KEAP1 - kelch like ECH associated protein 1 Gene

Homo sapiens

Also known as INrf2; KLHL19

Gene ID: 9817 | Gene type: protein coding

About KEAP1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,486,125-10,503,356 (from NCBI)

This gene has 10 transcripts (splice variants), 189 orthologues, 54 paralogues and is associated with 94 phenotypes. Ubiquitous expression in kidney (RPKM 10.4), prostate (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

KEAP1 Products(6)

mRNA	Protein	Name
XM_011528452.2	XP_011526754.1	kelch-like ECH-associated protein 1 isoform X1
NM_203500.2	NP_987096.1	kelch-like ECH-associated protein 1
XM_005260174.2	XP_005260231.1	kelch-like ECH-associated protein 1 isoform X1
XM_005260173.2	XP_005260230.1	kelch-like ECH-associated protein 1 isoform X1
NM_012289.4	NP_036421.2	kelch-like ECH-associated protein 1
XM_047439788.1	XP_047295744.1	kelch-like ECH-associated protein 1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17015834	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15601839	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	17015834	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	15572695	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	15601839	GOA
involved in negative regulation of response to oxidative stress	IDA IDA: Inferred from direct assay	15601839	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17015834	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15601839	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	20452972	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15572695	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	15601839	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15601839	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	20452972	GOA
located in midbody	IDA IDA: Inferred from direct assay	15166316	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KEAP1 Protein Structure

BTB

BACK

Kelch_1

0
100
200
300
400
500
624 a.a.

Protein Preferred Names

Protein Names

kelch-like ECH-associated protein 1

KEAP1 delta C	cytosolic inhibitor of Nrf2
kelch-like family member 19	kelch-like protein 19

KEAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KEAP1	Q14145	ATG5	Homo sapiens	A9UGY9	Validated Y2H	25416956
Intra	KEAP1	Q14145	GYPA	Homo sapiens	B8Q183	Y2H Array	25416956
Intra	KEAP1	Q14145	PTMA	Homo sapiens	P06454-2	Validated Y2H	25416956
Intra	KEAP1	Q14145	PTMA	Homo sapiens	P06454-2	Y2H Array	25416956
Intra	KEAP1	Q14145	KLHL3	Homo sapiens	Q8N4I8	Validated Y2H	25416956
Intra	KEAP1	Q14145	GPErik	Homo sapiens	Q14440	Y2H Array	25416956
Intra	KEAP1	Q14145	GPErik	Homo sapiens	Q14440	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	GPErik	Homo sapiens	Q14440	Validated Y2H	25416956
Intra	KEAP1	Q14145	RECK	Homo sapiens	Q6P9E2	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	RECK	Homo sapiens	Q6P9E2	Validated Y2H	32296183
Intra	KEAP1	Q14145	RECK	Homo sapiens	Q6P9E2	Validated Y2H	25416956
Intra	KEAP1	Q14145	OXR1	Homo sapiens	Q8N573-5	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	OXR1	Homo sapiens	Q8N573-5	Validated Y2H	25416956
Intra	KEAP1	Q14145	ATG5	Homo sapiens	Q9H1Y0	Validated Y2H	32296183
Intra	KEAP1	Q14145	ATG5	Homo sapiens	Q9H1Y0	Y2H Array	32296183
Intra	KEAP1	Q14145	ERICH5	Homo sapiens	Q6P6B1	Validated Y2H	32296183
Intra	KEAP1	Q14145	C2orf68	Homo sapiens	Q2NKX9	Validated Y2H	32296183
Intra	KEAP1	Q14145	PRKAG1	Homo sapiens	P54619	Validated Y2H	25416956
Intra	KEAP1	Q14145	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	KEAP1	Q14145	GPR151	Homo sapiens	Q8TDV0	Validated Y2H	32296183
Intra	KEAP1	Q14145	IQCC	Homo sapiens	Q4KMZ1	Validated Y2H	32296183
Intra	KEAP1	Q14145	PALB2	Homo sapiens	Q86YC2	Validated Y2H	32296183
Intra	KEAP1	Q14145	STAP2	Homo sapiens	Q9UGK3	Validated Y2H	32296183
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	37187359
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	ITC	18757741
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	16888629
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Tag CoIP	18757741
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	mRNA Display	31169361
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Pull Down	16888629
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Tag CoIP	31262713
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	X-Ray Diffraction	16888629
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Phage Display	39009827
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Y2H	21988832
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	SPR	31169361
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	19706542
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Pull Down	31169361
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	29792731
Intra	KEAP1	Q14145	ASTN1	Homo sapiens	O14525-2	Pull Down	31169361
Intra	KEAP1	Q14145	ASTN1	Homo sapiens	O14525-2	mRNA Display	31169361
Intra	KEAP1	Q14145	ASTN1	Homo sapiens	O14525-2	SPR	31169361
Intra	KEAP1	Q14145	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	32296183
Intra	KEAP1	Q14145	NIBAN2	Homo sapiens	Q96TA1	Anti Tag CoIP	31262713
Intra	KEAP1	Q14145	NIBAN2	Homo sapiens	Q96TA1	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	NFE2L1	Homo sapiens	Q14494	Phage Display	35044719
Intra	KEAP1	Q14145	NFE2L1	Homo sapiens	Q14494	FPS	35044719
Intra	KEAP1	Q14145	PLEC	Homo sapiens	Q15149	FPS	35044719
Intra	KEAP1	Q14145	PLEC	Homo sapiens	Q15149	Phage Display	35044719
Intra	KEAP1	Q14145	ITGB2	Homo sapiens	P05107	Y2H Array	32814053
Intra	KEAP1	Q14145	ITGB2	Homo sapiens	P05107	Y2H Pooling	32814053
Intra	KEAP1	Q14145	ITGB2	Homo sapiens	P05107	Validated Y2H	32814053
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Validated Y2H	25416956
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Pull Down	20452972
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20452972
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	39009827
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20173742
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Confocal	20452972
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	FPS	39009827
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	mRNA Display	31169361
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	34591642
Intra	KEAP1	Q14145	WHRN	Homo sapiens	Q9P202	Validated Y2H	32296183
Intra	KEAP1	Q14145	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	KEAP1	Q14145	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	KEAP1	Q14145	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	KEAP1	Q14145	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	25416956
Intra	KEAP1	Q14145	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32296183
Intra	KEAP1	Q14145	NUDT4	Homo sapiens	Q9NZJ9	Y2H Array	25416956
Cross	KEAP1	Q14145	Ikbkb	Mus musculus	O88351	Y2H	20600852
Intra	KEAP1	Q14145	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	KEAP1	Q14145	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	KEAP1	Q14145	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	KEAP1	Q14145	IFIH1	Homo sapiens	Q9BYX4	Validated Y2H	32296183
Intra	KEAP1	Q14145	GYPA	Homo sapiens	P02724	Y2H Array	31515488
Intra	KEAP1	Q14145	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	KEAP1	Q14145	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Validated Y2H	32296183
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Anti Tag CoIP	34591642
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KEAP1	Q14145	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KEAP1	Q14145	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Anti Tag CoIP	21988832
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Confocal	21988832
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Y2H	21988832
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Y2H Array	21988832
Intra	KEAP1	Q14145	TSC22D4	Homo sapiens	Q9Y3Q8	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	ZSCAN32	Homo sapiens	Q9NX65	Validated Y2H	25416956
Intra	KEAP1	Q14145	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	KEAP1	Q14145	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	31515488
Intra	KEAP1	Q14145	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	KEAP1	Q14145	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	KEAP1	Q14145	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Validated Y2H	25416956
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Y2H Array	25416956
Intra	KEAP1	Q14145	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Validated Y2H	32296183
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Y2H Array	31515488
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Validated Y2H	25416956
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Y2H Array	31515488
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Y2H Prey Pooling	32296183
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Y2H Array	25416956
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	20600852
Intra	KEAP1	Q14145	IKBKB	Homo sapiens	O14920	Pull Down	20600852
Intra	KEAP1	Q14145	IKBKB	Homo sapiens	O14920	Anti Bait CoIP	20600852
Intra	KEAP1	Q14145	KLHL3	Homo sapiens	Q9UH77	Validated Y2H	32296183
Intra	KEAP1	Q14145	MCMBP	Homo sapiens	Q9BTE3-2	Validated Y2H	32296183
Intra	KEAP1	Q14145	MAPKBP1	Homo sapiens	O60336	Validated Y2H	25416956
Intra	KEAP1	Q14145	MAPKBP1	Homo sapiens	O60336	Y2H Array	25416956
Intra	KEAP1	Q14145	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KEAP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75897	KEAP1 Protein, Human (sf9)	Q14145 (Q2-C624)	≥95%
HY-P75899	KEAP1 Protein, Human (sf9, His-GST)	Q14145 (Q2-C624)	≥95%

