2. Gene
  3. CDR2 - cerebellar degeneration related protein 2 Gene

CDR2 - cerebellar degeneration related protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Yo; CDR62

Gene ID: 1039 | Gene type: protein coding

About CDR2

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:22,345,936-22,374,619 (from NCBI)

This gene has 7 transcripts (splice variants), 274 orthologues and 1 paralogue. Broad expression in testis (RPKM 38.3), thyroid (RPKM 28.3) and 24 other tissues.

Summary

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CDR2 Products(1)

mRNA Protein Name
NM_001802.2 NP_001793.1 cerebellar degeneration-related protein 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11988016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cerebellar degeneration-related protein 2

Yo paraneoplastic antigen

CDR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CDR2 Q01850 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
Intra
CDR2 Q01850 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
CDR2 Q01850 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
25416956
Intra
CDR2 Q01850 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Array
25416956
Intra
CDR2 Q01850 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra
CDR2 Q01850 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 PDZD4 Homo sapiens Q17RL8
Validated Y2H
32296183
Intra
CDR2 Q01850 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra
CDR2 Q01850 DRC12 Homo sapiens Q494R4
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 DRC12 Homo sapiens Q494R4
Y2H Array
25416956
Intra
CDR2 Q01850 SH2D4A Homo sapiens Q9H788-2
Y2H Array
25416956
Intra
CDR2 Q01850 SH2D4A Homo sapiens Q9H788-2
Validated Y2H
25416956
Intra
CDR2 Q01850 COX5B Homo sapiens P10606
Y2H Array
31515488
Intra
CDR2 Q01850 COX5B Homo sapiens P10606
Y2H Array
25416956
Intra
CDR2 Q01850 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
CDR2 Q01850 CCDC13 Homo sapiens Q8IYE1
Validated Y2H
32296183
Intra
CDR2 Q01850 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra
CDR2 Q01850 TRIML2 Homo sapiens Q8N7C3
Y2H Array
32296183
Intra
CDR2 Q01850 CDR2L Homo sapiens Q86X02
Anti Tag CoIP
33961781
Intra
CDR2 Q01850 CDR2L Homo sapiens Q86X02
TAP
27173435
Intra
CDR2 Q01850 CDR2L Homo sapiens Q86X02
Anti Tag CoIP
28514442
Intra
CDR2 Q01850 CDR2L Homo sapiens Q86X02
Validated Y2H
32296183
Intra
CDR2 Q01850 DRC12 Homo sapiens Q494R4-2
Validated Y2H
32296183
Intra
CDR2 Q01850 RUNX1T1 Homo sapiens Q06455-2
Validated Y2H
32296183
Intra
CDR2 Q01850 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
CDR2 Q01850 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra
CDR2 Q01850 FAM110A Homo sapiens Q9BQ89
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
32296183
Intra
CDR2 Q01850 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra
CDR2 Q01850 HDAC4 Homo sapiens P56524
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 HDAC4 Homo sapiens P56524
Validated Y2H
25416956
Intra
CDR2 Q01850 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
CDR2 Q01850 TXLNA Homo sapiens P40222
Y2H Array
31515488
Intra
CDR2 Q01850 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra
CDR2 Q01850 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra
CDR2 Q01850 EIF4E2 Homo sapiens O60573
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 MORF4L2 Homo sapiens Q15014
Y2H
11988016
Intra
CDR2 Q01850 MORF4L2 Homo sapiens Q15014
IF
11988016
Intra
CDR2 Q01850 MORF4L2 Homo sapiens Q15014
Anti Tag CoIP
11988016
Intra
CDR2 Q01850 MORF4L2 Homo sapiens Q15014
Far-WB
11988016
Intra
CDR2 Q01850 SMARCE1 Homo sapiens Q969G3
Validated Y2H
32296183
Intra
CDR2 Q01850 PKN1 Homo sapiens Q16512
Validated Y2H
32296183
Intra
CDR2 Q01850 TXLNB Homo sapiens Q8N3L3
Validated Y2H
32296183
Intra
CDR2 Q01850 C4orf46 Homo sapiens Q504U0
Validated Y2H
32296183
Intra
CDR2 Q01850 C4orf46 Homo sapiens Q504U0
Anti Tag CoIP
33961781
Intra
CDR2 Q01850 C4orf46 Homo sapiens Q504U0
Anti Tag CoIP
28514442
Intra
CDR2 Q01850 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
CDR2 Q01850 TTR Homo sapiens P02766
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 TTR Homo sapiens P02766
Y2H Array
25416956
Intra
CDR2 Q01850 INO80B Homo sapiens Q9C086
Validated Y2H
32296183
Intra
CDR2 Q01850 FAM161A Homo sapiens Q3B820
Validated Y2H
25416956
Intra
CDR2 Q01850 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra
