    STING agonist-20 (compound 95) is a potent STING agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases .
    STING agonist-20
  • HY-144329
    STING agonist-11

    		STING Inflammation/Immunology Cancer
    STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC50 of 18 nM. Activation of STING is a highly promising approach in immunotherapy .
    STING agonist-11
  • HY-144328
    STING agonist-10

    		STING Inflammation/Immunology Cancer
    STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of STING with the EC50 of 2600 nM. Activation of STING is a highly promising approach in immunotherapy .
    STING agonist-10
  • HY-147010
    STING agonist-12

    		STING Inflammation/Immunology
    STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM .
    STING agonist-12
  • HY-103665A
    STING agonist-3 trihydrochloride
    5+ Cited Publications

    		 STING Cancer
    STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer .
    STING agonist-3 trihydrochloride
  • HY-153987
    STING agonist-33

    		Others Cancer
    STING agonist-33 (example 1) is an agonist of STING (stimulator of interferon genes) based on 4-ethyl-2-methylthiazole-5-carboxylic acid [1] .
    STING agonist-33
  • HY-144168A
    STING agonist-8 dihydrochloride

    		STING Inflammation/Immunology
    STING agonist-8 dihydrochloride (compound 5-AB) is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells .
    STING agonist-8 dihydrochloride
  • HY-144168
    STING agonist-8

    		STING Inflammation/Immunology
    STING agonist-8 is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB) .
    STING agonist-8
  • HY-150075
    STING agonist-19

    		Others Others
    STING agonist-19 can be used to synthesize ISAC (immune-stimulating antibody conjugates) molecule.
    STING agonist-19
  • HY-150074
    STING agonist-18

    		Others Cancer
    STING agonist-18 (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate .
    STING agonist-18
  • HY-19711
    STING agonist-1
    2 Publications Verification

    G10

    		 STING Virus Protease Infection
    STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM .
    STING agonist-1
  • HY-150074A
    STING agonist-18 diTFA

    		Others Cancer
    STING agonist-18 diTFA (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate .
    STING agonist-18 diTFA
  • HY-148346
    STING agonist-20-Ala-amide-PEG2-C2-NH2

    		Drug-Linker Conjugates for ADC STING Cancer
    STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer .
    STING agonist-20-Ala-amide-PEG2-C2-NH2
  • HY-148346A
    STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA

    		Drug-Linker Conjugates for ADC STING Cancer
    STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer .
    STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
  • HY-112921A
    diABZI STING agonist-1
    25+ Cited Publications

    		 STING Inflammation/Immunology
    diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1
  • HY-112921B
    diABZI STING agonist-1 trihydrochloride
    25+ Cited Publications

    		 STING Inflammation/Immunology Cancer
    diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1 trihydrochloride
  • HY-112921
    diABZI STING agonist-1 (tautomerism)

    		STING Inflammation/Immunology
    diABZI STING agonist-1 tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1 (tautomerism)
  • HY-B0984A
    Fendiline

    		STING Infection Cardiovascular Disease Cancer
    Fendiline is a STING agonist and has tumor growth inhibitory activity. Fendiline can be used for research on cancer and viral infections .
    Fendiline
  • HY-160406
    SNX281

    		STING Cancer
    SNX281 is a systemically active STING agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. SNX281 can be used in the study of anti-tumor immunity .
    SNX281
  • HY-139586A
    Ulevostinag (isomer 1)

    MK-1454 (isomer 1)

    		 STING Cancer
    Ulevostinag isomer 1 (MK-1454 isomer 1) is the isomer of Ulevostinag. Ulevostinag is a STING agonist .
    Ulevostinag (isomer 1)
  • HY-139586D
    Ulevostinag (isomer 4)

    MK-1454 (isomer 4)

    		 STING Cancer
    Ulevostinag isomer 4 (MK-1454 isomer 4) is the isomer of Ulevostinag. Ulevostinag is a STING agonist .
    Ulevostinag (isomer 4)
  • HY-139586B
    Ulevostinag (isomer 2)

    MK-1454 (isomer 2)

    		 STING Cancer
    Ulevostinag isomer 2 (MK-1454 isomer 2) is the isomer of Ulevostinag. Ulevostinag is a STING agonist .
    Ulevostinag (isomer 2)
  • HY-156290
    SAP-04

    		STING Inflammation/Immunology Cancer
    SAP-04 is a potent and orally active STING agonist. SAP-04 exhibits potent immunomodulatory effects for cancer therapy .
    SAP-04
  • HY-162133
    MSA-2-Pt

    		STING Cancer
    MSA-2-Pt is an orally active STING agonist that has good cell membrane permeability. MSA-2-Pt can induce cell death by Pt, which may release damaged DNA to activate the cGAS-STING pathway. Besides, MSA-2-Pt can activate the STING pathway directly by MSA-2. MSA-2-Pt can be used for the research of cancer .
    MSA-2-Pt
  • HY-164278
    diABZI-V/C-Mal

    		Ligands for Target Protein for PROTAC STING Cancer
    diABZI-V/C-Mal is a STING agonist.
    diABZI-V/C-Mal
  • HY-162465
    BDW568

    		STING Infection Inflammation/Immunology Cancer
    BDW568 is a STING agonist that can selectively activate the human STING A230 allele. BDW568 can be used to activate STING A230-engineered macrophages in macrophage-based immunotherapy .
    BDW568
  • HY-128481
    SB24011

    		STING Cancer
    SB24011 is a STING-TRIM29 interaction inhibitor with a IC50 value of 3.85 μM. SB24011 enhances STING immunity by upregating STING protein levels, thereby enhancing the immunotherapy effect of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity .
    SB24011

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