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Results for "

superoxide anions

" in MedChemExpress (MCE) Product Catalog:

44

Inhibitors & Agonists

4

Fluorescent Dye

1

Biochemical Assay Reagents

3

Peptides

20

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130015
    HKSOX-1 (5/6-mixture)
    2 Publications Verification

    		 Reactive Oxygen Species Others
    HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical .
    HKSOX-1 (5/6-mixture)
  • HY-130017
    HKSOX-1r (5/6-mixture)

    		Reactive Oxygen Species Others
    HKSOX-1r (5/6-mixture) is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1r (5/6-mixture) exhibits excellent selectivity and sensitivity towards superoxide anion radical .
    HKSOX-1r (5/6-mixture)
  • HY-N10450
    Kumujian A

    1-Ethoxycarbonyl-β-carboline

    		 Reactive Oxygen Species Inflammation/Immunology
    Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL) .
    Kumujian A
  • HY-N9895
    3,5-Dicaffeoyl-epi-quinic acid

    		Others Infection Inflammation/Immunology
    3,5-Dicaffeoyl-epi-quinic acid can be extracted from Chrysanthemum morifolium. 3,5-Dicaffeoyl-epi-quinic acid has antioxidant activities. 3,5-Dicaffeoyl-epi-quinic acid can scavenge DPPH radical and superoxide anion radical, with IC50s of 5.6 and 2.9 μg/mL respectively .
    3,5-Dicaffeoyl-epi-quinic acid
  • HY-121137
    BMPO

    BocMPO

    		 Others Others
    BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals .
    BMPO
  • HY-125792
    Nexinhib20

    		Reactive Oxygen Species Ras Inflammation/Immunology
    Nexinhib20 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC50 of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity .
    Nexinhib20
  • HY-N11895
    Isorabaichromone

    		Reactive Oxygen Species Inflammation/Immunology
    Isorabaichromone is a potent antioxidant agent. Isorabaichromone shows a potent antioxidative activity and exhibits DPPH radical and superoxide anion scavenging activities .
    Isorabaichromone
  • HY-126603
    Asperlactone

    		Others Infection
    Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .
    Asperlactone
  • HY-149422
    NIR-FP

    		Fluorescent Dye Neurological Disease
    NIR-FP is a near-infrared fluorescent probe with high sensitivity and selectivity for superoxide anion O 2-. O 2- is the main precursor of ROS, and ferroptosis-mediated epilepsy models can be dynamically tracked by detecting O 2-. Ferroptosis-mediated epilepsy models include: kainic acid (HY-N2309)-induced chronic epilepsy model, Pentylenetetrazole-induced acute epilepsy model, and pilocarpine (HY-B0726A)-induced epilepsy model .
    NIR-FP
  • HY-N9095
    Curculigoside C

    		Others Neurological Disease
    Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively .
    Curculigoside C
  • HY-N8217
    4-O-Cinnamoylquinic acid

    		Others Inflammation/Immunology
    4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .
    4-O-Cinnamoylquinic acid
  • HY-U00005
    AD 0261

    		Reactive Oxygen Species Inflammation/Immunology
    AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
    AD 0261
  • HY-N2183
    Baimaside

    Quercetin 3-O-sophoroside

    		 Others Others
    Baimaside (Quercetin 3-O-sophoroside) is isolated from the flowers of A. venetum, is a scavenger of superoxide anions .
    Baimaside
  • HY-156468
    Antioxidant agent-17

    		Others Inflammation/Immunology
    Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC50 of 9.06 nM .
    Antioxidant agent-17
  • HY-129064
    Superoxide dismutase, Porcine erythrocytes

    SOD

    		 SOD Inflammation/Immunology Cancer
    Superoxide dismutase, Porcine erythrocytes (SOD) is the only antioxidant enzyme that scavenges the superoxide anion by converting this free radical to oxygen and hydrogen peroxide, thus preventing peroxynitrite production and further damage. Superoxide dismutase, Porcine erythrocytes is extensively researched and used in anti-inflammatory, antitumor, radiation protection, and antisenility applications .
    Superoxide dismutase, Porcine erythrocytes
  • HY-N1579
    Pyrogallol
    3 Publications Verification

    		 Endogenous Metabolite Fungal Apoptosis Infection
    Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.
    Pyrogallol
  • HY-E70378
    Mn Superoxide dismutase

    Mn SOD

    		 Others Cardiovascular Disease Neurological Disease Cancer
    Mn Superoxide dismutase (Mn SOD) is an antioxidant enzyme present in mitochondria, which catalyzes the dismutation of superoxide anions (O2 ·-) into oxygen (O2) and hydrogen peroxide (H2O2). Mn Superoxide dismutase protects cells from oxidative damage and plays a role in transplant rejection, neurodegenerative diseases, cardiovascular diseases, and cancer .
    Mn Superoxide dismutase
  • HY-N11564
    Aristololactam IIIa

    		Elastase Inflammation/Immunology
    Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively .
    Aristololactam IIIa
  • HY-N9447
    Norbergenin
    1 Publications Verification

    		 Reactive Oxygen Species Neurological Disease
    Norbergenin, the O-demethyl derivative of bergenin, shows moderate antioxidant activity (IC50 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging) .
    Norbergenin
  • HY-N8447
    3'-O-Methylmurraol

    		Others Others
    3'-O-Methylmurraol is a coumarinthat can be found in Cnidium monnieri. 3'-O-Methylmurraol inhibits superoxide radical anion generation and elastase release .
    3'-O-Methylmurraol
  • HY-161502
    DHX-SP

    		Fluorescent Dye Others
    DHX-SP is a fluorescent probe, which visualizes superoxide anion (O2 ·–) and peroxynitrite (ONOO –) during ferroptosis of PC12 cells and in the Parkinson’s disease model .
    DHX-SP
  • HY-N12914
    Tanzawaic acid B

