Search Result

Results for "

vascular smooth muscle

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (1) Angiotensin Receptor (15) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (9) Autophagy (14) Bcl-2 Family (1) Biochemical Assay Reagents (1) Bradykinin Receptor (2) Calcium Channel (21) Cathepsin (1) CGRP Receptor (2) COX (1) Cyclic GMP-AMP Synthase (3) Drug Metabolite (2) EGFR (3) Endogenous Metabolite (15) Endothelin Receptor (2) ERK (7) Estrogen Receptor/ERR (1) Ferroptosis (2) FGFR (1) FLT3 (2) Fluorescent Dye (1) GABA Receptor (2) Guanylate Cyclase (1) Histamine Receptor (1) Histone Demethylase (4) HMG-CoA Reductase (HMGCR) (9) Interleukin Related (1) Isotope-Labeled Compounds (3) MEK (1) Mitophagy (2) NO Synthase (5) p38 MAPK (1) PDGFR (5) PERK (1) Phosphatase (2) Phosphodiesterase (PDE) (1) PKA (3) Potassium Channel (3) Prostaglandin Receptor (7) Protease Activated Receptor (PAR) (2) Ser/Thr Protease (2) Sodium Channel (2) Src (1) Thyroid Hormone Receptor (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (35) Cardiovascular Disease (77) Endocrinology (15) Infection (2) Inflammation/Immunology (10) Metabolic Disease (14) Neurological Disease (17)
Oligonucleotides:	Solubilizing Agents (1)

111

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: VEGFR VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108589

PNU 37883 hydrochloride PNU 37883A	Potassium Channel	Neurological Disease
PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, K_ATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells .

HY-N0455

L-Arginine 5+ Cited Publications	NO Synthase Endogenous Metabolite	Cardiovascular Disease Cancer
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455A

L-Arginine hydrochloride 5+ Cited Publications (S)-(+)-Arginine hydrochloride	NO Synthase Endogenous Metabolite	Cancer
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-121018

Daltroban BM-13505; SKF 96148	Prostaglandin Receptor	Cardiovascular Disease
Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury .

HY-N1082

Visnagin	Others	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles .

HY-B0309

Felodipine 1 Publications Verification	Calcium Channel Autophagy	Cardiovascular Disease
Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-134367

Ap2A disodium	Others	Cardiovascular Disease
Ap2A (disodium) is a symmetrical dinucleoside polyphosphate. Ap2A (disodium) can promote the growth of vascular smooth muscle cells .

HY-134368

Ap3A	Others	Cardiovascular Disease
Ap3A is a vasoactive molecule. Ap3A can promote the growth of vascular smooth muscle cells .

HY-142050

(R)-IDHP	Calcium Channel	Cardiovascular Disease
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca ²⁺ release and Ca ²⁺ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease .

HY-106890

E4177 57G709	Angiotensin Receptor PDGFR	Cardiovascular Disease
E4177 (57G709) is an orally active angiotensin II receptor antagonist. E4177 can inhibit the growth of vascular smooth muscle cells (HASMC) and the increase of cell surface area. In addition, E4177 can also increase the expression of platelet-derived growth factor (PDGF) receptor. E4177 can be used in the study of vascular diseases .

HY-N0455R

L-Arginine (Standard)	NO Synthase Endogenous Metabolite	Cardiovascular Disease Cancer
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455AR

L-Arginine hydrochloride (Standard)	NO Synthase Endogenous Metabolite	Cancer
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-101607A

KT-362 free acid	Calcium Channel	Cardiovascular Disease
KT-362 free acid is an intracellular calcium antagonist with antiarrhythmic and vasodilatory effects. KT-362 free acid shows an antagonistic effect against norepinephrine (NE) induced vasoconstriction response, achieved by reducing inositol phospholipid hydrolysis, thereby reducing intracellular calcium mobilization. KT-362 free acid can be used to study the contraction and relaxation mechanisms of vascular smooth muscle, especially in exploring the role of intracellular calcium mobilization and inositol phospholipid hydrolysis in vascular contraction .

