Search Result
Results for "
SUB1
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
263
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B0389S1
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Glucose-d<SUB>1SUB>; D-(+)-Glucose-d<SUB>1SUB>; Dextrose-d<SUB>1SUB>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
Cancer
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D-Glucose-d is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
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- HY-B0389S8
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Glucose-d<SUB>1SUB>-4; D-(+)-Glucose-d<SUB>1SUB>-4; Dextrose-d<SUB>1SUB>-4
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-RS13999
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Small Interfering RNA (siRNA)
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Others
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SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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SUB1 Human Pre-designed siRNA Set A
SUB1 Human Pre-designed siRNA Set A
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- HY-P10215
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Parasite
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Infection
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Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively [1].
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- HY-B0389S3
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Glucose-d<SUB>1SUB>-1; D-(+)-Glucose-d<SUB>1SUB>-1; Dextrose-d<SUB>1SUB>-1
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-W016577S4
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- HY-W099504S2
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- HY-N0210S6
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- HY-N0378S5
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- HY-41700S2
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- HY-B0389S7
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Glucose-d<SUB>1SUB>-3; D-(+)-Glucose-d<SUB>1SUB>-3; Dextrose-d<SUB>1SUB>-3
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S4
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Glucose-d<SUB>1SUB>-2; D-(+)-Glucose-d<SUB>1SUB>-2; Dextrose-d<SUB>1SUB>-2
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d1-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S2
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Glucose-d<SUB>12SUB>-1; D-(+)-Glucose-d<SUB>12SUB>-1; Dextrose-d<SUB>12SUB>-1
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d12-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-19696S2
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Tauroursodeoxycholic acid-d<SUB>4SUB>-1; TUDCA-d<SUB>4SUB>-1; UR 906-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
ERK
Caspase
Endogenous Metabolite
Apoptosis
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Cancer
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Tauroursodeoxycholate-d4-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
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- HY-B0389S23
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Glucose-d<SUB>2SUB>-1; D-(+)-Glucose-d<SUB>2SUB>-1; Dextrose-d<SUB>2SUB>-1
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Endogenous Metabolite
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Metabolic Disease
Cancer
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D-Glucose-d2-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol
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- HY-B0228S7
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- HY-109037S2
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MYK461-d<SUB>1SUB>; SAR439152-d<SUB>1SUB>
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Isotope-Labeled Compounds
Myosin
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Cardiovascular Disease
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Mavacamten-d1 (MYK461-d1; SAR439152-d1) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
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- HY-B0763S2
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KC-404-d<SUB>7SUB>-1; AV-411-d<SUB>7SUB>-1; MN-166-d<SUB>7SUB>-1
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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Ibudilast-d7-1 is the deuterium labeled Ibudilast[1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[2].
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- HY-B0141S6
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- HY-B0152S
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6-Aminopurine-d<SUB>1SUB>; Vitamin B4-d<SUB>1SUB>
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DNA/RNA Synthesis
Endogenous Metabolite
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Cancer
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Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
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- HY-B1411S1
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- HY-B0479S1
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Thiophenicol-d<SUB>3SUB>-1; Dextrosulphenidol-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
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Infection
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Thiamphenicol-d3-1 (Thiophenicol-d3-1; Dextrosulphenidol-d3-1) is the deuterium-labeled Thiamphenicol (HY-B0479) [1]. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria) .
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- HY-B0511S
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- HY-14648S1
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- HY-B0234S4
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E1-d<SUB>2SUB>-1; Oestrone-d<SUB>2SUB>-1
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
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Endocrinology
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Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-14648S5
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Hexadecadrol-d<SUB>3SUB>-1; Prednisolone F-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
Antibiotic
Autophagy
Glucocorticoid Receptor
SARS-CoV
ADC Cytotoxin
Mitophagy
Complement System
Bacterial
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Cancer
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Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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- HY-23188
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- HY-N2037AS1
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Norcoclaurine-d<SUB>4SUB>-1 hydrochloride; Demethyl-Coclaurine-d<SUB>4SUB>-1 hydrochloride
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Isotope-Labeled Compounds
MAP3K
MDM-2/p53
Apoptosis
ROS Kinase
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Infection
Cardiovascular Disease
Endocrinology
Cancer
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Higenamine-d4-1 (Norcoclaurine-d4-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases [1] .
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- HY-17043S2
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- HY-14649S6
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Vitamin A acid-d<SUB>3SUB>-1; all-trans-Retinoic acid-d<SUB>3SUB>-1; ATRA-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
RAR/RXR
PPAR
Endogenous Metabolite
Autophagy
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Metabolic Disease
Cancer
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Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha [1] .
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- HY-G0016S1
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- HY-13593S1
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CB-1348-d<SUB>8SUB>-1; WR-139013-d<SUB>8SUB>-1
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Isotope-Labeled Compounds
DNA Alkylator/Crosslinker
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Cancer
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Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
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- HY-10162S3
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AZD2281-d<SUB>4SUB>-1; KU0059436-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
PARP
Autophagy
Mitophagy
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Cancer
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Olaparib-d4-1 (AZD2281-d4-1) is the deuterium labeled Olaparib (HY-10162). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator [1] .
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- HY-50898S3
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GW572016-d<SUB>4SUB>-1; GW2016-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
EGFR
Autophagy
Ferroptosis
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Cancer
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Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
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- HY-70057S1
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FCE 26743-d<SUB>4SUB>-1; EMD 1195686-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
Monoamine Oxidase
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Neurological Disease
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Safinamide-d4-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].
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- HY-B0400S7
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Sorbitol-d<SUB>1SUB>-2; D-Glucitol-d<SUB>1SUB>-2
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Endogenous Metabolite
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Others
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D-Sorbitol-d-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-B0400S8
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Sorbitol-d<SUB>2SUB>-1; D-Glucitol-d<SUB>2SUB>-1
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Endogenous Metabolite
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Others
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D-Sorbitol-d2-1 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-100442S1
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ABR-215757-d<SUB>5SUB>-1; ABR 25757-d<SUB>5SUB>-1
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SARS-CoV
Isotope-Labeled Compounds
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Metabolic Disease
Inflammation/Immunology
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Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice [1] .
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- HY-B0801S4
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MDL-16455-d<SUB>3SUB>-1; Terfenadine carboxylate-d<SUB>3SUB>-1
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Histamine Receptor
Isotope-Labeled Compounds
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Inflammation/Immunology
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Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research [1] .
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- HY-13966S
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2-DG-d<SUB>1SUB>; 2-Deoxy-D-arabino-hexose-d<SUB>1SUB>; D-Arabino-2-deoxyhexose-d<SUB>1SUB>
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Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
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Cancer
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2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].
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- HY-10585S4
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VPA-d<SUB>4SUB>-1; 2-Propylpentanoic Acid-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
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Cancer
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Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-108506S2
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BIA 2-005-d<SUB>4SUB>-1; GP 47779-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
Sodium Channel
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Neurological Disease
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Licarbazepine-d4-1 is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779) is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects[1].
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- HY-A0095S1
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BIMT-17-d<SUB>4SUB>-1; BIMT-17BS-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
5-HT Receptor
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Neurological Disease
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Flibanserin-d4-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].
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- HY-15592S2
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GSK-1265744-d<SUB>3SUB>-1; S/GSK1265744-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
HIV Integrase
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Infection
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Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research [1]
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- HY-B1659S3
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- HY-B1716S1
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L-5-HTP-d<SUB>3SUB>-1; Oxitriptan-d<SUB>3SUB>-1
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Endogenous Metabolite
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Metabolic Disease
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L-5-Hydroxytryptophan-d3-1 is the deuterium labeled L-5-Hydroxytryptophan[1]. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[2]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[3][4][5][6].
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- HY-13331S2
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Cortexolone 17 alpha-propionate-d<SUB>5SUB>-1; Cortexolone 17α-propionate-d<SUB>5SUB>-1; CB-03-01-d<SUB>5SUB>-1
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Isotope-Labeled Compounds
Androgen Receptor
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Endocrinology
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Clascoterone-d5-1 (Cortexolone 17 alpha-propionate-d5-1) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist [1].
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- HY-B0158S4
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- HY-B0389S18
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Glucose-13C<SUB>3SUB>-1; D-(+)-Glucose-13C<SUB>3SUB>-1; Dextrose-13C<SUB>3SUB>-1
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S25
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Glucose-13C,d<SUB>1SUB>; D-(+)-Glucose-13C,d<SUB>1SUB>; Dextrose-13C,d<SUB>1SUB>
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Endogenous Metabolite
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Metabolic Disease
Cancer
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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- HY-B0892S4
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- HY-W032013S
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Octanol-d<SUB>17SUB>
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Calcium Channel
Endogenous Metabolite
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Metabolic Disease
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1-Octanol-d17 is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].
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- HY-W032013S1
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Octanol-d<SUB>2SUB>
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Calcium Channel
Endogenous Metabolite
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Metabolic Disease
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1-Octanol-d2 is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].
