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Results for "

TYR inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ack1 (1) Anaplastic lymphoma kinase (ALK) (1) Angiotensin-converting Enzyme (ACE) (2) Apoptosis (5) Bcr-Abl (1) Biochemical Assay Reagents (1) Btk (3) Caspase (1) Cathepsin (3) Cholinesterase (ChE) (1) Dengue virus (1) Dipeptidyl Peptidase (1) Endogenous Metabolite (2) ERK (1) FAK (2) Flavivirus (1) FLT3 (1) Histone Methyltransferase (1) HIV (1) Influenza Virus (1) Insulin Receptor (1) Isotope-Labeled Compounds (1) JAK (1) JNK (2) MEK (1) Monoamine Oxidase (1) Opioid Receptor (1) Paraptosis (1) Phosphatase (2) Phosphodiesterase (PDE) (1) PKA (1) PKC (1) Proteasome (2) Ras (1) SARS-CoV (2) Src (2) STAT (4) TGF-β Receptor (1) Tyrosinase (2) VEGFR (1) Virus Protease (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (2) Endocrinology (1) Infection (6) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (7)

By Targets:

Ack1 (1)

Anaplastic lymphoma kinase (ALK) (1)

Angiotensin-converting Enzyme (ACE) (2)

Apoptosis (5)

Bcr-Abl (1)

Biochemical Assay Reagents (1)

Btk (3)

Caspase (1)

Cathepsin (3)

Cholinesterase (ChE) (1)

Dengue virus (1)

Dipeptidyl Peptidase (1)

Endogenous Metabolite (2)

ERK (1)

FAK (2)

Flavivirus (1)

FLT3 (1)

Histone Methyltransferase (1)

HIV (1)

Influenza Virus (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (1)

JAK (1)

JNK (2)

MEK (1)

Monoamine Oxidase (1)

Opioid Receptor (1)

Paraptosis (1)

Phosphatase (2)

Phosphodiesterase (PDE) (1)

PKA (1)

PKC (1)

Proteasome (2)

Ras (1)

SARS-CoV (2)

Src (2)

STAT (4)

TGF-β Receptor (1)

Tyrosinase (2)

VEGFR (1)

Virus Protease (2)

Xanthine Oxidase (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (5)

Metabolic Disease (6)

Neurological Disease (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114782

H-Tyr-Tyr-OH L-TYRosyl-L-TYRosine	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC₅₀ value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure .

HY-100749

HeE1-2Tyr	Flavivirus Dengue virus SARS-CoV	Infection
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC₅₀ of 27.6 μM) activity in vitro .

HY-138208

Z-Phe-Tyr(tBu)-diazomethylketone	Cathepsin SARS-CoV	Infection
Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection .

HY-P5312A

Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr acetate	Virus Protease	Infection
Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr acetate is the acetate salt form of Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr. Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr acetate is the substrate for WNV NS2B NS3 protease, which is utilized for the development of WNV protease substrate peptide selective inhibitor .

HY-W008452

H-Tyr(3-I)-OH	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-153445

MEK-IN-6	ERK MEK	Cancer
MEK-IN-6 (Example 69) is a MEK inhibitor. MEK-IN-6 inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells (IC₅₀: 2 nM). MEK-IN-6 can be used for research of cancer .

HY-158235

Tyrosinase-IN-27	Tyrosinase	Others
Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC₅₀: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices .

HY-P4293

Z-Leu-Tyr-Chloromethylketone	Proteasome Cathepsin	Others
Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor .

HY-W008452S

H-Tyr(3-I)-OH-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

HY-P5312

Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr	Virus Protease	Infection
Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a WNV NS2B-NS3 protease substrate. Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is used for WNV NS2B-NS3 protease substrate peptide selective inhibitor development .

HY-139984

BIIB091	Btk	Neurological Disease Inflammation/Immunology
BIIB091 is a potent, selective, orally active and reversible BTK inhibitor, with an IC₅₀ of <0.5 nM. BIIB091 binds the BTK protein to sequester TYR-551 into an inactive conformation with excellent affinity. BIIB091 can be used for the research of multiple sclerosis .

HY-128140

Z-FY-CHO 5 Publications Verification Z-Phe-TYR-CHO	Cathepsin	Neurological Disease Metabolic Disease
Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor .

HY-P4291

Z-Leu-Leu-Tyr-COCHO	Proteasome	Others
Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a K_i value of 3.0 nM .