HY-B0309R

Felodipine (Standard)	Calcium Channel Autophagy	Cardiovascular Disease
Felodipine (Standard) is the analytical standard of Felodipine. This product is intended for research and analytical applications. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-14664A

Fluvastatin sodium 10+ Cited Publications XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-B1815

Xanthinol Nicotinate Xanthinol Niacinate	Others	Cardiovascular Disease
Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-14664

Fluvastatin 10+ Cited Publications XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-14664AR

Fluvastatin sodium (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Fluvastatin (sodium) (Standard) is the analytical standard of Fluvastatin (sodium). This product is intended for research and analytical applications. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-160980

Sornidipine	Calcium Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Sornidipine is a calcium channel blocker. Sornidipine also reduces neurogenic inflammation. Sornidipine reduces the inflow of calcium ions into cells by blocking L-type calcium channels, thereby reducing the contraction of vascular smooth muscle, leading to vasodilation and decreased blood pressure. Sornidipine can be used to study the cardiovascular system especially in hypertension and related cardiovascular diseases .

HY-15404

Darusentan Lu-135252	Endothelin Receptor	Cardiovascular Disease Endocrinology
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a K_i of 1.4 nM to the ET-A receptor and a K_i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors . Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K_i of 13 nM .

HY-138822

2,3-Diphospho-D-glyceric acid pentasodium salt 2,3-DPG pentasodium salt	Others	Cardiovascular Disease
2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects .

HY-14664B

(3R,5S)-Fluvastatin (3R,5S)-XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-14664DS

(3S,5R)-Fluvastatin-d6 (3S,5R)-XU 62-320-d₆ free acid	Autophagy	Cardiovascular Disease Cancer
(3S,5R)-Fluvastatin-d₆ is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

HY-112417

Ki11502	PDGFR FLT3 Apoptosis Akt PERK Bcl-2 Family	Cardiovascular Disease Cancer
Ki11502 is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGF β/α receptors with IC₅₀ values less than 10 nM. Ki11502 selectively inhibits PDGF β receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Ki11502 can induce Apoptosis) and exhibits profound antiproliferative effects on select subsets of leukemia, including those with Imatinib (HY-15463) resistant mutations. Ki11502 is highly suitable for studying the role of PDGF in vascular diseases, particularly the role of proteoglycans in atherosclerosis .

HY-N0252

Catharanthine (+)-3,4-Didehydrocoronaridine	Calcium Channel	Cardiovascular Disease Neurological Disease Cancer
Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-N0252A

Catharanthine Tartrate (+)-3,4-Didehydrocoronaridine Tartrate	Calcium Channel	Cardiovascular Disease Neurological Disease Cancer
Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine Tartrate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity .

HY-N0252B

Catharanthine Sulfate (+)-3,4-Didehydrocoronaridine Sulfate	Calcium Channel	Cardiovascular Disease Neurological Disease Cancer
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine Sulfate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity .

HY-N0252R

Catharanthine (Standard)	Calcium Channel	Cardiovascular Disease Neurological Disease Cancer
Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-126206

Quazodine MJ-1988	Phosphodiesterase (PDE)	Cardiovascular Disease
Quazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research .

HY-119750

Budralazine	Others	Cardiovascular Disease
Budralazine is a vasodilator, which dilates the vascular smooth muscle and exhibits hypotensive efficacy. Budralazine inhibits the central sympathetic nerve and exhibits an anti-tachycardic effect .

HY-N8444

Triptoquinone A	Interleukin Related	Cardiovascular Disease
Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .

HY-P0206A

Bradykinin acetate	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease	Cardiovascular Disease Endocrinology
Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P0206

Bradykinin 10+ Cited Publications	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease	Cardiovascular Disease Endocrinology
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P0049

Argipressin 10+ Cited Publications Arg8-vasopressin; AVP	Vasopressin Receptor	Neurological Disease Cancer
Argipressin (Arg8-vasopressin) binds to the *V1, V2, V3-vascular* arginine vasopressin receptor, with a K_d** value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

HY-P2563

[Tyr(P)4] Angiotensin II	Angiotensin Receptor	Metabolic Disease
[Tyr(P)4] Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels .

HY-N0590

Corynoxeine 5 Publications Verification	ERK	Cardiovascular Disease
Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-P1564

[Sar1, Ile8]-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease Endocrinology
[Sar1, Ile8]-Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.

