Il2 - interleukin 2 Gene

Mus musculus

Also known as Il-2

Gene ID: 16183 | Gene type: protein coding

About Il2

Chromosome 3: 37,174,672-37,180,108 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 89 orthologues and is associated with 95 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Apr 2022]

Il2 Products(1)

mRNA	Protein	Name
NM_008366.3	NP_032392.1	interleukin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	1588041	MGI
enables cytokine activity	IMP IMP: Inferred from mutant phenotype	12874832	MGI
enables interleukin-2 receptor binding	IDA IDA: Inferred from direct assay	1588041	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell proliferation	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of activated T cell proliferation	IDA IDA: Inferred from direct assay	7584142	MGI
acts upstream of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	1830926	MGI
acts upstream of or within cellular response to biotic stimulus	IDA IDA: Inferred from direct assay	23262141	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	12082633	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	28396406	MGI
acts upstream of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
involved in negative regulation of T-helper 17 cell differentiation	IGI IGI: Inferred from genetic interaction	25642768	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	7589135	MGI
acts upstream of or within negative regulation of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	22968459	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	7584142	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	1830926	MGI
acts upstream of or within positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	1830926	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	1830926	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of or within positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	17213291	MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of or within regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within regulation of T cell homeostatic proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	10485657	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	1830926	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il2 Protein Structure

IL2

0
100
169 a.a.

Protein Preferred Names

Protein Names

interleukin-2

T-cell growth factor

TCGF

Recombinant Il2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7077	IL-2 Protein, Mouse	P04351 (A21-Q169)	≥95%
HY-P78151	IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi)	P04351 (A21-Q169)	≥95%
HY-P78312	IL-2 Protein, Mouse (HEK293, His-Avi)	P04351 (A21-Q169)	≥95%
HY-P70646AF	Animal-Free IL-2 Protein, Mouse (His)	P04351 (A21-Q169)	≥95%

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13756	Tacrolimus		99.93%	Unkown
HY-A0003	Lenalidomide	Inducer	99.95%	Yes
HY-B1046	Clofazimine		99.79%	Unkown
HY-13756A	Tacrolimus monohydrate		99.67%	Yes
HY-B0722	Histamine dihydrochloride	Inhibitor	99.51%	Yes
HY-A0003B	Lenalidomide hemihydrate	Inducer	99.67%	Yes
HY-A0003A	Lenalidomide hydrochloride		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108738	Daclizumab	Inhibitor	95.00%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0594	Deacetylasperulosidic Acid	Inhibitor	99.86%	Phase 4
HY-153220	NX-2127	Inhibitor	99.72%	Phase 1
HY-132304	CC-90005	Inhibitor	99.67%	Phase 1

