2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Zenocutuzumab

Zenocutuzumab  (Synonyms: MCLA-128; PB4188; R040517)

Cat. No.: HY-P99507 Purity: 99.20%
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Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3.

For research use only. We do not sell to patients.

CAS No. : 1969309-56-5

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Based on 1 publication(s) in Google Scholar

Zenocutuzumab Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Bispecific; Humanized

In Vitro

Zenocutuzumab (0.001-1000 nM; 96 hours) inhibits cell growth in lung and breast cancer cell lines[1].
Zenocutuzumab (0.1-1000 nM; 24 hours) inhibits HER3 and AKT phosphorylation, induces markers of apoptosis and cell cycle arrest in lung and breast cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zenocutuzumab Related Antibodies

Cell Viability Assay[1]

Cell Line: Human bronchiolar epithelial cell lines (HBEC)
Concentration: 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 96 h
Result: Reduced the growth of isogenic HBEC expressing either CD74-NRG1 or VAMP2-NRG1 fusions.

Western Blot Analysis[1]

Cell Line: HBEC-CD74-NRG1, LUAD-0061AS3, MDA-MB-175-VII cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 24 hours
Result: Inhibited HER3, STAT3, AKT, p70S6K, and S6 phosphorylation.
In Vivo

Zenocutuzumab (2.5-25 mg/kg; i.p.; once weekly; for 28 days) causes a statistically significant reduction of growth, including tumor regression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 to 12-week-old female NSG™ (LUAD-0061AS3), BALB/c nude (OV-10–0050) or athymic nude (ST2891, ST3204 and CTG-0953) mice injected with NRG1 fusion-positive patient-derived xenograft (PDX) tumors[1].
Dosage: 2.5 mg/kg, 8 mg/kg, or 25 mg/kg
Administration: i.p.; once weekly; for 28 days
Result: Blocked growth of lung and ovarian cancer PDX models.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Zenocutuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Zenocutuzumab. The EC50 for this effect is 107.82 ng/mL.
Purity & Documentation
References
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Zenocutuzumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zenocutuzumab1969309-56-5MCLA-128 PB4188 R040517MCLA128MCLA 128PB4188PB 4188PB-4188R040517R 040517R-040517EGFREpidermal growth factor receptorErbB-1HER1HER2HER3humanized IgG1 antibodySTAT3AKTp70S6Kand S6 phosphorylationInhibitorinhibitorinhibit

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