CDR2 Q01850 MKKS Homo sapiens Q9NPJ1
Validated Y2H
32296183
Intra
CDR2 Q01850 FAM161B Homo sapiens Q96MY7
Validated Y2H
32296183
Intra
CDR2 Q01850 MRPL28 Homo sapiens Q13084
Validated Y2H
25416956
Intra
CDR2 Q01850 MRPL28 Homo sapiens Q13084
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 LENG1 Homo sapiens Q96BZ8
Validated Y2H
32296183
Intra
CDR2 Q01850 LENG1 Homo sapiens Q96BZ8
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 C2CD6 Homo sapiens Q53TS8
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 C2CD6 Homo sapiens Q53TS8
Y2H Array
25416956
Intra
CDR2 Q01850 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
CDR2 Q01850 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
CDR2 Q01850 KANSL1 Homo sapiens Q7Z3B3
Y2H Array
31515488
Intra
CDR2 Q01850 KANSL1 Homo sapiens Q7Z3B3
Validated Y2H
25416956
Intra
CDR2 Q01850 KANSL1 Homo sapiens Q7Z3B3
Y2H Array
25416956
Intra
CDR2 Q01850 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
CDR2 Q01850 TCHP Homo sapiens Q9BT92
MAPPIT
32296183
Intra
CDR2 Q01850 TCHP Homo sapiens Q9BT92
Y2H Array
31515488
Intra
CDR2 Q01850 TCHP Homo sapiens Q9BT92
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 TCHP Homo sapiens Q9BT92
Validated Y2H
32296183
Intra
CDR2 Q01850 TCHP Homo sapiens Q9BT92
Y2H Array
25416956
Intra
CDR2 Q01850 NTAQ1 Homo sapiens Q96HA8
Y2H Array
31515488
Intra
CDR2 Q01850 NTAQ1 Homo sapiens Q96HA8
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 CHIC2 Homo sapiens Q9UKJ5
Validated Y2H
32296183
Intra
CDR2 Q01850 CHIC2 Homo sapiens Q9UKJ5
Y2H Array
25416956
Intra
CDR2 Q01850 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra
CDR2 Q01850 RCOR3 Homo sapiens Q9P2K3
Validated Y2H
25416956
Intra
CDR2 Q01850 MNS1 Homo sapiens Q8NEH6
Validated Y2H
32296183
Intra
CDR2 Q01850 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
25416956
Intra
CDR2 Q01850 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
CDR2 Q01850 ENKD1 Homo sapiens Q9H0I2
Y2H Array
25416956
Intra
CDR2 Q01850 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
CDR2 Q01850 ANKRD36BP1 Homo sapiens Q96IX9
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 ANKRD36BP1 Homo sapiens Q96IX9
Validated Y2H
25416956
Intra
CDR2 Q01850 ANKRD36BP1 Homo sapiens Q96IX9
Y2H Array
25416956
Intra
CDR2 Q01850 BEX2 Homo sapiens Q9BXY8
Validated Y2H
32296183
Intra
CDR2 Q01850 CDK18 Homo sapiens Q07002
Validated Y2H
32296183
Intra
CDR2 Q01850 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra
CDR2 Q01850 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra
CDR2 Q01850 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
CDR2 Q01850 TEAD4 Homo sapiens Q15561
Validated Y2H
32296183
Intra
CDR2 Q01850 RSPH14 Homo sapiens Q9UHP6
Y2H Array
25416956
Intra
CDR2 Q01850 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
CDR2 Q01850 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
25416956
Intra
CDR2 Q01850 SCNM1 Homo sapiens Q9BWG6
Y2H Array
25416956
Intra
CDR2 Q01850 LIN37 Homo sapiens Q96GY3
Validated Y2H
25416956
Intra
CDR2 Q01850 LIN37 Homo sapiens Q96GY3
Y2H Prey Pooling
25416956
Intra
CDR2 Q01850 CCDC87 Homo sapiens Q9NVE4
Validated Y2H
32296183
Intra
CDR2 Q01850 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
25416956
Intra
CDR2 Q01850 TBC1D22B Homo sapiens Q9NU19
Y2H Array
29892012
Intra
CDR2 Q01850 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDR2 Proteins

Cat. No. Product Name Accession Purity
HY-P72127 CDR2 Protein, Human (His) Q01850 (M1-S454) ≥95%

Related Diseases

Diseases Alias
Cerebellar Degeneration
Paraneoplastic Cerebellar Degeneration

Pcd

Paraneoplastic Cerebellar Ataxia

Rapidely Progressive Cerebellar Syndrome

Subacute Cerebellar Degeneration
Anosognosia
Phenytoin Allergy

Dilantin Allergy
Acute Diffuse Nephritis

Acute Diffuse Glomerulonephritis
Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 9

CMS9

Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency

Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145814 HSP90-IN-9 Inhibitor / Unkown
HY-RS02423 CDR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02424 CDR2L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDR2 VGNC VGNC:60717
Mus musculus CDR2 MGD MGI:1100885
Rattus norvegicus CDR2 RGD RGD:1310578
Bos taurus CDR2 VGNC VGNC:27153
Macaca mulatta CDR2 VGNC VGNC:70993
Canis familiaris CDR2 VGNC VGNC:39078
Others CDR2 NCBI