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- HY-W087024S
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- HY-Y0308S
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Exsiccated sodium phosphate-d<SUB>1SUB>
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Isotope-Labeled Compounds
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Others
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Phosphate dibasic-d2 (sodium) is the deuterium labeled Sodium phosphate dibasic[1].
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- HY-W032013S3
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Octanol-d<SUB>5SUB>
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Calcium Channel
Endogenous Metabolite
Isotope-Labeled Compounds
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Others
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1-Octanol-d5 is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations [1] .
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- HY-B0492S
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- HY-141636S
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1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d<SUB>9SUB>-1; PAPC-d<SUB>9SUB>-1; PC(16:0/20:4)-d<SUB>9SUB>-1
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Isotope-Labeled Compounds
Endogenous Metabolite
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Cardiovascular Disease
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1-PalMitoyl-2-arachidoyllecithin-d9-1 (1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d9-1) is deuterium labeled 1-PalMitoyl-2-arachidoyllecithin. 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells [1].
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- HY-90006S
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5-FU-d<SUB>1SUB>
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Nucleoside Antimetabolite/Analog
HIV
Apoptosis
Endogenous Metabolite
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Cancer
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5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].
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- HY-135810S1
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Desethylhydroxychloroquine-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
Influenza Virus
Parasite
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Infection
Inflammation/Immunology
|
|
Cletoquine-d4-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
|
-
- HY-B0412S4
-
-
- HY-B0111S1
-
-
- HY-N0131S1
-
-
- HY-N0210S5
-
-
- HY-152070S1
-
-
- HY-122426S1
-
-
- HY-W004263S
-
-
- HY-W004292S1
-
|
Undecyl alcohol-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Undecanol-d4 is the deuterium labeled 1-Undecanol[1]. 1-Undecanol produced from 2-tridecanol by the organism[2].
|
-
- HY-W004293S
-
-
- HY-Y1004S3
-
-
- HY-Y1004S4
-
-
- HY-124891S
-
|
N-Phenylpyrrole-d<SUB>9SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Phenylpyrrole-d9 (N-Phenylpyrrole-d9) is the deuterium labeled 1-Phenylpyrrole (HY-124891). 1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents [1].
|
-
- HY-66008S1
-
|
N-Acetyl-5-aminosalicylic acid-d<SUB>3SUB>-1; N-Acetyl-ASA-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
|
Others
|
|
N-Acetyl mesalazine-d3-1 is deuterium labeled 5-acetamido-2-hydroxybenzoic acid.
|
-
- HY-B0158S3
-
-
- HY-A0042S2
-
|
CGP 33101-15N,d<SUB>2SUB>-1; E 2080-15N,d<SUB>2SUB>-1; RUF 331-15N,d<SUB>2SUB>-1
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Rufinamide- 15N,d2-1 (CGP 33101- 15N,d2-1; E 2080- 15N,d2-1; RUF 331- 15N,d2-1) is 15N- and deuterium-labeled Rufinamide (HY-A0042) [1].
|
-
- HY-18341S4
-
|
Levothyroxine-13C<SUB>6SUB>-1; T4-13C<SUB>6SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Thyroid Hormone Receptor
|
Endocrinology
|
|
L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) [1] .
|
-
- HY-B0122SS1
-
-
- HY-B0113S1
-
|
H 16868-d<SUB>3SUB>-1
|
Proton Pump
Autophagy
Bacterial
Phospholipase
|
Infection
Metabolic Disease
Cancer
|
|
Omeprazole-d3-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
|
-
- HY-B0451AS3
-
-
- HY-113139S
-
-
- HY-17430S1
-
-
- HY-B0114S1
-
|
GP 47680-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Sodium Channel
Apoptosis
|
Neurological Disease
Cancer
|
|
Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
|
-
- HY-B0196S1
-
-
- HY-B0561S2
-
-
- HY-B0901S1
-
-
- HY-17376S1
-
|
SCH 58235-d<SUB>4SUB>-1
|
Keap1-Nrf2
Autophagy
|
Cardiovascular Disease
Cancer
|
|
Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
|
-
- HY-145119AS
-
|
VV116; GS-621763-d<SUB>1SUB> hydrobromide
|
SARS-CoV
RSV
Influenza Virus
|
Infection
|
|
Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 [1] .
|
-
- HY-12987S2
-
-
- HY-14956S1
-
|
TG-873870-d<SUB>3SUB>-1
|
Bacterial
|
Inflammation/Immunology
|
|
Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].
|
-
- HY-15780S1
-
|
OPC-34712-d<SUB>8SUB>-1
|
Isotope-Labeled Compounds
Dopamine Receptor
Adrenergic Receptor
5-HT Receptor
|
Neurological Disease
|
|
Brexpiprazole-d8-1 (OPC-34712-d8-1) is the deuterium labeled Brexpiprazole (HY-15780) [1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM) .
|
-
- HY-15917S1
-
|
DTTl-d<SUB>10SUB>-1
|
Isotope-Labeled Compounds
Disulfidptosis
|
Cancer
|
|
DL-dithiothreitol-d10-1 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond [1] .
|
-
- HY-B0197S
-
|
GR-85548A-d<SUB>3SUB>-1
|
5-HT Receptor
|
Neurological Disease
|
|
Naratriptan-d3 is the deuterium labeled Naratriptan[1]. Naratriptan is a selective 5-HT1 receptor subtype agonist[2].
|
-
- HY-N1380S4
-
|
2-Methoxyphenol-d<SUB>4SUB>-1
|
COX
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Guaiacol-d4-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].
|
-
- HY-W014286S
-
-
- HY-W014559S3
-
-
- HY-W016577S3
-
-
- HY-W032015S3
-
-
- HY-W099504S1
-
-
- HY-W099521S
-
-
- HY-W101642S
-
-
- HY-145119S
-
|
VV116 free base; GS-621763-d<SUB>1SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119) [1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .
|
-
- HY-153939S
-
|
RG7388-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
|
Cancer
|
|
Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia [1] .
|
-
- HY-113136S
-
|
N1-Methylguanosine-d<SUB>3SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
1-Methylguanosine-d3 is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker.
|
-
- HY-13678S1
-
|
SM 7338-d<SUB>6SUB>-1
|
Bacterial
Antibiotic
|
Infection
|
|
Meropenem-d6-1 (SM 7338-d6-1) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) [1].
|
-
- HY-19822S1
-
|
RAD1901-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Cancer
|
|
Elacestrant-d4-1 is the deuterium labeled Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively [1] .
|
-
- HY-10846S1
-
|
OPC-67683-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
|
Cancer
|
|
Delamanid-d4-1 is deuterated labeled Delamanid.Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids [1].
|
-
- HY-W032013S2
-
-
- HY-Y1004S6
-
-
- HY-17386S2
-
-
- HY-14281S2
-
-
- HY-122272S2
-
-
- HY-B0258S1
-
-
- HY-B0740S3
-
|
MK130-d<SUB>3SUB>-1 hydrochloride
|
Isotope-Labeled Compounds
5-HT Receptor
Parasite
|
Infection
Neurological Disease
|
|
Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases [1]
|
-
- HY-W012477S
-
|
Photoinitiator-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Hydroxycyclohexyl phenyl ketone-d5 (Photoinitiator-184-d5) is the deuterium labeled 1-Hydroxycyclohexyl phenyl ketone (HY-W012477) [1].
|
-
- HY-10284S3
-
-
- HY-76025S
-
|
p-Dibromobenzene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans[1].
|
-
- HY-13956A
-
|
(R)-U 72107-d<SUB>1SUB>
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
(R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities.
|
-
- HY-W654010
-
|
SM-13496-d<SUB>8SUB>-1 hydrochloride
|
Isotope-Labeled Compounds
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM [1].
|
-
- HY-B1565S
-
-
- HY-Y1139S
-
|
Heptanedioic acid-d<SUB>4SUB>; 1,5-Pentanedicarboxylic acid-d<SUB>4SUB>; 1,7-Heptanedioic acid-d<SUB>4SUB>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Pimelic acid-d4 is the deuterium labeled Pimelic acid[1]. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
|
-
- HY-Y0921S1
-
|
1,2-(RS)-Propanediol-d<SUB>2SUB>; 1,2-Propylene glycol-d<SUB>2SUB>; Propylene glycol-d<SUB>2SUB>
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Neurological Disease
|
|
(±)-1,2-Propanediol-d2 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
|
-
- HY-Y0921S
-
|
1,2-(RS)-Propanediol-d<SUB>8SUB>; 1,2-Propylene glycol-d<SUB>8SUB>; Propylene glycol-d<SUB>8SUB>
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Neurological Disease
|
|
(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
|
-
- HY-Y0921S2
-
|
1,2-(RS)-Propanediol-d<SUB>6SUB>; 1,2-Propylene glycol-d<SUB>6SUB>; Propylene glycol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
|
(±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
|
-
- HY-B0228S
-
|
Adenine riboside-d<SUB>1SUB>; D-Adenosine-d
|
Nucleoside Antimetabolite/Analog
Autophagy
Apoptosis
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].