HY-P3577

[Tyr0] Gastric Inhibitory Peptide (23-42), human	Insulin Receptor	Metabolic Disease
[Tyr0] Gastric Inhibitory Peptide (23-42), human, a glucose-dependent insulinotropic polypeptide (GIP), is a weak inhibitor of gastric acid secretion that also stimulates insulin secretion. [Tyr0] Gastric Inhibitory Peptide (23-42), human can be used in diabetes, obesity research .

HY-W011258

H-Tyr-Phe-OH L-TYRosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

HY-P3786

H-Arg-Gly-Tyr-Ala-Leu-Gly-OH	PKA PKC	Cancer
H-Arg-Gly-Tyr-Ala-Leu-Gly-OH is a competitive and CAMP dependent protein kinase inhibitor .

HY-146666

STAT3-IN-9	Apoptosis STAT	Cancer
STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase .

HY-N2134

Mirificin Puerarin apioside	Tyrosinase	Endocrinology
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM .

HY-12289A

Defactinib hydrochloride Maximum Cited Publications 38 Publications Verification VS-6063 hydrochloride; PF 04554878 hydrochloride	FAK	Cancer
Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

HY-P0073

Tyr-Gly-Gly-Phe-Met-OH 2 Publications Verification Met-Enkephalin; Methionine enkephalin; Metenkefalin	Opioid Receptor	Neurological Disease Cancer
Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

HY-12352

HJC0416	STAT Apoptosis	Cancer
HJC0416 is a potent and orally active STAT3 inhibitor. HJC0416 shows antiprolifeative activity and induces apoptosis. HJC0416 decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein. HJC0416 shows anti-tumor activity .

HY-164546

WB436B	STAT Apoptosis	Cancer
WB436B is a highly selective STAT3 inhibitor. WB436B can selectively inhibit STAT3-Tyr705 phosphorylation and the expression of STAT3 target genes, showing cytotoxic effects on pancreatic cancer cells and inducing apoptosis. WB436B can suppress tumor growth and metastasis in pancreatic cancer mouse models, extending the survival of tumor-bearing mice .

HY-18674

K-Ras-IN-1	Ras	Cancer
K-Ras-IN-1 is a small molecule K-Ras inhibitor. K-Ras-IN-1 binds to K-Ras (WT), K-Ras (G12D), K-Ras (G12V), and H-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. K-Ras-IN-1 is promising for research of pancreatic, colon and lung cancer .

HY-141566

EZH2-IN-5	Histone Methyltransferase	Cancer
EZH2-IN-5 is a potent EZH2 inhibitor with IC₅₀ values of 1.52 nM and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively .

HY-P4633

γ-Glu-Tyr	Dipeptidyl Peptidase	Metabolic Disease
γ-Glu-Tyr, a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC₅₀=6.77 mM), is a potentially functional component of the type 2 diabetes diet .

HY-P1200

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .

HY-P1200A

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-151209

MAO-B-IN-15	Monoamine Oxidase	Neurological Disease
MAO-B-IN-15 is a selective MAO-B inhibitor (IC₅₀: 13.5 μM) that forms π-π interaction with Tyr 326 residue. MAO-B-IN-15 can be used in the research of Parkinson’s disease .

HY-162257

BTK-IN-34	Btk	Cancer
BTK-IN-34 (compound 9h) is a selective BTK inhibitor. BTK-IN-34 shows antiproliferative activity in RAMOS cells through selective inhibition of pBTK (Tyr223) without affecting Lyn and Syk, upstream proteins in the BCR signaling pathway .

HY-151808

JS25	Btk	Cancer
JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC₅₀ value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitt’s lymphoma. JS25 effectively crosses the blood-brain barrier .

HY-15841

CEP-37440	Anaplastic lymphoma kinase (ALK) FAK	Cancer
CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC₅₀ values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397) .

HY-15290

AIM-100 3 Publications Verification	Ack1	Cancer
AIM-100 is a potent and selective Ack1 inhibitor with an IC₅₀ of 21.58 nM. AIM-100 also inhibits Tyr ²⁶⁷ phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect .

HY-169173

AL284	Cholinesterase (ChE)	Infection
AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes .

HY-D0846

Diethyl pyrocarbonate	Biochemical Assay Reagents	Neurological Disease
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .

HY-133512

NCGC00249987	Phosphatase	Cancer
NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC₅₀s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells .

HY-115452

G5-7	JAK Apoptosis	Cancer
G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr ¹⁰⁶⁸) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study .