KEAP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80732	Keap1 Antibody	WB, IHC-P	Human, Mouse

Related Diseases

Diseases

Alias

Fumarase Deficiency

Fumaric Aciduria	FMRD
Fumarate Hydratase Deficiency	Deficiency, Fumarase

Parkinson Disease 17

PARK17	Parkinson'S Disease 17
Autosomal Dominant Parkinson Disease 17	Parkinson Disease, Type 17

Penis Carcinoma In Situ

Carcinoma In Situ Of Penis	Bowen'S Disease Of Penis
Grade Iii Squamous Intraepithelial Lesion Of Penis	Penile Intraepithelial Neoplasia Grade Iii
Queyrat'S Erythroplasia	Erythroplasia Of Queyrat
Pin - [Penile Intraepithelial Neoplasia]

Diabetes Mellitus

Diabetes

Microphthalmia, Isolated 1

Isolated Microphthalmia 1	MCOP1
Mcop	Anophthalmia, Clinical, Isolated
Microphthalmos, Autosomal Recessive

Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors

Euthyroid Goiter	MNG1
Simple Goiter	Goiter Euthyroid
Goiter, Nontoxic, With Intrathyroidal Calcification	Multinodular Goiter, Adolescent
Familial Multinodular Goiter	Fmng
Familial Mng	Familial Multinodular Goiter Syndrome
Goiter Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors	Goiter Nontoxic With Intrathyroidal Calcification
Goiter Non-Toxic With Intrathyroidal Calcification	Multinodular Goiter Adolescent
Goiter, Multinodular, Type 1, With/Without Sertoli-Leydig Cell Tumors	Endemic Goiter

Trichothiodystrophy 4, Nonphotosensitive

Amish Brittle Hair Brain Syndrome	TTD4
Trichothiodystrophy, Nonphotosensitive 1	Hair-Brain Syndrome
Bids Syndrome	Ttdn1
Abhs	Pollitt Syndrome
Trichothiodystrophy-Neurocutaneous Syndrome	Nonphotosensitive Trichothiodystrophy 4
Trichorrhexis Nodosa Syndrome	Trichothiodystrophy 4, Non-Photosensitive
Trichothiodystrophy Non-Photosensitive 1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Pulmonary Large Cell Neuroendocrine Carcinoma

Large Cell Lung Neuroendocrine Carcinoma

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Malignant Squamous Cell Tumor
Squamous Carcinoma	Squamous Cell Epithelioma
Squamous Cell Skin Cancer	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung	Squamous Cell Lung Carcinoma
Epidermoid Cell Carcinoma Of The Lung	Squamous Cell Lung Cancer

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Large Cell Carcinoma With Rhabdoid Phenotype

Large Cell Lung Carcinoma With Rhabdoid Phenotype

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0005	Curcumin		98.84%	Phase 4
HY-13755	Sulforaphane		99.75%	Phase 4

