Search Result

Results for "

side-chain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (5) Amino Acid Derivatives (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (4) c-Myc (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) Endogenous Metabolite (4) Epigenetic Reader Domain (1) Fluorescent Dye (3) Fungal (1) GLP Receptor (1) iGluR (2) Insulin Receptor (2) Isotope-Labeled Compounds (1) MMP (1) Notch (1) PAK (1) PKC (1) Prostaglandin Receptor (2) RXFP Receptor (2) Ser/Thr Protease (1) SOD (1) Sodium Channel (1) Toll-like Receptor (TLR) (3) TRP Channel (1) Wnt (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (3) Endocrinology (4) Infection (5) Inflammation/Immunology (7) Metabolic Disease (8) Neurological Disease (8)
Click Chemistry:	DBCO (3) Azide (4) Alkynes (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010712

Fmoc-His(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH₂. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation .

HY-156628

Opevesostat	Cytochrome P450	Others
Opevesostat is a cholesterol side-chain cleavage enzyme (CYP11A1) inhibitor .

HY-13987

(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid D-phenylalanine analogue	Others	Others
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.

HY-P2727

Chondroitinase ABC ChABC	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury .

HY-147232

N-Acryloyl-1-pyrenebutylamine	Fluorescent Dye	Others
N-Acryloyl-1-pyrenebutylamine is a potent fluorescent derivatization agent. N-Acryloyl-1-pyrenebutylamine combines with an alkyl-acrylamide side-chain to give fluorescence function on the polymer. .

HY-148614

Isocaproaldehyde 4-Methylpentanal; 4-Methylvaleraldehyde	Others	Metabolic Disease
Isocaproaldehyde is a product of side-chain cleavage of cholesterol. Isocaproaldehyde is an endogenous specific substrate of mouse vas deferens protein (MVDP) .

HY-124279

14-Pentadecenoic acid	Others	Others
14-Pentadecenoic acid is a 15-carbon long-chain fatty acid that contains an olefin functional group on the terminal carbon of its fatty tail. 14-Pentadecenoic acid can be used as a fibrous scaffold biomaterial for tissue engineering applications, as well as a metal-forming side-chain polymer for constructing capillary columns in gas chromatography .

HY-W010712S1

Fmoc-His(Trt)-OH-15N3	Isotope-Labeled Compounds	Others
Fmoc-His(Trt)-OH- ¹⁵N₃ is the ¹⁵N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].

HY-151787

Fmoc-L-Lys(N3-Aca-DIM)-OH	ADC Linker	Others
Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151786

Fmoc-L-Lys(Pentynoyl-DIM)-OH	ADC Linker	Others
Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-120128

MTSEA hydrobromide	Others	Neurological Disease
MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain approximately the size of lysine .

HY-119847

Abafungin BAY-W-6341	Fungal	Infection
Abafungin, a antifungal agent, inhibitis the transmethylation at the C-24 position of the sterol side chain, catalyzed by the enzyme sterol-C-24-methyltransferase.

HY-E70103

α-L-Arabinofuranosidase	Others	Others
α-L-Arabinofuranosidase is a glycosidic hydrolase. α-L-Arabinofuranosidase hydrolyse the nonreducing termini of the a-l-arabinofuranosyl residues as side chains of arabinoxylan, arabinan and arabinogalactan .

HY-101737

24-Norursodeoxycholic acid Norucholic acid; nor-UDCA	Others	Inflammation/Immunology
24-norursodeoxycholic acid (Norucholic acid) is a side chain-shortened C₂₃ homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.

HY-104031

tCFA15	Notch	Neurological Disease
tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.

HY-116917

G-9791	PAK	Cancer
G-9791, a poyridone side chain analogue, is a potent PAK inhibitor with K_i values of 0.95 nM and 2.0 nM for PAK1 and PAK2, respectively .

HY-162397

Neopetromin	Others	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

HY-136829

BPH-675	Others	Others
BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC₅₀ of 0.71 μM .

