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Results for "

curcumin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Androgen Receptor (1) Apoptosis (14) Autophagy (11) Bacterial (5) Caspase (1) Cholinesterase (ChE) (2) COX (4) Cytochrome P450 (2) Drug Metabolite (1) Endogenous Metabolite (2) Epigenetic Reader Domain (4) ERK (2) Fatty Acid Synthase (FASN) (1) Ferroptosis (4) Fungal (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (4) HIV (1) HSP (1) Influenza Virus (3) Interleukin Related (3) Isotope-Labeled Compounds (6) Keap1-Nrf2 (8) Liposome (1) Mitophagy (4) mTOR (2) NF-κB (6) NO Synthase (3) p38 MAPK (1) Reactive Oxygen Species (4) STAT (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) TrxR (2) VEGFR (1)
By Research Areas:	Cancer (29) Infection (4) Inflammation/Immunology (17) Metabolic Disease (7) Neurological Disease (5)

By Targets:

Amyloid-β (2)

Androgen Receptor (1)

Apoptosis (14)

Autophagy (11)

Bacterial (5)

Caspase (1)

Cholinesterase (ChE) (2)

COX (4)

Cytochrome P450 (2)

Drug Metabolite (1)

Endogenous Metabolite (2)

Epigenetic Reader Domain (4)

ERK (2)

Fatty Acid Synthase (FASN) (1)

Ferroptosis (4)

Fungal (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Acetyltransferase (4)

HIV (1)

HSP (1)

Influenza Virus (3)

Interleukin Related (3)

Isotope-Labeled Compounds (6)

Keap1-Nrf2 (8)

Liposome (1)

Mitophagy (4)

mTOR (2)

NF-κB (6)

NO Synthase (3)

p38 MAPK (1)

Reactive Oxygen Species (4)

STAT (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

TrxR (2)

VEGFR (1)

By Research Areas:

Cancer (29)

Infection (4)

Inflammation/Immunology (17)

Metabolic Disease (7)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0005

*Curcumin* Maximum Cited Publications 76 Publications Verification Diferuloylmethane; Natural Yellow 3; Turmeric yellow	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis	Cancer
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-138795

Curcumin-β-D-glucuronide	Others	Cancer
Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer .

HY-148598

Curcumin 5-8 CUR5-8	Apoptosis Autophagy	Metabolic Disease
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity .

HY-N0007A

Bisdemethoxycucurmin curcumin III; Didemethoxycurcumin	Others	Inflammation/Immunology
Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities .

HY-N0007S

Bisdemethoxycurcumin-d8 curcumin III-d₈; Didemethoxycurcumin-d₈	Apoptosis Autophagy	Cancer
Bisdemethoxycurcumin-d₈ is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.

HY-N0006

Demethoxycurcumin 3 Publications Verification curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-143421

Curcumin monoglucuronide CMG	Drug Metabolite	Cancer
Curcumin monoglucuronide is known as a glucuronic acid conjugate, which is one of the in vivo metabolites of curcumin. Curcumin monoglucuronide is used for research on the metabolism of curcumin and examination of its development as a pharmaceutical. Curcumin monoglucuronide has the potential for the research of cancer disease (extracted from patent WO2022004873A1) .

HY-N0005R

Curcumin (Standard)	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis	Cancer
Curcumin (Standard) is the analytical standard of Curcumin. This product is intended for research and analytical applications. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-150673S

Curcumin diglucoside-d6	Isotope-Labeled Compounds	Others
Curcumin diglucoside-d₆ is the deuterium labeled Curcumin diglucoside[1].

HY-150674S

Curcumin-diglucoside tetraacetate-d6 curcumin-d6-β-di-glucoside tetraacetate; Diglucosylcurcumin-d6 octaacetate	Isotope-Labeled Compounds	Others
Curcumin-diglucoside tetraacetate-d₆ is the deuterium labeled Curcumin-diglucoside tetraacetate[1].

HY-N0005S

Curcumin-d6 Diferuloylmethane-d₆; Natural Yellow 3-d₆; Turmeric yellow-d₆	Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus	Infection Metabolic Disease Inflammation/Immunology
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-N0006S1

Demethoxycurcumin-d4 curcumin II-d₄; Desmethoxycurcumin-d₄; Monodemethoxycurcumin-d₄	Apoptosis Autophagy Bacterial	Cancer
Demethoxycurcumin-d₄ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties[1].

