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ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs .
LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively .
DYRKtide is a biological active peptide. (Dyrktide is designed as the optimal substrate sequence efficiently phosphorylated by DYRK1A, which is a dual-specificity protein kinase that is thought to be involved in brain development.)
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM .
MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) .
DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity .
DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity .
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .
Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM .
Dyrk1A-IN-11 (compound 166) is a potent dual-specificity tyrosine phosphorylation- regulated 1A (DYRK1A) inhibitor with an EC50 value of 0.0021 µM. Dyrk1A-IN-11 inhibits the Phospho-Tau (Thr212) with an EC50 value of 0.0361 µM .
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .
Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5 .
Dyrk1A-IN-3 (Compound 8b), a highly selective dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC50=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease .
BML-260 is a potent inhibitor of dual-specific phosphatases JSP-1 and DUSP22. BML-260 can activate UCP1 and thermogenesis in adipocytes in a JSP-1-independent manner. The effect of BML-260 on adipocytes is partially achieved through the activation of CREB, STAT3, and PPAR signaling pathways. BML-260 can be used in the research of inflammatory and proliferative disorders associated with JNK signaling dysfunction as well as obesity .
Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively) . Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ25-35 in the same model .
BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells .
BCI ((E)-BCI) hydrochloride is a DUSP6(dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research .
BCI ((E)-BCI) is a DUSP6(dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research .
Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
Afatinib (BIBW 2992) oxalate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib oxalate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively . NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM) .
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
Dyrk1A-IN-12 (compound S43) is a Dyrk (Dual specificity tyrosine phosphorylation regulated kinase 1A inhibitor. Dyrk1A-IN-12 inhibits Dyrk1A with a IC50 of 95 nM. Dyrk1A-IN-12 shows anti-EV-A71 activity with an EC50 of 4.4 μM, CC50 of 12.8 μM and SI of 2.9. Dyrk1A-IN-12 shows potent inhibition against herpes simplex virus (HSV) .
Afatinib (dimaleate) (Standard) is the analytical standard of Afatinib (dimaleate). This product is intended for research and analytical applications. Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
Afatinib (dimaleate) (Standard) is the analytical standard of Afatinib (dimaleate). This product is intended for research and analytical applications. Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
(R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
DYRKtide is a biological active peptide. (Dyrktide is designed as the optimal substrate sequence efficiently phosphorylated by DYRK1A, which is a dual-specificity protein kinase that is thought to be involved in brain development.)
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM .
Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM .
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
Afatinib (dimaleate) (Standard) is the analytical standard of Afatinib (dimaleate). This product is intended for research and analytical applications. Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
DUSP3, a dual-specificity phosphatase, preferentially dephosphorylates phosphotyrosines. Its main function involves inactivating ERK1 and ERK2, thereby modulating associated cellular signaling pathways. DUSP3 Protein, Human (His) is the recombinant human-derived DUSP3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of DUSP3 Protein, Human (His) is 184 a.a., with molecular weight of 18-22 kDa.
DYRK1A protein has dual serine/threonine and tyrosine kinase activities. DYRK1A Protein, Human is the recombinant human-derived DYRK1A protein, expressed by E. coli , with tag free. The total length of DYRK1A Protein, Human is 359 a.a., .
DYRK1A protein has dual serine/threonine and tyrosine kinase activities. DYRK1A Protein, Human (His) is the recombinant human-derived DYRK1A protein, expressed by E. coli , with N-6*His labeled tag. The total length of DYRK1A Protein, Human (His) is 359 a.a., .
DUSP14 protein can inactivate MAP kinase and dephosphorylate ERK, JNK and p38 MAP kinase. Its negative regulation extends to TCR signaling, where DUSP14 dephosphorylates the MAP3K7 adapter TAB1, resulting in inactivation. DUSP14 Protein, Human (His-MBP) is the recombinant human-derived DUSP14 protein, expressed by E. coli , with N-His labeled tag.
DYRK2 is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including the mitotic cell cycle, cell proliferation, apoptosis, cytoskeletal organization, and neurite outgrowth. DYRK2 operates downstream of ATM to phosphorylate p53/TP53 at the “Ser-46” site, leading to DNA damage-induced apoptosis. DYRK2 Protein, Human (GST) is the recombinant human-derived DYRK2 protein, expressed by E. coli , with N-GST labeled tag. The total length of DYRK2 Protein, Human (GST) is 600 a.a., .
The DYRK4 protein may play a non-essential role in spermatogenesis, suggesting involvement in sperm cell development. Although specific functions and molecular mechanisms are unknown, its association with spermatogenesis suggests that it plays a role in complex pathways controlling male germ cell maturation. DYRK4 Protein, Human (Sf9, GST) is the recombinant human-derived DYRK4 protein, expressed by Sf9 insect cells , with GST tagged.
The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (Sf9, GST, FLAG) is the recombinant human-derived TTK protein, expressed by Sf9 insect cells , with C-Flag, N-GST labeled tag. The total length of TTK Protein, Human (Sf9, GST, FLAG) is 857 a.a.
The CLK2 protein is a dual-specificity kinase that phosphorylates serine- and arginine-rich (SR) proteins in the spliceosome complex. CLK2 Protein, Human (GST) is the recombinant human-derived CLK2 protein, expressed by E. coli , with N-GST labeled tag. The total length of CLK2 Protein, Human (GST) is 367 a.a., .
