2. Gene
  3. Fap - fibroblast activation protein Gene

Fap - fibroblast activation protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SIMP

Gene ID: 14089 | Gene type: protein coding

About Fap

Summary

This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]

Fap Products(1)

mRNA Protein Name
NM_007986.3 NP_032012.1 prolyl endopeptidase FAP
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
9688278 MGI
Biological Process GO Annotation Evidence Reference Source
involved in melanocyte apoptotic process IDA
IDA: Inferred from direct assay
15133496 MGI
involved in melanocyte proliferation IDA
IDA: Inferred from direct assay
15133496 MGI
involved in negative regulation of cell proliferation involved in contact inhibition IDA
IDA: Inferred from direct assay
15133496 MGI
involved in positive regulation of execution phase of apoptosis IDA
IDA: Inferred from direct assay
15133496 MGI
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
15133496 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
24038871 MGI
located in basal part of cell IDA
IDA: Inferred from direct assay
24038871 MGI
located in cell surface IDA
IDA: Inferred from direct assay
15133496 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl endopeptidase FAP

FAPalpha

dipeptidyl peptidase FAP

fibroblast activation protein alpha

gelatine degradation protease FAP

integral membrane serine protease

post-proline cleaving enzyme

seprase

serine integral membrane protease

surface-expressed protease

Recombinant Fap Proteins

Cat. No. Product Name Accession Purity
HY-P77934 FAP Protein, Mouse (HEK293, His) P97321-1 (L26-D761) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-P3392 Zilganersen / Phase 3
HY-137331 FAPI-46 98.57% Phase 2
HY-147057 FAP-2286 99.54% Phase 1
HY-147057A FAP-2286 acetate / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99269 Sibrotuzumab ≥95.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (39)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101801 Ac-Gly-BoroPro ≥98.0% Unkown
HY-128643 FAPI-4 98.42% Unkown
HY-145983 Suc-Gly-Pro-AMC 99.16% Unkown
HY-153552A NH2-UAMC1110 TFA Inhibitor 99.89% Unkown
HY-100684 UAMC-1110 Inhibitor 99.58% Unkown
HY-147173 FAPI-74 99.84% Unkown
HY-145938 OncoFAP 99.77% Unkown
HY-47979A FAP-IN-2 TFA Inhibitor 99.92% Unkown
HY-P10131 3BP-3940 99.96% Unkown
HY-136641 NOTA-FAPI Inhibitor 99.26% Unkown
HY-47979 FAP-IN-2 Inhibitor 99.82% Unkown
HY-164316 FT-FAPI-12_9 95.29% Unkown
HY-164725 FAPI-mFS Inhibitor 99.78% Unkown
HY-139401 FAPI-34 99.67% Unkown
HY-164364A DOTAGA.(SA.FAPi)2 TFA Inhibitor 96.81% Unkown
HY-128642 FAPI-2 98.94% Unkown
HY-125366 ARI-3099 / Unkown
HY-P3441A 3BP-4089 TFA 99.64% Unkown
HY-D2363 DOTA.SA.FAPi TFA Inhibitor 99.26% Unkown
HY-P3392A Zilganersen sodium Inhibitor 91.43% Unkown
HY-164316A FT-FAPI-12_9 TFA 99.48% Unkown
HY-172137 FAPI-FUSCC-07 Ligand / Unkown
HY-D2281 [99mTc]Tc-6–1 / Unkown
HY-149860 FAP-IN-1 Inhibitor / Unkown
HY-P3441 3BP-4089 / Unkown
HY-161262 SB03178 Inhibitor / Unkown
HY-103323 Fas C-Terminal Tripeptide Inhibitor / Unkown
HY-146182 FSDD3I / Unkown
HY-153552 NH2-UAMC1110 Inhibitor / Unkown
HY-158326 FAP-IN-4 Inhibitor / Unkown
HY-146180 FSDD0I / Unkown
HY-161074 PNT6555 96.55% Unkown
HY-128642A FAPI-2 TFA 98.05% Unkown
HY-148361 Fluorogen binding modulator-1 / Unkown
HY-146181 FSDD1I / Unkown
HY-170779 DOTA-NI-FAPI-04 Inhibitor / Unkown
HY-163079 AlF-PD-FAPI / Unkown
HY-164364B DOTAGA.(SA.FAPi)2 analogue TFA Inhibitor / Unkown
HY-W668749 3BP-3580 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fap NCBI NCBI:2191
Macaca fascicularis Fap NCBI NCBI:102134935
Rattus norvegicus Fap NCBI NCBI:192203