2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Azide-PEG3-Tos

Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Azide-PEG3-Tos Chemical Structure

Azide-PEG3-Tos Chemical Structure

CAS No. : 178685-33-1

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Based on 1 publication(s) in Google Scholar

Azide-PEG3-Tos Related Antibodies

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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  • Purity & Documentation

  • References

  • Customer Review

Description

Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target[1][2]

PEGs

 

Non-cleavable Linker

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azide-PEG3-Tos Related Antibodies
Molecular Weight

329.37

Formula

C13H19N3O5S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[N-]=[N+]=NCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (303.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0361 mL 15.1805 mL 30.3610 mL
5 mM 0.6072 mL 3.0361 mL 6.0722 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.15%

SDS (393 KB)

COA (243 KB) HNMR (113 KB) RP-HPLC (334 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0361 mL 15.1805 mL 30.3610 mL 75.9025 mL
5 mM 0.6072 mL 3.0361 mL 6.0722 mL 15.1805 mL
10 mM 0.3036 mL 1.5180 mL 3.0361 mL 7.5902 mL
15 mM 0.2024 mL 1.0120 mL 2.0241 mL 5.0602 mL
20 mM 0.1518 mL 0.7590 mL 1.5180 mL 3.7951 mL
25 mM 0.1214 mL 0.6072 mL 1.2144 mL 3.0361 mL
30 mM 0.1012 mL 0.5060 mL 1.0120 mL 2.5301 mL
40 mM 0.0759 mL 0.3795 mL 0.7590 mL 1.8976 mL
50 mM 0.0607 mL 0.3036 mL 0.6072 mL 1.5180 mL
60 mM 0.0506 mL 0.2530 mL 0.5060 mL 1.2650 mL
80 mM 0.0380 mL 0.1898 mL 0.3795 mL 0.9488 mL
100 mM 0.0304 mL 0.1518 mL 0.3036 mL 0.7590 mL
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Azide-PEG3-Tos Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azide-PEG3-Tos178685-33-1PROTAC LinkersADC LinkerAntibody-drug conjugates linkerPEGADClinkerPROTACnon-cleavableInhibitorinhibitorinhibit

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