2. Gene
  3. Braf - B-Raf proto-oncogene, serine/threonine kinase Gene

Braf - B-Raf proto-oncogene, serine/threonine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 114486 | Gene type: protein coding

About Braf

Primary_assembly 4: 68,384,649-68,510,463 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 220 orthologues, 23 paralogues and is associated with 97 phenotypes. Biased expression in Brain (RPKM 22.7), Lung (RPKM 19.6) and 9 other tissues.

Summary

Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of ERK1 and ERK2 cascade; and response to cAMP. Located in neuron projection; nucleus; and plasma membrane. Used to study bile duct adenoma; cholangiocarcinoma; intrahepatic cholangiocarcinoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRaf (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Braf Products(13)

mRNA Protein Name
XM_006236359.4 XP_006236421.3 serine/threonine-protein kinase B-raf isoform X13
XM_039108633.1 XP_038964561.1 serine/threonine-protein kinase B-raf isoform X4
XM_039108631.1 XP_038964559.1 serine/threonine-protein kinase B-raf isoform X2
XM_039108634.1 XP_038964562.1 serine/threonine-protein kinase B-raf isoform X5
XM_039108635.1 XP_038964563.1 serine/threonine-protein kinase B-raf isoform X7
XM_006236357.4 XP_006236419.3 serine/threonine-protein kinase B-raf isoform X6
XM_039108630.1 XP_038964558.1 serine/threonine-protein kinase B-raf isoform X1
XM_039108636.1 XP_038964564.1 serine/threonine-protein kinase B-raf isoform X8
XM_039108632.1 XP_038964560.1 serine/threonine-protein kinase B-raf isoform X3
XM_039108637.1 XP_038964565.1 serine/threonine-protein kinase B-raf isoform X10
XM_039108639.1 XP_038964567.1 serine/threonine-protein kinase B-raf isoform X12
XM_231692.10 XP_231692.4 serine/threonine-protein kinase B-raf isoform X9
XM_039108638.1 XP_038964566.1 serine/threonine-protein kinase B-raf isoform X11
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
10648842 RGD
enables MAP kinase kinase kinase activity IMP
IMP: Inferred from mutant phenotype
16508002 RGD
enables mitogen-activated protein kinase kinase binding IMP
IMP: Inferred from mutant phenotype
16508002 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15150271 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15150271 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15917294 RGD
enables small GTPase binding IDA
IDA: Inferred from direct assay
12138204 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
12138204 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18194435 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19720729 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10648842 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16508002 RGD
involved in response to cAMP IMP
IMP: Inferred from mutant phenotype
19720729 RGD
involved in response to peptide hormone IMP
IMP: Inferred from mutant phenotype
19720729 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in postsynapse IDA
IDA: Inferred from direct assay
1884206 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Braf Protein Structure

RBD_BRAF

RBD_BRAF: cd17134 (169 - 250)

C1_B-Raf

C1_B-Raf: cd20871 (248 - 307)

STKc_Raf

STKc_Raf: cd14062 (535 - 787)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 847 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase B-raf

