Search Result

Isoforms Recommended:	Quinolone

Results for "

quinolone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Acyltransferase (1) Angiotensin Receptor (2) Antibiotic (46) Apoptosis (1) Bacterial (61) Beta-lactamase (1) Cannabinoid Receptor (1) DNA/RNA Synthesis (7) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (5) Mitochondrial Metabolism (1) Monoamine Oxidase (2) NF-κB (1) Parasite (6) PARP (1) Reactive Oxygen Species (1) Sirtuin (1) TAM Receptor (1) Topoisomerase (20)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Endocrinology (1) Infection (67) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (6)

By Targets:

Acetyl-CoA Carboxylase (1)

Acyltransferase (1)

Angiotensin Receptor (2)

Antibiotic (46)

Apoptosis (1)

Bacterial (61)

Beta-lactamase (1)

Cannabinoid Receptor (1)

DNA/RNA Synthesis (7)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (1)

Isotope-Labeled Compounds (5)

Mitochondrial Metabolism (1)

Monoamine Oxidase (2)

NF-κB (1)

Parasite (6)

PARP (1)

Reactive Oxygen Species (1)

Sirtuin (1)

TAM Receptor (1)

Topoisomerase (20)

By Research Areas:

Cancer (13)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (67)

Inflammation/Immunology (8)

Metabolic Disease (2)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124352

2-Nonyl-3-hydroxy-4-quinolone	Bacterial	Others
2-nonyl-3-hydroxy-4-Quinolone (C9-PQS) is a quinolone compound produced by P. aeruginosa and other related bacterias. 2-nonyl-3-hydroxy-4-Quinolone is a quorum sensing (QS) signal molecule that controls the expression of many virulence genes as a function of cell population density .

HY-128200

*Pseudomonas quinolone* signal** 1 Publications Verification PQS	Bacterial	Infection
Pseudomonas Quinolone Signal (Compound C), a signaling molecule produced by Pseudomonas aeruginosa, can activate lasB. Pseudomonas Quinolone Signal can be used in the study of virulence regulation in Pseudomonas aeruginosa .

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Monoamine Oxidase	Neurological Disease
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM .

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Monoamine Oxidase	Neurological Disease
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

HY-N9520

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC₅₀=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa .

HY-N0968

1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone	Others	Others
1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone, as a colorless oil, is a quinolone alkaloid isolated from the fruit of Evodia rutaecarpa BENTHAM (Rutaceae) .

HY-129503

2-Heptyl-4-quinolone	Others	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-D0113

7-Hydroxy-4-methyl-2(1H)-quinolone	Reactive Oxygen Species	Others
7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Acyltransferase Angiotensin Receptor Bacterial	Infection Cardiovascular Disease Metabolic Disease
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

HY-122260

S-25932	Bacterial	Infection
S-25932 is a potent 4-quinolones antibacterial agent. S-25932 shows broad gram-negative antibacterial activity. S-25932 shows inhibition for Enterobacter aerogenes, Enterobacter addlomerans, Enterobacter coloacae, Escherichia coli with MIC₉₀ values of 1.0, 2.0, 1.0, 0.25 µg/mL, respectively .

HY-17460B

Garenoxacin mesylate BMS 284756 mesylate	Bacterial Topoisomerase Antibiotic	Infection
Garenoxacin (BMS 284756) mesylate is an orally active quinolone antibiotic and Garenoxacin mesylate has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes. Garenoxacin mesylate also inhibits Gyrase and TOPO IV .

HY-113642

CP-67804	Topoisomerase	Cancer
CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .

HY-B0455B

Lomefloxacin (aspartate) SC47111A (aspartate)	Bacterial Antibiotic	Infection
Lomefloxacin (SC47111A) aspartate is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin aspartate can be used for researching respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .

HY-150041

TL4830031	TAM Receptor	Cancer
TL4830031 (compound 8i), a quinolone antibiotic derivatives, is a potent Axl inhibitor with an IC₅₀ value of 26 nM. TL4830031 inhibits the phosphorylation of Axl. TL4830031 inhibits cell invasion and migration. TL4830031 can be used for cancer research .

HY-146098

Antibacterial agent 105	Bacterial Antibiotic	Infection
Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC₉₀=2.64 μM)。Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC₉₀s of 11.18, 11.18，0.70，1.40，44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum,BCG, E. aerogenes and S. aureus, respectively .

HY-117657

(-)-BO 2367	Topoisomerase Bacterial	Inflammation/Immunology Cancer
(-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC₅₀ values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent .

HY-106410A

Zabofloxacin hydrochloride DW-224a	Bacterial Topoisomerase Antibiotic	Infection
Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) .

HY-59208

4-Quinolinol Kynurine	Endogenous Metabolite	Neurological Disease Cancer
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-131477A

Sinaﬂoxacin free base	Antibiotic	Infection
Sinaﬂoxacin free base is a quinolone antibiotic .