|
-
- HY-109506S3
-
|
129Y83-d<SUB>9SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
DPPC-d9-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].
|
-
- HY-N1429S2
-
|
12-Deoxycholyltaurine-d<SUB>4SUB>-1 sodium
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
|
-
- HY-N7092S18
-
-
- HY-N0210S7
-
-
- HY-N0210S8
-
-
- HY-N0210S11
-
-
- HY-W004051S
-
-
- HY-W012856S
-
-
- HY-W015849S
-
-
- HY-W016931S
-
-
- HY-W017554S
-
-
- HY-W130478S
-
-
- HY-W142175S
-
|
1-Phenyl-1-butyne-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Butynylbenzene-d5 is the deuterium labeled 1-Butynylbenzene[1]. 1-Butynylbenzene-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-66011AS3
-
|
BAY 12-8039-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Moxifloxacin-d3-1 hydrochloride (BAY 12-8039-d3-1) is a deuterium labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [1] .
|
-
- HY-W865379
-
-
- HY-13631ES2
-
-
- HY-N0384S4
-
|
Vanilacetic acid-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency [1].
|
-
- HY-34487S3
-
|
Resorcinol dimethyl ether-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3-Dimethoxybenzene-d3 (Resorcinol dimethyl ether-d3) is the deuterium labeled 1,3-Dimethoxybenzene (HY-34487). 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds [1].
|
-
- HY-Y0678S
-
|
Trimethyl phloroglucinol-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
1,3,5-Trimethoxybenzene-d3 (Trimethyl phloroglucinol-d3) is the deuterium labeled 1,3,5-Trimethoxybenzene (HY-Y0678). 1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor [1].
|
-
- HY-41676S
-
|
1-Chloro-4-benzonitrile-d<SUB>4SUB>; 1-Chloro-4-cyanobenzene-d<SUB>4SUB>; 1-Cyano-4-chlorobenzene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
4-Chlorobenzonitrile-d4 is the deuterium labeled 4-Chlorobenzonitrile[1].
|
-
- HY-114041S1
-
|
RvE1-d<SUB>4SUB>-1
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].
|
-
- HY-W052227S
-
-
- HY-107343S1
-
|
Ethyl docosahexaenoate-d<SUB>5SUB>-1
|
Isotope-Labeled Compounds
|
Others
|
|
Docosahexaenoic acid ethyl ester-d5-1 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2][3].
|
-
- HY-W094751S
-
-
- HY-15025S2
-
|
UK-92480-d<SUB>3SUB>N<SUB>-1
|
Phosphodiesterase (PDE)
|
Cancer
|
|
Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
|
-
- HY-W342440S
-
-
- HY-W016152S
-
|
m-Methoxyphenyl bromide-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-3-methoxybenzene-d3 is the deuterium labeled 1-Bromo-3-methoxybenzene. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified [1].
|
-
- HY-Y1805S
-
|
Tetralin solvent-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4-Tetrahydronaphthalene-d4 (Tetralin solvent-d4) is the deuterium labeled 1,2,3,4-Tetrahydronaphthalene (HY-Y1805) [1].
|
-
- HY-W012934S
-
|
N-Ethyl-pyrrolidone-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Ethylpyrrolidin-2-one-d5 (N-Ethyl-pyrrolidone-d5) is deuterium labeled 1-Ethylpyrrolidin-2-one [1].
|
-
- HY-N0215S13
-
|
(S)-2-Amino-3-phenylpropionic acid-d<SUB>1SUB>
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-109541S
-
|
DMPC-d<SUB>58SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d58 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S1
-
|
DMPC-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d4 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S2
-
|
DMPC-d<SUB>9SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d9 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S3
-
|
DMPC-d<SUB>13SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d13 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S4
-
|
DMPC-d<SUB>63SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d63 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S5
-
|
DMPC-d<SUB>67SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-112530S
-
|
DSPE-d<SUB>70SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis
|
-
- HY-113424AS
-
|
DOPC-d<SUB>9SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
1,2-Dioleoyl-sn-glycero-3-phosphocholine-d9 is deuterium labeled 1,2-Dioleoyl-sn-glycero-3-phosphocholine. 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelle
|
-
- HY-113482S
-
-
- HY-W009719S
-
|
2,3-DICHLOROBROMOBENZENE-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,3-dichlorobenzene-d3 is the deuterium labeled 1-Bromo-2,3-dichlorobenzene[1].
|
-
- HY-W009981S
-
|
2,4-Difluorobromobenzene-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,4-difluorobenzene-d3 is the deuterium labeled 1-Bromo-2,4-difluorobenzene[1].
|
-
- HY-W011883S
-
|
3,5-DIBROMOFLUOROBENZENE-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3-Dibromo-5-fluorobenzene-d3 is the deuterium labeled 1,3-Dibromo-5-fluorobenzene[1].
|
-
- HY-W131797
-
-
- HY-Y0566S
-
|
Triethylenediamine-d<SUB>12SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,4-Diazabicyclo[2.2.2]octane-d12 is the deuterium labeled 1,4-Diazabicyclo[2.2.2]octane[1].
|
-
![1,4-Diazabicyclo[2.2.2]octane-d12](//file.medchemexpress.eu/product_pic/hy-y0566s.gif)
- HY-N9933S
-
-
- HY-W011885S
-
|
N-Lauryl-2-pyrrolidone-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Dodecylpyrrolidin-2-one-d6 (N-Lauryl-2-pyrrolidone-d6) is deuterium-labeled 1-Dodecylpyrrolidin-2-one (HY-W011885) [1].
|
-
- HY-11018S1
-
-
- HY-W654320
-
-
- HY-B0402S
-
|
1-Adamantanamine-d<SUB>15SUB>; 1-Aminoadamantane-d<SUB>15SUB>
|
Influenza Virus
Orthopoxvirus
SARS-CoV
Apoptosis
|
Infection
Neurological Disease
Cancer
|
|
Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].
|
-
- HY-130462S
-
|
POPC-d<SUB>31SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
|
-
- HY-130462S1
-
|
POPC-d<SUB>82SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d82 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
|
-
- HY-B0228S8
-
-
- HY-79779S
-
|
α,4-Dibromotoluene-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-4-(bromomethyl)benzene-d6 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene[1].
|
-
- HY-79779S1
-
|
α,4-Dibromotoluene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-4-(bromomethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene[1].
|
-
- HY-B0402S1
-
|
1-Adamantanamine-d<SUB>6SUB>; 1-Aminoadamantane-d<SUB>6SUB>
|
Apoptosis
CDK
SARS-CoV
Bcl-2 Family
Influenza Virus
Orthopoxvirus
|
Cancer
|
|
Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7].
|
-
- HY-W015784S
-
-
- HY-W097453S2
-
-
- HY-W768340
-
|
D-(+)-Saccharose-13C<SUB>6SUB>-1
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al [1].
|
-
- HY-W654353
-
|
T-α-MCA-d<SUB>4SUB>-1 sodium
|
Isotope-Labeled Compounds
FXR
Endogenous Metabolite
|
Others
|
|
Tauro-α-muricholic acid-d4-1 (sodium) is deuterium labeled Tauro-α-muricholic acid (sodium). Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal [1] .
|
-
- HY-W015824S3
-
-
- HY-W013376S
-
|
1-(Diphenylmethyl)piperazine-d<SUB>8SUB>; 1-Benzhydrylpiperazine-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Norcyclizine-d8 is the deuterium labeled Norcyclizine [1].
|
-
- HY-B0762S1
-
|
O-Acetyl-L-carnitine-d<SUB>3SUB>-1 (hydrochloride)
|
Endogenous Metabolite
|
Neurological Disease
|
|
Acetyl-L-carnitine-d3-1 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].
|
-
- HY-B0151S2
-
|
3β-Hydroxy-5-pregnen-20-one-d<SUB>4SUB>-1
|
Cannabinoid Receptor
TRP Channel
Endogenous Metabolite
Autophagy
|
Neurological Disease
|
|
Pregnenolone-d4-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
|
-
- HY-N0210S12
-
-
- HY-W014431S
-
|
3-Fluoro-5-bromochlorobenzene-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-3-chloro-5-fluorobenzene-d3 is the deuterium labeled 1-Bromo-3-chloro-5-fluorobenzene[1].
|
-
- HY-W105111S
-
|
2,3,5-Trichlorobromobenzene-d<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,3,5-trichlorobenzene-d2 is the deuterium labeled 1-Bromo-2,3,5-trichlorobenzene[1].