HY-P1512

Antioxidant peptide A	SOD	Cancer
Antioxidant peptide A is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. The side chains of Antioxidant peptide A are believed to contribute to strong radical scavenging activities of peptides in the cancer cell.

HY-N2380

N-Benzoyl-(2R,3S)-3-phenylisoserine	Others	Cancer
N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol .

HY-139276

Pal-Glu(OSu)-OH	GLP Receptor	Others
Pal-Glu(OSu)-OH is a side chain of Liraglutide. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used for type 2 diabetes mellitus research .

HY-145263

VD2173	Ser/Thr Protease	Cancer
VD2173 is a side chain cyclized macrocyclic peptide inhibitor of HGF-activating serine proteases. VD2173 potently inhibits matriptase and hepsin. VD2173 can be used for the research of lung cancer .

HY-122106

RS-104966	MMP	Others
RS-104966 is a potent collagenase-1 (MMP-1) inhibitor. RS-104966 induces a conformational change in the side chains of the S10 pocket of MMP-1 .

HY-129748

SQ-24798	Others	Others
SQ-24,798 is a compound that inhibits carboxypeptidase B with high affinity and specificity. Its inhibitory effect may be achieved through the binding of the sulfhydryl group to the zinc ion of the enzyme and specific side chains.

HY-W017189

3-Phenylbutyric acid	Endogenous Metabolite	Metabolic Disease
3-Phenylbutyric acid is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain. 3-Phenylbutyric acid can be used to isolate Rhodococcus rhodochrous PB1 from compost soil .

HY-D0807

5-IAF 5-Iodoacetamidofluorescein	Fluorescent Dye	Cancer
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-N1077

Vomifoliol	Cholinesterase (ChE) Endogenous Metabolite	Others
Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate antileishmanial activity .

HY-W014134

p-APMSF hydrochloride p-Amidinophenylmethylsulfonylfluoride hydrochloride	Others	Others
p-APMSF is an irreversible inhibitor of serinase. p-APMSF has substrate specificity for positively charged side chains of amino acids, lysine, or arginine. p-APMSF can be used to study the irreversible inhibition of trypsin and thrombin .

HY-135585

LY88074	Others	Endocrinology
LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner .

HY-151781

Fmoc-L-Dap(Poc)-OH	ADC Linker	Others
Fmoc-L-Dap(Poc)-OH is a click chemistry reagent containing an azide group. Amino acid building block suitable for side chain Click conjugation with standard protocols and together with tetrazine linkers in copper-free Click conjugation (Diels-Alder) .

HY-113630A

20β-22-Azacholesterol	Others	Others
20β-22-Azacholesterol is the β-configuration of 22-Azacholesterol (HY-113630). 20β-22-Azacholesterol is an inhibitor for cholesterol side chain cleavage reactions .

HY-137002

Fmoc-N-Me-Arg(Pbf)-OH	Amino Acid Derivatives	Others
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .

HY-N9457

Norcholic acid	Others	Metabolic Disease Endocrinology
Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine .

HY-13620

Elinafide LU 79553	Others	Cancer
Elinafide is an anticancer agent with a naphthalimide structure that targets DNA. Elinafide interferes with cell metabolism by inserting a planar ring into the DNA double helix and interacting with enzymes through its side chain. The IC₅₀ value of Elinafide for HT-29 cells is 0.014 μM .

HY-N9439

6-O-β-D-Galactopyranosyl-D-galactose	Others	Others
6-O-β-D-Galactopyranosyl-D-galactose, a disaccharide, is a part of the polysaccharide main chain with β-(1→6)-glycoside bonds with a side chain bonded to the main one by the β-(1→3) bond .

HY-145657

Benzoquinoquinoxaline BQQ	Others	Others
Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with an aminoalkyl side chain. Benzoquinoquinoxaline preferentially binds to DNA triplex structures, intercalates between the bases, thus, stabilising the triplex conformation. Conjugation of Benzoquinoquinoxaline to 1,10-phenanthroline specifically binds and cleaves double strand DNA at the site of formation of a triplex structure .