HY-106410

Zabofloxacin DW-224a Free base	Bacterial Topoisomerase Antibiotic	Infection
Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) .

HY-B0343A

Sarafloxacin hydrochloride 2 Publications Verification A-56620 hydrochloride	Bacterial Antibiotic	Infection
Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic agent.

HY-U00221

Amifloxacin Win49375	Bacterial	Infection
Amifloxacin (Win49375) is a synthetic antibacterial agent of the quinolone class.

HY-21509

8-Hydroxycoumarin 1 Publications Verification	Others	Others
8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone .

HY-19081

KB-5246	Bacterial Antibiotic	Infection
KB-5246 is a tetracyclic quinolone and displays antibacterial activities.

HY-103331

COR170	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a K_i value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection .

HY-105608

Narceine Narcein	Others	Metabolic Disease
Narceine (Narcein), a quinolone derivative, is an opium alkaloid with anti-diabetic property .

HY-W020111

7-Chloro-4-(piperazin-1-yl)quinoline	Sirtuin Parasite	Infection
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC₅₀ of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of *P. falciparum* with IC₅₀s of 1.18 μM and 0.97 μM, respectively .

HY-P2073

Cyclo(δ-Ala-L-Val)	Bacterial	Infection
Cyclo(Δ-Ala-L-Val) is a cyclic dipeptide and a putative quinolone signal (QS) molecule produced by Pseudomonas aeruginosa .

HY-B0526

Flumequine 3 Publications Verification R-802	Bacterial Topoisomerase Antibiotic	Infection Cancer
Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC₅₀ of 15 μM (3.92 μg/mL).

HY-14957

Ozenoxacin T-3912	Bacterial Antibiotic	Infection
Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

HY-B0343BS

Sarafloxacin-d8 hydrochloride trihydrate A-56620-d₈ hydrochloride trihydrate	Bacterial	Inflammation/Immunology
Sarafloxacin-d₈ (hydrochloride trihydrate) is the deuterium labeled Sarafloxacin hydrochloride trihydrate. Sarafloxacin hydrochloride trihydrate is a quinolone antibiotic compound[1][2].

HY-B0343AR

Sarafloxacin hydrochloride (Standard)	Bacterial Antibiotic	Infection
Sarafloxacin (hydrochloride) (Standard) is the analytical standard of Sarafloxacin (hydrochloride). This product is intended for research and analytical applications. Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic agent.

HY-16745A

Lascufloxacin hydrochloride KRP-AM1977 hydrochloride	Others	Infection
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.

HY-16487

Temafloxacin TMFX; TA-167 free acid; A-62254 free acid	Bacterial Antibiotic	Infection
Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections .

HY-113595

Temafloxacin hydrochloride TMFX hydrochloride; TA-167; A-62254	Antibiotic Bacterial	Infection
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections .

HY-108279

Ulifloxacin	Antibiotic Bacterial	Infection
Ulifloxacin is a broad-spectrum quinolone antibiotic. Ulifloxacin is the active metabolite of Prulifloxacin (HY-B0024). Ulifloxacin has anti-bacterial activity .

HY-123614

PD 140248 hydrochloride	Bacterial	Infection
PD 140248 hydrochloride is a quinolone broad-spectrum antibacterial agent with good in vitro bacteriostatic activity, especially having a significant inhibitory effect on Gram-positive bacteria .

HY-N2060

Evocarpine	Apoptosis Bacterial	Infection Inflammation/Immunology Cancer
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-B0343AS

Sarafloxacin-d8 hydrochloride A-56620-d₈ hydrochloride	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Sarafloxacin-d8 (A-56620-d8) hydrochloride is the deuterium labeled Sarafloxacin hydrochloride. Sarafloxacin hydrochloride (A-56620 hydrochloride) is a quinolone antibiotic drug.

HY-123271

Ro 23-9424	Bacterial Antibiotic	Infection
Ro 23-9424 is a broad-spectrum cephalosporin composed of a cephalosporin and a quinolone moiety. Ro 23-9424 shows antimicrobial activity in vivo and in vitro .

HY-B0455A

Lomefloxacin SC47111A	Bacterial Antibiotic	Infection
Lomefloxacin (SC47111A) is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .

HY-17460A

Garenoxacin Mesylate hydrate BMS284756 Mesylate hydrate	Bacterial Topoisomerase DNA/RNA Synthesis Antibiotic	Infection
Garenoxacin (BMS284756) Mesylate hydrate is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .

HY-17460

Garenoxacin BMS284756	Bacterial Topoisomerase DNA/RNA Synthesis Antibiotic	Infection
Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .

HY-B0455

Lomefloxacin hydrochloride SC47111A hydrochloride	Bacterial Antibiotic	Infection
Lomefloxacin (SC47111A) hydrochloride is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin hydrochloride is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .

HY-109855

CP-67015	Topoisomerase Antibiotic Bacterial	Infection
CP-67015, a quinolone antibiotic, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects .

HY-B1036

Decoquinate	Parasite	Infection
Decoquinate is a quinolone derivative that can be used for research of coccidiosis in domestic ruminants. Decoquinate also has potent activity against both Plasmodium hepatic development and red cell replication .

HY-B0526S

Flumequine-13C3	Isotope-Labeled Compounds Bacterial Topoisomerase Antibiotic	Infection Cancer
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-163482

ELQ-596	Parasite	Infection
ELQ-596 is a quinolone derivative, that exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice .

HY-163484

ELQ-650	Parasite	Infection
ELQ-650 is a quinolone derivative, that exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-650 attenuates babesiosis in immunosuppressed mice .

HY-105033

Irloxacin Pirfloxacin	Bacterial	Infection
Irloxacin (Pirfloxacin) is a quinolone antibacterial agent. Irloxacin shows greater activity with an acid pH. Irloxacin has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. Orally active .

Cat. No.	Product Name

HY-L0107V

Life Chemicals Natural Product-like Compound Library

13,236 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.

Cat. No.	Product Name	Type

HY-D0113

7-Hydroxy-4-methyl-2(1H)-quinolone	Fluorescent Dyes/Probes
7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-59208

4-Quinolinol Kynurine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Quinoline Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-N2060

Evocarpine	Infection Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Quinoline Alkaloids Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bacterial
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-N1637

1-Methyl-2-pentyl-4(1H)-quinolinone	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields	Bacterial
1-Methyl-2-pentyl-4(1H)-quinolinone, a quinolone alkaloid isolated from the fruits of Evodia Rutaecarpa, possesses antibacterial and cytotoxic activities for cancer cells .

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Alkaloids Neurological Disease Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Disease Research Fields	Monoamine Oxidase
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM .

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Quinoline Alkaloids Plants	Monoamine Oxidase
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

HY-N9520

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Disease Research Fields	Angiotensin Receptor
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC₅₀=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa .

HY-N0968

1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone	Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Other Diseases Quinoline Alkaloids Plants Disease Research Fields	Others
1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone, as a colorless oil, is a quinolone alkaloid isolated from the fruit of Evodia rutaecarpa BENTHAM (Rutaceae) .

HY-129503

2-Heptyl-4-quinolone	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Acyltransferase Angiotensin Receptor Bacterial
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

HY-105608

Narceine Narcein	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields Papaveraceae Corydalis longipes	Others
Narceine (Narcein), a quinolone derivative, is an opium alkaloid with anti-diabetic property .

HY-B0398

Nalidixic acid 1 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic Topoisomerase
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-124199

Cephalochromin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC₅₀ of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL .

HY-B0398R

Nalidixic acid (Standard)	Structural Classification Microorganisms Antibiotics Resistance Selection Source classification Antibacterial Disease Research Other Antibiotics	Bacterial Antibiotic Topoisomerase
Nalidixic acid (Standard) is the analytical standard of Nalidixic acid. This product is intended for research and analytical applications. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-N10907

4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl-	Structural Classification Alkaloids Source classification Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley	Bacterial
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively .

Cat. No.	Product Name	Chemical Structure

HY-14957AS

Ozenoxacin-d3 hydrochloride
Ozenoxacin-d₃ (hydrochloride) is the deuterium labeled Ozenoxacin hydrochloride. Ozenoxacin hydrochloride is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections[1][2][3].

HY-B0455S

Lomefloxacin-d5 hydrochloride
Lomefloxacin-d₅ (hydrochloride) is the deuterium labeled Lomefloxacin hydrochloride. Lomefloxacin (SC47111A) hydrochloride is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin hydrochloride is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc.[1][2].

HY-B0343BS

Sarafloxacin-d8 hydrochloride trihydrate
Sarafloxacin-d₈ (hydrochloride trihydrate) is the deuterium labeled Sarafloxacin hydrochloride trihydrate. Sarafloxacin hydrochloride trihydrate is a quinolone antibiotic compound[1][2].

HY-B0343AS

Sarafloxacin-d8 hydrochloride
Sarafloxacin-d8 (A-56620-d8) hydrochloride is the deuterium labeled Sarafloxacin hydrochloride. Sarafloxacin hydrochloride (A-56620 hydrochloride) is a quinolone antibiotic drug.

HY-B0526S

Flumequine-13C3
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-W018677S

Quinoxaline-d4
Quinoxaline-d₄ is the deuterium labeled Quinoxaline[1]. Quinoxaline is a chemical compound that acts as an intermediate for anti-tuberculosis agent Pyrazinamide. Quinoxaline presents a structure that is similar to quinolone antibiotics[2].

HY-14957S

Ozenoxacin-d3
Ozenoxacin-d₃ is the deuterium-labeled Ozenoxacin (HY-14957). Ozenoxacin-d₃ is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].

HY-B1085S

Cinoxacin-d5

Cinoxacin-d₅ is the deuterium-labeled Cinoxacin (HY-B1085) . Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis .

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