|
-
- HY-N7092S23
-
|
D(-)-Fructose-13C<SUB>3SUB>-1
|
Isotope-Labeled Compounds
|
Others
|
|
D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-W110726S
-
-
- HY-W110726S1
-
|
Pentyl Vinyl Ketone (stabilized with BHT)-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Octen-3-one-d3 is deuterated labeled 3-Ethyl-2,5-dimethylpyrazine.
|
-
- HY-Y0921S3
-
|
1,2-(RS)-Propanediol-13C<SUB>3SUB>; 1,2-Propylene glycol-13C<SUB>3SUB>; Propylene glycol-13C<SUB>3SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
|
(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish [1] .
|
-
- HY-115702S
-
|
PAF C-16-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine-d4 is the deuterium labeled 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine[1].
|
-
- HY-B0896S1
-
|
Glyceryl triacetate-d<SUB>5SUB>; 1,2,3-Triacetoxypropane-d<SUB>5SUB>
|
Isotope-Labeled Compounds
Fungal
Endogenous Metabolite
|
Others
|
|
Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
|
-
- HY-122426S2
-
|
Undecyl bromide-d<SUB>4SUB>; undecane, 1-bromo-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromoundecane-d4 is the deuterium labeled 1-Bromoundecane[1].
|
-
- HY-B0896S2
-
|
Glyceryl triacetate-d<SUB>9SUB>; 1,2,3-Triacetoxypropane-d<SUB>9SUB>
|
Fungal
Endogenous Metabolite
|
Others
|
|
Glyceryl Triacetate-d9 is the deuterium labeled Triacetin[1]. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
|
-
- HY-W013504S
-
|
4-Bromo-α,α,α-trifluorotoluene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-4-(trifluoromethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(trifluoromethyl)benzene[1].
|
-
- HY-W013948S
-
|
Propanal, (2,4-dinitrophenyl)hydrazone-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(2,4-Dinitrophenyl)-2-propylidenehydrazine-d3 is the deuterium labeled 1-(2,4-Dinitrophenyl)-2-propylidenehydrazine[1].
|
-
- HY-Y0219S1
-
-
- HY-W192474S
-
-
- HY-Y0743S
-
-
- HY-W756596
-
|
3-Chloropropane-1,2-diyl dioctanoate-d<SUB>5SUB>
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
1,2-Dioctanoyl-3-chloropropanediol-d5 is deuterium labeled 1,2-Dioctanoyl-3-chloropropanediol. 1,2-Dioctanoyl-3-chloropropanediol (3-Chloropropane-1,2-diyl dioctanoate) is an ester product [1].
|
-
- HY-W654409
-
|
Hexafluoroisopropyl alcohol-d<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,1,1,3,3,3-Hexafluoropropan-2-ol-d2 (Hexafluoroisopropyl alcohol-d2) is deuterium labeled 1,1,1,3,3,3-Hexafluoropropan-2-ol [1].
|
-
- HY-W777599
-
|
(Rac)-Naproxen-13C,d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
|
Others
|
|
(±)-Naproxen- 13C,d3-1 ((Rac)-Naproxen- 13C,d3-1) is 13C and deuterium labeled (±)-Naproxen [1].
|
-
- HY-145473S
-
|
15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE-d<SUB>11SUB>; 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d<SUB>11SUB>
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 (15(S)-HETE-SAPE-d11) is deuterium labeled 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes [1].
|
-
- HY-15029S1
-
-
- HY-10003S
-
|
1-hydroxycholecalciferol-d<SUB>7SUB>; 1.alpha.-Hydroxyvitamin D3-d<SUB>7SUB>
|
VD/VDR
|
Metabolic Disease
|
|
Alfacalcidol-d7 is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis[1][2][3][4].
|
-
- HY-N0229S4
-
|
L-2-Aminopropionic acid-13C,d<SUB>1SUB>
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-Alanine- 13C,d is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0537S12
-
-
- HY-N0537S13
-
-
- HY-D0837S
-
|
Glyoxaline-d<SUB>4SUB>; 1,3-Diaza-2,4-cyclopentadiene-d<SUB>4SUB>
|
Endogenous Metabolite
|
Others
|
|
Imidazole-d4 is the deuterium labeled Imidazole[1].
|
-
- HY-Y0531S
-
-
- HY-100441S1
-
-
- HY-W010265S
-
|
1-Phenylbutan-1-one-d<SUB>5SUB>; 1-Phenyl-1-butanone-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Butyrophenone-d5 is the deuterium labeled Butyrophenone[1].
|
-
- HY-Y1039S
-
|
1-Monostearin-d<SUB>40SUB>; 2,3-dihydroxypropyl stearate-d<SUB>40SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Stearoyl-rac-glycerol-d40 is the deuterium labeled 1-Stearoyl-rac-glycerol[1].
|
-
- HY-Y1039S1
-
|
1-Monostearin-d<SUB>35SUB>; 2,3-dihydroxypropyl stearate-d<SUB>35SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Stearoyl-rac-glycerol-d35 is the deuterium labeled 1-Stearoyl-rac-glycerol.
|
-
- HY-Y1217S
-
|
Hydroxycyclohexane-d<SUB>12SUB>; NSC 54711-d<SUB>12SUB>; Naxol-d<SUB>12SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Cyclohexanol-d12 is the deuterium labeled 1-Cyclohexanol[1].
|
-
- HY-Y1217S1
-
|
Hydroxycyclohexane-d<SUB>11SUB>; NSC 54711-d<SUB>11SUB>; Naxol-d<SUB>11SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Cyclohexanol-d11 is the deuterium labeled 1-Cyclohexanol[1].
|
-
- HY-B0166S8
-
|
L-Ascorbate-1; Vitamin C-13C<SUB>6SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Reactive Oxygen Species
Calcium Channel
Apoptosis
|
Cancer
|
|
L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) [1]. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
|
-
- HY-W777649
-
-
- HY-114553S
-
|
5F-PB-223-Carboxyindolemetabolite-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d5 (5F-PB-223-Carboxyindolemetabolite-d5) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid [1].
|
-
- HY-B0456S1
-
|
Vitamin B2-13C<SUB>4SUB>,15N<SUB>2SUB>-1; E101-13C<SUB>4SUB>,15N<SUB>2SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-Y1641S
-
|
Ethylene dithioglycol-d<SUB>4SUB>; Ethylene glycol-d4, dithio-; Ethylenedithiol-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Ethanedithiol-d4 is the deuterium labeled 1,2-Ethanedithiol[1].
|
-
- HY-78004S1
-
|
Dibenzil-d<SUB>4SUB>; s-Diphenylethane-d<SUB>4SUB>; Bibenzyl-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) [1].
|
-
- HY-131325S
-
|
N2,N4-Diethyl-6-(methoxy-d<SUB>3SUB>)-1,3,5-triazine-2,4-diamine
|
Isotope-Labeled Compounds
|
Others
|
|
Simeton-d3 (N2,N4-Diethyl-6-(methoxy-d3)-1,3,5-triazine-2,4-diamine) is deuterium labeled Simeton [1].
|
-
- HY-Y1309S
-
|
Furro ER-d<SUB>8SUB>; NSC 9586-d<SUB>8SUB>; Nako TRB-d<SUB>8SUB>
|
Endogenous Metabolite
|
Others
|
|
1-Naphthol-d8 is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].
|
-
- HY-W392083S
-
-
- HY-W392083S1
-
|
(1,3E,5Z)-UNDECATRIENE-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
(1,3E,5Z)-Undeca-1,3,5-triene-d5 is deuterated labeled 2-Methyl-3-(methyldisulfanyl)furan.
|
-
- HY-Y1309S1
-
-
- HY-W050145S
-
|
1,6-Anhydro-β-D-glucopyranose-d<SUB>7SUB>; 1,6-Anhydro-β-D-glucose-d<SUB>7SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Levoglucosan-d7 is the deuterium labeled Levoglucosan. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature[1][2].
|
-
- HY-34444S
-
|
Bondelane A-d<SUB>8SUB>; Cyclic tetramethylene sulfone-d<SUB>8SUB>; Cyclotetramethylene sulfone-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan[1].
|
-
- HY-Y0727S
-
|
1,5-Pentanedibromide-d<SUB>4SUB>; Pentamethylene bromide-d<SUB>4SUB>; Pentamethylene dibromide-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,5-Dibromopentane-d4 is the deuterium labeled 1,5-Dibromopentane[1].
|
-
- HY-Y0727S1
-
|
1,5-Pentanedibromide-d<SUB>10SUB>; Pentamethylene bromide-d<SUB>10SUB>; Pentamethylene dibromide-d<SUB>10SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,5-Dibromopentane-d10 is the deuterium labeled 1,5-Dibromopentane[1].
|
-
- HY-W048482S
-
|
DMT-2'O-TBDMS-rU phosphoramidite-13C<SUB>2SUB>,d<SUB>1SUB>
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W040193S
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>70SUB>; DSPC-d<SUB>70SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70 is the deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].
