Braf - Braf transforming gene Gene

Mus musculus

Also known as B-raf; Braf2; Braf-2; C230098H17; D6Ertd631e; 9930012E13Rik

Gene ID: 109880 | Gene type: protein coding

About Braf

Chromosome 6: 39,580,171-39,702,397 reverse strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 220 orthologues, 23 paralogues and is associated with 76 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 6.7), bladder adult (RPKM 6.5) and 25 other tissues.

Summary

Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRaf (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Braf Products(1)

mRNA	Protein	Name
NM_139294.5	NP_647455.3	serine/threonine-protein kinase B-raf

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16116448	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	17563371	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	18228248	MGI
acts upstream of or within CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	23334952	MGI
acts upstream of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	15199148	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	23334952	MGI
acts upstream of or within T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	18228248	MGI
acts upstream of or within alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	23334952	MGI
acts upstream of or within cell differentiation	IGI IGI: Inferred from genetic interaction	10704835	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	22628551	MGI
acts upstream of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9207797	MGI
acts upstream of or within face development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within head morphogenesis	IMP IMP: Inferred from mutant phenotype	24733831	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16342120	MGI
acts upstream of or within myeloid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	15784729	MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9207797	MGI
acts upstream of or within negative regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	15199148	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16980614	MGI
acts upstream of or within negative regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23616533	MGI
acts upstream of or within positive T cell selection	IMP IMP: Inferred from mutant phenotype	23334952	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	22892241	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	15199148	MGI
acts upstream of or within positive regulation of axon regeneration	IDA IDA: Inferred from direct assay	24733831	MGI
acts upstream of or within positive regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	24733831	MGI
acts upstream of or within positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	24733831	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	24733831	MGI
acts upstream of or within positive regulation of stress fiber assembly	IGI IGI: Inferred from genetic interaction	15199148	MGI
acts upstream of or within positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	15199148	MGI
acts upstream of or within positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	15199148	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	16342120	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16342120	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17563371	MGI
acts upstream of or within regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	18228248	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: Inferred from genetic interaction	24733831	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	22891351	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	23022482	MGI
acts upstream of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	15199148	MGI
acts upstream of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	15199148	MGI
acts upstream of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23616533	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	16342120	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body	IDA IDA: Inferred from direct assay	16980614	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15736129	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16342120	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16342120	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	16116448	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	16980614	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15736129	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Braf Protein Structure

RBD_BRAF

C1_B-Raf

STKc_Raf

0
200
400
600
804 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase B-raf

B-Raf proto-oncogene serine/threonine-protein kinase (p94)