    (+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E

    		 Reactive Oxygen Species Others
    Tanzawaic acid B ((+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E) is a superoxide anion production inhibitor and can be isolated from Penicillium citrinum .
    Tanzawaic acid B
  • HY-132132
    Neutrophil elastase inhibitor 3

    		Elastase Inflammation/Immunology
    Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release .
    Neutrophil elastase inhibitor 3
  • HY-N2183R
    Baimaside (Standard)

    		Others Others
    Baimaside (Standard) is the analytical standard of Baimaside. This product is intended for research and analytical applications. Baimaside (Quercetin 3-O-sophoroside) is isolated from the flowers of A. venetum, is a scavenger of superoxide anions .
    Baimaside (Standard)
  • HY-N4096
    Tsugaric acid A

    		Others Inflammation/Immunology
    Tsugaric acid A can significantly inhibit superoxide anion formation. Tsugaric acid A also protects human keratinocytes against damage induced by ultraviolet B (UV B) light. Tsugaric acid A can protect keratinocytes from photodamage.
    Tsugaric acid A
  • HY-N1579R
    Pyrogallol (Standard)

    		Endogenous Metabolite Fungal Apoptosis Infection
    Pyrogallol (Standard) is the analytical standard of Pyrogallol. This product is intended for research and analytical applications. Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.
    Pyrogallol (Standard)
  • HY-P10724
    fMIFL

    		Formyl Peptide Receptor (FPR) Bacterial Infection
    fMIFL is an FPR1 agonist. fMIFL can activate several signaling pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, secretion of granule exocytosis, and the production of superoxide anions. fMIFL can be used in research on bacterial infections and tissue damage .
    fMIFL
  • HY-N3464
    Isopedicin

    		Phosphodiesterase (PDE) Metabolic Disease
    Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity .
    Isopedicin
  • HY-116730
    CHS-111

    		Reactive Oxygen Species Others
    CHS-111 is a benzyl indazole inhibitor of superoxide anion O 2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC50 of 3.9 μM .
    CHS-111
  • HY-P1118
    Ac9-25

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .
    Ac9-25
  • HY-P1118A
    Ac9-25 TFA

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .
    Ac9-25 TFA
  • HY-D0720
    Lucigenin
    4 Publications Verification

    NSC-151912; L-6868

    		 Fluorescent Dye Reactive Oxygen Species Others
    Lucigenin is a chemiluminescence probe. Lucigenin can be used to detect the production of endogenous superoxide anion radical (O 2-). Lucigenin is extremely sensitive to chloride ions, while it combined with chloride ions, the fluorescence will be quenched. Lucigenin also can be used as a chloride indicator. Ex/Em=455/505 nm .
    Lucigenin
  • HY-18743
    Coelenterazine
    3 Publications Verification

    		 Reactive Oxygen Species Cancer
    Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .
    Coelenterazine
  • HY-N7885
    (25R)-Spirost-4-ene-3,12-dione

    (-)-(25R)-Spirost-4-ene-3,12-dione

    		 Others Inflammation/Immunology
    (25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .
    (25R)-Spirost-4-ene-3,12-dione
  • HY-156241
    Meliadubin B

    		NO Synthase Fungal Infection Inflammation/Immunology
    Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC50 of 182.50 μM.
    Meliadubin B
  • HY-117971
    BVT173187

    		Others Others
    BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.
    BVT173187
  • HY-N9295
    3,4-Seco-4(23),20(29)-lupadiene-3,28-dioic acid

    		Others Metabolic Disease
    3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid (Compound 5) is a triterpenoid compound. 3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid has a strong inhibitory effect on the production of superoxide anions, and the inhibitory rate is 86.9±2.8% at 1 μM .
    3,4-Seco-4(23),20(29)-lupadiene-3,28-dioic acid
  • HY-101283
    HCH6-1
    3 Publications Verification

    		 Formyl Peptide Receptor (FPR) Inflammation/Immunology
    HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
    HCH6-1
  • HY-121586
    Nafazatrom

    Bay g 6575

    		 Others Cardiovascular Disease
    Nafazatrom (Bay g 6575) is an orally active cardioprotective agent that protects against ischemic damage. Nafazatrom dose-dependently inhibits neutrophil aggregation, superoxide anion generation, arachidonic acid metabolism, and to a lesser extent the release of β-glucosidase, platelet aggregation or arachidonic acid in vitro. Acid metabolism has no significant effect. In a dog ischemia-reperfusion model, Nafazatrom (10 mg/kg; po) reduced infarct size and the occurrence of arrhythmias and rescued ischemic myocardial function without affecting any hemodynamic changes. The basis of Nafazatrom's cardioprotection may be inhibition of neutrophil function and cellular infiltration in vitro .
    Nafazatrom
  • HY-119038
    ML-7

    		Others Cardiovascular Disease
    ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury .
    ML-7
  • HY-W744699
    Larixol

    (+)-Larixol

    		 Src ERK Akt Inflammation/Immunology
    Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC50: 1.98 μM), cathepsin G release (IC50: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .
    Larixol
  • HY-W745090
    Isomaltulose monohydrate

    		Formyl Peptide Receptor (FPR) Src ERK Akt p38 MAPK Others
    Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC50: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .
    Isomaltulose monohydrate
  • HY-130743
    Dieugenol

    Bis-eugenol; Dehydrodieugenol

    		 Parasite Infection
    Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
    Dieugenol
  • HY-150175
    HKSOX-1

    		Fluorescent Dye Inflammation/Immunology
    HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2 •−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2 •−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2 •− roles in inflammation, mitochondrial stress, and other physiological processes .
    HKSOX-1

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