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Results for "

STING activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	STING (43) ADC Cytotoxin (1) Akt (1) AMPK (1) Apoptosis (1) Autophagy (2) Bacterial (3) DNA/RNA Synthesis (1) Endogenous Metabolite (6) Ferroptosis (1) HSV (1) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) PARP (2) PROTACs (1) SARS-CoV (1)
By Research Areas:	Cancer (24) Infection (13) Inflammation/Immunology (28)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Targets Recommended: STING

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151970

STING-IN-4	STING	Inflammation/Immunology
STING-IN-4 (Compound 1) is a *STING* inhibitor that inhibits STING expression and hence reducing activation of STING and nuclear factor-κB (NF-κB) signaling. STING-IN-4 shows anti-inflammatory activity and can be used for the research of sepsis .

HY-147010

STING agonist-12	STING	Inflammation/Immunology
STING agonist-12 (Compound 53) is a potent, orally active human *STING* activator with an EC₅₀ of 185 nM .

HY-138683

STING-IN-3 2 Publications Verification	STING	Inflammation/Immunology
STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING .

HY-144329

STING agonist-11	STING	Inflammation/Immunology Cancer
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of *STING* with EC₅₀ of 18 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-144328

STING agonist-10	STING	Inflammation/Immunology Cancer
STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of *STING* with the EC₅₀ of 2600 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-162465

BDW568	STING	Infection Inflammation/Immunology Cancer
BDW568 is a *STING* agonist that can selectively activate the human STING ^A230 allele. BDW568 can be used to activate STING ^A230-engineered macrophages in macrophage-based immunotherapy .

HY-152960

STING agonist-27	STING	Infection
STING agonist-27 (CF509) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .

HY-152962

STING agonist-29	STING	Infection
STING agonist-29 (CF511) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .

HY-160910

STING agonist-35	STING ADC Cytotoxin	Cancer
STING agonist-35 (Compoind 1a) is an agonist for stimulator of interferon genes (STING), which activates the wild type STING and mutated type STING (R232H), with a rate of 99% and 92%. STING agonist-35 is a potent payload for ADC .

HY-139179

STING agonist-14	STING	Infection Cancer
STING agonist-14 (compound 12b) is a potent *STING* agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections .

HY-148606

STING modulator-3	STING	Cancer
STING modulator-3 is a *STING* inhibitor. STING modulator-3 inhibits R232 STING with an K_i value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells .

HY-145010

SN-011 3 Publications Verification	STING	Inflammation/Immunology
SN-011 is a potent and selective mouse and human *STING* inhibitor, with an IC₅₀ of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease .

HY-143321

STING agonist-13	STING	Cancer
STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate *STING* downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .

HY-149267

STING agonist-30	STING SARS-CoV	Infection
STING agonist-30 is a potent *STING* agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) .

HY-152956

STING agonist-23	STING	Infection
STING agonist-23 (CF502) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152957

STING agonist-24	STING	Infection
STING agonist-24 (CF504) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152958

STING agonist-25	STING	Infection
STING agonist-25 (CF505) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152959

STING agonist-26	STING	Infection
STING agonist-26 (CF508) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152961

STING agonist-28	STING	Infection
STING agonist-28 (CF510) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152955

STING agonist-22	STING	Infection Inflammation/Immunology
STING agonist-22 (CF501) is a potent non-nucleotide *STING* agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research .

HY-123963

C-178 4 Publications Verification	STING	Inflammation/Immunology
C-178 is a potent and selective covalent inhibitor of *STING. C-178 binds to Cys91 and suppresses the STING* responses elicited by distinct bona fide activators in mouse but not human .

HY-112906

C-176 Maximum Cited Publications 65 Publications Verification	STING	Inflammation/Immunology
C-176 is a selective and blood-brain barrier permeable *STING* inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of *STING* .

HY-162133

MSA-2-Pt	STING	Cancer
MSA-2-Pt is an orally active *STING* agonist that has good cell membrane permeability. MSA-2-Pt can induce cell death by Pt, which may release damaged DNA to activate the cGAS-STING pathway. Besides, MSA-2-Pt can activate the STING pathway directly by MSA-2. MSA-2-Pt can be used for the research of cancer .

HY-168034

diABZI-4	STING	Infection Inflammation/Immunology
diABZI-4 is an oral active *STING* agonist with broad-spectrum antiviral activity. diABZI-4 induces the production of pro-inflammatory cytokines and lymphocyte activation by activating *STING, thereby inhibiting the replication of influenza A virus (IAV), SARS-CoV-2, and human rhinovirus (HRV), with an EC₅₀* range of 11.8-199 nM .

