MAX - MYC associated factor X Gene

Homo sapiens

Also known as bHLHd4

Gene ID: 4149 | Gene type: protein coding

About MAX

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:65,006,101-65,102,695 (from NCBI)

This gene has 20 transcripts (splice variants), 283 orthologues and is associated with 89 phenotypes. Ubiquitous expression in spleen (RPKM 18.6), lymph node (RPKM 17.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with Other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and Apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

MAX Products(29)

mRNA	Protein	Name
NM_001271068.2	NP_001257997.1	protein max isoform g
NM_001271069.2	NP_001257998.1	protein max isoform h
NM_001320415.2	NP_001307344.1	protein max isoform i
NM_001407094.1	NP_001394023.1	protein max isoform a
NM_001407095.1	NP_001394024.1	protein max isoform b
NM_001407096.1	NP_001394025.1	protein max isoform j
NM_001407097.1	NP_001394026.1	protein max isoform j
NM_001407098.1	NP_001394027.1	protein max isoform k
NM_001407099.1	NP_001394028.1	protein max isoform l
NM_001407100.1	NP_001394029.1	protein max isoform l
NM_001407101.1	NP_001394030.1	protein max isoform l
NM_001407102.1	NP_001394031.1	protein max isoform l
NM_001407103.1	NP_001394032.1	protein max isoform c
NM_001407104.1	NP_001394033.1	protein max isoform c
NM_001407105.1	NP_001394034.1	protein max isoform i
NM_001407106.1	NP_001394035.1	protein max isoform i
NM_001407107.1	NP_001394036.1	protein max isoform i
NM_001407108.1	NP_001394037.1	protein max isoform m
NM_001407109.1	NP_001394038.1	protein max isoform m
NM_001407110.1	NP_001394039.1	protein max isoform m
NM_001407111.1	NP_001394040.1	protein max isoform n
NM_001407112.1	NP_001394041.1	protein max isoform n
NM_001407113.1	NP_001394042.1	protein max isoform g
NM_001407114.1	NP_001394043.1	protein max isoform o
NM_002382.5	NP_002373.3	protein max isoform a
NM_145112.3	NP_660087.1	protein max isoform b
NM_145113.3	NP_660088.1	protein max isoform c
NM_145114.3	NP_660089.1	protein max isoform d
NM_197957.4	NP_932061.1	protein max isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9399572	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8425218	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15674325	GOA
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8521822	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	26070438	GOA
enables E-box binding	IMP IMP: Inferred from mutant phenotype	16171389	GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8425219	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9184233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9184233	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8521822	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8425218	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8425218	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
part of Mad-Max complex	IPI IPI: Inferred from physical interaction	12553908	GOA
part of Myc-Max complex	IPI IPI: Inferred from physical interaction	12553908	GOA
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	8425219	GOA
located in chromatin	IDA IDA: Inferred from direct assay	12837246	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10723141	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	9399572	GOA
part of protein-DNA complex	IMP IMP: Inferred from mutant phenotype	16171389	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAX Protein Structure

HLH

0
100
160 a.a.