HY-P1564A

[Sar1, Ile8]-Angiotensin II TFA AngiotensinII TFA; Angiotensin 2 TFA	Angiotensin Receptor	Others
[Sar1, Ile8]-Angiotensin II (TFA) is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.

HY-W539944

Argipressin acetate Arg8-vasopressin acetate; AVP acetate	Vasopressin Receptor Apoptosis	Neurological Disease
Argipressin (Arg8-vasopressin) (acetate) binds to the *V1, V2, V3-vascular* arginine vasopressin receptor, with a K_d** value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1 .

HY-19529

Ro 46-2005	Endothelin Receptor	Cardiovascular Disease Endocrinology
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

HY-14290

Pinacidil 4 Publications Verification P-1134	Potassium Channel	Cardiovascular Disease
Pinacidil is a potent activator of potassium channel. Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K ⁺-channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy .

HY-N3729

(-)-Denudatin B Denudatin B	Calcium Channel	Cardiovascular Disease
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels . And (-)-Denudatin B has nonspecific antiplatelet action

HY-122622

PF-04471141 hydrochloride	Others	Others
PF-04471141 (hydrochloride) is a compound that regulates intracellular cAMP and cGMP concentrations. It is a PDE1 inhibitor and has different effects on different PDE enzymes in regulating intracellular signaling molecule concentrations and cell proliferation in vascular smooth muscle cells.

HY-N13111

Neoliensinine	Others	Others
Neoliensinine is a benzylisoquinoline that effectively inhibits KCl (124 mM)-induced contraction of isolated mesenteric vascular smooth muscle (MVSM) with an IC₅₀ value of 2.407 μM. Neoliensinine can be isolated from the embryo of Nelumbo nucifera Gaertn., a traditional Chinese medicine.

HY-167736

(2R)-Naroparcil	Others	Others
(2R)-Naroparcil is an isomer of Naroparcil, a 4-methylumbelliferyl beta-D-xyloside analog that plays a role in promoting vascular smooth muscle cell proliferation and has been shown to inhibit thrombus formation in the Wessler slough model.

HY-B1394

Khellin 1 Publications Verification	EGFR	Cardiovascular Disease Cancer
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC₅₀ of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

HY-B1394R

Khellin (Standard)	EGFR	Cardiovascular Disease Cancer
Khellin (Standard) is the analytical standard of Khellin. This product is intended for research and analytical applications. Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

HY-14664D

Fluvastatin sodium monohydrate XU 62-320 monohydrate	HMG-CoA Reductase (HMGCR) Apoptosis	Cardiovascular Disease Cancer
Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC₅₀ of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-N0484

Liensinine 5+ Cited Publications	Autophagy Mitophagy Apoptosis	Cardiovascular Disease Cancer
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library

1,208 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,208 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type

HY-110210

BODIPY-FL NHS ester BODIPY FL,SE	Fluorescent Dyes/Probes
BODIPY-FL NHS ester (BODIPY FL, SE) is an amine-reactive fluorescent probe. The maximum excitation/emission values are 502/511 nm. BODIPY-FL NHS ester can be used to synthesize protease substrates .

Cat. No.	Product Name	Type

HY-W040255

1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine

PGPC

Cell Assay Reagents

1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) is a bioactive molecule that has the activity of inducing inflammation, proliferation or apoptosis. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine can be used as an important tool to study the response of vascular smooth muscle cells and macrophages. The application areas of 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine include the mechanism research of inflammation-related diseases and compound development.

Cat. No.	Product Name	Target	Research Area

HY-P4853

Adrenomedullin (rat)	Peptides	Cardiovascular Disease
Adrenomedullin (rat) is an effective vasodilator peptide. Adrenomedullin is actively secreted by endothelial cells (EC) and vascular smooth muscle cells (VSMC) .