The DYRK4 protein may play a non-essential role in spermatogenesis, suggesting involvement in sperm cell development. Although specific functions and molecular mechanisms are unknown, its association with spermatogenesis suggests that it plays a role in complex pathways controlling male germ cell maturation. DYRK4 Protein, Human (Sf9, His, FLAG) is the recombinant human-derived DYRK4 protein, expressed by Sf9 insect cells , with N-Flag, N-8*His labeled tag. The total length of DYRK4 Protein, Human (Sf9, His, FLAG) is 520 a.a., .
DYRK3 is a dual-specificity protein kinase that dissociates membraneless organelles such as stress granules and nuclear speckles in mitosis. DYRK3 Protein, Human (sf9, His-GST) is the recombinant human-derived DYRK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of DYRK3 Protein, Human (sf9, His-GST) is 588 a.a., with molecular weight of ~80 KDa.
The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (K857G, Sf9, FLAG) is the recombinant human-derived TTK protein, expressed by Sf9 insect cells , with C-Flag labeled tag and K857G mutation.
The MEK1 protein is a dual-specificity kinase that plays a crucial role in the MAP kinase pathway.MEK1 regulates various cellular processes such as growth, adhesion, survival, and differentiation, as well as transcription, metabolism, and cytoskeletal rearrangements.MEK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived MEK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with tag free. The total length of MKK6 Protein, Human (sf9) is 334 a.a., with molecular weight of ~37 kDa.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9, His-GST) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of MKK6 Protein, Human (sf9, His-GST) is 334 a.a., with molecular weight of ~60 kDa.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with tag free. The total length of MKK6 Protein, Human (S207D, T211D, sf9) is 334 a.a., with molecular weight of ~38 kDa.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K6 Protein, Human (Baculovirus, His) is the recombinant human-derived MAP2K6 protein, expressed by Sf9 insect cells , with N-6*His labeled tag.
MAP2K7 protein is a dual-specificity kinase involved in the MAP kinase signal transduction pathway. MAP2K7 Protein, Human (Sf9) is the recombinant human-derived MAP2K7 protein, expressed by Sf9 insect cells , with tag free. The total length of MAP2K7 Protein, Human (Sf9) is 418 a.a., .
MAP2K7 protein is a dual-specificity kinase involved in the MAP kinase signal transduction pathway. MAP2K7 Protein, Human (Sf9, His, GST) is the recombinant human-derived MAP2K7 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of MAP2K7 Protein, Human (Sf9, His, GST) is 418 a.a., .
The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (P. pastoris, His-GST) is the recombinant human-derived MAP2K4 protein, expressed by P. pastoris , with N-6*His, N-GST labeled tag. The total length of MAP2K4 Protein, Human (P. pastoris, His-GST) is 398 a.a., with molecular weight of 71.5 kDa.
The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (Sf9) is the recombinant human-derived MAP2K4 protein, expressed by Sf9 insect cells , tag free.
dualspecificity protein phosphatase VHR; VHR; Vaccinia H1-related phosphatase
WB, IHC-F, IHC-P, ICC/IF, FC, IP
Human
DUSP3 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 20 kDa, targeting to DUSP3. It can be used for WB,IHC-F,IHC-P,ICC/IF,FC,IP assays with tag free, in the background of Human.
DUSP1; CL100; MKP1; PTPN10; VH1; dualspecificity protein phosphatase 1; dualspecificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100
WB, IHC-P, ICC/IF, IP, FC
Human, Mouse, Rat
DUSP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 39 kDa, targeting to DUSP1. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.
DUSP6 Antibody (YA2280) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2280), targeting DUSP6, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). DUSP6 Antibody (YA2280) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
CDC25C Antibody (YA2624) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2624), targeting CDC25C, with a predicted molecular weight of 53 kDa (observed band size: 60 kDa). CDC25C Antibody (YA2624) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.
Phospho-MEK1 (Ser298) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Phospho-MEK1 (Ser298). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
Phospho-MEK1 (Thr292) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Phospho-MEK1 (Thr292). It can be used for WB assays with tag free, in the background of Mouse, Rat.
MEK5 Antibody (YA3140) is a non-conjugated IgG antibody, targeting MEK5, with a predicted molecular weight of 50 kDa. MEK5 Antibody (YA3140) can be used for WB, ICC/IF experiment in human background.
MEK2 Antibody (YA3059) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3059), targeting MEK2, with a predicted molecular weight of 44 kDa (observed band size: 44 kDa). MEK2 Antibody (YA3059) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse background.
MEK3 Antibody (YA3214) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3214), targeting MEK3, with a predicted molecular weight of 39 kDa (observed band size: 38-40 kDa). MEK3 Antibody (YA3214) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
MAP2K6 Antibody (YA1088) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1088), targeting MAP2K6, with a predicted molecular weight of 37 kDa (observed band size: 40 kDa). MAP2K6 Antibody (YA1088) can be used for WB, IP experiment in human, rat background.
Phospho-MEK4 (Ser80) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to Phospho-MEK4 (Ser80). It can be used for WB,IP assays with tag free, in the background of Human.
MEK7 Antibody (YA2647) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2647), targeting MEK7, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). MEK7 Antibody (YA2647) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
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