HY-W096122

DTSSP Crosslinker disodium	Others	Others
DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .

HY-W414380

Bdp tr nhs ester	Fluorescent Dye	Others
Bdp tr nhs ester is a chemiluminescent coupling compound with a long excited state lifetime for immunoassays and is suitable for microscopy and fluorescence polarization analysis applications. NHS ester can react specifically and efficiently with the side chains of primary amines such as lysine residues or amino silane coated surfaces under neutral or weakly basic conditions to form covalent bonds .

HY-P2834

Penicillin amidase, E. coli PGA	Biochemical Assay Reagents	Infection Cancer
Penicillin amidase (EC 3.5.1.11) (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics .

HY-131618

Hippuryl-Arg Bz-Gly-Arg	Amino Acid Derivatives	Others
Hippuryl-Arg (Bz-Gly-Arg) is a substrate used for fluorescence detection and is commonly used in biochemical studies, especially in studying enzyme activity. The phenylalanine portion of Hippuryl-Arg is connected by an aromatic side chain, which allows it to be detected under ultraviolet light. Hippuryl-Arg is used to detect enzymes that recognize and cut peptide bonds containing arginine .

HY-118051

LY 186826	Antibiotic	Infection
LY 186826 is a γ-lactam antibiotic containing an aminothioazole methoxyacetic acid side chain at the C-7 position. LY186826 exhibits potent antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria. LY186826 is inactivated by β-lactamases and Enterobacterases, showing stronger activity against Enterobacter strains.

HY-118242

RU 45144	Others	Others
RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.

HY-150502

Poly(styrenyl acetal trehalose) pSAT	Biochemical Assay Reagents	Others
Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals. Poly(styrenyl acetal trehalose) stabilizes a variety of proteins and enzymes against fluctuations in temperature, and does not trigger the innate immune response. Poly(styrenyl acetal trehalose) can be used in synthesis of protein-polymer conjugates for reduced renal clearance of the biomolecule .

HY-121841

Cannabidiorcol O-1821; CBD-C1	TRP Channel	Inflammation/Immunology Cancer
Cannabidiorcol (CBDO, CBD-C1, O-1821) is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors (CBs) and is an agonist of the transient receptor potential channel (TRP channel), through which it produces antiinflammatory effects, but can also promote tumorigenesis at high concentrations .

HY-163267

ZNL0325	Others	Others
ZNL0325 is a covalent probe based on pyrazolopyrimidine. ZNL0325 features an acrylamide side chain at the C3 position, which is capable of forming covalent bonds with multiple kinases that possess a cysteine at the αD-1 position, including BTK, EGFR, BLK, and JAK3. ZNL0325 can be used in the research of creating structurally distinct covalent kinase inhibitors .

HY-123564

Mcl1-IN-7	Others	Others
Mcl1-IN-7 (compound 11) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. By covalently targeting the non-catalytic lysine side chain of Mcl-1, it has higher potency than non-covalent counterparts and can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.

HY-P4062

Insulin peglispro BIL	Insulin Receptor	Metabolic Disease
Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins .

HY-135593

LY88074 analog 1	Others	Endocrinology
LY88074 analog 1 is a benzothiophene compound with nitrogen-containing non-basic side chains, Compound 26, extracted from patent EP0747380A1. LY88074 analog 1 is an agent for alleviating the symptoms of post-menopausal symptoms, such as osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. LY88074 analog 1 can be used alone or in combination with estrogen or progestin .

HY-P4890

Relaxin H3 (human)	RXFP Receptor	Neurological Disease
Relaxin H3 (human) is a kind of relaxin peptide. Relaxin H3 (human) exerts antifibrotic actions via RXFP1 .

HY-P4890A

Relaxin H3 (human) (TFA)	RXFP Receptor	Neurological Disease
Relaxin H3 (human) (TFA) is a kind of relaxin peptide. Relaxin H3 (human) (TFA) exerts antifibrotic actions via RXFP1 .