HY-N0006S

Demethoxycurcumin-d7 curcumin II-d₇; Desmethoxycurcumin-d₇; Monodemethoxycurcumin-d₇	Isotope-Labeled Compounds Apoptosis Autophagy Bacterial	Inflammation/Immunology Cancer
Demethoxycurcumin-d₇ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.

HY-139211

Difluorinated Curcumin 3,4-Difluorobenzylidene curcumin	Others	Cancer
Difluorinated Curcumin (3,4-Difluorobenzylidene curcumin) is a fluorinated curcumin analog with high bioavailability and anticancer activity. Difluorinated Curcumin inhibits the self-renewal ability of tumor stem/stem-like cells, clonogenicity, invasiveness and angiogenesis of tumor cells. Difluorinated Curcumin also increases cell sensitivity to chemotherapy .

HY-N0007

(E,E)-Bisdemethoxycurcumin 3 Publications Verification (E,E)-curcumin III; (E,E)-Didemethoxycurcumin	Apoptosis Autophagy	Cancer
(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .

HY-143676S

*(1E,4Z,6E)-Curcumin-d6*	Isotope-Labeled Compounds	Others
(1E,4Z,6E)-Curcumin-d₆ is the deuterium labeled (1E,4Z,6E)-Curcumin[1].

HY-163451

Apoptosis inducer 17	Apoptosis	Cancer
Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells .

HY-W009731

Dibenzoylmethane	Keap1-Nrf2	Metabolic Disease Cancer
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-N2521

Tetramethylcurcumin FLLL31	STAT Apoptosis	Inflammation/Immunology Cancer
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

HY-W009731R

Dibenzoylmethane (Standard)	Keap1-Nrf2	Metabolic Disease Cancer
Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-126154

L48H37	Toll-like Receptor (TLR)	Inflammation/Immunology
L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment .

HY-N0894

Octahydrocurcumin Hexahydrobisdemethoxycurcumin	Reactive Oxygen Species	Others
Octahydrocurcumin is a hydrogenated derivative of curcumin and a metabolite of curcumin.

HY-151342

Ser@TPP@CUR	Others	Others
Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

HY-N0007R

(E,E)-Bisdemethoxycurcumin (Standard)	Apoptosis Autophagy	Cancer
(E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .

HY-100977

Dimethoxycurcumin DiMC; CHC 004; Di-O-methylcurcumin	NO Synthase NF-κB	Inflammation/Immunology
Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities .

HY-N0893

Tetrahydrocurcumin 1 Publications Verification HZIV 81-2	Cytochrome P450 Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.

HY-N7275

Di-O-methyldemethoxycurcumin	Interleukin Related	Inflammation/Immunology
Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits IL-6 production with an EC₅₀ of 16.20 μg/mL. Anti-inflammatory and antioxidant properties .

HY-100977S

Dimethoxycurcumin-d6 DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆	Isotope-Labeled Compounds	Inflammation/Immunology
Dimethoxycurcumin-d₆ is the deuterium labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin is a derivative of Curcumin that has anti-inflammatory and antioxidant activities .

HY-N0007AR

Bisdemethoxycucurmin (Standard)	Others	Inflammation/Immunology
Bisdemethoxycucurmin (Standard) is the analytical standard of Bisdemethoxycucurmin. This product is intended for research and analytical applications. Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities .

HY-116117

Salicylcurcumin	Others	Others
Salicylcurcumin is a synthetic curcumin analogue with antioxidant activity. Salicylcurcumin may affect lipid peroxidation in fish, favoring increased survival, disease resistance, and ultimately growth rate .

HY-N7080

Dihydroferulic acid Hydroferulic acid	Others	Metabolic Disease
Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC₅₀ value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid .

HY-N0929

Hexahydrocurcumin	COX Reactive Oxygen Species	Cancer
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-107336

Cyclovalone Beveno	COX	Inflammation/Immunology
Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities . Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active .