|
-
- HY-W040193S1
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>74SUB>; DSPC-d<SUB>74SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-W040193S2
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>79SUB>; DSPC-d<SUB>79SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-W040193S3
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>83SUB>; DSPC-d<SUB>83SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].
|
-
- HY-W040193S4
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>4SUB>; DSPC-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
|
-
- HY-W040193S5
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>9SUB>; DSPC-d<SUB>9SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
|
-
- HY-W040193S6
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>13SUB>; DSPC-d<SUB>13SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d13 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-Y0093S
-
|
α,ω-Nonanediol-d<SUB>14SUB>; 1,9-Dihydroxynonane-d<SUB>14SUB>; Nonamethylene Glycol-d<SUB>14SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
NSC 5416-d14 is the deuterium labeled NSC 5416[1].
|
-
- HY-Y1044S
-
|
1,5-Pentamethylene glycol-d<SUB>10SUB>; Pentamethylene glycol-d<SUB>10SUB>; Pentylene glycol-d<SUB>10SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,5-Dihydroxypentane-d10 is the deuterium labeled 1,5-Dihydroxypentane[1].
|
-
- HY-Y1772S
-
|
p-Iodotoluene-d<SUB>7SUB>; p-Methyliodobenzene-d<SUB>7SUB>; p-Tolyl iodide-d<SUB>7SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Iodo-4-methylbenzene-d7 is the deuterium labeled 1-Iodo-4-methylbenzene[1].
|
-
- HY-12650S
-
|
DS5565-13C<SUB>2SUB>,d<SUB>1SUB> (Mixture of Diastereomers)
|
Isotope-Labeled Compounds
|
Others
|
|
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS [1].
|
-
- HY-W285163S
-
|
Formyl Ciprofloxacin-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
|
-
- HY-113123S1
-
|
14:0 Lyso PC-d<SUB>7SUB>; 1-myristoyl-sn-glycero-3-phosphatidylcholine-d<SUB>7SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
LysoPC(14:0/0:0)-d7 (14:0 Lyso PC-d7) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect [1] .
|
-
- HY-W699983
-
|
Glyoxaline-15N<SUB>2SUB>; 1,3-Diaza-2,4-cyclopentadiene-15N<SUB>2SUB>
|
Isotope-Labeled Compounds
Thrombopoietin Receptor
Ser/Thr Protease
|
Neurological Disease
Inflammation/Immunology
|
|
Imidazole- 15N2 (Glyoxaline- 15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease [1] .
|
-
- HY-Y0860S
-
|
1,6-Dibromohexane-d<SUB>12SUB>; Hexamethylene dibromide-d<SUB>12SUB>; NSC 7306-d<SUB>12SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,6-Dibromo-n-hexane-d12 is the deuterium labeled 1,6-Dibromo-n-hexane[1].
|
-
- HY-W013053S
-
|
DBA-d<SUB>14SUB>; 1,2,5,6-Dibenzanthracene-d<SUB>14SUB>; Benzo[k]tetraphene-d<SUB>14SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Dibenz[a,h]anthracene-d14 is the deuterium Dibenz[a,h]anthracene.
|
-
![Dibenz[a,h]anthracene-d14](//file.medchemexpress.eu/product_pic/hy-w013053s.gif)
- HY-W242724
-
|
1,4-Dibromobutane-d<SUB>8SUB>; Tetramethylene Bromide-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d8 is the deuterium labeled 1,4-Dibromo-butane[1].
|
-
- HY-W762019S
-
|
1,2,3,4,7,8-HxCDD-13C<SUB>12SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,7,8-Hexachloro dibenzo-p-dioxin- 13C12 (1,2,3,4,7,8-HxCDD- 13C12) is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin [1].
|
-
- HY-41681S
-
|
1-Chloro-6-hexanol-d<SUB>6SUB>; 1-Chloro-6-hydroxyhexane-d<SUB>6SUB>; 6-Chlorohexanol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
6-Chloro-1-hexanol-d6 is the deuterium labeled 6-Chloro-1-hexanol[1].
|
-
- HY-W662572S
-
|
N-(5,7-Dimethoxy-d<SUB>6SUB>[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide
|
Isotope-Labeled Compounds
|
Others
|
|
Pyroxsulam-d6 (N-(5,7-Dimethoxy-d6[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide [1].
|
-
- HY-W050145S2
-
|
1,6-Anhydro-β-D-glucopyranose-13C<SUB>6SUB>; 1,6-Anhydro-β-D-glucose-13C<SUB>6SUB>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Levoglucosan- 13C6 is the 13C labeled Levoglucosan[1]. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature[2].
|
-
- HY-151997S
-
|
1,2-Olein-3-laurin-13C3; TG(18:1/18:1/12:0)-13C<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dioleoyl-3-lauroyl-rac-glycerol- 13C3 is the 13C-labeled 1,2-Dioleoyl-3-lauroyl-rac-glycerol (HY-165089), 1,2-Dioleoyl-3-lauroyl-rac-glycerol (1,2-Olein-3-laurin) is a triglyceride identified by specific analytical methods in human milk, infant formula, other mammalian milk, and vegetable oils, with specific structural and distribution characteristics.
|
-
- HY-Y0219S
-
|
s-Triazole13C<SUB>2SUB>,15N<SUB>3SUB>; Pyrrodiazole13C<SUB>2SUB>,15N<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128[1].
|
-
- HY-A0052S
-
|
Telaprevir, (R)-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4 is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.
|
-
![(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4](//file.medchemexpress.eu/product_pic/hy-a0052s.gif)
- HY-Y0045S
-
|
1-(1,3-Thiazol-2-yl)ethanone-13C<SUB>2SUB>; 1-(Thiazol-2-yl)ethanone-13C<SUB>2SUB>; Methyl 2-thiazolyl ketone-13C<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Acetylthiazole- 13C2 is 13C labeled Fructose-phenylalanine.
|
-
- HY-33948S
-
|
1,1-Dimethylethanolamine-d<SUB>6SUB>; 2-Amino-α,α-dimethylethanol-d<SUB>6SUB>; 2-Hydroxy-2-methyl-1-propylamine-d<SUB>6SUB>; 2-Hydroxy-2-methylpropan-1-amine-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Amino-2-methylpropan-2-ol-d6 is the deuterium labeled 1-Amino-2-methylpropan-2-ol[1].
|
-
- HY-34123S
-
|
2-(2-Bromoethyl)-1H-isoindole-1,3(2H)-dione-d<SUB>4SUB>; 1-Bromo-2-phthalimidoethane-d<SUB>4SUB>; 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl bromide-d<SUB>4SUB>; 2-(2-Bromoethyl)-2,3-dihydro-1H-isoindole-1,3-dione
|
Isotope-Labeled Compounds
|
Others
|
|
N-(2-Bromoethyl)phthalimide-d4 is the deuterium labeled N-(2-Bromoethyl)phthalimide[1].
|
-
- HY-59354S1
-
|
1,2-Dihydro-3,6-pyridazine-13C<SUB>4SUB>-dione; 3,6-Dihydroxypyridazine-13C<SUB>4SUB>; 3,6-Pyridazine-13C<SUB>4SUB>-diol; Maleic hydrazide-13C<SUB>4SUB>
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Cancer
|
|
1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins [1] .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-109541S2
-
|
DMPC-d<SUB>9SUB>
|
Drug Delivery
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d9 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S
-
|
DMPC-d<SUB>58SUB>
|
Drug Delivery
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d58 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S1
-
|
DMPC-d<SUB>4SUB>
|
Drug Delivery
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d4 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S3
-
|
DMPC-d<SUB>13SUB>
|
Drug Delivery
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d13 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S4
-
|
DMPC-d<SUB>63SUB>
|
Drug Delivery
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d63 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S5
-
|
DMPC-d<SUB>67SUB>
|
Drug Delivery
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10215
-
|
|
Parasite
|
Infection
|
|
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively [1].
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| Cat. No. |
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* This product has been "discontinued".
Optimized version of product available:
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| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B0389S1
-
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|
|
D-Glucose-d is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
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-
-
- HY-B0389S8
-
|
|
|
D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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-
-
- HY-B0389S7
-
|
|
|
D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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-
-
- HY-B0389S3
-
|
|
|
D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
-
- HY-W016577S4
-
|
|
|
1-Bromoheptane-d1 is the deuterium labeled 1-Bromoheptane[1].
|
-
-
- HY-W099504S2
-
|
|
|
1-Heptanol-d1 is the deuterium labeled 1-Heptanol[1].
|
-
-
- HY-N0210S6
-
|
|
|
D-Galactose-d-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
|
-
-
- HY-N0378S5
-
|
|
|
D-Mannitol-d is the deuterium labeled D-Mannitol.
|
-
-
- HY-41700S2
-
|
|
|
D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1].
|
-
-
- HY-B0389S4
-
|
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D-Glucose-d1-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S2
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D-Glucose-d12-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-19696S2
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Tauroursodeoxycholate-d4-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
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- HY-B0389S23
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D-Glucose-d2-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol
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- HY-B0228S7
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Adenosine-d-1 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys
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- HY-109037S2
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Mavacamten-d1 (MYK461-d1; SAR439152-d1) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
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- HY-B0763S2
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Ibudilast-d7-1 is the deuterium labeled Ibudilast[1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[2].