HY-P0206

Bradykinin 10+ Cited Publications	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease	Cardiovascular Disease Endocrinology
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P0049

Argipressin 10+ Cited Publications Arg8-vasopressin; AVP	Vasopressin Receptor	Neurological Disease Cancer
Argipressin (Arg8-vasopressin) binds to the *V1, V2, V3-vascular* arginine vasopressin receptor, with a K_d** value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-P10616

Salusin-α	Peptides	Cardiovascular Disease
Salusin-α is an endogenous bioactive peptide with hemodynamic and cell proliferation activities. Salusin-α can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate, but its effect is weaker than that of Salusin-β (HY-P10617). Salusin-α has potential application value in cardiovascular disease research .

HY-P3060

Atriopeptin II (rat, mouse)	Peptides	Cardiovascular Disease
Atriopeptin II rat, mouse is an atrial natriuretic peptide, which acts as diuretic and natriuretic agent, and a potent relaxant of vascular smooth muscle .

HY-P0206A

Bradykinin acetate	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease	Cardiovascular Disease Endocrinology
Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-105183

PD 145065	Peptides	Others
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC₅₀ value of 4 nM for the ET_A receptor for rabbit renal artery vascular smooth muscle cells .

HY-P2563

[Tyr(P)4] Angiotensin II	Angiotensin Receptor	Metabolic Disease
[Tyr(P)4] Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels .

HY-P1564

[Sar1, Ile8]-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease Endocrinology
[Sar1, Ile8]-Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.

HY-P1564A

[Sar1, Ile8]-Angiotensin II TFA AngiotensinII TFA; Angiotensin 2 TFA	Angiotensin Receptor	Others
[Sar1, Ile8]-Angiotensin II (TFA) is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.

HY-W539944

Argipressin acetate Arg8-vasopressin acetate; AVP acetate	Vasopressin Receptor Apoptosis	Neurological Disease
Argipressin (Arg8-vasopressin) (acetate) binds to the *V1, V2, V3-vascular* arginine vasopressin receptor, with a K_d** value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1 .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P5389

Connexin mimetic peptide 40GAP27	Peptides	Others
Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)

HY-P10617

Salusin-β	Peptides	Cardiovascular Disease
Salusin-β is an endogenous bioactive peptide with significant hemodynamic and mitogenic activity. Salusin-β can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate. In addition, Salusin-β can stimulate the release of arginine vasopressin from the pituitary gland in rats. This makes Salusin-β have important application potential in cardiovascular disease research .

HY-P1471

Adrenomedullin (AM) (22-52), human 1 Publications Verification 22-52-Adrenomedullin (human)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .

HY-P1471A

Adrenomedullin (AM) (22-52), human TFA 22-52-Adrenomedullin (human) (TFA)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH₂ terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .

HY-13948

Angiotensin II human Maximum Cited Publications 111 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948A

Angiotensin II human acetate Maximum Cited Publications 111 Publications Verification Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948B

Angiotensin II human TFA Maximum Cited Publications 111 Publications Verification Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0455

L-Arginine 5+ Cited Publications	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields Cancer	NO Synthase Endogenous Metabolite
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455A

L-Arginine hydrochloride 5+ Cited Publications (S)-(+)-Arginine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	NO Synthase Endogenous Metabolite
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N1082

Visnagin	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Artemisia cana Pursh Source classification Umbelliferae Plants Disease Research Fields	Others
Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles .

HY-N0252

Catharanthine (+)-3,4-Didehydrocoronaridine	Apocynaceae Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-N0252A

Catharanthine Tartrate (+)-3,4-Didehydrocoronaridine Tartrate	Apocynaceae Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Cancer	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine Tartrate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity .

HY-142050

(R)-IDHP	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Calcium Channel
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca ²⁺ release and Ca ²⁺ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease .

HY-N0455R

L-Arginine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	NO Synthase Endogenous Metabolite
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455AR

L-Arginine hydrochloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	NO Synthase Endogenous Metabolite
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0252B

Catharanthine Sulfate (+)-3,4-Didehydrocoronaridine Sulfate	Cardiovascular Disease Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine Sulfate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity .

HY-N0252R

Catharanthine (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-N8444

Triptoquinone A	Quinones Structural Classification Source classification Celastraceae Plants Tripterygium wilfordii Hook. f. Naphthalene Quinones	Interleukin Related
Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .

HY-P0206

Bradykinin 10+ Cited Publications	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-N0590

Corynoxeine 5 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Plants Disease Research Fields Indole Alkaloids	ERK
Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.