Cat. No.	Product Name

HY-L913

Tyrosine Focused Covalent Fragment Library

124 compounds

Recently, significant advancements in tyrosine-targeting electrophiles have primarily occurred in the field of protein-protein interactions (PPIs), where cysteine residues are often underrepresented and novel chemistries are needed to address these interfaces. In this context, tyrosines are frequently more accessible compared to more buried binding sites. Moreover, they are commonly found at "hot spots," which are functional epitopes of PPIs, with 12.3% of the residues consisting of tyrosines. This prevalence is likely due to the hydrophobic nature of tyrosine, its ability to participate in aromatic π-interactions, and its capacity for hydrogen bonding. Beyond PPIs, some progress has also been made in covalent tyrosine targeting in other areas where more commonly addressed side chains are lacking. Even though tyrosine has a slightly lower pKa value compared to the protonated lysine side chain (approximately 10 vs. 10.5 for the unprotected amino acid side chains), significantly less progress has been made in the development of tyrosine-targeted covalent ligands compared to lysine. This is likely due to the reduced flexibility of the tyrosine side chain and the greater steric hindrance of its hydroxy group, which makes it more challenging to adopt suitable reaction geometries.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 124 fragment molecules which can target tyrosine residue and can be used for fragment-based covalent drug discovery.

HY-L0119V

Asinex PPI Pre-Plated Library

3,253 compounds

Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.

The PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. The designs cover β-turn / loop mimetics and α-helix mimetics. Since helices present at the interface in 62% of all protein-protein interactions. This library focused on designs including mimics with the substitution geometry of an a-helices, as well as designs that mimic the location of “hot-spot” side chains in helix-mediated PPIs.

Cat. No.	Product Name	Type

HY-D0807

5-IAF 5-Iodoacetamidofluorescein	Fluorescent Dyes/Probes
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-W414380

Bdp tr nhs ester

Fluorescent Dyes/Probes

Bdp tr nhs ester is a chemiluminescent coupling compound with a long excited state lifetime for immunoassays and is suitable for microscopy and fluorescence polarization analysis applications. NHS ester can react specifically and efficiently with the side chains of primary amines such as lysine residues or amino silane coated surfaces under neutral or weakly basic conditions to form covalent bonds .

Cat. No.	Product Name	Type

HY-D1056A3

Lipopolysaccharides, from E. coli O26:B6

LPS, from Escherichia coli (O26:B6)

Carbohydrates

Lipopolysaccharides, from E. coli O26:B6 is a lipopolysaccharide endotoxin and TLR-4 activator that activates the disease-related molecular pattern (PAMP) of the immune system and induces cell secretion of migratory bodies. Lipopolysaccharides, from E. coli O26:B6 consists of an antigen-specific O-chain, some cells lack an O-antigen-side chain, and is recognized by the core-specific monoclonal antibody MAb J8-4C10 .

HY-D1056E

Lipopolysaccharides, from P. aeruginosa 10

LPS, from Pseudomonas aeruginosa (10)

Carbohydrates

Lipopolysaccharides from P. aeruginosa 10 are lipopolysaccharide endotoxins composed of an O-specific antigen chain, a core oligosaccharide, and lipid A. The lipopolysaccharides from P. aeruginosa 10 have a fatty acid composition that differs from that of typical Enterobacteriaceae, with unusually high levels of phosphorylation (with detected triphosphate residues) and a unique external region of the core oligosaccharide, while the O-specific side chains are often rich in novel amino sugars. The susceptibility of Lipopolysaccharides from P. aeruginosa 10 to viruses is related to the high molecular weight polysaccharide content in its components. The absence of high molecular weight polysaccharides increases its sensitivity to bacteriophages .