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- HY-B0141S6
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Estradiol-d2-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].
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- HY-B0152S
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Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
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- HY-B1411S1
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i-Inositol-d is the deuterium labeled i-Inositol[1].
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- HY-B0479S1
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Thiamphenicol-d3-1 (Thiophenicol-d3-1; Dextrosulphenidol-d3-1) is the deuterium-labeled Thiamphenicol (HY-B0479) [1]. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria) .
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- HY-B0511S
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Biotin-d2-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.
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- HY-14648S1
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Dexamethasone-d5-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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- HY-B0234S4
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Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-14648S5
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Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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- HY-23188
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Loratadine-d5-1 is a deuterated labeled Loratadine-d5-1 [1].
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- HY-N2037AS1
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Higenamine-d4-1 (Norcoclaurine-d4-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases [1] .
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- HY-17043S2
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Loratadine-d4-1 (Loratidine-d4-1) is deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators [1].
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- HY-14649S6
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Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha [1] .
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- HY-G0016S1
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N-acetyl Dapsone-d4-1 is the deuterium labeled N-acetyl Dapsone, which is a metabolite of Dapsone.
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- HY-13593S1
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Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
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- HY-10162S3
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Olaparib-d4-1 (AZD2281-d4-1) is the deuterium labeled Olaparib (HY-10162). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator [1] .
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- HY-50898S3
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Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
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- HY-70057S1
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Safinamide-d4-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].
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- HY-B0400S7
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D-Sorbitol-d-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-B0400S8
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D-Sorbitol-d2-1 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-100442S1
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Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice [1] .
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- HY-B0801S4
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Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research [1] .
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- HY-13966S
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2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].
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- HY-10585S4
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Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-108506S2
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Licarbazepine-d4-1 is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779) is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects[1].
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- HY-A0095S1
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Flibanserin-d4-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].
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- HY-15592S2
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Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research [1]
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- HY-B1659S3
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Glycerol-d is the deuterium labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
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- HY-B1716S1
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L-5-Hydroxytryptophan-d3-1 is the deuterium labeled L-5-Hydroxytryptophan[1]. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[2]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[3][4][5][6].
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- HY-13331S2
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Clascoterone-d5-1 (Cortexolone 17 alpha-propionate-d5-1) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist [1].
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- HY-B0158S4
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Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol
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- HY-B0389S18
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D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S25
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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- HY-B0892S4
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Benzyl alcohol-d1 is the deuterium labeled Benzyl alcohol[1].
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- HY-W032013S
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1-Octanol-d17 is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].
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- HY-W032013S1
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1-Octanol-d2 is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].
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- HY-W087024S
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1-Phenylpentane-d5 is the deuterium labeled 1-Phenylpentane[1].
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- HY-Y0308S
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Phosphate dibasic-d2 (sodium) is the deuterium labeled Sodium phosphate dibasic[1].
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- HY-W032013S3
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1-Octanol-d5 is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations [1] .
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- HY-14444S
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Plinabulin-d1 is an active compound.
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- HY-B0492S
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(rac)-(trans)-Paroxetine-d4 (hydrochloride) is the deuterium labeled (rac)-(trans)-Paroxetine hydrochloride[1].
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- HY-141636S
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1-PalMitoyl-2-arachidoyllecithin-d9-1 (1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d9-1) is deuterium labeled 1-PalMitoyl-2-arachidoyllecithin. 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells [1].
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- HY-90006S
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5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].
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- HY-135810S1
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Cletoquine-d4-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
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- HY-B0412S4
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Estriol-d3-1 is the deuterium labeled Estriol.
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- HY-B0111S1
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Drospirenone-d4-1 is deuterium labeled Drospirenone.
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- HY-N0131S1
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Stigmasterol-d5-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases[1].
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- HY-N0210S5
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D-Galactose-d is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-152070S1
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Demethylmaprotiline-d2-1 is the deuterium labeled Demethylmaprotiline[1].
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- HY-122426S1
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1-Bromoundecane-d3 is the deuterium labeled 1-Bromoundecane[1].
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- HY-W004263S
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1-Eicosanol-d41 is the deuterium labeled 1-Eicosanol[1]. 1-Eicosanol is a natural compound with antioxidant activity isolated from Hypericum carinatum[2].
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- HY-W004292S1
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1-Undecanol-d4 is the deuterium labeled 1-Undecanol[1]. 1-Undecanol produced from 2-tridecanol by the organism[2].
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- HY-W004293S
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n-Tridecyl Alcohol-d27 is the deuterium labeled 1-Tridecanol[1].
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- HY-Y1004S3
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1-Decanol-d5 is the deuterium labeled 1-Decanol[1].
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- HY-Y1004S4
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1-Decanol-d4 is the deuterium labeled 1-Decanol[1].
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- HY-124891S
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1-Phenylpyrrole-d9 (N-Phenylpyrrole-d9) is the deuterium labeled 1-Phenylpyrrole (HY-124891). 1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents [1].
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- HY-66008S1
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N-Acetyl mesalazine-d3-1 is deuterium labeled 5-acetamido-2-hydroxybenzoic acid.
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- HY-B0158S3
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Cytidine-d2-1 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catech
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- HY-A0042S2
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Rufinamide- 15N,d2-1 (CGP 33101- 15N,d2-1; E 2080- 15N,d2-1; RUF 331- 15N,d2-1) is 15N- and deuterium-labeled Rufinamide (HY-A0042) [1].
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- HY-18341S4
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L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) [1] .
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- HY-B0122SS1
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Topiramate- 13C6-1 (McN 4853- 13C6-1; RWJ 17021- 13C6-1) is 13C-labeled Topiramate (HY-B0122) [1].
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- HY-B0113S1
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Omeprazole-d3-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
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- HY-B0451AS3
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Dopamine-d2-1 (hydrochloride) is the deuterium labeled Dopamine hydrochloride [1].
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- HY-113139S
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1-Methylinosine-d3 is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA[1].
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- HY-17430S1
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Amprenavir-d4-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.
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- HY-B0114S1
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Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
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- HY-B0196S1
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Venlafaxine-d6-1 is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].
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- HY-B0561S2
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Spironolactone-d3-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].
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- HY-B0901S1
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Bromperidol-d4-1 is deuterium labeled Bromperidol.
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- HY-17376S1
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Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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- HY-145119AS
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Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 [1] .
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- HY-12987S2
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Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3][4].
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- HY-14956S1
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Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].
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-
- HY-15780S1
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Brexpiprazole-d8-1 (OPC-34712-d8-1) is the deuterium labeled Brexpiprazole (HY-15780) [1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM) .
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-
- HY-15917S1
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DL-dithiothreitol-d10-1 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond [1] .
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- HY-B0197S
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Naratriptan-d3 is the deuterium labeled Naratriptan[1]. Naratriptan is a selective 5-HT1 receptor subtype agonist[2].
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-
- HY-N1380S4
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Guaiacol-d4-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].
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-
- HY-W014286S
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1,3-Diphenylurea-d10 is the deuterium labeled 1,3-Diphenylurea[1].
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-
- HY-W014559S3
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1-Bromononane-d4-1 is the deuterium labeled 1-Bromononane[1].
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-
- HY-W016577S3
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1-Bromoheptane-d7 is the deuterium labeled 1-Bromoheptane[1].
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-
- HY-W032015S3
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1-Bromooctane-d4 is the deuterium labeled 1-Bromooctane[1].
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-
- HY-W099504S1
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1-Heptanol-d7 is the deuterium labeled 1-Heptanol[1].
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-
- HY-W099521S
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1-Chlorooctane-d17 is the deuterium labeled 1-Chlorooctane[1].
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-
- HY-W101642S
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1,3-Diisopropylbenzene-d18 is the deuterium labeled 1,3-Diisopropylbenzene[1].
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-
- HY-145119S
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GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119) [1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .
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- HY-153939S
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Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia [1] .
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-
- HY-113136S
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1-Methylguanosine-d3 is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker.
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- HY-13678S1
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Meropenem-d6-1 (SM 7338-d6-1) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) [1].
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- HY-19822S1
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Elacestrant-d4-1 is the deuterium labeled Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively [1] .
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-
- HY-10846S1
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Delamanid-d4-1 is deuterated labeled Delamanid.Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids [1].
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- HY-W032013S2
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1-Octanol-d2-1 is deuterated labeled Cinnamyl acetate (HY-N7125). Cinnamyl acetate has a wide application in the flavor and fragrance industry [1]. Cinnamyl acetate is a new broad spectrum antibacterial agent .