Pre-clinical Phase

Bioactive Molecules (71)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100218A	RSL3		99.90%	Unkown
HY-112675	4-Octyl itaconate	Activator	99.98%	Unkown
HY-19543	Brusatol		99.89%	Unkown
HY-101140	KI696	Inhibitor	99.26%	Unkown
HY-110258	ML334	Activator	99.76%	Unkown
HY-134205A	CBR-470-1	Activator	98.03%	Unkown
HY-111126	K67	Activator	98.43%	Unkown
HY-145879	Nrf2 activator-2	Activator	98.92%	Unkown
HY-120371	CPUY192018	Inhibitor	98.99%	Unkown
HY-13755A	(R)-Sulforaphane		99.48%	Unkown
HY-W009731	Dibenzoylmethane	Activator	≥98.0%	Unkown
HY-110275	RA839		98.54%	Unkown
HY-131592	Tricetin		99.19%	Unkown
HY-149508	Nrf2-IN-3		99.19%	Unkown
HY-B0854	Mancozeb		/	Unkown
HY-139047	SW157765	Inhibitor	98.67%	Unkown
HY-101140A	KI696 isomer	Inhibitor	99.32%	Unkown
HY-149010	NXPZ-2	Inhibitor	/	Unkown
HY-100218C	(1R,3R)-RSL3	Control	99.52%	Unkown
HY-P1328	TAT-14	Activator	99.66%	Unkown
HY-122054A	BPK-29 hydrochloride	Inhibitor	98.28%	Unkown
HY-150579	Keap1-Nrf2-IN-13	Inhibitor	96.77%	Unkown
HY-110258B	(R,S,R)-ML334	Control	98.57%	Unkown
HY-139620A	MS83 epimer 1		98.36%	Unkown
HY-122054	BPK-29		99.4%	Unkown
HY-121523	MIND4-17	Activator	99.93%	Unkown
HY-139620	MS83	Chemical	/	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-151362	Keap1-Nrf2-IN-14	Inhibitor	/	Unkown
HY-162152	biKEAP1	Inhibitor	/	Unkown
HY-RS07230	KEAP1 Human Pre-designed siRNA Set A		/	Unkown
HY-112675S	4-Octyl itaconate-13C5-1		/	Unkown
HY-124834	Nrf2 activator-10		/	Unkown
HY-124941	7-Deacetylgedunin	Activator	/	Unkown
HY-139862	Keap1-Nrf2-IN-3	Inhibitor	/	Unkown
HY-141439	TBE 31	Activator	/	Unkown
HY-143892	Keap1-Nrf2-IN-5	Inhibitor	/	Unkown
HY-143893	Keap1-Nrf2-IN-6	Inhibitor	/	Unkown
HY-144099	Keap1-Nrf2-IN-4		/	Unkown
HY-146577	Keap1-Nrf2-IN-7	Inhibitor	/	Unkown
HY-146578	Keap1-Nrf2-IN-8	Inhibitor	/	Unkown
HY-147924	Keap1-Nrf2-IN-11	Inhibitor	/	Unkown
HY-149245	Keap1-Nrf2-IN-15	Inhibitor	/	Unkown
HY-150578	Keap1-Nrf2-IN-12	Inhibitor	/	Unkown
HY-155997	Anti-inflammatory agent 56	Inhibitor	/	Unkown
HY-156065	S217879	Activator	/	Unkown
HY-157928	Keap1-Nrf2-IN-18	Inhibitor	/	Unkown
HY-157929	Keap1-Nrf2-IN-19	Inhibitor	/	Unkown
HY-159495	Keap1-Nrf2-IN-21		/	Unkown
HY-160876	BC-1901S	Activator	/	Unkown
HY-161643	S21-1011		/	Unkown
HY-168065	Keap1-Nrf2-IN-22	Inhibitor	/	Unkown
HY-168161	Keap1-Nrf2-IN-23	Inhibitor	/	Unkown
HY-168526	Keap1-Nrf2-IN-24	Inhibitor	/	Unkown
HY-168640	RIP3 activator 1		/	Unkown
HY-168709	Nrf2 activator 18	Activator	/	Unkown
HY-169315	Nrf2 activator 17	Activator	/	Unkown
HY-170301	Keap1-IN-1	Inhibitor	/	Unkown
HY-171035	PRL-295	Inhibitor	/	Unkown
HY-N10313	Dehydrobruceine B		/	Unkown
HY-N8160	Dehydrocurdione		/	Unkown
HY-P10530	Nrf2 (69-84)		/	Unkown
HY-P1328A	TAT-14 TFA	Activator	/	Unkown
HY-P5480	Keap1-Nrf2-IN-16		/	Unkown
HY-P5909	Keap1-Nrf2 probe		/	Unkown
HY-P5909F	FITC-labelled Keap1-Nrf2 probe		/	Unkown
HY-RS07231	Keap1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07232	Keap1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-147548	Keap1-Nrf2-IN-10	Inhibitor	/	Unkown
HY-162096	Keap1-Nrf2-IN-17	Inhibitor	/	Unkown
HY-W505984	TPNA10168	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KEAP1	MGD	MGI:1858732
Felis catus	KEAP1	VGNC	VGNC:63076
Macaca mulatta	KEAP1	VGNC	VGNC:73891
Canis familiaris	KEAP1	VGNC	VGNC:42332
Rattus norvegicus	KEAP1	RGD	RGD:621619
Bos taurus	KEAP1	VGNC	VGNC:30537
Others	KEAP1	NCBI

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