HY-153766

PDE5-IN-9	Phosphodiesterase (PDE)	Cardiovascular Disease
PDE5-IN-9 (Compound 59) is a PDE5 inhibitor (IC₅₀: 11.2 μM). PDE5-IN-9 shows interaction with Gln 817, Tyr 612, and Ala 767 amino acid residues. PDE5-IN-9 can be used for research of cardiovascular disease .

HY-W104477

3-Fluoro-L-tyrosine	Others	Metabolic Disease
3-Fluoro-L-tyrosine is a tyrosine analogue, inhibits transamination by tyrosine aminotransferase (TAT). And 3-FluoroL-tyrosine has been shown to be biologically incorporated into proteins in place of tyrosine. 3-Fluoro-L-tyrosine pretends to be the substrate of rat liver tyrosine aminotransferase, markedly disturbs the Tyr-TAT association .

HY-156242

BQZ-485	Paraptosis	Cancer
BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events .

HY-118798

DA 3003-2 NSC663285	Phosphatase	Cancer
DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr ¹⁵ Cdc2. DA 3003-2 has the potential for the research of prostate cancer .

HY-162801

Neuraminidase-IN-21	Influenza Virus	Infection
Neuraminidase-IN-21 (Compound 6d) is an influenza H1N1 virus Neuraminidase inhibitor, with IC₅₀s of 0.30 µM for Neuraminidase, and 30.01 µM for H1N1 strain of influenza. Neuraminidase-IN-21 formsg three hydrogen bonds with Arg292, Arg371, and Tyr406 of Neuraminidase .

HY-123201

KRN383 analog	FLT3	Cancer
KRN383 analog is an analog of KRN383. KRN383 is an orally active Flt3 inhibitor that inhibits the autophosphorylation of Flt3 bearing internal tandem duplications (ITDs) and the Asp835Tyr (D835Y) point mutation with IC₅₀ values of < or =5.9 and 43 nM, respectively. KRN383 also inhibits the proliferation of the ITD-positive cell lines with IC₅₀ values of < or =2.9 nM. KRN383 can be used for the research of acute myeloid leukemia .

HY-123486

HS-438	Apoptosis Bcr-Abl	Cancer
HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML) .

HY-P5395

TAT-GluR23A Fusion Peptide	HIV	Others
TAT-GluR23A Fusion Peptide is a biological active peptide. (This is the GluR23A sequence, a control inactive peptide used as a mutant counterpart to glutamate receptor endocytosis inhibitor (GluR23Y), connected to an 11 amino acid cell permeable HIV Trans-Activator of Transcription (TAT) protein transduction domain (PTD). GluR23A is derived from GluR23Y amino acids 869 to 877, with Ala substituted for Tyr, and thus lacking essential phosphorylation sites.Control peptide of HY-P2259)

HY-11010

AS601245 5+ Cited Publications	JNK	Neurological Disease Inflammation/Immunology Cancer
AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .

HY-122179

NUCC-555	TGF-β Receptor	Inflammation/Immunology
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice .

HY-11010A

AS601245 TFA	JNK	Neurological Disease Inflammation/Immunology Cancer
AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .

HY-122010

NVP-AAD777	VEGFR	Others
NVP-AAD777 is a specific inhibitor of VEGFR-2, demonstrated in vivo by its effective suppression of phospho-VEGFR-2 (Tyr1175) signaling in rat lung tissues. Unlike the nonspecific VEGFR inhibitor SUG-5416, NVP-AAD777 did not induce emphysematous changes in the lungs after three weeks of treatment, even when combined with exposure to cigarette smoke. Additionally, there were no alterations observed in vascular density compared to control animals. This indicates NVP-AAD777's targeted action in inhibiting VEGFR-2 without adverse pulmonary effects, highlighting its potential therapeutic utility in managing conditions associated with aberrant VEGFR-2 signaling .

HY-164445

STAT3-IN-32	STAT	Cancer
STAT3-IN-32 (compound 2p) is an orally active, potent STAT3 dual phosphorylation inhibitor with an indole-containing tetra-aromatic heterocycle scaffold. STAT3-IN-32 exhibits STAT3 luciferase inhibition activity using HEK293T cells with an IC₅₀ of 5.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC₅₀ of 4.2 nM. STAT3-IN-32 significantly blocks p-Tyr705 and p-Ser727 and causes the abrogation of the corresponding nuclear transcription and mitochondrial oxidative phosphorylation functions of STAT3 by targeting the STAT3 SH2 domain (K_D=21.3 nM). STAT3-IN-32 exhibits significant suppressive effects in a pancreatic cancer xenograft model .

Cat. No.	Product Name	Type