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-
- HY-Y1004S6
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1-Decanol-d2-2 is deuterated labeled cis,cis-3,6-Nonadienal.
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-
- HY-17386S2
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Rosiglitazone-d4-1 (BRL 49653-d4-1) is deuterium-labeled Rosiglitazone (HY-17386) [1].
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-
- HY-14281S2
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Trilostane-d3-1 (Win 24540-d3-1) is deuterium-labeled Trilostane (HY-14281) [1].
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-
- HY-122272S2
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Paroxetine-d6-1 is a deuterated labeled Paroxetine [1]. Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .
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-
- HY-B0258S1
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Gemfibrozil-d6-1 (CI-719-d6-1) is the deuterium labeled Gemfibrozil (HY-B0258). Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively [1].
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-
- HY-B0740S3
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Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases [1]
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-
- HY-W012477S
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1-Hydroxycyclohexyl phenyl ketone-d5 (Photoinitiator-184-d5) is the deuterium labeled 1-Hydroxycyclohexyl phenyl ketone (HY-W012477) [1].
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-
- HY-10284S3
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Linagliptin-d3-1 (BI 1356-d3-1) is the deuterium labeled Linagliptin (HY-10284). Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM [1].
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-
- HY-76025S
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1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans[1].
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-
- HY-13956A
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(R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities.
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-
- HY-W654010
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Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM [1].
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-
- HY-B1565S
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UV Absorber 326-d3 (Bumetrizole-d3-1) is deuterium labeled UV Absorber 326 [1].
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-
- HY-Y1139S
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Pimelic acid-d4 is the deuterium labeled Pimelic acid[1]. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
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- HY-Y0921S1
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(±)-1,2-Propanediol-d2 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
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-
- HY-Y0921S
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(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
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-
- HY-Y0921S2
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(±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
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-
- HY-B0228S
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Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].
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-
- HY-109506S3
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DPPC-d9-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].
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- HY-N1429S2
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Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
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-
- HY-N7092S18
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D-Fructose-d2-1 is the deuterium labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
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- HY-N0210S7
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D-Galactose-d-2 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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-
- HY-N0210S8
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D-Galactose-d-3 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-N0210S11
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D-Galactose-d2-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-W004051S
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1-Bromo-2-chlorobenzene-d4 is the deuterium labeled 1-Bromo-2-chlorobenzene[1].
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-
- HY-W012856S
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1-Ethyl-3-methylbenzene-d5 is the deuterium labeled 1-Ethyl-3-methylbenzene[1].
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-
- HY-W015849S
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1-Fluoro-4-methoxybenzene-d4 is the deuterium labeled 1-Fluoro-4-methoxybenzene[1].
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-
- HY-W016931S
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1-Bromo-4-chlorobutane-d8 is the deuterium labeled 1-Bromo-4-chlorobutane[1].
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-
- HY-W017554S
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1-Chloro-2-methoxybenzene-d3 is the deuterium labeled 1-Chloro-2-methoxybenzene[1].
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-
- HY-W130478S
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1-Phenylhexane-d5 is the deuterium labeled 1-Phenylhexane[1].
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-
- HY-W142175S
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1-Butynylbenzene-d5 is the deuterium labeled 1-Butynylbenzene[1]. 1-Butynylbenzene-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-66011AS3
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Moxifloxacin-d3-1 hydrochloride (BAY 12-8039-d3-1) is a deuterium labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [1] .
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-
- HY-W865379
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(S)-Avadomide-d1 (SP-3164; CC 122-d1) is deuterated labeled (S)-Avadomide-d1 (HY-W865379).
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- HY-13631ES2
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Deruxtecan-d4-1 is the deuterium labeled Adenosine 5'-monophosphate disodium salt [1].
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- HY-N0384S4
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Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency [1].
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- HY-34487S3
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1,3-Dimethoxybenzene-d3 (Resorcinol dimethyl ether-d3) is the deuterium labeled 1,3-Dimethoxybenzene (HY-34487). 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds [1].
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- HY-Y0678S
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1,3,5-Trimethoxybenzene-d3 (Trimethyl phloroglucinol-d3) is the deuterium labeled 1,3,5-Trimethoxybenzene (HY-Y0678). 1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor [1].
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- HY-41676S
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4-Chlorobenzonitrile-d4 is the deuterium labeled 4-Chlorobenzonitrile[1].
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- HY-114041S1
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Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].
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- HY-W052227S
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Fmoc-DL-Ala-OH-d is the deuterium labeled DL-Alanine-2-N-fmoc.
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-
- HY-107343S1
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Docosahexaenoic acid ethyl ester-d5-1 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2][3].
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- HY-W094751S
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1-Pyrenamin-d9 is the deuterium labeled 1-Pyrenamin[1].
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- HY-15025S2
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Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
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- HY-W342440S
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1,1-Diethoxynonane-d10 is a deuterated labeled 1,1-Diethoxynonane [1].
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- HY-W016152S
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1-Bromo-3-methoxybenzene-d3 is the deuterium labeled 1-Bromo-3-methoxybenzene. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified [1].
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- HY-Y1805S
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1,2,3,4-Tetrahydronaphthalene-d4 (Tetralin solvent-d4) is the deuterium labeled 1,2,3,4-Tetrahydronaphthalene (HY-Y1805) [1].
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- HY-W012934S
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1-Ethylpyrrolidin-2-one-d5 (N-Ethyl-pyrrolidone-d5) is deuterium labeled 1-Ethylpyrrolidin-2-one [1].
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- HY-N0215S13
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L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
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- HY-109541S
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1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d58 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
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- HY-109541S1
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1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d4 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
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- HY-109541S2
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1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d9 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
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- HY-109541S3
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1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d13 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
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- HY-109541S4
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1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d63 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
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- HY-109541S5
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1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
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- HY-112530S
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1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis
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- HY-113424AS
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1,2-Dioleoyl-sn-glycero-3-phosphocholine-d9 is deuterium labeled 1,2-Dioleoyl-sn-glycero-3-phosphocholine. 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelle
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-
- HY-113482S
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1β-Hydroxydeoxycholic Acid-d5 is the deuterium labeled 1β-Hydroxydeoxycholic Acid[1].
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- HY-W009719S
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1-Bromo-2,3-dichlorobenzene-d3 is the deuterium labeled 1-Bromo-2,3-dichlorobenzene[1].
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- HY-W009981S
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1-Bromo-2,4-difluorobenzene-d3 is the deuterium labeled 1-Bromo-2,4-difluorobenzene[1].
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-
- HY-W011883S
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1,3-Dibromo-5-fluorobenzene-d3 is the deuterium labeled 1,3-Dibromo-5-fluorobenzene[1].
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-
- HY-W131797
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1-Iodoethane-1,1,2,2,2-d5 is the deuterium labeled 1-Iodoethane[1].
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-
- HY-Y0566S
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1,4-Diazabicyclo[2.2.2]octane-d12 is the deuterium labeled 1,4-Diazabicyclo[2.2.2]octane[1].
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- HY-N9933S
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Tauro-β-muricholic acid-d4-1 (T-βMCA-d4-1) sodium is the deuterium labeled Tauro-β-muricholic acid (HY-N9933) [1].
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-
- HY-W011885S
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1-Dodecylpyrrolidin-2-one-d6 (N-Lauryl-2-pyrrolidone-d6) is deuterium-labeled 1-Dodecylpyrrolidin-2-one (HY-W011885) [1].
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- HY-11018S1
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Risperidone-d4-1 (R 64 766-d4-1) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
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-
- HY-W654320
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Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL [1] .
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- HY-B0402S
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Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].
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- HY-130462S
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
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- HY-130462S1
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d82 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
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- HY-B0228S8
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Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys
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- HY-79779S
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1-Bromo-4-(bromomethyl)benzene-d6 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene[1].
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- HY-79779S1
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1-Bromo-4-(bromomethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene[1].
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- HY-B0402S1
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Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7].
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- HY-W015784S
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1,4-Benzenedimethanol-d4 is the deuterium labeled 1,4-Benzenedimethanol[1].
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- HY-W097453S2
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6-(Methylthio)purine-d3-1 is the deuterium labeled 6-(Methylthio)purine[1].
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- HY-W768340
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Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al [1].
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- HY-W654353
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Tauro-α-muricholic acid-d4-1 (sodium) is deuterium labeled Tauro-α-muricholic acid (sodium). Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal [1] .
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- HY-W015824S3
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DL-Aspartic acid- 13C1 is the 13C labeled DL-Aspartic acid[1].
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- HY-W013376S
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Norcyclizine-d8 is the deuterium labeled Norcyclizine [1].
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- HY-B0762S1
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Acetyl-L-carnitine-d3-1 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].
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- HY-B0151S2
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Pregnenolone-d4-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
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- HY-N0210S12
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D-Galactose- 13C,d is the deuterium and 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-W014431S
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1-Bromo-3-chloro-5-fluorobenzene-d3 is the deuterium labeled 1-Bromo-3-chloro-5-fluorobenzene[1].