HY-157214

NVS-STG2	STING	Cancer
NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models .

HY-162874

diABZI-V/C-DBCO	STING	Inflammation/Immunology Cancer
diABZI-V/C-DBCO (Compound 3) is a potent *STING* agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate *STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC₅₀* values for diABZI-V/C-DBCO and diABZI-amine in activating *STING* in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC₅₀ values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research .

HY-130116A

IACS-8779 disodium	STING	Cancer
IACS-8779 disodium is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. IACS-8779 disodium shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma .

HY-155100

BI 7446	STING	Inflammation/Immunology Cancer
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research .

HY-148029

Dazostinag disodium TAK-676	STING	Cancer
Dazostinag disodium (TAK-676) is an agonist of *STING, triggering the activation* of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity .

HY-12885A

2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) 50+ Cited Publications ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).

HY-12212

Omaveloxolone 15+ Cited Publications RTA 408	Keap1-Nrf2 STING Apoptosis	Inflammation/Immunology Cancer
Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

HY-113469

Cyclic GMP 1 Publications Verification	STING Endogenous Metabolite	Inflammation/Immunology
Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .

HY-12512

cGAMP 10+ Cited Publications Cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-12885

2’3’-c-di-AM(PS)2 (Rp,Rp) 50+ Cited Publications ADU-S100; MIW815; ML RR-S2 CDA	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .

HY-110385

cGAMP disodium 10+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates* a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-110385A

cGAMP diammonium 10+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates* a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-12885B

2’3’-c-di-AM(PS)2 (Rp,Rp) (ammonium salt) 50+ Cited Publications ADU-S100 ammonium salt; MIW815 ammonium salt; ML RR-S2 CDA ammonium salt	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .

HY-151513

Iso5-2DC18	Others	Cancer
Iso5-2DC18 is a lipid that can be used for the synthesis of amine containing lipids. These amine containing lipids can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity .

HY-155109

Antitumor agent-114	STING	Inflammation/Immunology Cancer
Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research .

HY-163461

4F-DDC	PARP	Cancer
4F-DDC is a novel PARP1 inhibitor with an IC₅₀ value of 82 nM. 4F-DDC induces DNA damage and activates the cGAS–STING pathway. 4F-DDC inhibits the growth of HCC-1937-derived tumor xenografts .

HY-158126

G-quadruplex ligand 2	DNA/RNA Synthesis	Cancer
G-quadruplex ligand 2 (compound A3) is a triphenylamine-based ligand that targets mitochondrial DNA G4s. G-quadruplex ligand 2 activates the *cGAS-STING* pathway. G-quadruplex ligand 2 inhibits tumor growth and metastasis via regulation of TME .

HY-10249

GSK-690693 30+ Cited Publications	Akt AMPK Autophagy	Cancer
GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC₅₀s of 2 nM, 13 nM, 9 nM for Akt1, Akt2 and Akt3, respectively. GSK-690693 is also an AMPK inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation .

HY-12326A

c-di-AMP disodium 2 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) sodium is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium 2 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP diammonium is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12885C

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt ADU-S100 enantiomer ammonium salt; MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt	Others	Inflammation/Immunology
2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 2’3’-c-di-AM(PS)2 (Rp,Rp). 2’3’-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferon genes (STING) .

HY-158045

PROTAC PARP1 degrader-1	PROTACs PARP	Inflammation/Immunology Cancer
PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker; Pink: PARP1 inhibitor) .

HY-162944

NA-Ir	Ferroptosis Mitochondrial Metabolism STING Autophagy	Cancer
NA-Ir is a ferroptosis inducer. NA-Ir induces ferroptinophagy by targeting mitochondrial DNA (mtDNA) and activating the *cGAS-STING* pathway, while also triggering the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), leading to lipid peroxidation and ferroptosis (Ferroptosis). NA-Ir exhibits higher anticancer activity under light irradiation and selectively inhibits cancer cells with high H₂S levels .

HY-160222

HSV-60mer sodium	HSV STING	Infection Inflammation/Immunology
HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome . Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR)-, DNA-dependent activator of IRFs (DAI)-, and RNA polymerase III (Pol III)-independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3)-dependent manner.

Cat. No.	Product Name

HY-L031

Small Molecule Immuno-Oncology Compound Library

535 compounds

Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines.

MCE Small Molecule Immuno-Oncology Compound Library offers 535 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

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