HY-N3729

(-)-Denudatin B Denudatin B	Cardiovascular Disease Classification of Application Fields Piper betle L. Source classification Lignans Piperaceae Phenylpropanoids Plants Disease Research Fields	Calcium Channel
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels . And (-)-Denudatin B has nonspecific antiplatelet action

HY-N13111

Neoliensinine	Structural Classification Monophenols Source classification Phenols Nelumbo nucifera Gaertn. Plants Nymphaeaceae	Others
Neoliensinine is a benzylisoquinoline that effectively inhibits KCl (124 mM)-induced contraction of isolated mesenteric vascular smooth muscle (MVSM) with an IC₅₀ value of 2.407 μM. Neoliensinine can be isolated from the embryo of Nelumbo nucifera Gaertn., a traditional Chinese medicine.

HY-B1394

Khellin 1 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Artemisia cana Pursh Source classification Lignans Phenylpropanoids Umbelliferae Plants Disease Research Fields	EGFR
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC₅₀ of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

HY-B1394R

Khellin (Standard)	Structural Classification Artemisia cana Pursh Source classification Lignans Phenylpropanoids Umbelliferae Plants	EGFR
Khellin (Standard) is the analytical standard of Khellin. This product is intended for research and analytical applications. Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

HY-N0484

Liensinine 5+ Cited Publications	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Alkaloid Dimers	Autophagy Mitophagy Apoptosis
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-N3931

Gardneramine	Structural Classification Alkaloids Nepenthes mirabilis (Lour.) Druce Source classification Plants Nepenthaceae	Others
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .

HY-113209

8-Isoprostaglandin F2α	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

HY-126304

β-Glycerophosphate disodium salt hydrate 5+ Cited Publications	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Endogenous Metabolite ERK
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

HY-D0886

β-Glycerophosphate disodium salt pentahydrate 5+ Cited Publications	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Phosphatase Endogenous Metabolite ERK
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

HY-N0485

Liensinine Diperchlorate 5+ Cited Publications	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Disease Research Fields Nymphaeaceae	Autophagy Mitophagy
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-B1671

(+)-Kavain	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N2484

Methylnissolin Astrapterocarpan	Cardiovascular Disease Monophenols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Disease Research Fields	PDGFR ERK
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade .

HY-B1671R

(+)-Kavain (Standard)	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-B0660

Eicosapentaenoic Acid 10+ Cited Publications EPA; Timnodonic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Histone Demethylase
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-W011269

Eicosapentaenoic Acid sodium EPA sodium; Timnodonic acid sodium	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Histone Demethylase
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-N4267

Yangambin	Cardiovascular Disease other families Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Disease Research Fields	Calcium Channel
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca ²⁺ influx through voltage-gated Ca ²⁺ channels, leading to the reduction in [Ca ²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation . Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM .

HY-13948

Angiotensin II human Maximum Cited Publications 111 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Angiotensin Receptor Apoptosis
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-B0660R

Eicosapentaenoic Acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Histone Demethylase
Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

Cat. No.	Product Name	Chemical Structure

HY-B0309S2

Felodipine-d3
Felodipine-d₃ is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-14664CS

(3S,5R)-Fluvastatin-d6 sodium
(3S,5R)-Fluvastatin-d₆ (sodium) is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

HY-14664AS

Fluvastatin-d6 sodium
Fluvastatin-d₆ (sodium) is deuterium labeled Fluvastatin sodium. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.

HY-14664DS

(3S,5R)-Fluvastatin-d6
(3S,5R)-Fluvastatin-d₆ is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

HY-B0309S1

Felodipine-d5
Felodipine-d₅ is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-132670S

(R)-(-)-Felodipine-d5

(R)-(-)-Felodipine-d₅ is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-113209S1

8-iso Prostaglandin F2α-d9

8-iso Prostaglandin F2α-d₉ is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

HY-113209S2

8-Isoprostaglandin F2α-13C5

8-Isoprostaglandin F2α- ¹³C₅ is ¹³C labeled 8-Isoprostaglandin F2α (HY-113209). 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

Cat. No.	Product Name		Classification

HY-N0455

L-Arginine 5+ Cited Publications		Solubilizing Agents
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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