Max - Max protein Gene

Mus musculus

Also known as bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8

Gene ID: 17187 | Gene type: protein coding

About Max

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; lens; limb cartilage condensation; and liver. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]

Max Products(4)

mRNA	Protein	Name
NM_001146176.2	NP_001139648.1	protein max isoform 2
NM_001361663.2	NP_001348592.1	protein max isoform 3
NM_001361664.2	NP_001348593.1	protein max isoform 4
NM_008558.3	NP_032584.2	protein max isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8521822	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8521822	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9764821	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20434984	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10601024	MGI
acts upstream of or within regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	8521822	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8521822	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Myc-Max complex	IPI IPI: Inferred from physical interaction	20434984	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20434984	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein max

myc-associated factor X	myc-binding novel HLH/LZ protein
protein myn

Max Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Max	P28574	Myc	Mus musculus	P01108	EMSA	9764821
Intra	Max	P28574	Myc	Mus musculus	P01108	Anti Tag CoIP	20946988
Intra	Max	P28574	Myc	Mus musculus	P01108	Y2H Array	20211142
Intra	Max	P28574	Myc	Mus musculus	P01108	Pull Down	20946988

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145723A	MAX-40279 hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12702	10058-F4	Inhibitor	99.77%	Unkown
HY-135969	Glycol chitosan	Inhibitor	61.22%	Unkown
HY-124675	MYCMI-6		98.14%	Unkown
HY-100996	10074-G5	Inhibitor	98.11%	Unkown
HY-100669	Mycro 3	Inhibitor	98.11%	Unkown
HY-122683	sAJM589	Inhibitor	98.34%	Unkown
HY-12703	KSI-3716	Inhibitor	98.94%	Unkown
HY-145723	MAX-40279	Inhibitor	97.10%	Unkown
HY-153064	MAX-10181	Inhibitor	98.07%	Unkown
HY-144878	VPC-70619	Inhibitor	≥99.0%	Unkown
HY-131021	Janelia Fluor® 549, Azide		/	Unkown
HY-150259	MDEG-541	Degrader	98.05%	Unkown
HY-N5072	Desmethylglycitein	Inhibitor	98.98%	Unkown
HY-120115	PARPi-FL	Inhibitor	99.74%	Unkown
HY-134975	NY2267	Inhibitor	98.53%	Unkown
HY-137551	Tiafenacil		99.20%	Unkown
HY-145723C	MAX-40279 hemiadipate	Inhibitor	99.26%	Unkown
HY-130736	Janelia Fluor® 549, SE		/	Unkown
HY-131022	Janelia Fluor® 549 TFA		96.56%	Unkown
HY-133536	PA Janelia Fluor® 549, SE		98.02%	Unkown
HY-147291	VPC-70063		99.92%	Unkown
HY-N6878	Cauloside D		99.69%	Unkown
HY-N6919	Cauloside C	Inhibitor	99.66%	Unkown
HY-N7273	Soyasaponin III	Inducer	99.73%	Unkown
HY-145723B	MAX-40279 hemifumarate	Inhibitor	99.56%	Unkown
HY-125636	Mycro1		/	Unkown
HY-125978	JY-3-094	Inhibitor	/	Unkown
HY-126979	Mycro2		/	Unkown
HY-131023	Janelia Fluor® 549, Maleimide TFA		/	Unkown
HY-131024	Janelia Fluor® 549, Tetrazine		/	Unkown
HY-136784	Rhod-2 potassium		/	Unkown
HY-169334	BDK-IN-1	Inhibitor	/	Unkown
HY-N1228	Soyacerebroside I		/	Unkown
HY-N4074	6"-O-Malonylglycitin		/	Unkown
HY-N6999	Soyasaponin Ac		/	Unkown
HY-P10699	MAX1		/	Unkown
HY-RS08177	MAX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-115796	VU0477886		/	Unkown
HY-115839A	Detajmium L-tartrate		/	Unkown
HY-N12273	Soyasaponin Ae		/	Unkown
HY-W591768	(E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Max	NCBI	NCBI:4149

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