Protein Preferred Names

Protein Names

protein max

class D basic helix-loop-helix protein 4

MAX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAX	P61244	UNC45A	Homo sapiens	Q9H3U1	Y2H Array	31515488
Intra	MAX	P61244	UNC45A	Homo sapiens	Q9H3U1	Y2H Prey Pooling	25416956
Intra	MAX	P61244	VRK3	Homo sapiens	Q8IV63	TAP	25609649
Intra	MAX	P61244	MECP2	Homo sapiens	P51608	TAP	25609649
Intra	MAX	P61244	LIG3	Homo sapiens	P49916	TAP	25609649
Intra	MAX	P61244	FOXK2	Homo sapiens	Q01167	Pull Down	25609649
Intra	MAX	P61244	FOXK2	Homo sapiens	Q01167	TAP	25609649
Intra	MAX	P61244	MGA	Homo sapiens	Q8IWI9	TAP	27705803
Intra	MAX	P61244	MGA	Homo sapiens	Q8IWI9	Anti Tag CoIP	33961781
Intra	MAX	P61244	MGA	Homo sapiens	Q8IWI9	TAP	25609649
Intra	MAX	P61244	MGA	Homo sapiens	Q8IWI9	Y2H	21988832
Intra	MAX	P61244	MGA	Homo sapiens	Q8IWI9	TAP	24981860
Intra	MAX	P61244	MACROH2A1	Homo sapiens	O75367	TAP	25609649
Intra	MAX	P61244	TFAP2A	Homo sapiens	P05549	TAP	25609649
Intra	MAX	P61244	EEF1D	Homo sapiens	P29692	TAP	25609649
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Y2H Prey Pooling	32296183
Intra	MAX	P61244	MYC	Homo sapiens	P01106	PLA	24951594
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Anti Bait CoIP	17418410
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Anti Tag CoIP	20691906
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Y2H Array	32296183
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Anti Tag CoIP	33961781
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Pull Down	9184233
Intra	MAX	P61244	MYC	Homo sapiens	P01106	TAP	27705803
Intra	MAX	P61244	MYC	Homo sapiens	P01106	PLA	18620061
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Y2H	21988832
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Anti Bait CoIP	20691906
Intra	MAX	P61244	MYC	Homo sapiens	P01106	TAP	25609649
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Anti Bait CoIP	12821782
Intra	MAX	P61244	MYC	Homo sapiens	P01106	Anti Bait CoIP	17157259
Intra	MAX	P61244	L3MBTL2	Homo sapiens	Q969R5	Anti Tag CoIP	33961781
Intra	MAX	P61244	L3MBTL2	Homo sapiens	Q969R5	TAP	25609649
Intra	MAX	P61244	L3MBTL2	Homo sapiens	Q969R5	TAP	27705803
Intra	MAX	P61244	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	16189514
Intra	MAX	P61244	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	MAX	P61244	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	MAX	P61244	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	MAX	P61244	E2F6	Homo sapiens	O75461	TAP	27705803
Intra	MAX	P61244	E2F6	Homo sapiens	O75461	Anti Tag CoIP	33961781
Intra	MAX	P61244	E2F6	Homo sapiens	O75461	TAP	25609649
Intra	MAX	P61244	TFDP1	Homo sapiens	Q14186	TAP	25609649
Intra	MAX	P61244	TFDP1	Homo sapiens	Q14186	Anti Tag CoIP	33961781
Intra	MAX	P61244	TFDP1	Homo sapiens	Q14186	TAP	27705803
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	Y2H Prey Pooling	25416956
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	Validated Y2H	25416956
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	Y2H Array	25416956
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	TAP	27705803
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	Anti Tag CoIP	33961781
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	Pull Down	9184233
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	Y2H Pooling	16189514
Intra	MAX	P61244	MXI1	Homo sapiens	P50539	TAP	25609649
Intra	MAX	P61244	MNT	Homo sapiens	Q99583	Anti Tag CoIP	33961781
Intra	MAX	P61244	MNT	Homo sapiens	Q99583	TAP	25609649
Intra	MAX	P61244	MNT	Homo sapiens	Q99583	TAP	27705803
Intra	MAX	P61244	MNT	Homo sapiens	Q99583	Pull Down	9184233
Intra	MAX	P61244	MXD1	Homo sapiens	Q05195	TAP	27705803
Intra	MAX	P61244	MXD1	Homo sapiens	Q05195	Anti Tag CoIP	33961781
Intra	MAX	P61244	XRCC1	Homo sapiens	P18887	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70388	MAX Protein, Human (His)	P61244-2 (M1-S151)	≥95%
HY-P73832	MAX Protein, Human (sf9, His-GST)	P61244-1/NP_002373 (M1-S160)	≥95%

Related Diseases

Diseases

Alias

Hereditary Paraganglioma-Pheochromocytoma Syndromes

Hereditary Pheochromocytoma-Paraganglioma	Hereditary Paraganglioma-Pheochromocytoma
Familial Pheochromocytoma-Paraganglioma	Paragangliomas 2
Paragangliomas 3	Paragangliomas 4
Sdhx-Related Paraganglioma-Pheochromocytoma	Familial Paraganglioma Syndrome
Familial Paraganglioma-Pheochromocytoma Syndromes	Fpgl
Fpgl/Pheo	Paragangliomas 1
Paraganglioma

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome	Common Syndrome
Bap1 Cancer Syndrome	Bap1-Tpds
Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms	Tumor Predisposition Syndrome
Tumor Susceptibility Linked To Germline Bap1 Mutations	Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms
Tumor Predisposition

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Paraganglioma

Chemodectoma	Glomus Body Tumor
Paragangliomas	Carotid Body Paraganglioma
Extra-Adrenal Paraganglioma

Spastic Paraplegia 84, Autosomal Recessive

SPG84	Hereditary Spastic Paraplegia 84
Spastic Paraplegia 84 Autosomal Recessive	Doid:0112347

Spastic Paraplegia 85, Autosomal Recessive

SPG85	Hereditary Spastic Paraplegia 85
Spastic Paraplegia 85 Autosomal Recessive	Doid:0112345

Spastic Paraplegia 86, Autosomal Recessive

SPG86	Hereditary Spastic Paraplegia 86
Spastic Paraplegia 86 Autosomal Recessive	Doid:0112342

Esophagus Leiomyoma

Leiomyoma Of Esophagus

Persistent Generalized Lymphadenopathy

Pgl	Persistant Generalized Lymphadenopathy

Multiple Endocrine Neoplasia, Type Iia

Multiple Endocrine Neoplasia Type 2a	Sipple Syndrome
Multiple Endocrine Neoplasia Type 2	MEN2A
Men2	Ptc Syndrome
Multiple Endocrine Neoplasia, Type 2	Multiple Endocrine Neoplasia Iia
Men 2a	Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia, Type 2a	Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia Ii	Men2 Syndrome
Men-2a Syndrome	Multiple Neoplasia 2a
Multiple Neoplasia Type 2