HY-N0893R

Tetrahydrocurcumin (Standard)	Cytochrome P450 Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Tetrahydrocurcumin (Standard) is the analytical standard of Tetrahydrocurcumin. This product is intended for research and analytical applications. Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.

HY-163458

Anti-inflammatory agent 77	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 77 (C12) is a β-cycloacinamide derived mono-carbonyl curcumin analog and an inhibitor of interleukin-6 (IL-6). Anti-inflammatory agent 77 can be used in the study of wound healing .

HY-135702

UBS109	NF-κB	Others
UBS109, as a curcumin analogue, can promote the differentiation and mineralization of osteoblasts. UBS109 shows to regulate bone cell function by activating Smad and inhibiting NF-kB. UBS109 can be used in bone tissue engineering and osteoporosis research .

HY-149265

ROS-generating agent 1	Reactive Oxygen Species TrxR Ferroptosis Apoptosis	Cancer
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities .

HY-150228

MitoCur-1	Others	Cancer
MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy .

HY-138962

κ-Carrageenan K-Carrageenan Karra Type	Apoptosis	Inflammation/Immunology Cancer
κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective agent carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation .

HY-N0929R

Hexahydrocurcumin (Standard)	COX Reactive Oxygen Species	Cancer
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-119272

EF24 1 Publications Verification	ERK Caspase	Cancer
EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .

HY-136477

Pentagamavunon-1 PGV-1	Apoptosis COX VEGFR NF-κB	Cancer
Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation .

HY-N1967

Dihydrocurcumin	Fatty Acid Synthase (FASN)	Metabolic Disease
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways .

HY-N0006R

Demethoxycurcumin (Standard)	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-137315S

TML-6-d3	Isotope-Labeled Compounds Amyloid-β Keap1-Nrf2 mTOR NF-κB	Neurological Disease
TML-6-d₃ is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

HY-139804

CTK7A	Epigenetic Reader Domain Histone Acetyltransferase HIF/HIF Prolyl-Hydroxylase	Cancer
CTK7A is a curcumin derivative with anticancer activity by inhibiting the HAT activity of p300 and reducing the autoacetylation of p300, thereby affecting its interaction with HIF-1α. The inhibition of CTK7A leads to decreased HIF-1α accumulation and activity, which can be used for cancer treatment research .

HY-134635

Dehydrozingerone	Bacterial Fungal HIV	Infection Neurological Disease Cancer
Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC₅₀ value of 0.50 mM .

HY-137315

TML-6	Amyloid-β NF-κB mTOR Keap1-Nrf2	Neurological Disease
TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research .

HY-123715

Anticancer agent 255	Others	Cancer
Anticancer agent 255 is a monocarbonylated curcumin-1,2,3-oxazole conjugate with significant anticancer activity. The IC₅₀ values of Anticancer agent 255 in prostate cancer cells PC-3 and DU-145 are 8.8μM and 9.5μM respectively. The IC₅₀ values of Anticancer agent 255 against breast cancer cells MCF-7, MDA-MB-231 and 4T1 are 6μM, 10μM and 6.4μM, showing good anti-cancer activity Effect. Anticancer agent 255 can induce mitochondria-mediated apoptosis in cancer cells and prevent cell cycle progression. Anticancer agent 255 down-regulated the cell proliferation marker PCNA and inhibited the activation of cell survival proteins. Anticancer agent 255 up-regulated the pro-apoptotic protein Bax and down-regulated the anti-apoptotic protein Bcl-2 .

HY-120914

TrxR1-IN-B19 GO-Y015	TrxR Apoptosis	Cancer
TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis .

Cat. No.	Product Name	Type

HY-W440901

DSPE-PEG-SPDP (MW 5000)

Drug Delivery

DSPE-PEG-SPDP, MW 5000 is an amphiphilic polyPEG which forms lipid bilayer in water. It can be used to encapsualte therapeutic agents. The core can encapsulate hydrophilic nutrients, such as protein/peptide and mRNA/DNA/siRNA etc. while the lipid bilayer can solubilize hydrophobic drugs, such as doxorubicin, curcumin etc. The SPDP moiety can react with thiol molecule to form a disulfide bond. Reagent grade, for research use only.

Cat. No.	Product Name	Category	Target	Chemical Structure