proto-oncogene B-Raf

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10201	Sorafenib	Inhibitor	99.92%	Yes
HY-14660	Dabrafenib	Inhibitor	99.94%	Yes
HY-12057	Vemurafenib	Inhibitor	99.85%	Yes
HY-10331	Regorafenib	Inhibitor	99.93%	Yes
HY-10201A	Sorafenib Tosylate	Inhibitor	99.91%	Yes
HY-14660A	Dabrafenib Mesylate	Inhibitor	99.95%	Yes
HY-10331A	Regorafenib monohydrate	Inhibitor	99.96%	Yes
HY-13308	Regorafenib Hydrochloride	Inhibitor	99.58%	Yes
HY-10331B	Regorafenib mesylate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10320	Doramapimod	Inhibitor	99.98%	Phase 2
HY-112089	Naporafenib	Inhibitor	99.86%	Phase 2
HY-109080	Belvarafenib	Inhibitor	99.71%	Phase 2
HY-18972	Plixorafenib	Inhibitor	99.94%	Phase 2
HY-153341	CFT1946	Degrader	99.84%	Phase 2
HY-111940	LUT014	Inhibitor	97.23%	Phase 2
HY-18652	Avutometinib	Inhibitor	99.02%	Phase 1
HY-12558	LY3009120	Inhibitor	98.66%	Phase 1
HY-18957	Lifirafenib	Inhibitor	98.73%	Phase 1
HY-15200	Agerafenib	Inhibitor	99.78%	Phase 1
HY-15199	Agerafenib hydrochloride	Inhibitor	/	Phase 1
HY-19343	XL-281	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10966	SB-590885	Inhibitor	99.77%	Unkown
HY-51424	PLX-4720	Inhibitor	99.91%	Unkown
HY-50864	GDC-0879	Inhibitor	99.69%	Unkown
HY-11004	AZ 628	Inhibitor	99.85%	Unkown
HY-18997	PLX7904	Inhibitor	98.94%	Unkown
HY-14177	Raf inhibitor 1	Inhibitor	98.11%	Unkown
HY-137487	PROTAC BRAF-V600E degrader-1	Inhibitor	98.02%	Unkown
HY-12846	CCT196969	Inhibitor	99.36%	Unkown
HY-107779	BI-882370	Inhibitor	99.16%	Unkown
HY-100510	RAF709	Inhibitor	99.45%	Unkown
HY-12787	L-779450	Inhibitor	98.75%	Unkown
HY-77113	B-Raf IN 11	Inhibitor	99.55%	Unkown
HY-147405	Tinlorafenib	Inhibitor	98.20%	Unkown
HY-10247	BRAF inhibitor	Inhibitor	98.97%	Unkown
HY-111758	PROTAC B-Raf degrader 1	Inhibitor	99.78%	Unkown
HY-12291	HG6-64-1	Inhibitor	99.69%	Unkown
HY-145120	B-Raf IN 2	Inhibitor	98.29%	Unkown
HY-117273	AZ304	Inhibitor	99.96%	Unkown
HY-142160	GNE-9815	Inhibitor	98.28%	Unkown
HY-148059	Uplarafenib	Inhibitor	99.15%	Unkown
HY-18227	B-Raf IN 1	Inhibitor	99.94%	Unkown
HY-15198	KG5	Inhibitor	99.79%	Unkown
HY-18507	AD57	Inhibitor	98.08%	Unkown
HY-126298	RAF mutant-IN-1	Inhibitor	/	Unkown
HY-155942	B-Raf IN 19	Inhibitor	/	Unkown
HY-115933	EGFR/BRAF-IN-1	Inhibitor	/	Unkown
HY-144271	RAF-IN-1	Inhibitor	/	Unkown
HY-147854	B-Raf IN 9	Inhibitor	/	Unkown
HY-147853	B-Raf IN 8	Inhibitor	/	Unkown
HY-162873	MEK/RAF-IN-1	Inhibitor	/	Unkown
HY-168512	BRAFV600E-IN-1	Inhibitor	/	Unkown
HY-146492	VEGFR-2/BRAF-IN-2	Inhibitor	/	Unkown
HY-13810	PF-04880594	Inhibitor	/	Unkown
HY-146491	VEGFR-2/BRAF-IN-1	Inhibitor	/	Unkown
HY-16063	ARQ-736	Inhibitor	/	Unkown
HY-144269	SHR902275	Inhibitor	/	Unkown
HY-147852	B-Raf IN 7	Inhibitor	/	Unkown
HY-137488	PROTAC BRAF-V600E degrader-2	Inhibitor	/	Unkown
HY-150250	B-Raf IN 13	Inhibitor	/	Unkown
HY-149415	Multi-kinase-IN-5	Inhibitor	/	Unkown
HY-18318	Takeda-6D	Inhibitor	/	Unkown
HY-12847	CCT241161	Inhibitor	/	Unkown
HY-164530	SKLB646	Inhibitor	/	Unkown
HY-14177A	Raf inhibitor 1 dihydrochloride	Inhibitor	/	Unkown
HY-120676	B-Raf IN 18	Inhibitor	/	Unkown
HY-164529	SJ-C1044	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Braf	NCBI	NCBI:673

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