2. GPCR/G Protein
  3. Taste Receptor
  4. Dulcoside A

Dulcoside A is a glycoside that can be isolated from Stevia rebaudiana that elicits sweet and bitter taste through activation of TAS1R. Dulcoside A also exhibits anti-inflammatory activity.

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Dulcoside A Chemical Structure

Dulcoside A Chemical Structure

CAS No. : 64432-06-0

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Based on 1 publication(s) in Google Scholar

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Dulcoside A Related Antibodies

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Description

Dulcoside A is a glycoside that can be isolated from Stevia rebaudiana that elicits sweet and bitter taste through activation of TAS1R. Dulcoside A also exhibits anti-inflammatory activity[1][2].

In Vitro

Dulcoside A produces sweetness by activating sweet taste receptors hTAS1R2/hTAS1R3 with a sweet taste threshold of 32.9 μM. Dulcoside A also activates bitter taste receptors hTAS2R4 and hTAS2R14, thereby producing bitter taste with a sweet taste threshold of 49 μM. Dulcoside A activates the hTAS1R2/hTAS1R3, hTAS2R4 and hTAS2R14 with the threshold concentrations of 38.8 μM, 200 μM and 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dulcoside A Related Antibodies
In Vivo

Dulcoside A inhibits TPA (HY-18739)-induced inflammation with a LD50 of 92.5 μg/ear (0.12 μM/ear) in mouse ear edema model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

788.87

Formula

C38H60O17
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]3([H])[C@@](C4)(CC[C@]1([H])[C@@](C)(CCC2)C(O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO)=O)C[C@@](C4=C)(O[C@@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O6)O)O[C@@]7([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O7)O)O)CC3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (126.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2676 mL 6.3382 mL 12.6764 mL
5 mM 0.2535 mL 1.2676 mL 2.5353 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2676 mL 6.3382 mL 12.6764 mL 31.6909 mL
5 mM 0.2535 mL 1.2676 mL 2.5353 mL 6.3382 mL
10 mM 0.1268 mL 0.6338 mL 1.2676 mL 3.1691 mL
15 mM 0.0845 mL 0.4225 mL 0.8451 mL 2.1127 mL
20 mM 0.0634 mL 0.3169 mL 0.6338 mL 1.5845 mL
25 mM 0.0507 mL 0.2535 mL 0.5071 mL 1.2676 mL
30 mM 0.0423 mL 0.2113 mL 0.4225 mL 1.0564 mL
40 mM 0.0317 mL 0.1585 mL 0.3169 mL 0.7923 mL
50 mM 0.0254 mL 0.1268 mL 0.2535 mL 0.6338 mL
60 mM 0.0211 mL 0.1056 mL 0.2113 mL 0.5282 mL
80 mM 0.0158 mL 0.0792 mL 0.1585 mL 0.3961 mL
100 mM 0.0127 mL 0.0634 mL 0.1268 mL 0.3169 mL
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Dulcoside A Related Classifications

Keywords:

Dulcoside A64432-06-0Taste ReceptorInhibitorinhibitorinhibit

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