2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB-269970

SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors.

For research use only. We do not sell to patients.

SB-269970 Chemical Structure

SB-269970 Chemical Structure

CAS No. : 201038-74-6

Size Price Stock Quantity
5 mg USD 112 In-stock
10 mg USD 174 In-stock
25 mg USD 371 In-stock
50 mg USD 576 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of SB-269970:

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Description

SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors[1][2].

IC50 & Target

Human 5-HT7 Receptor

8.3 (pKi)

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
3.71 nM
Compound: SB-269970
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
[PMID: 27475109]
In Vivo

SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL6/J mice[2]
Dosage: 3, 10, 30 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly blocked amphetamine and ketamine-induced hyperactivity.
Molecular Weight

352.49

Formula

C18H28N2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (283.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8370 mL 14.1848 mL 28.3696 mL
5 mM 0.5674 mL 2.8370 mL 5.6739 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8370 mL 14.1848 mL 28.3696 mL 70.9240 mL
5 mM 0.5674 mL 2.8370 mL 5.6739 mL 14.1848 mL
10 mM 0.2837 mL 1.4185 mL 2.8370 mL 7.0924 mL
15 mM 0.1891 mL 0.9457 mL 1.8913 mL 4.7283 mL
20 mM 0.1418 mL 0.7092 mL 1.4185 mL 3.5462 mL
25 mM 0.1135 mL 0.5674 mL 1.1348 mL 2.8370 mL
30 mM 0.0946 mL 0.4728 mL 0.9457 mL 2.3641 mL
40 mM 0.0709 mL 0.3546 mL 0.7092 mL 1.7731 mL
50 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4185 mL
60 mM 0.0473 mL 0.2364 mL 0.4728 mL 1.1821 mL
80 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8865 mL
100 mM 0.0284 mL 0.1418 mL 0.2837 mL 0.7092 mL
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SB-269970 Related Classifications

Keywords:

SB-269970201038-74-6SB269970SB 2699705-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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