2. Gene
  3. Keap1 - Kelch-like ECH-associated protein 1 Gene

Keap1 - Kelch-like ECH-associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Inrf2

Gene ID: 117519 | Gene type: protein coding

About Keap1

Primary_assembly 8: 19,768,375-19,777,862 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 189 orthologues, 53 paralogues and is associated with 28 phenotypes. Biased expression in Muscle (RPKM 121.2), Adrenal (RPKM 18.2) and 9 other tissues.

Summary

Predicted to enable disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including regulation of gene expression; response to thyroid hormone; and selenium compound metabolic process. Located in several cellular components, including adherens junction; focal adhesion; and nucleus. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Keap1 Products(1)

mRNA Protein Name
NM_057152.2 NP_476493.2 kelch-like ECH-associated protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11439354 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to carbohydrate stimulus IDA
IDA: Inferred from direct assay
20026152 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11439354 RGD
involved in cytoplasmic sequestering of transcription factor IMP
IMP: Inferred from mutant phenotype
11439354 RGD
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
20026152 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11439354 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
17316384 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
22649286 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
22649286 RGD
involved in selenium compound metabolic process IEP
IEP: Inferred from expression pattern
16978024 RGD
Cellular Component GO Annotation Evidence Reference Source
located in adherens junction IDA
IDA: Inferred from direct assay
14506708 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
14506708 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20026152 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Keap1 Protein Structure

BTB_POZ_KLHL19_KEAP1

BTB_POZ_KLHL19_KEAP1: cd18248 (55 - 179)

PHA03098

PHA03098: cl33709 (94 - 598)

Kelch

Kelch: sd00038 (361 - 408)

Kelch

Kelch: sd00038 (412 - 455)

Kelch

Kelch: sd00038 (459 - 502)

Kelch

Kelch: sd00038 (506 - 550)

Kelch

Kelch: sd00038 (553 - 596)

  • 0
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  • 500
  • 624 a.a.
Protein Preferred Names Protein Names

kelch-like ECH-associated protein 1

cytosolic inhibitor of Nrf2

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-13755 Sulforaphane 99.75% Phase 4
Pre-clinical Phase
Bioactive Molecules (71)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100218A RSL3 99.90% Unkown
HY-112675 4-Octyl itaconate Activator 99.98% Unkown
HY-19543 Brusatol 99.89% Unkown
HY-101140 KI696 Inhibitor 99.26% Unkown
HY-110258 ML334 Activator 99.76% Unkown
HY-134205A CBR-470-1 Activator 98.03% Unkown
HY-111126 K67 Activator 98.43% Unkown
HY-145879 Nrf2 activator-2 Activator 98.92% Unkown
HY-120371 CPUY192018 Inhibitor 98.99% Unkown
HY-13755A (R)-Sulforaphane 99.48% Unkown
HY-W009731 Dibenzoylmethane Activator ≥98.0% Unkown
HY-110275 RA839 98.54% Unkown
HY-131592 Tricetin 99.19% Unkown
HY-149508 Nrf2-IN-3 99.19% Unkown
HY-B0854 Mancozeb / Unkown
HY-139047 SW157765 Inhibitor 98.67% Unkown
HY-101140A KI696 isomer Inhibitor 99.32% Unkown
HY-149010 NXPZ-2 Inhibitor / Unkown
HY-100218C (1R,3R)-RSL3 Control 99.52% Unkown
HY-P1328 TAT-14 Activator 99.66% Unkown
HY-122054A BPK-29 hydrochloride Inhibitor 98.28% Unkown
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% Unkown
HY-110258B (R,S,R)-ML334 Control 98.57% Unkown
HY-139620A MS83 epimer 1 98.36% Unkown
HY-122054 BPK-29 Inhibitor 99.4% Unkown
HY-121523 MIND4-17 Activator 99.93% Unkown
HY-139620 MS83 Chemical / Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-151362 Keap1-Nrf2-IN-14 Inhibitor / Unkown
HY-162152 biKEAP1 Inhibitor / Unkown
HY-RS07230 KEAP1 Human Pre-designed siRNA Set A / Unkown
HY-112675S 4-Octyl itaconate-13C5-1 / Unkown
HY-124834 Nrf2 activator-10 / Unkown
HY-124941 7-Deacetylgedunin Activator / Unkown
HY-139862 Keap1-Nrf2-IN-3 Inhibitor / Unkown
HY-141439 TBE 31 Activator / Unkown
HY-143892 Keap1-Nrf2-IN-5 Inhibitor / Unkown
HY-143893 Keap1-Nrf2-IN-6 Inhibitor / Unkown
HY-144099 Keap1-Nrf2-IN-4 / Unkown
HY-146577 Keap1-Nrf2-IN-7 Inhibitor / Unkown
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / Unkown
HY-147924 Keap1-Nrf2-IN-11 Inhibitor / Unkown
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / Unkown
HY-150578 Keap1-Nrf2-IN-12 Inhibitor / Unkown
HY-155997 Anti-inflammatory agent 56 Inhibitor / Unkown
HY-156065 S217879 Activator / Unkown
HY-157928 Keap1-Nrf2-IN-18 Inhibitor / Unkown
HY-157929 Keap1-Nrf2-IN-19 Inhibitor / Unkown
HY-159495 Keap1-Nrf2-IN-21 / Unkown
HY-160876 BC-1901S Activator / Unkown
HY-161643 S21-1011 / Unkown
HY-168065 Keap1-Nrf2-IN-22 Inhibitor / Unkown
HY-168161 Keap1-Nrf2-IN-23 Inhibitor / Unkown
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / Unkown
HY-168640 RIP3 activator 1 / Unkown
HY-168709 Nrf2 activator 18 Activator / Unkown
HY-169315 Nrf2 activator 17 Activator / Unkown
HY-170301 Keap1-IN-1 Inhibitor / Unkown
HY-171035 PRL-295 Inhibitor / Unkown
HY-N10313 Dehydrobruceine B / Unkown
HY-N8160 Dehydrocurdione / Unkown
HY-P10530 Nrf2 (69-84) / Unkown
HY-P1328A TAT-14 TFA Activator / Unkown
HY-P5480 Keap1-Nrf2-IN-16 / Unkown
HY-P5909 Keap1-Nrf2 probe / Unkown
HY-P5909F FITC-labelled Keap1-Nrf2 probe / Unkown
HY-RS07231 Keap1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07232 Keap1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-147548 Keap1-Nrf2-IN-10 Inhibitor / Unkown
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / Unkown
HY-W505984 TPNA10168 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Keap1 NCBI NCBI:9817
Mus musculus Keap1 NCBI NCBI:50868