1. Gene
  2. Il2 - interleukin 2 Gene

Il2 - interleukin 2 Gene

Mus musculus

Also known as Il-2

Gene ID: 16183 | Gene type: protein coding

About Il2

Chromosome 3: 37,174,672-37,180,108 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 89 orthologues and is associated with 95 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Apr 2022]

Il2 Products(1)

mRNA Protein Name
NM_008366.3 NP_032392.1 interleukin-2 precursor

Il2 Protein Structure

IL2

IL2: smart00189 (0 - 167)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

interleukin-2

T-cell growth factor

TCGF

Recombinant Il2 Proteins

Cat. No. Product Name Accession Purity
HY-P7077 IL-2 Protein, Mouse P04351 (A21-Q169) ≥95%
HY-P78151 IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) P04351 (A21-Q169) ≥95%
HY-P78312 IL-2 Protein, Mouse (HEK293, His-Avi) P04351 (A21-Q169) ≥95%
HY-P70646AF Animal-Free IL-2 Protein, Mouse (His) P04351 (A21-Q169) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Il2 NCBI NCBI:3558
Canis familiaris Il2 NCBI NCBI:403989
Macaca fascicularis Il2 NCBI NCBI:102129830
Susscrofa domestica Il2 NCBI
Leporidae Il2 NCBI
Rattus norvegicus Il2 NCBI NCBI:116562
Macaca mulatta Il2 NCBI NCBI:708017