HY-D1056B3

Lipopolysaccharides, from Klebsiella pneumoniae

LPS, from bacterial (Klebsiella pneumoniae)

Carbohydrates

Lipopolysaccharides, from Klebsiella, are lipopolysaccharide endotoxins. Lipopolysaccharides, from Klebsiella pneumoniae, consist of three parts: lipid A, core oligosaccharide, and O-specific antigen or O-side chain. In smooth LPS, the core region is divided into two areas: the inner core near the lipid A and the outer core that provides attachment sites for the O-antigen. In the lipopolysaccharide of Klebsiella pneumoniae, the l,d-HeppII at the O-3 position can be replaced by an α-d-galacturonic acid residue (α-d-GalpA). In most studied Enterobacteriaceae, the core LPS contains inner core phosphorylation modifications, but the core LPS of Klebsiella pneumoniae lacks this modification. The unique core structure plays an important role in the outer membrane permeability and pathogenesis of Klebsiella pneumoniae .

HY-W127487

N-Octadecanoyl-L-homoserine lactone

Drug Delivery

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.

Cat. No.	Product Name	Target	Research Area

HY-W010712

Fmoc-His(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH₂. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation .

HY-P1512A

Antioxidant peptide A TFA	Peptides	Cancer
Antioxidant peptide A TFA is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. The side chains of Antioxidant peptide A are believed to contribute to strong radical scavenging activities of peptides in the cancer cell .

HY-137002

Fmoc-N-Me-Arg(Pbf)-OH	Amino Acid Derivatives	Others
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .

HY-P1195

PDZ1 Domain inhibitor peptide	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-P1512

Antioxidant peptide A	SOD	Cancer
Antioxidant peptide A is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. The side chains of Antioxidant peptide A are believed to contribute to strong radical scavenging activities of peptides in the cancer cell.

HY-P4062

Insulin peglispro BIL	Insulin Receptor	Metabolic Disease
Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins .

HY-P4890

Relaxin H3 (human)	RXFP Receptor	Neurological Disease
Relaxin H3 (human) is a kind of relaxin peptide. Relaxin H3 (human) exerts antifibrotic actions via RXFP1 .

HY-P4890A

Relaxin H3 (human) (TFA)	RXFP Receptor	Neurological Disease
Relaxin H3 (human) (TFA) is a kind of relaxin peptide. Relaxin H3 (human) (TFA) exerts antifibrotic actions via RXFP1 .

HY-P10204

FZD7 antagonist 1	Wnt	Cancer
FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a with IC₅₀ value of 9.2 nM. FZD7 antagonist 1 blocks TcdB−FZD interaction via targeting FZD receptors .

HY-151641

3-Azido-L-alanine	Peptides	Others
3-Azido-L-alanine is an aliphatic functionalized amino acid with side chain lengths of up to four carbons . 3-Azido-L-alanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P1195A

PDZ1 Domain inhibitor peptide TFA	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-P3479

Insulin (swine)	Insulin Receptor	Metabolic Disease
Insulin (swine) is a porcine-derived insulin used in diabetes research .

HY-P1372

PKC ζ pseudosubstrate	PKC	Others
PKC ζ pseudosubstrate, a PKC ζ inhibitor peptide, can be attached to cell permeabilization vector peptide .

HY-P10014

Bibapcitide	Peptides	Cardiovascular Disease
Bibapcitide, a 26 amino acid, inhibits thrombosis .

HY-P3432

DfTat	Peptides	Others
DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2380

N-Benzoyl-(2R,3S)-3-phenylisoserine	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Taxaceae Source classification Plants Disease Research Fields Taxus wallichiana Zucc. Cancer	Others
N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol .

HY-W017189

3-Phenylbutyric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Phenylbutyric acid is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain. 3-Phenylbutyric acid can be used to isolate Rhodococcus rhodochrous PB1 from compost soil .

HY-N1077

Vomifoliol	Structural Classification Natural Products Classification of Application Fields Source classification Plants Endogenous metabolite Agricultural Research Human Gut Microbiota Metabolites Microorganisms other families Other Diseases Abscisic acid Phytohormone Disease Research Fields	Cholinesterase (ChE) Endogenous Metabolite
Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate antileishmanial activity .

HY-N9457

Norcholic acid	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Others
Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine .

HY-N9439

6-O-β-D-Galactopyranosyl-D-galactose	Polysaccharides Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
6-O-β-D-Galactopyranosyl-D-galactose, a disaccharide, is a part of the polysaccharide main chain with β-(1→6)-glycoside bonds with a side chain bonded to the main one by the β-(1→3) bond .