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- HY-W105111S
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1-Bromo-2,3,5-trichlorobenzene-d2 is the deuterium labeled 1-Bromo-2,3,5-trichlorobenzene[1].
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- HY-N7092S23
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D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
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- HY-W110726S
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1-Octen-3-one-d5 is deuterated labeled 2-Ethyl-3-methoxypyrazine.
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- HY-W110726S1
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1-Octen-3-one-d3 is deuterated labeled 3-Ethyl-2,5-dimethylpyrazine.
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- HY-Y0921S3
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(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish [1] .
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- HY-115702S
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1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine-d4 is the deuterium labeled 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine[1].
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- HY-B0896S1
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Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-122426S2
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1-Bromoundecane-d4 is the deuterium labeled 1-Bromoundecane[1].
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- HY-B0896S2
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Glyceryl Triacetate-d9 is the deuterium labeled Triacetin[1]. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-W013504S
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1-Bromo-4-(trifluoromethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(trifluoromethyl)benzene[1].
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- HY-W013948S
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1-(2,4-Dinitrophenyl)-2-propylidenehydrazine-d3 is the deuterium labeled 1-(2,4-Dinitrophenyl)-2-propylidenehydrazine[1].
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- HY-Y0219S1
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NSC 83128-d3 is the deuterium labeled NSC 83128[1].
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- HY-W192474S
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1-(Furan-2-yl)ethane-1-thiol-d3 is deuterated labeled Allyl methyl disulfide.
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- HY-Y0743S
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1-(Pyridin-2-yl)ethan-1-one-d6 is deuterated labeled 3,5-Dimethyl-2-vinylpyrazine.
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- HY-W756596
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1,2-Dioctanoyl-3-chloropropanediol-d5 is deuterium labeled 1,2-Dioctanoyl-3-chloropropanediol. 1,2-Dioctanoyl-3-chloropropanediol (3-Chloropropane-1,2-diyl dioctanoate) is an ester product [1].
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- HY-W654409
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1,1,1,3,3,3-Hexafluoropropan-2-ol-d2 (Hexafluoroisopropyl alcohol-d2) is deuterium labeled 1,1,1,3,3,3-Hexafluoropropan-2-ol [1].
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- HY-W777599
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(±)-Naproxen- 13C,d3-1 ((Rac)-Naproxen- 13C,d3-1) is 13C and deuterium labeled (±)-Naproxen [1].
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- HY-145473S
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1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 (15(S)-HETE-SAPE-d11) is deuterium labeled 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes [1].
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- HY-15029S1
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(±)-Naproxen-d3-1 is the deuterium labeled (±)-Naproxen[1].
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- HY-10003S
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Alfacalcidol-d7 is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis[1][2][3][4].
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- HY-N0229S4
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L-Alanine- 13C,d is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-N0537S12
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Xylose-d-3 is the deuterium labeled Xylose.
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- HY-N0537S13
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Xylose-d-4 is the deuterium labeled Xylose.
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- HY-D0837S
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Imidazole-d4 is the deuterium labeled Imidazole[1].
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- HY-Y0531S
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1-Adamantanol-d15 is the deuterium labeled 1-Adamantanol[1].
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- HY-100441S1
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Treprostinil- 13C2,d is the 13C- and deuterium labeled Treprostinil. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
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- HY-W010265S
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Butyrophenone-d5 is the deuterium labeled Butyrophenone[1].
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- HY-Y1039S
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1-Stearoyl-rac-glycerol-d40 is the deuterium labeled 1-Stearoyl-rac-glycerol[1].
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- HY-Y1039S1
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1-Stearoyl-rac-glycerol-d35 is the deuterium labeled 1-Stearoyl-rac-glycerol.
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- HY-Y1217S
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1-Cyclohexanol-d12 is the deuterium labeled 1-Cyclohexanol[1].
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- HY-Y1217S1
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1-Cyclohexanol-d11 is the deuterium labeled 1-Cyclohexanol[1].
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- HY-B0166S8
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L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) [1]. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
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- HY-W777649
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Oxypurinol- 13C, 15N2-1 (Oxipurinol- 13C, 15N2-1) is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol, the major active metabolite of Allopurinoll (HY-B0219), is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout [1].
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- HY-114553S
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1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d5 (5F-PB-223-Carboxyindolemetabolite-d5) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid [1].
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- HY-B0456S1
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Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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- HY-Y1641S
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1,2-Ethanedithiol-d4 is the deuterium labeled 1,2-Ethanedithiol[1].
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- HY-78004S1
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1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) [1].
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- HY-131325S
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Simeton-d3 (N2,N4-Diethyl-6-(methoxy-d3)-1,3,5-triazine-2,4-diamine) is deuterium labeled Simeton [1].
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- HY-Y1309S
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1-Naphthol-d8 is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].
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- HY-W392083S
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(1,3E,5E)-Undeca-1,3,5-triene-d5 is deuterated labeled 5-Octyldihydrofuran-2(3H)-one.
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- HY-W392083S1
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(1,3E,5Z)-Undeca-1,3,5-triene-d5 is deuterated labeled 2-Methyl-3-(methyldisulfanyl)furan.
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- HY-Y1309S1
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1-Naphthol-d7 is the deuterium labeled Naphthol [1].
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- HY-W050145S
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Levoglucosan-d7 is the deuterium labeled Levoglucosan. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature[1][2].
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- HY-34444S
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1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan[1].
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- HY-Y0727S
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1,5-Dibromopentane-d4 is the deuterium labeled 1,5-Dibromopentane[1].
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- HY-Y0727S1
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1,5-Dibromopentane-d10 is the deuterium labeled 1,5-Dibromopentane[1].
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- HY-W048482S
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rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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- HY-W040193S
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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70 is the deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].
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- HY-W040193S1
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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
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- HY-W040193S2
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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
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- HY-W040193S3
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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].
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- HY-W040193S4
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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
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- HY-W040193S5
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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
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- HY-W040193S6
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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d13 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
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- HY-Y0093S
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NSC 5416-d14 is the deuterium labeled NSC 5416[1].
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- HY-Y1044S
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1,5-Dihydroxypentane-d10 is the deuterium labeled 1,5-Dihydroxypentane[1].
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- HY-Y1772S
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1-Iodo-4-methylbenzene-d7 is the deuterium labeled 1-Iodo-4-methylbenzene[1].
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- HY-12650S
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Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS [1].
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- HY-W285163S
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1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
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- HY-113123S1
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LysoPC(14:0/0:0)-d7 (14:0 Lyso PC-d7) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect [1] .
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- HY-W699983
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Imidazole- 15N2 (Glyoxaline- 15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease [1] .
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- HY-Y0860S
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1,6-Dibromo-n-hexane-d12 is the deuterium labeled 1,6-Dibromo-n-hexane[1].
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- HY-W013053S
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Dibenz[a,h]anthracene-d14 is the deuterium Dibenz[a,h]anthracene.
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-
- HY-W242724
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1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d8 is the deuterium labeled 1,4-Dibromo-butane[1].
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-
- HY-W762019S
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1,2,3,4,7,8-Hexachloro dibenzo-p-dioxin- 13C12 (1,2,3,4,7,8-HxCDD- 13C12) is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin [1].
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-
- HY-41681S
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6-Chloro-1-hexanol-d6 is the deuterium labeled 6-Chloro-1-hexanol[1].
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-
- HY-W662572S
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Pyroxsulam-d6 (N-(5,7-Dimethoxy-d6[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide [1].
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- HY-W050145S2
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Levoglucosan- 13C6 is the 13C labeled Levoglucosan[1]. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature[2].
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- HY-151997S
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1,2-Dioleoyl-3-lauroyl-rac-glycerol- 13C3 is the 13C-labeled 1,2-Dioleoyl-3-lauroyl-rac-glycerol (HY-165089), 1,2-Dioleoyl-3-lauroyl-rac-glycerol (1,2-Olein-3-laurin) is a triglyceride identified by specific analytical methods in human milk, infant formula, other mammalian milk, and vegetable oils, with specific structural and distribution characteristics.
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- HY-Y0219S
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NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128[1].
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- HY-A0052S
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(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4 is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.
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-
- HY-Y0045S
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2-Acetylthiazole- 13C2 is 13C labeled Fructose-phenylalanine.
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- HY-33948S
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1-Amino-2-methylpropan-2-ol-d6 is the deuterium labeled 1-Amino-2-methylpropan-2-ol[1].
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- HY-34123S
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N-(2-Bromoethyl)phthalimide-d4 is the deuterium labeled N-(2-Bromoethyl)phthalimide[1].
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- HY-59354S1
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1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins [1] .
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Classification |
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- HY-RS13999
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siRNAs
Pre-designed siRNA Sets
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SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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