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99664	Inolimomab	Inhibitor	98.78%	Phase 3
HY-P99499	Cetrelimab		≥99.0%	Phase 3
HY-P99410	Ordesekimab	Inhibitor	95.00%	Phase 2
HY-P99752	Nemvaleukin alfa		99.50%	Phase 2
HY-P99902	Simlukafusp alfa	Inhibitor	95.90%	Phase 2
HY-P99328	Tucotuzumab		≥95.0%	Phase 2
HY-P99728	Melredableukin alfa		/	Phase 2
HY-P99498	Cergutuzumab amunaleukin	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (80)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6607	Tryptanthrin		99.89%	Unkown
HY-138568	HPK1-IN-3	Inhibitor	99.32%	Unkown
HY-110177	SP-100030	Inhibitor	99.86%	Unkown
HY-110117	BIRT 377	Inhibitor	98.07%	Unkown
HY-18303	AMG-47a	Inhibitor	99.34%	Unkown
HY-133987	AP-1/NF-κB activation inhibitor 1	Inhibitor	99.03%	Unkown
HY-131140	BD750	Inhibitor	99.10%	Unkown
HY-113618B	RO2959 monohydrochloride	Inhibitor	98.21%	Unkown
HY-N0600	Ginsenoside F3	Modulator	99.84%	Unkown
HY-134820	MLT-943	Inhibitor	99.77%	Unkown
HY-126328	PKC-theta inhibitor 1	Inhibitor	99.73%	Unkown
HY-119424	SP4206	Inhibitor	98.55%	Unkown
HY-13756S	Tacrolimus-13C,d2		98.36%	Unkown
HY-162734	BRD5075	Inhibitor	98.08%	Unkown
HY-21293	SU5201	Inhibitor	99.45%	Unkown
HY-P3143A	BMSpep-57 hydrochloride	Inhibitor	99.69%	Unkown
HY-106755	Tucaresol	Inhibitor	98.95%	Unkown
HY-P1997	Ferrichrome Iron-free		≥98.0%	Unkown
HY-113618A	RO2959 hydrochloride	Inhibitor	/	Unkown
HY-P1453A	CMD178 TFA	Inhibitor	98.61%	Unkown
HY-112778	NFAT Transcription Factor Regulator-1	Inhibitor	99.37%	Unkown
HY-150051	IL-2-IN-1	Inhibitor	99.95%	Unkown
HY-A0003S	Lenalidomide-d5	Inducer	99.32%	Unkown
HY-P3143	BMSpep-57	Inhibitor	99.84%	Unkown
HY-164756	PKCTheta-IN-2	Inhibitor	99.49%	Unkown
HY-P1453	CMD178	Inhibitor	/	Unkown
HY-100849	JAK 3i	Inhibitor	/	Unkown
HY-108161	LF 1695	Activator	/	Unkown
HY-110113	CTA056	Inhibitor	/	Unkown
HY-112335	Lck Inhibitor III	Inhibitor	/	Unkown
HY-115756	4-Maleimidosalicylic acid		/	Unkown
HY-117843	Ppc-1		/	Unkown
HY-121743	Ro26-4550	Antagonist	/	Unkown
HY-121874	EP009	Inhibitor	/	Unkown
HY-141864	ITK/TRKA-IN-1	Inhibitor	/	Unkown
HY-142648A	(R)-MLT-985	Inhibitor	/	Unkown
HY-145675A	(R)-TCB2		/	Unkown
HY-147504	Anticancer agent 63		/	Unkown
HY-149206	HPK1-IN-33	Inhibitor	/	Unkown
HY-149232	HPK1-IN-35	Inhibitor	/	Unkown
HY-149916	A2AR-antagonist-1	Antagonist	/	Unkown
HY-149917	ITK degrader 1	Degrader	/	Unkown
HY-153952	Immuno modulator-1	Inhibitor	/	Unkown
HY-156149	CYP51/PD-L1-IN-1	Inhibitor	/	Unkown
HY-156150	CYP51/PD-L1-IN-2	Inhibitor	/	Unkown
HY-156151	CYP51/PD-L1-IN-3	Inhibitor	/	Unkown
HY-157569	PD1-PDL1-IN 2		/	Unkown
HY-157838	HMC-B17	Inhibitor	/	Unkown
HY-161389	SP-alkyne	Inhibitor	/	Unkown
HY-163194	Cbl-b-IN-16	Inhibitor	/	Unkown
HY-163496	HPK1-IN-45	Inhibitor	/	Unkown
HY-163747	VEGFR-2-IN-47	Inhibitor	/	Unkown
HY-163849	Mizoribine prodrug-1		/	Unkown
HY-163850	Mizoribine prodrug-2 trifluoroacetate	Inhibitor	/	Unkown
HY-168282	DD205-291	Degrader	/	Unkown
HY-169317	DGKζ-IN-6	Inhibitor	/	Unkown
HY-169318	DGKζ-IN-7	Inhibitor	/	Unkown
HY-N12988	Dihydrobonducellin	Inhibitor	/	Unkown
HY-N1726	cis-Burchellin	Inhibitor	/	Unkown
HY-P3083	N-Myristoyl-Lys-Arg-Thr-Leu-Arg	Inhibitor	/	Unkown
HY-P3736	Myelopeptide-2	Inducer	/	Unkown
HY-P5870	KTX-Sp2	Inhibitor	/	Unkown
HY-RS06728	IL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06729	Il2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06730	Il2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06748	IL2RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06749	IL2RB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06750	IL2RG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-101687	Nosantine racemate		/	Unkown
HY-115464	NC1153		/	Unkown
HY-123187	AS2553627	Inhibitor	/	Unkown
HY-123590	BC12-4	Inhibitor	/	Unkown
HY-132243	NFAT Inhibitor-3	Inhibitor	/	Unkown
HY-13644	Gusperimus		/	Unkown
HY-159902	KRN7000 analog 3	Activator	/	Unkown
HY-161335	HPK1-IN-43		/	Unkown
HY-163902	SP100030 analogue 1	Inhibitor	/	Unkown
HY-A0003S2	Lenalidomide-13C5,15N	Inducer	/	Unkown
HY-N12783	Digitoxigenin-3-O-β-D-quinovoside	Inhibitor	/	Unkown
HY-RS16278	IL2RB Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99680	Keliximab	Inhibitor	98.23%	Unkown
HY-P990086	Vopikitug	Inhibitor	/	Unkown
HY-P990736	Efercoleukin alfa		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il2	NCBI	NCBI:3558
Canis familiaris	Il2	NCBI	NCBI:403989
Macaca fascicularis	Il2	NCBI	NCBI:102129830
Susscrofa domestica	Il2	NCBI
Leporidae	Il2	NCBI
Rattus norvegicus	Il2	NCBI	NCBI:116562
Macaca mulatta	Il2	NCBI	NCBI:708017

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