Duodenal Somatostatinoma

Duodenal Delta Cell Somatostatin Producing Tumor

Duodenal Somatostatin-Producing Neuroendocrine Tumor

Sweeney-Cox Syndrome

SWCOS

Malignant Pheochromocytoma

Pheochromocytoma, Malignant

Adrenal Medulla Cancer

Adrenal Medulla Neoplasm	Adrenal Medulla Tumor
Malignant Neoplasm Of Adrenal Medulla	Malignant Tumor Of The Adrenal Medulla
Adrenal Medulla Carcinoma	Neoplasm Of Adrenal Medulla

Peripheral Nervous System Benign Neoplasm

Autonomic Nervous System Benign Neoplasm

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Paraganglioma And Gastric Stromal Sarcoma

Carney-Stratakis Syndrome	Paraganglioma And Gastrointestinal Stromal Tumor
Carney Dyad	Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma
Paraganglioma And Gist	Carney-Stratakis Dyad
Gist-Paraganglioma Dyad	PGGSS
Paraganglioma, Gastric Stromal Sarcoma	Gastrointestinal Stromal Tumors

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Neurofibromatosis, Type I

Von Recklinghausen Disease	Neurofibromatosis 1
Neurofibromatosis, Type 1	NF1
Neurofibromatosis, Peripheral Type	Neurofibromatosis Type I
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion	Familial Spinal Neurofibromatosis
Fsnf	Peripheral Neurofibromatosis
Von Recklinghausen'S Neurofibromatosis	Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion
Neurofibromatosis Peripheral Type	Von Recklinghausen Syndrome
Neurofibromatosis Type 1	Von Recklinghausen Neuropathy
Nf1 - [Neurofibromatosis Type 1]	Recklinghausen Disease

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145723A	MAX-40279 hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12702	10058-F4	Inhibitor	99.77%	Unkown
HY-135969	Glycol chitosan	Inhibitor	61.22%	Unkown
HY-124675	MYCMI-6		98.14%	Unkown
HY-100996	10074-G5	Inhibitor	98.11%	Unkown
HY-100669	Mycro 3	Inhibitor	98.11%	Unkown
HY-122683	sAJM589	Inhibitor	98.34%	Unkown
HY-12703	KSI-3716	Inhibitor	98.94%	Unkown
HY-145723	MAX-40279	Inhibitor	97.10%	Unkown
HY-153064	MAX-10181	Inhibitor	98.07%	Unkown
HY-144878	VPC-70619	Inhibitor	≥99.0%	Unkown
HY-N5072	Desmethylglycitein	Inhibitor	98.98%	Unkown
HY-131021	Janelia Fluor® 549, Azide		/	Unkown
HY-150259	MDEG-541	Degrader	98.05%	Unkown
HY-120115	PARPi-FL	Inhibitor	99.74%	Unkown
HY-137551	Tiafenacil		99.20%	Unkown
HY-134975	NY2267	Inhibitor	98.53%	Unkown
HY-145723C	MAX-40279 hemiadipate	Inhibitor	99.26%	Unkown
HY-130736	Janelia Fluor® 549, SE		/	Unkown
HY-131022	Janelia Fluor® 549 TFA		96.56%	Unkown
HY-133536	PA Janelia Fluor® 549, SE		98.02%	Unkown
HY-147291	VPC-70063		99.92%	Unkown
HY-N6878	Cauloside D		99.69%	Unkown
HY-N6919	Cauloside C	Inhibitor	99.66%	Unkown
HY-N7273	Soyasaponin III	Inducer	99.73%	Unkown
HY-145723B	MAX-40279 hemifumarate	Inhibitor	99.56%	Unkown
HY-125636	Mycro1		/	Unkown
HY-125978	JY-3-094	Inhibitor	97.04%	Unkown
HY-126979	Mycro2	Inhibitor	/	Unkown
HY-131023	Janelia Fluor® 549, Maleimide TFA		/	Unkown
HY-131024	Janelia Fluor® 549, Tetrazine		/	Unkown
HY-136784	Rhod-2 potassium		/	Unkown
HY-169334	BDK-IN-1	Inhibitor	/	Unkown
HY-169921	c-Myc inhibitor 15	Inhibitor	/	Unkown
HY-N1228	Soyacerebroside I		/	Unkown
HY-N4074	6"-O-Malonylglycitin		/	Unkown
HY-N6999	Soyasaponin Ac		/	Unkown
HY-P10699	MAX1		/	Unkown
HY-RS08177	MAX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-115796	VU0477886		/	Unkown
HY-115839A	Detajmium L-tartrate		/	Unkown
HY-N12273	Soyasaponin Ae		/	Unkown
HY-W591768	(E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MAX	VGNC	VGNC:74667
Rattus norvegicus	MAX	RGD	RGD:621101
Felis catus	MAX	VGNC	VGNC:80920
Canis familiaris	MAX	VGNC	VGNC:43045
Mus musculus	MAX	MGD	MGI:96921
Bos taurus	MAX	VGNC	VGNC:31269
Others	MAX	NCBI

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