v-raf murine sarcoma viral oncogene homolog B

v-raf murine sarcoma viral oncogene homolog B1

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib Inhibitor 99.92% Yes
HY-14660 Dabrafenib Inhibitor 99.94% Yes
HY-12057 Vemurafenib Inhibitor 99.85% Yes
HY-10331 Regorafenib Inhibitor 99.93% Yes
HY-10201A Sorafenib Tosylate Inhibitor 99.91% Yes
HY-14660A Dabrafenib Mesylate Inhibitor 99.95% Yes
HY-10331A Regorafenib monohydrate Inhibitor 99.96% Yes
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% Yes
HY-10331B Regorafenib mesylate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Phase
HY-10320 Doramapimod Inhibitor 99.98% Phase 2
HY-112089 Naporafenib Inhibitor 99.86% Phase 2
HY-109080 Belvarafenib Inhibitor 99.71% Phase 2
HY-18972 Plixorafenib Inhibitor 99.94% Phase 2
HY-153341 CFT1946 Degrader 99.84% Phase 2
HY-111940 LUT014 Inhibitor 97.23% Phase 2
HY-18652 Avutometinib Inhibitor 99.02% Phase 1
HY-12558 LY3009120 Inhibitor 98.66% Phase 1
HY-18957 Lifirafenib Inhibitor 98.73% Phase 1
HY-15200 Agerafenib Inhibitor 99.63% Phase 1
HY-15199 Agerafenib hydrochloride Inhibitor / Phase 1
HY-19343 XL-281 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (45)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10966 SB-590885 Inhibitor 99.77% Unkown
HY-51424 PLX-4720 Inhibitor 99.91% Unkown
HY-50864 GDC-0879 Inhibitor 99.69% Unkown
HY-11004 AZ 628 Inhibitor 99.85% Unkown
HY-18997 PLX7904 Inhibitor 98.94% Unkown
HY-12846 CCT196969 Inhibitor 99.36% Unkown
HY-14177 Raf inhibitor 1 Inhibitor 98.11% Unkown
HY-137487 PROTAC BRAF-V600E degrader-1 Inhibitor 98.02% Unkown
HY-107779 BI-882370 Inhibitor 99.16% Unkown
HY-12787 L-779450 Inhibitor 98.75% Unkown
HY-100510 RAF709 Inhibitor 99.45% Unkown
HY-77113 B-Raf IN 11 Inhibitor 99.55% Unkown
HY-147405 Tinlorafenib Inhibitor 98.20% Unkown
HY-10247 BRAF inhibitor Inhibitor 98.97% Unkown
HY-12291 HG6-64-1 Inhibitor 99.69% Unkown
HY-145120 B-Raf IN 2 Inhibitor 98.29% Unkown
HY-111758 PROTAC B-Raf degrader 1 Inhibitor 99.78% Unkown
HY-117273 AZ304 Inhibitor 99.96% Unkown
HY-142160 GNE-9815 Inhibitor 98.28% Unkown
HY-148059 Uplarafenib Inhibitor 99.15% Unkown
HY-18227 B-Raf IN 1 Inhibitor 99.94% Unkown
HY-15198 KG5 Inhibitor 99.79% Unkown
HY-18507 AD57 Inhibitor 98.08% Unkown
HY-126298 RAF mutant-IN-1 Inhibitor / Unkown
HY-115933 EGFR/BRAF-IN-1 Inhibitor / Unkown
HY-147854 B-Raf IN 9 Inhibitor / Unkown
HY-144271 RAF-IN-1 Inhibitor / Unkown
HY-147853 B-Raf IN 8 Inhibitor / Unkown
HY-162873 MEK/RAF-IN-1 Inhibitor / Unkown
HY-168512 BRAFV600E-IN-1 Inhibitor / Unkown
HY-146492 VEGFR-2/BRAF-IN-2 Inhibitor / Unkown
HY-13810 PF-04880594 Inhibitor / Unkown
HY-146491 VEGFR-2/BRAF-IN-1 Inhibitor / Unkown
HY-16063 ARQ-736 Inhibitor / Unkown
HY-144269 SHR902275 Inhibitor / Unkown
HY-147852 B-Raf IN 7 Inhibitor / Unkown
HY-137488 PROTAC BRAF-V600E degrader-2 Inhibitor / Unkown
HY-150250 B-Raf IN 13 Inhibitor / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-18318 Takeda-6D Inhibitor / Unkown
HY-12847 CCT241161 Inhibitor / Unkown
HY-164530 SKLB646 Inhibitor / Unkown
HY-14177A Raf inhibitor 1 dihydrochloride Inhibitor / Unkown
HY-120676 B-Raf IN 18 Inhibitor / Unkown
HY-164529 SJ-C1044 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Braf NCBI NCBI:673