HY-P2834

Penicillin amidase, E. coli PGA	Classification of Application Fields Disease Research Fields Cancer	Biochemical Assay Reagents
Penicillin amidase (EC 3.5.1.11) (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics .

HY-12545

Brevetoxin-3 PbTx-3	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Sodium Channel
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺?channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

HY-148614

Isocaproaldehyde 4-Methylpentanal; 4-Methylvaleraldehyde	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
Isocaproaldehyde is a product of side-chain cleavage of cholesterol. Isocaproaldehyde is an endogenous specific substrate of mouse vas deferens protein (MVDP) .

HY-162397

Neopetromin	Structural Classification Monophenols Microorganisms Source classification Phenols	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

HY-113630A

20β-22-Azacholesterol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
20β-22-Azacholesterol is the β-configuration of 22-Azacholesterol (HY-113630). 20β-22-Azacholesterol is an inhibitor for cholesterol side chain cleavage reactions .

Cat. No.	Product Name	Chemical Structure

HY-W010712S1

Fmoc-His(Trt)-OH-15N3
Fmoc-His(Trt)-OH- ¹⁵N₃ is the ¹⁵N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81223

	CYP11A1 Antibody Cholesterol 20 22 desmolase antibody Cholesterol desmolase antibody; Cholesterol monooxygenase (side chain cleaving) antibody; Cholesterol side chain cleavage enzyme antibody; Cholesterol side chain cleavage enzyme mitochondrial antibody; Cholesterol side-chain cleavage enzyme antibody; CP11A_HUMAN antibody; CYP11A antibody; CYP11A1 antibody; CYPXIA1 antibody; Cytochrome P450 11A1 antibody; Cytochrome P450 11A1 mitochondrial antibody; Cytochrome P450 family 11 subfamily A polypeptide 1 antibody; Cytochrome P450 subfamily XIA antibody; Cytochrome P450(scc) antibody; Cytochrome P450C11A1 antibody; mitochondrial antibody; P450SCC antibody; Steroid 20 22 lyase antibody	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	CYP11A1 Antibody is an unconjugated, approximately 53 kDa, rabbit-derived, anti-CYP11A1 polyclonal antibody. CYP11A1 Antibody can be used for: WB,IHC-F,IHC-P,ICC/IF expriments in human, mouse, rat background without labeling.

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Cat. No.	Product Name		Classification

HY-W336328

3-Azido-L-alanine hydrochloride		Azide
3-Azido-L-alanine hydrochloride is an aliphatic functionalized amino acid with side chain lengths of up to four carbons . 3-Azido-L-alanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151835

DBCO-PEG24-NHS ester		DBCO
DBCO-PEG24-NHS ester is a click chemistry reagent. DBCO-PEG24-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

HY-151827

DBCO-PEG2-NHS ester		DBCO
DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

HY-151787

Fmoc-L-Lys(N3-Aca-DIM)-OH		Azide
Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151786

Fmoc-L-Lys(Pentynoyl-DIM)-OH		Azide Alkynes
Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151781

Fmoc-L-Dap(Poc)-OH		Alkynes
Fmoc-L-Dap(Poc)-OH is a click chemistry reagent containing an azide group. Amino acid building block suitable for side chain Click conjugation with standard protocols and together with tetrazine linkers in copper-free Click conjugation (Diels-Alder) .

HY-151641

3-Azido-L-alanine		Azide
3-Azido-L-alanine is an aliphatic functionalized amino acid with side chain lengths of up to four carbons . 3-Azido-L-alanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-160773

DBCO-PEG6-NHS ester		DBCO
DBCO-PEG6-NHS ester is a click chemistry PEG reagent containing an NHS ester that reacts specifically with primary amines, such as side chains of lysine residues or aminosilane-coated surfaces, under neutral or slightly alkaline conditions. , efficient reaction to form covalent bonds. DBCO-PEG6-NHS ester also contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

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